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Dietary supplement

Betaine HCl Ingredients & Drug Interactions

by Klaire Labs

Betaine HCl label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Betaine HCl against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Betaine HCl is a dietary supplement by Klaire Labs with 1 active ingredient. Its ingredients are commonly taken for low stomach acid (hypochlorhydria), bloating and gas, indigestion.Based on those ingredients, 36 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Betaine Hydrochloride. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Betaine HCl by Klaire Labs

Ask about any prescription or over-the-counter medication and we check it for interactions with Betaine HCl by Klaire Labs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Betaine HCl by Klaire Labs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Betaine HCl by Klaire Labs contains one active ingredient: betaine hydrochloride. It's meant to increase stomach acid, which the product aims to support digestion and stomach function.

The capsule also contains inactive ingredients—microcrystalline cellulose, hydroxypropyl methylcellulose, water, ascorbyl palmitate, and silicon dioxide—which are fillers and binders.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Betaine Hydrochloride's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: supplemental source of hydrochloric acid.
  • We looked for evidence on: Dyspepsia, Low stomach acid, Hypochlorhydria, Indigestion.
  • The closest evidence on file: Betaine Hydrochloride is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia (Natural Medicines).

We don't have reliable evidence to rate how well betaine HCl works for the conditions it's often sold for—indigestion (dyspepsia), low thyroid function (hypothyroidism), diarrhea, rheumatoid arthritis, food allergies, or hay fever. The data we hold shows insufficient evidence for each.

That doesn't mean it doesn't help; it means the research isn't solid enough for us to say one way or the other.

The evidence, ingredient by ingredient Betaine Hydrochloride

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Betaine HCl can irritate your stomach and is not safe if you have ulcers, gastritis (stomach inflammation), or true acid reflux disease. The hydrochloric acid it produces may worsen ulcers or cause heartburn.

The safety data advises against use during pregnancy and breastfeeding—there isn't enough information to know it's safe in either situation, so talk with your doctor or pharmacist for personalized advice.

Side effects, ingredient by ingredient Betaine Hydrochloride

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Betaine Hydrochloride.
  • The most serious interaction on file is rated Minor.
  • For scale: 36 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications if you take proton pump inhibitors (PPIs), H2-blockers, or antacids. Betaine HCl increases stomach acid, which may make these drugs less effective.

Use the medication checker on this page before you start.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.

Betaine HCl is meant to boost stomach acid for digestion, but the evidence for how well it works isn't established in our data. If you take any medication that lowers stomach acid—PPIs, H2-blockers, or antacids—you'll want to check it against this product first.

And if you have ulcers, gastritis, or reflux, skip it and talk to your pharmacist.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Betaine HCl, straight from the product label.

Brand Klaire Labs
Barcode (UPC) 828054001213
Net contents 100 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Nov 22, 2024
DSLD ID 322253
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Betaine HCl by Klaire Labs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
100
UPC/BARCODE
828054001213
IngredientAmount% DV
Betaine Hydrochloride648 mg--

Other ingredients: Hydroxypropyl Methylcellulose, Water, Microcrystalline Cellulose, Ascorbyl Palmitate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Free of the following common allergens: milk/casein, eggs, fish, shellfish, tree nuts, peanuts, wheat, gluten, soybeans, corn, and yeast. Contains no artificial colors, flavors, or preservatives.

Produced under a strict quality management system in compliance with Good Manufacturing Practices (GMPs) and third-party quality certifications.

Suggested/Recommended/Usage/Directions

Suggested use: 1 capsule, 1 to 2 times daily at the beginning of each meal or as directed by a healthcare professional. Do not chew or open capsules.

Formula

Betaine hydrochloride supplies a supplemental source of hydrochloric acid, an acid.

Each 648 mg capsule is equivalent to a measurement of 10 grains of betaine HCl.

Precautions

This product should only be taken by people who have reduced levels of stomach acid.

Do not use if shrinkwrap is broken or missing.

Caution: If you are pregnant, nursing, have a medical condition, or taking prescription drugs, consult your physician before using this product.

Keep out of reach of children.

Storage

Store in a cool, dry place (59 degrees F-85 degrees F) away from direct light.

FDA Statement of Identity

Dietary Supplement

General Statements

SFI

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Betaine HCl by Klaire Labs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Betaine HCl label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Betaine HCl by Klaire Labs

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.

Betaine Hydrochloride

Interacts with
36 drugs
648 mg per serving

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is l...

Betaine Hydrochloride monograph & interactions

Other (inactive) ingredients: Hydroxypropyl Methylcellulose, Water, Microcrystalline Cellulose, Ascorbyl Palmitate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Betaine HCl by Klaire Labs Drug Interactions

Want to check YOUR meds against Betaine HCl?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
36Drugs
36 Minor

Ingredients driving the most interactions

Betaine Hydrochloride 36

Individual Drug Interactions

The ingredients in Betaine HCl interact with 36 drugs. Click any drug to see the details.

1 of the 1 ingredient in Betaine HCl interact with drugs. Each result below shows which ingredient is responsible. Betaine Hydrochloride

Each ingredient & the kinds of drugs it affects

For each ingredient in Betaine HCl with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Betaine Hydrochloride3 drug types · 36 drugs

Antacids

Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
In human research, betaine hydrochloride increases stomach acidity. Antacids are taken to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with antacids might decrease the effects of the antacids.

Likelihood Possible Evidence D
H2-Blockers

Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
In human research, betaine hydrochloride increases stomach acidity. H2-blockers are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with H2-blockers might decrease the effects of H2-blockers.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
In human research, betaine hydrochloride increases stomach acidity. PPIs are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with PPIs might decrease the effects of PPIs

Likelihood Possible Evidence D
Betaine Hydrochloride full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Betaine HCl, from the product label.

Klaire Labs

See all Klaire Labs products
Name
SFI USA
City
Reno
State
NV
ZipCode
89521
Web Address
Klaire.com
Pharmacist Counseling Corner

Betaine HCl by Klaire Labs: Common Questions

Does Betaine HCl by Klaire Labs interact with any medications?
Yes. Based on its ingredients, Betaine HCl has a known interaction with 36 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Betaine HCl contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Betaine HCl if I have acid reflux or heartburn?
No. Betaine HCl increases stomach acid and is not safe for people with true acid reflux disease. It may also cause heartburn. If you have reflux or gastritis, talk to your pharmacist before considering this product.
Is Betaine HCl safe during pregnancy?
The safety data advises against it during pregnancy. There isn't enough information to know it's safe, so talk with your doctor or pharmacist for personalized advice.
Can I breastfeed while taking Betaine HCl?
Safety during breastfeeding hasn't been established, so the data advises against use. Talk with your doctor or pharmacist to weigh your options.
What is betaine hydrochloride supposed to do?
Betaine HCl is meant to increase stomach acid to support digestion. The product is often sold for indigestion, low thyroid function, diarrhea, and other conditions, but we don't have reliable evidence showing how well it works for any of them.
What are the side effects?
The main concern is stomach irritation. Betaine HCl can irritate the stomach lining and cause heartburn. If you have ulcers or gastritis, it may worsen healing or cause discomfort.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Betaine HCl is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Betaine HCl label
Go deeper

The Full Monographs Behind Betaine HCl’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Betaine Hydrochloride

Interacts with 36 drugs

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is limited and mostly based on tradition rat...

Read the full Betaine Hydrochloride monograph →
Sources

Sources & How We Checked

Betaine HCl's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Betaine Hydrochloride 2 references
  1. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 PubMed
  2. Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032-7. PubMed

See these in context on the Betaine Hydrochloride monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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