Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Big Noise Blue Lemonade Ingredients & Drug Interactions

by Redcon1

Big Noise Blue Lemonade label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Big Noise Blue Lemonade against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Big Noise Blue Lemonade is a dietary supplement by Redcon1 with 8 active ingredients. Its ingredients are commonly taken for constipation (laxative), dry skin (moisturizer), dry, irritated eyes.Based on those ingredients, 1,367 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Rhodiola rosea root extract, Agmatine Sulfate, Huperzine A. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Big Noise Blue Lemonade by Redcon1

Ask about any prescription or over-the-counter medication and we check it for interactions with Big Noise Blue Lemonade by Redcon1 — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Big Noise Blue Lemonade by Redcon1

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 8 of its 8 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Big Noise Blue Lemonade contains 8 active ingredients. Glycerol monostearate and BetaPower (betaine anhydrous) are osmotic agents — they draw water into the intestines and are used to support constipation and athletic performance.

CDP choline (citicoline) and L-Alpha glycerylphosphorylcholine (alpha-GPC) are cholinergic compounds that support brain function and have been studied for cognitive aging and Alzheimer disease. Agmatine sulfate and huperzine A are neurotransmitter modulators; huperzine A blocks the breakdown of acetylcholine to support memory and cognition.

Astragalus is a traditional herb with immunostimulatory properties. Rhodiola rosea root extract is an adaptogenic herb studied for stress, mood, and cognitive function.

The product also contains inactive ingredients including maltodextrin, sucralose, acesulfame-K, disodium phosphate, and silica.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: non-stimulant preworkout pump with mental clarity.
  • We looked for evidence on: Athletic performance, Cognitive function, Memory, Age-related cognitive decline, mental focus, blood flow — and 1 related terms.
  • The strongest evidence on file: Glycerol is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Citicoline is rated "Possibly Effective" for Age-related cognitive decline.
  • Also on file: Huperzine A is rated "Insufficient Reliable Evidence To Rate" for Athletic performance, Memory.

The evidence for these ingredients varies widely. Alpha-GPC is rated possibly effective for Alzheimer disease.

Huperzine A is also rated possibly effective for Alzheimer disease. Glycerol monostearate is rated likely effective for constipation and possibly effective for athletic performance.

BetaPower (betaine anhydrous) is rated effective for homocystinuria (a rare metabolic disorder) and possibly effective for high homocysteine levels. For most other uses — including cognitive function, athletic performance, anxiety, depression, and memory — the evidence we hold is insufficient to rate these ingredients, meaning the studies either don't exist, are too limited, or conflict with each other.

The evidence, ingredient by ingredient Glycerol Citicoline Agmatine Astragalus Rhodiola Alpha-gpc Betaine Anhydrous Huperzine A

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 8 of the 8 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 8 of 8.
  • General safety write-ups exist for 8 of 8.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of these ingredients are generally well tolerated at typical doses, but several carry important cautions. Glycerol can cause bloating, diarrhea, nausea, vomiting, dizziness, and headache at larger doses.

CDP choline and alpha-GPC are generally well tolerated, though alpha-GPC has been rarely associated with stroke with use of at least 2 months and may cause headache, insomnia, dizziness, nausea, and diarrhea. Agmatine, astragalus, and rhodiola are generally well tolerated short-term, but long-term human safety data is limited for all three.

Huperzine A is a pharmacologically active compound that can cause dose-dependent cholinergic side effects — blurred vision, constipation, diarrhea, dizziness, dry mouth, nausea, sweating, and vomiting. CDP choline, agmatine, astragalus, alpha-GPC, and huperzine A all advise against use in pregnancy due to insufficient safety data.

CDP choline and agmatine advise against breastfeeding; astragalus and huperzine A also advise against it. BetaPower safety in breastfeeding is not well established; rhodiola safety data for both pregnancy and breastfeeding is insufficient.

Side effects, ingredient by ingredient Glycerol Citicoline Agmatine Astragalus Rhodiola Alpha-gpc Betaine Anhydrous Huperzine A

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 8 matched ingredients can interact with medications — Huperzine A, Rhodiola, Astragalus, Alpha-gpc, Agmatine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs; diabetes medications; lithium.
  • For scale: 1,368 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Big Noise Blue Lemonade, check if you take any cholinergic drugs or anticholinergic drugs (like scopolamine), blood pressure medications, blood sugar medications, immunosuppressants, lithium, cyclophosphamide, or drugs metabolized by your liver's CYP2C9, CYP3A4, or CYP1A2 enzymes, or P-glycoprotein substrates — huperzine A, rhodiola, agmatine, and astragalus all carry documented interactions with one or more of these drug types. If you take losartan (Cozaar), rhodiola may raise its levels.

Use the medication checker on this page with your exact prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a pre-workout supplement aimed at cognitive support and performance. If you take any blood pressure medication, blood sugar medication, or any drug metabolized by your liver, run this product through the medication checker below first — the interactions are real and could affect how your drugs work.

If you're pregnant or breastfeeding, talk to your doctor or pharmacist before starting it. Huperzine A in particular is a potent compound, so use it with care and medical guidance.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 8 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Big Noise Blue Lemonade, straight from the product label.

Brand Redcon1
Barcode (UPC) 647603261027
Net contents 11.1 Oz(s); 315 Gram(s)
Market status On market
Date entered into DSLD Oct 23, 2020
DSLD ID 236996
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Big Noise Blue Lemonade by Redcon1, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
10.5 Gram(s)
Maximum serving Sizes:
10.5 Gram(s)
Servings per container
30
UPC/BARCODE
647603261027
IngredientAmount% DV
Glycerol Monostearate3 Gram(s)--
CDP Choline250 mg--
Agmatine Sulfate1 Gram(s)--
Astragalus1 Gram(s)--
Rhodiola rosea root extract200 mg--
L-Alpha Glycerylphosphorylcholine300 mg--
BetaPower2.5 Gram(s)--
Huperzine A200 mcg--

Other ingredients: Disodium Phosphate, Sucralose, Acesulfame-K, Maltodextrin, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

The Objective: Non-stimulant preworkout pump with the power of nootropics. The combination brings massive pumps with intense mental clarity and focus.

Blue Lemonade Naturally and artificially flavored

Formulation

Non-stimulant preworkout pump with the power of nootropics.

Pump up the volume, bring the noise Pump

Blood flow/pumps Increase blood oxygen Mental focus

Suggested/Recommended/Usage/Directions

Big Noise Suggested Use: To maximum pre-workout pumps and muscular volume, mix (1) scoop with 4-6 ounces of water 30 minutes prior to training. Do not exceed more than (1) scoop per day.

Precautions

Do not exceed more than (1) scoop per day.

Warning: Keep out of the reach of children.

This product is intended to be consumed by healthy adults 18 years of age or older. Before using this product, seek advice from your pharmacist or physician.

Avoid using this product if you have any pre-existing medical condition including but not limited to: high or low blood pressure, cardiac arrhythmia, stroke, heart, liver or kidney disease, seizure disorder, thyroid disease, psychiatric disease, diabetes, difficulty urinating due to prostate enlargement or if you are taking MAO Inhibitor or any other medication or supplements. Do not use if you are pregnant or nursing, prone to dehydration or exposed to excessive heat. Discontinue use and consult your healthcare professional.

FDA Statement of Identity

Dietary Supplement

Storage

Store at 59-86 degrees Fahrenheit. Protect from light and moisture.

General Statements

Product does not completely fill container. Settling occurs in shipping.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Big Noise Blue Lemonade by Redcon1 label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Big Noise Blue Lemonade label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Big Noise Blue Lemonade by Redcon1

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size10.5 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Glycerol Monostearate

No known
interactions
3 Gram(s) per serving

Glycerol (glycerin) is a sweet, syrupy compound made naturally in the body and widely used in foods, skin products, and medicines. It is well establis...

Glycerol Monostearate monograph & interactions

CDP Choline

No known
interactions
250 mg per serving

Citicoline is a naturally occurring compound involved in making brain cell membranes and the messenger chemical acetylcholine. It is popularly taken f...

CDP Choline monograph & interactions

Agmatine Sulfate

Interacts with
258 drugs
1 Gram(s) per serving

Agmatine is a compound your body makes from the amino acid arginine, and it is sold mainly as a workout and 'pump' supplement. Human evidence for most...

Agmatine Sulfate monograph & interactions

Astragalus

Interacts with
208 drugs
1 Gram(s) per serving

Astragalus is a root used for centuries in traditional Chinese medicine, mainly to support the immune system and help the body cope with stress. While...

Astragalus monograph & interactions

Rhodiola rosea root extract

Interacts with
1,271 drugs
200 mg per serving

Rhodiola is an herb traditionally used to fight fatigue and help the body cope with stress. Some small studies suggest it may modestly reduce fatigue...

Rhodiola rosea root extract monograph & interactions

L-Alpha Glycerylphosphorylcholine

Interacts with
16 drugs
300 mg per serving

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition...

L-Alpha Glycerylphosphorylcholine monograph & interactions

BetaPower

No known
interactions
2.5 Gram(s) per serving

Betaine anhydrous (also called trimethylglycine) is a compound found in foods like beets, spinach, and whole grains, and is sold as a supplement and a...

BetaPower monograph & interactions

Huperzine A

Interacts with
219 drugs
200 mcg per serving Form: Toothed Clubmoss

Huperzine A is a purified compound from a Chinese clubmoss that acts like a mild cholinesterase inhibitor, similar in mechanism to some prescription A...

Huperzine A monograph & interactions

Other (inactive) ingredients: Disodium Phosphate, Sucralose, Acesulfame-K, Maltodextrin, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Big Noise Blue Lemonade by Redcon1 Drug Interactions

Want to check YOUR meds against Big Noise Blue Lemonade?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,367Drugs
831 Moderate 536 Minor

Ingredients driving the most interactions

Rhodiola rosea root extract 1,271
Agmatine Sulfate 258
Huperzine A 219
Astragalus 208
L-Alpha Glycerylphosphorylcholine 16

Individual Drug Interactions

The ingredients in Big Noise Blue Lemonade interact with 1,367 drugs. Click any drug to see the details.

5 of the 8 ingredients in Big Noise Blue Lemonade interact with drugs. Each result below shows which ingredient is responsible. Rhodiola rosea root extract Agmatine Sulfate Huperzine A Astragalus L-Alpha Glycerylphosphorylcholine

Each ingredient & the kinds of drugs it affects

For each ingredient in Big Noise Blue Lemonade with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Rhodiola rosea root extract10 drug types · 1,271 drugs

Antidiabetes Drugs

Theoretically, taking rhodiola with antidiabetes drugs might increase the risk of hypoglycemia.
In vitro and animal research shows that rhodiola extract can decrease blood glucose due to alpha-glucosidase activity.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking rhodiola with antihypertensive drugs might increase the risk of hypotension.
In vitro and animal research shows that rhodiola extract inhibits angiotensin-converting enzyme (ACE) and might lower blood pressure.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP2C9.
In vitro research shows that rhodiola inhibits CYP2C9. This effect is highly variable and appears to be dependent on the rhodiola product studied. Also, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days reduces the metabolism of losartan, a CYP2C9 substrate, by 21% after 4 hours.

Likelihood Possible Evidence B
Immunosuppressants

Theoretically, rhodiola use might interfere with immunosuppressive therapy.
In vitro and animal research show that rhodiola has immunostimulatory effects.

Likelihood Possible Evidence D
Losartan (Cozaar)

Rhodiola might increase the levels and adverse effects of losartan.
A clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days reduces the metabolism of losartan, a CYP2C9 substrate, by 21% after 4 hours.

Likelihood Probable Evidence B
P-Glycoprotein Substrates

Theoretically, rhodiola might increase levels of P-glycoprotein substrates.
In vitro research shows that rhodiola inhibits P-glycoprotein. Theoretically, using rhodiola with P-glycoprotein substrates might increase drug levels and potentially increase the risk of adverse effects.

Likelihood Possible Evidence D
Antidepressant Drugs

Theoretically, rhodiola might increase the risk of adverse effects when taken with antidepressants.
A review of adverse event reports in Poland identified cases of tachyarrhythmias, myalgia, arthralgia, gum pain, restless leg syndrome, swallowing disorders, and changes in consciousness when rhodiola was taken in combination with paroxetine, escitalopram, fluoxetine, sertraline, trazodone, and/or duloxetine.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.
A review of adverse event reports in Poland identified cases of excessive sedation, myoclonus, hypotension, and hallucinations when rhodiola was taken with haloperidol, diazepam, or alprazolam.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
In vitro research shows that rhodiola inhibits CYP1A2. This effect is highly variable and appears to be dependent on the rhodiola product studied. However, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days does not inhibit the metabolism of caffeine, a CYP1A2 substrate.

Likelihood Possible Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
In vitro research shows that rhodiola inhibits CYP3A4. This effect is highly variable and appears to be dependent on the rhodiola product studied. However, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days does not inhibit the metabolism of midazolam, a CYP3A4 substrate.

Likelihood Possible Evidence B
Rhodiola rosea root extract full monograph & interactions

Agmatine Sulfate2 drug types · 258 drugs

Antidiabetes Drugs

Theoretically, agmatine might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal and in vitro research suggest that agmatine has mild hypoglycemic effects.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that agmatine can modestly decrease heart rate and blood pressure.

Likelihood Possible Evidence D
Agmatine Sulfate full monograph & interactions

Huperzine A2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, huperzine A might decrease the effects of anticholinergic drugs.
Huperzine A has acetylcholinesterase (AChE) inhibiting effects. In animal models, huperzine A reversed cognitive deficits induced by scopolamine, an anticholinergic drug.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, concurrent use of huperzine A with cholinergic drugs might increase the effects and side effects of these medications.
Huperzine A can inhibit acetylcholinesterase (AChE) and might cause cumulative effects if used with cholinergic drugs.

Likelihood Possible Evidence B
Huperzine A full monograph & interactions

Astragalus4 drug types · 208 drugs

Antidiabetes Drugs

Theoretically, taking astragalus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research in humans shows that astragalus might have hypoglycemic effects. Theoretically, taking astragalus, especially in combination with other hypoglycemic agents, might increase the risk of hypoglycemia.

Likelihood Probable Evidence A
Cyclophosphamide

Theoretically, astragalus might interfere with cyclophosphamide therapy.
Evidence regarding the effect of astragalus on immunosuppression caused by cyclophosphamide is conflicting. Some animal research suggests that astragalus reverses cyclophosphamide-induced immunosuppression. However, other animal research shows no effect.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, astragalus might interfere with immunosuppressive therapy.
Astragalus seems to stimulate immune function. Theoretically, taking astragalus might decrease the effects of immunosuppressive therapy.

Likelihood Possible Evidence D
Lithium

Theoretically, astragalus might increase levels and adverse effects of lithium.
Animal research suggests that astragalus has diuretic properties. Theoretically, due to this diuretic effect, astragalus might reduce excretion and increase levels of lithium.

Likelihood Probable Evidence D
Astragalus full monograph & interactions

L-Alpha Glycerylphosphorylcholine1 drug type · 16 drugs

Scopolamine (Transderm Scop)

Theoretically, alpha-GPC might decrease the effects of scopolamine.
A small clinical study shows that alpha-GPC can partially counteract the attention and memory impairment effects caused by scopolamine given intramuscularly. Whether alpha-GPC can decrease the beneficial anti-motion sickness effects of the scopolamine patch (Transderm Scop) is unclear.

Likelihood Possible Evidence B
L-Alpha Glycerylphosphorylcholine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Big Noise Blue Lemonade, from the product label.

Redcon1

See all Redcon1 products
Name
Redcon1 Supplements
Street Address
1141 S Rogers Circle Suite 3
City
Boca Raton
State
FL
ZipCode
33487
Phone Number
561-961-8349
Web Address
www.redcon1.com
Pharmacist Counseling Corner

Big Noise Blue Lemonade by Redcon1: Common Questions

Does Big Noise Blue Lemonade by Redcon1 interact with any medications?
Yes. Based on its ingredients, Big Noise Blue Lemonade has a known interaction with 1,367 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Big Noise Blue Lemonade contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant?
The safety data isn't there for most of these ingredients in pregnancy. CDP choline, agmatine, astragalus, rhodiola, alpha-GPC, and huperzine A all advise against use in pregnancy. BetaPower safety in pregnancy also isn't well established. Talk to your doctor or pharmacist before taking it if you're pregnant — they can give you personalized advice based on your situation.
Can I take this while breastfeeding?
Several ingredients advise against breastfeeding use: CDP choline, agmatine, astragalus, alpha-GPC, and huperzine A. BetaPower and rhodiola safety while breastfeeding is not well established. Check with your doctor or pharmacist if you're breastfeeding before starting this product.
Will this cause stomach upset?
It could. Glycerol can cause bloating, diarrhea, nausea, and vomiting, especially in larger amounts. Agmatine, CDP choline, alpha-GPC, BetaPower, and huperzine A can all cause gastrointestinal side effects like nausea, diarrhea, and vomiting in some people. Start with a lower dose and see how you feel.
What is huperzine A and what does it do?
Huperzine A is a compound that blocks the enzyme that breaks down acetylcholine, a brain chemical involved in memory and learning. It's rated possibly effective for Alzheimer disease. It's pharmacologically active, meaning it can cause real side effects like cholinergic effects (blurred vision, dry mouth, nausea, dizziness), so use it carefully and under medical guidance.
Is this for improving workouts or brain function?
It's marketed as a pre-workout, but several ingredients target brain function. Glycerol is possibly effective for athletic performance, while alpha-GPC and huperzine A are studied for cognitive support, particularly Alzheimer disease. Most of the cognitive claims lack strong evidence in our data, though — the evidence is insufficient to rate them for general cognitive health or athletic performance.
Will this interact with my blood pressure or diabetes medication?
Possibly. Rhodiola, agmatine, and astragalus all carry Moderate-severity interactions with blood pressure and blood sugar medications. Using them together could theoretically increase your risk of low blood pressure or low blood sugar. Check your exact medications using the tool on this page, and talk to your pharmacist or doctor before starting — don't skip this step.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Big Noise Blue Lemonade is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Big Noise Blue Lemonade label
Go deeper

The Full Monographs Behind Big Noise Blue Lemonade’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glycerol

Glycerol (glycerin) is a sweet, syrupy compound made naturally in the body and widely used in foods, skin products, and medicines. It is well established as a laxative and a skin and eye moi...

Read the full Glycerol monograph → Herb & supplement monograph

Citicoline

Citicoline is a naturally occurring compound involved in making brain cell membranes and the messenger chemical acetylcholine. It is popularly taken for memory, focus, and brain aging, and s...

Read the full Citicoline monograph → Herb & supplement monograph

Agmatine

Interacts with 258 drugs

Agmatine is a compound your body makes from the amino acid arginine, and it is sold mainly as a workout and 'pump' supplement. Human evidence for most of its claimed benefits is limited and...

Read the full Agmatine monograph → Herb & supplement monograph

Astragalus

Interacts with 208 drugs

Astragalus is a root used for centuries in traditional Chinese medicine, mainly to support the immune system and help the body cope with stress. While early studies are interesting, strong h...

Read the full Astragalus monograph → Herb & supplement monograph

Rhodiola

Interacts with 1,271 drugs

Rhodiola is an herb traditionally used to fight fatigue and help the body cope with stress. Some small studies suggest it may modestly reduce fatigue and improve mood, but the evidence is li...

Read the full Rhodiola monograph → Herb & supplement monograph

Alpha-gpc

Interacts with 16 drugs

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition in people with dementia, but evidence i...

Read the full Alpha-gpc monograph → Herb & supplement monograph

Betaine Anhydrous

Betaine anhydrous (also called trimethylglycine) is a compound found in foods like beets, spinach, and whole grains, and is sold as a supplement and as a prescription medicine for a rare gen...

Read the full Betaine Anhydrous monograph → Herb & supplement monograph

Huperzine A

Interacts with 219 drugs

Huperzine A is a purified compound from a Chinese clubmoss that acts like a mild cholinesterase inhibitor, similar in mechanism to some prescription Alzheimer's drugs. Some small studies sug...

Read the full Huperzine A monograph →
Sources

Sources & How We Checked

Big Noise Blue Lemonade's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 76 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glycerol 8 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Wagner DR. Hyperhydrating with glycerol: implications for athletic performance. J Am Diet Assoc 1999;99:207-12. PubMed
  3. Yu YL, Kumana CR, Lauder IJ, et al. Treatment of acute cortical infarct with intravenous glycerol. A double-blind, placebo-controlled randomized trial. Stroke 1993;24:1119-24. PubMed
  4. Frei A, Cottier C, Wunderlich P, Ludin E. Glycerol and dextran combined in the therapy of acute stroke. A placebo-controlled, double-blind trial with a planned interim analysis. Stroke 1987;18:373-9. PubMed
  5. Balaskas E, Szepietowski JC, Bessis D, Ioannides D, Ponticelli C, Ghienne C, Taberly A, Dupuy P. Randomized, double-blind study with glycerol and paraffin in uremic xerosis. Clin J Am Soc Nephrol. 2011 Apr;6(4):748-52. PubMed
  6. Blanchet-Bardon C, Tadini G, Machado Matos M, Delarue A. Association of glycerol and paraffin in the treatment of ichthyosis in children: an international, multicentric, randomized, controlled, double-blind study. J Eur Acad Dermatol Venereol. 2012 Aug;26 PubMed
  7. Kajita N, Kanamori K, Yamamoto S, Yoshida K. Generalized Urticaria Caused by a Glycerin Enema in an Infant. J Investig Allergol Clin Immunol 2022;32(4):318-319. PubMed
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Citicoline 11 references
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Agmatine 3 references
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Astragalus 13 references
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  9. Tian H, Lu J, He H, et al.The effect of Astragalus as an adjuvant treatment in type 2 diabetes mellitus: A (preliminary) meta-analysis. J Ethnopharmacol. 2016;191:206-215. doi: 10.1016/j.jep.2016.05.062. PubMed
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Rhodiola 13 references
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Alpha-gpc 4 references
  1. Di Perri R, Coppola G, Ambrosio LA, et al. A multicentre trial to the evaluate the efficacy and tolerability of alpha-glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia. J Int Med Res 1991;19:330-41.
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Betaine Anhydrous 11 references
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Huperzine A 13 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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