Major interaction on record — check this product against your medications before combining. Based on 4 of 6 ingredients. Check your meds →
Dietary supplement

Bio Shape Ingredients & Drug Interactions

by Biotivia

Bio Shape label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Bio Shape against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Bio Shape is a dietary supplement by Biotivia with 6 active ingredients. Its ingredients are commonly taken for blood sugar support in type 2 diabetes, weight loss and appetite control, insulin sensitivity.Based on those ingredients, 1,082 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Advantra Z, Capsicum, Chromium Picolinate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Bio Shape by Biotivia

Ask about any prescription or over-the-counter medication and we check it for interactions with Bio Shape by Biotivia — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Bio Shape by Biotivia

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Bio Shape contains 6 active ingredients. Chromium picolinate helps support healthy blood sugar levels.

Caralluma fimbriata is a plant extract traditionally used for appetite. Capsicum (the compound in chili peppers) contains capsaicin, which may help with certain pain conditions and blood sugar.

Advantra Z is a standardized extract of bitter orange that contains a stimulant called synephrine. 7-Keto and Slendesta Potato protein extract round out the blend — the first is a natural compound related to DHEA, the second a plant protein extract.

The product also contains L-leucine as an inactive ingredient (a filler or binder). These inactive ingredients help hold the capsule together but play no active role in the product's effects.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Advanced weight control and appetite suppression.
  • We looked for evidence on: Obesity, Binge eating disorder, Prader-Willi syndrome (PWS), Impaired glucose tolerance (Prediabetes), Diabetes, Metabolic syndrome — and 4 related terms.
  • The strongest evidence on file: Chromium is rated "Possibly Effective" for Diabetes (Natural Medicines).
  • Also on file: Chromium is rated "Possibly Ineffective" for Impaired glucose tolerance (Prediabetes).
  • Also on file: Caralluma is rated "Possibly Ineffective" for Obesity.

The evidence for Bio Shape's ingredients is mixed. Chromium picolinate is likely effective for chromium deficiency and possibly effective for type 2 diabetes, though it's possibly ineffective for prediabetes.

Capsicum is likely effective for nerve pain after shingles (postherpetic neuralgia) and diabetic nerve damage, and possibly effective for cluster headaches and back pain. For the other ingredients, the evidence is much thinner.

Caralluma shows possibly ineffective evidence for weight loss, and there is insufficient reliable evidence for its effects on anxiety or other conditions. For 7-Keto, Slendesta, and Advantra Z (bitter orange), we hold no effectiveness ratings in our data.

The evidence, ingredient by ingredient Chromium Caralluma Bitter Orange Capsicum

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Chromium picolinate is generally well tolerated at typical supplement doses, though high or long-term doses carry risks. Common side effects are rare but include gastrointestinal upset, headaches, insomnia, irritability, and mood changes.

Very rare cases of kidney or liver damage have been reported. Chromium should be avoided in pregnancy and breastfeeding unless a doctor recommends it.

Caralluma is generally well tolerated short-term but may cause abdominal bloating, gas, constipation, or stomach upset in the first two weeks — these usually subside. Safety long-term is not well established.

It should be avoided during pregnancy and breastfeeding. Capsicum is generally well tolerated in food amounts or standard supplement doses but commonly causes burning sensation, heartburn, gas, and nausea.

Bitter orange (Advantra Z) can raise blood pressure and heart rate, particularly with caffeine or other stimulants, and should be avoided in pregnancy and breastfeeding. We have no safety data on file for 7-Keto or Slendesta.

Side effects, ingredient by ingredient Chromium Caralluma Bitter Orange Capsicum

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 3 of the 4 matched ingredients can interact with medications — Chromium, Capsicum, Bitter Orange.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; heart-rhythm medications.
  • For scale: 1,083 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Bio Shape, double-check with your pharmacist if you take monoamine oxidase inhibitors (MAOIs) for depression, midazolam or other sedatives, CYP3A4 substrates (many heart, cholesterol, and immune medications), antidiabetes drugs or insulin, stimulants or caffeine, drugs that affect heart rhythm, dextromethorphan (cough suppressant), blood thinners (anticoagulants) or antiplatelet drugs, levothyroxine (thyroid hormone), theophylline (asthma medication), aspirin, ACE inhibitors (blood pressure medication), or ciprofloxacin (antibiotic). The product contains ingredients checked for interactions with all of these drug types.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Bio Shape is a multi-ingredient product aimed at metabolism and appetite support, but its contents — especially bitter orange — interact with numerous medications and carry cardiovascular cautions. If you take any prescription drug, especially for depression, diabetes, anxiety, heart rhythm, or blood thinning, check your medications on this page before starting.

Talk to your pharmacist or doctor about whether this product fits your health profile.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 22, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Bio Shape, straight from the product label.

Brand Biotivia
Barcode (UPC) 094922172549
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Apr 22, 2016
DSLD ID 58374
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Bio Shape by Biotivia, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
Servings per container
60
UPC/BARCODE
094922172549
IngredientAmount% DV
Chromium Picolinate40 ug--
7-Keto100 mg--
Caralluma fimbriata extract250 mg--
Slendesta Potato protein extract150 mg--
Advantra Z50 mg--
Capsicum3 mg--

Other ingredients: L-Leucine

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Advanced Weight Control

-Advanced combination of carb and fat burners, appetite suppressor, and satiety enhancer for maximum weight control benefits.* -This unique combination promotes thermogenesis and lipolysis.* -Helps maintain normal blood sugar levels and improves metabolism.*

-Manufactured in US facility in accordance with cGMP FDA regulations.

Formula

6 All Natural Ingredients 550MG

V-caps: vegetable hydroxypropyl methylcellulose

FDA Statement of Identity

DIETARY SUPPLEMENT

Seals/Symbols

Vcaps

Formulation

Contains NO animal ingredients, fillers, silica, artificial colors, and NO Magnesium Stearate

-All Natural with NO stimulants.

-non-GMO, gluten-free and preservative-free.

Precautions

WARNING: Keep out of reach of children.

Do not use if outer seal is broken or missing.

Always consult your doctor before taking any dietary supplements.

Brand IP Statement(s)

Slendesta, 7-Keto, Advantra Z are registered trademarks of Kemin Industries, Inc., InterHealth Nutraceuticals, Inc. and NutraTech, Inc. respectively.

FDA Disclaimer Statement

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, or prevent any disease or illness.

Suggested/Recommended/Usage/Directions

Usage Instructions: Take two capsules daily, 1 capsule in the morning and 1 capsule in evening with water 1 hour before meals.

Storage

Storage Instructions: Store in cool dark place or refrigerate. Close tightly.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Bio Shape by Biotivia label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Bio Shape label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Bio Shape by Biotivia

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Chromium Picolinate

Interacts with
178 drugs
40 ug per serving

Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control i...

Chromium Picolinate monograph & interactions

7-Keto

100 mg per serving

Caralluma fimbriata extract

No known
interactions
250 mg per serving

Caralluma fimbriata is an edible succulent plant from India that is marketed mainly as an appetite suppressant and weight-loss aid. Some small studies...

Caralluma fimbriata extract monograph & interactions

Slendesta Potato protein extract

150 mg per serving

Advantra Z

Interacts with
957 drugs
50 mg per serving Form: Synephrine

Bitter orange is a citrus fruit whose extracts contain synephrine, a mild stimulant often added to weight-loss and energy supplements. Evidence that i...

Advantra Z monograph & interactions

Capsicum

Interacts with
239 drugs
3 mg per serving

Capsicum (chili pepper) contains capsaicin, which is best known and best studied as a topical treatment for certain types of pain. Topical capsaicin p...

Capsicum monograph & interactions

Other (inactive) ingredients: L-Leucine. These complete the product’s ingredient list but are not active constituents.

Interaction report

Bio Shape by Biotivia Drug Interactions

Want to check YOUR meds against Bio Shape?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,082Drugs
10 Major 965 Moderate 107 Minor

Ingredients driving the most interactions

Advantra Z 957
Capsicum 239
Chromium Picolinate 178

Individual Drug Interactions

The ingredients in Bio Shape interact with 1,082 drugs. Click any drug to see the details.

3 of the 6 ingredients in Bio Shape interact with drugs. Each result below shows which ingredient is responsible. Advantra Z Capsicum Chromium Picolinate

Each ingredient & the kinds of drugs it affects

For each ingredient in Bio Shape with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Advantra Z13 drug types · 957 drugs

Midazolam (Versed)

Bitter orange might increase blood levels of midazolam.
One small clinical study shows that bitter orange juice can increase midazolam levels, likely through inhibition of cytochrome P450 3A4 (CYP3A4). Theoretically, bitter orange might increase the risk of midazolam-related adverse effects.

Likelihood Probable Evidence B
Monoamine Oxidase Inhibitors (Maois)

Theoretically, taking MAOIs with synephrine-containing bitter orange preparations might increase the hypertensive effects of synephrine, potentially leading to hypertensive crisis.
Bitter orange contains tyramine, octopamine, and synephrine, which are MAO substrates.

Likelihood Probable Evidence D
Antidiabetes Drugs

Theoretically, bitter orange might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Some clinical research shows that drinking a tea containing bitter orange and Indian snakeroot reduces fasting and postprandial glucose levels in patients with type 2 diabetes who are using antidiabetes drugs. However, it is unclear if these effects are due to bitter orange, Indian snakeroot, or the combination. An animal study also shows that p-synephrine in combination with gliclazide , a sulfonylurea, causes an additional 20% to 44% decrease in glucose levels when compared with gliclazide alone.

Likelihood Possible Evidence B
Caffeine

Bitter orange might increase blood pressure and heart rate when taken with caffeine.
Small clinical studies show that taking bitter orange in combination with caffeine can increase blood pressure and heart rate in otherwise healthy normotensive adults. Theoretically, this might increase the risk of serious cardiovascular adverse effects.

Likelihood Possible Evidence B
Colchicine

Bitter orange might affect colchicine levels.
Colchicine is a substrate of P-glycoprotein and cytochrome P450 3A4 (CYP3A4). Bitter orange has been reported to inhibit CYP3A4 and increase levels of CYP3A4 substrates. However, one small clinical study in healthy adults shows that drinking bitter orange juice 240 mL twice daily for 4 days and taking a single dose of colchicine 0.6 mg on the 4th day decreases colchicine peak serum levels by 24%, time to peak serum level by 1 hour, and overall exposure to colchicine by 20%. The clinical significance of this finding is unclear.

Likelihood Possible Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Bitter orange might increase levels of drugs metabolized by CYP3A4.
Small clinical studies suggest that single or multiple doses of freshly squeezed bitter orange juice 200-240 mL can inhibit CYP3A4 metabolism of drugs, causing increased drug levels and potentially increasing the risk of adverse effects. However, the extent of the effect of bitter orange on CYP3A4-mediated drug interactions is unknown. Some evidence suggests that bitter orange selectively inhibits intestinal CYP3A4, but not hepatic CYP3A4. Its effect on P-glycoprotein, which strongly overlaps with CYP3A4 interactions, is unclear. One small clinical study shows that drinking 8 ounces of freshly squeezed bitter orange juice has no effect on cyclosporine, which seems to be more dependent on hepatic CYP3A4 and P-glycoprotein than intestinal CYP3A4.

Likelihood Possible Evidence B
Dextromethorphan (Robitussin Dm, Others)

Bitter orange might increase blood levels of dextromethorphan.
One small clinical study shows that bitter orange juice increases dextromethorphan levels, likely through cytochrome P450 3A4 (CYP3A4) inhibition. Theoretically, bitter orange might increase the risk for dextromethorphan-related adverse effects.

Likelihood Possible Evidence B
Felodipine (Plendil)

Bitter orange might increase blood levels of felodipine.
One small clinical study shows that bitter orange juice increases felodipine levels, likely through cytochrome P450 3A4 (CYP3A4) inhibition. Theoretically, bitter orange might increase the risk for felodipine-related adverse effects.

Likelihood Probable Evidence B
Indinavir (Crixivan)

Bitter orange might increase blood levels of indinavir.
One small clinical study shows that bitter orange juice slightly increases indinavir levels, but this effect is likely to be clinically insignificant. Bitter orange selectively inhibits intestinal cytochrome P450 3A4 (CYP3A4); however, the metabolism of indinavir seems to be more dependent on hepatic CYP3A4. The effect of bitter orange on other protease inhibitors has not been studied.

Likelihood Possible Evidence B
Qt Interval-Prolonging Drugs

Theoretically, bitter orange might have an additive effect when combined with drugs that prolong the QT interval, potentially increasing the risk of ventricular arrhythmias.
One case report suggests that taking bitter orange in combination with other stimulants such as caffeine might prolong the QT interval in some patients.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Bitter orange juice might increase blood levels of sildenafil.
A small clinical study in healthy adult males shows that drinking freshly squeezed bitter orange juice 250 mL daily for 3 days and taking a single dose of sildenafil 50 mg on the 3rd day increases the peak plasma concentration of sildenafil by 18% and the overall exposure to sildenafil by 44%. Theoretically, this may be due to inhibition of cytochrome P450 3A4 by bitter orange.

Likelihood Probable Evidence B
Stimulant Drugs

Theoretically, bitter orange might increase the risk of hypertension and adverse cardiovascular effects when taken with stimulant drugs.
Bitter orange appears to have stimulant effects.

Likelihood Possible Evidence B
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, bitter orange might increase levels of drug metabolized by CYP2D6.
In vitro research shows that octopamine, a constituent of bitter orange, weakly inhibits CYP2D6 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Advantra Z full monograph & interactions

Capsicum6 drug types · 239 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, capsicum may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro research shows that capsicum might increase the effects of antiplatelet drugs. Also, population research shows that capsicum is associated with an increased risk of self-reported bleeding in patients taking warfarin. However, clinical research shows that taking a single dose of capsaicin (Asian Herbex Ltd.), the active ingredient in capsicum, 400-800 mcg orally in combination with aspirin 500 mg does not decrease platelet aggregation when compared with taking aspirin 500 mg alone. Also, there was no notable effect on measures of platelet aggregation with capsaicin. It is unclear whether capsaicin must be used in more than a single dose to affect platelet aggregation.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, taking capsicum with antidiabetes drugs might increase the risk of hypoglycemia.
Preliminary clinical research shows that consuming capsicum 5 grams along with a glucose drink attenuates the rise in plasma glucose after 30 minutes by 21%, decreases the 2-hour postprandial area under the curve of plasma glucose by 11%, and increases the 2-hour postprandial area under the curve of plasma insulin by 58% in healthy individuals when compared with placebo. Other clinical research shows that taking capsicum 5 mg daily for 28 days significantly reduces postprandial blood glucose and insulin levels, but not fasting blood glucose and insulin levels, in patients with gestational diabetes.

Likelihood Possible Evidence B
Aspirin

Theoretically, taking capsicum with aspirin might reduce the bioavailability of aspirin.
Animal research shows that acute or chronic intake of capsicum pepper reduces oral aspirin bioavailability. This has not been shown in humans.

Likelihood Possible Evidence D
Theophylline

Theoretically, taking capsicum with theophylline might increase the levels and adverse effects of theophylline.
In animal research, oral administration of capsicum reduced excretion of theophylline. However, capsicum does not seem to affect the pharmacokinetics of theophylline when administered intravenously.

Likelihood Possible Evidence D
Ace Inhibitors (Aceis)

Theoretically, using topical capsaicin may increase the risk of ACE inhibitor-induced cough.
There is one case report of a topically applied capsaicin cream contributing to the cough reflex in a patient using an ACEI. However, it is unclear if this interaction is clinically significant.

Likelihood Unlikely Evidence D
Ciprofloxacin (Cipro)

Theoretically, taking capsicum with ciprofloxacin might increase levels and adverse effects of ciprofloxacin.
Animal research shows that concomitant use of capsaicin, the active constituent of capsicum, and ciprofloxacin increases the bioavailability of ciprofloxacin by up to 70%.

Likelihood Possible Evidence D
Capsicum full monograph & interactions

Chromium Picolinate5 drug types · 178 drugs

Antidiabetes Drugs

Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Some research shows that taking chromium might lower blood glucose levels, especially in patients with poorly controlled type 2 diabetes.

Likelihood Possible Evidence A
Insulin

Theoretically, concomitant use of chromium and insulin might increase the risk of hypoglycemia.
In clinical research, chromium has been shown to increase insulin sensitivity,

Likelihood Possible Evidence B
Levothyroxine (Synthroid, Others)

Chromium might bind levothyroxine in the intestinal tract and decrease levothyroxine absorption.
Clinical research in healthy volunteers shows that taking chromium picolinate 1000 mcg with levothyroxine 1 mg decreases serum levels of levothyroxine by 17% when compared to taking levothyroxine alone. Advise patients to take levothyroxine at least 30 minutes before or 3-4 hours after taking chromium.

Likelihood Probable Evidence B
Aspirin

Theoretically, aspirin might increase chromium absorption.
Animal research suggests that aspirin may increase chromium absorption and chromium levels in the blood.

Likelihood Possible Evidence D
Nonsteroidal Anti-Inflammatory Drugs (Nsaids)

NSAIDs might increase chromium levels in the body.
Drugs that are prostaglandin inhibitors, such as NSAIDs, seem to increase chromium absorption and retention.

Likelihood Possible Evidence D
Chromium Picolinate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Bio Shape, from the product label.

Biotivia

See all Biotivia products
Name
Vitaspan, LLC
Street Address
2503 N. Harrison St. #311
City
Arlington
State
VA
ZipCode
22207
Phone Number
1-866-459-2773
Web Address
www.biotivia.com
Pharmacist Counseling Corner

Bio Shape by Biotivia: Common Questions

Does Bio Shape by Biotivia interact with any medications?
Yes. Based on its ingredients, Bio Shape has a known interaction with 1,082 medications, including 10 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Bio Shape contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Bio Shape if I'm on thyroid medication?
If you take levothyroxine (Synthroid), you should talk to your pharmacist first. Chromium in this product may reduce how much thyroid hormone your body absorbs — research shows it can lower blood levels by about 17%. Your doctor may need to adjust the timing or dose of your thyroid medication if you add Bio Shape.
What should I watch for if I take this with diabetes medication?
Both chromium and bitter orange (Advantra Z) may lower blood sugar on their own, so combined with diabetes drugs or insulin, there's a risk of low blood sugar (hypoglycemia). Symptoms include shakiness, sweating, confusion, and dizziness. Check your blood sugar more often when you start, and let your doctor know if you see a pattern of lows.
Is Bio Shape safe to take with caffeine or coffee?
The bitter orange in this product can raise blood pressure and heart rate, and doing so alongside caffeine increases that risk. If you drink coffee or take caffeine pills, mention both to your pharmacist before starting Bio Shape, especially if you have high blood pressure or heart concerns.
What side effects might I experience from this product?
The most common are gastrointestinal: upset stomach, gas, bloating, nausea, and heartburn from the capsicum and caralluma. Caralluma side effects typically ease within the first two weeks. Bitter orange may cause headache or dizziness. If you experience chest pain, severe dizziness, or unusual heart symptoms, stop and seek medical attention.
Can I take Bio Shape while pregnant or breastfeeding?
No. Chromium and bitter orange should be avoided during pregnancy and breastfeeding unless a doctor specifically recommends them. Caralluma is advised against during both. We have no safety data on file for the other ingredients. Talk with your OB-GYN or midwife before considering any supplement while pregnant or nursing.
Does chromium in this product actually help with blood sugar or weight loss?
Chromium is likely effective if you're deficient in it and possibly effective for type 2 diabetes in some cases, though research is mixed. For weight loss or prediabetes, the evidence is weak or unhelpful. Caralluma shows possibly ineffective evidence for weight loss. Bio Shape may have other effects, but they're not well established in the data we hold.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Bio Shape label
Go deeper

The Full Monographs Behind Bio Shape’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Chromium

Interacts with 178 drugs

Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control in certain people with type 2 diabetes, b...

Read the full Chromium monograph → Herb & supplement monograph

Caralluma

Caralluma fimbriata is an edible succulent plant from India that is marketed mainly as an appetite suppressant and weight-loss aid. Some small studies suggest it may modestly reduce appetite...

Read the full Caralluma monograph → Herb & supplement monograph

Bitter Orange

Interacts with 957 drugs

Bitter orange is a citrus fruit whose extracts contain synephrine, a mild stimulant often added to weight-loss and energy supplements. Evidence that it works for weight loss or performance i...

Read the full Bitter Orange monograph → Herb & supplement monograph

Capsicum

Interacts with 239 drugs

Capsicum (chili pepper) contains capsaicin, which is best known and best studied as a topical treatment for certain types of pain. Topical capsaicin products are supported by reasonable evid...

Read the full Capsicum monograph →
Sources

Sources & How We Checked

Bio Shape's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 190 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Chromium 53 references
  1. Cerulli J, Grabe DW, Gauthier I, et al. Chromium picolinate toxicity. Ann Pharmacother 1998;32:428-31. PubMed
  2. Urberg M, Zemel MB. Evidence for synergism between chromium and nicotinic acid in the control of glucose tolerance in elderly humans. Metabolism 1987;36:896-9. PubMed
  3. Mohamedshah FY, Moser-Veillon PB, Yamini S, et al. Distribution of a stable isotope of chromium (53Cr) in serum, urine, and breast milk in lactating women. Am J Clin Nutr 1998;67:1250-5. PubMed
  4. Wasser WG, Feldman NS, D'Agati VD. Chronic renal failure after ingestion of over-the-counter chromium picolinate. [letter]. Ann Intern Med 1997;126:410. PubMed
  5. Mertz W. Interaction of chromium with insulin: a progress report. Nutr Rev 1998;56:174-7. PubMed
  6. Anderson RA. Chromium, glucose intolerance and diabetes. J Am Coll Nutr 1998;17:548-55. PubMed
  7. McLeod MN, Gaynes BN, Golden RN. Chromium potentiation of antidepressant pharmacotherapy for dysthymic disorder in 5 patients. J Clin Psych 1999;60:237-40. PubMed
  8. Fowler JF Jr. Systemic contact dermatitis caused by oral chromium picolinate. Cutis 2000;65:116. DOI
  9. Trent LK, Thieding-Cancel D. Effects of chromium picolinate on body composition. J Sports Med Phys Fitness 1995;35:273-80.
  10. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  11. Rabinovitz H, Friedensohn A, Leibovitz A, et al. Effect of chromium supplementation on blood glucose and lipid levels in type 2 diabetes mellitus elderly patients. Int J Vitam Nutr Res 2004;74:178-82. PubMed
  12. Lanca S, Alves A, Vieira AI, et al. Chromium-induced toxic hepatitis. Eur J Intern Med 2002;13:518-20. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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