Biothin Wildcrafted Apple Extract Ingredients & Drug Interactions
by Dr. Mercola
What is this page for?
First and foremost: checking Biothin Wildcrafted Apple Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Biothin Wildcrafted Apple Extract is a dietary supplement by Dr. Mercola with 1 active ingredient. Its ingredients are commonly taken for general nutrition and fiber intake, heart and cholesterol health, blood sugar and weight management.Based on those ingredients, 300 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Apple Fruit Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Biothin Wildcrafted Apple Extract by Dr. Mercola
Ask about any prescription or over-the-counter medication and we check it for interactions with Biothin Wildcrafted Apple Extract by Dr. Mercola — and tell you which ingredient is responsible.
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HelloPharmacist Scorecard of Biothin Wildcrafted Apple Extract by Dr. Mercola
Four independent checks of what is known — a summary of the available information, not a grade of the product itself.
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
None of the active ingredients could be matched to our evidence database, so intended use can't be graded.
Why this rating?
- None of the active ingredients could be matched to a HelloPharmacist monograph, so intended use can't be graded against our evidence data.
Every active ingredient lists its own amount on the label.
Why this rating?
- The label discloses an exact amount for 1 of its 1 active ingredient.
- “Apple Fruit Extract” is listed as a grouped ingredient — the label gives one combined amount (600 mg) without saying how much of each component you get.
None of the active ingredients could be matched to our interaction database.
Why this rating?
- We couldn't match any ingredient to a HelloPharmacist monograph, so there was nothing to check interactions against.
None of the active ingredients could be matched to our safety data.
Why this rating?
- We couldn't match any ingredient to a HelloPharmacist monograph, so there was no safety data to measure.
HelloPharmacist summaryFully disclosed formula with no assessable stated purpose. Medication interactions could not be assessed, and safety information could not be assessed.
Assessment coverage: 0 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Biothin Wildcrafted Apple Extract, straight from the product label.
| Brand | Dr. Mercola |
|---|---|
| Barcode (UPC) | 810094212094 |
| Net contents | 60 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Mar 22, 2024 |
| DSLD ID | 308625 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Biothin Wildcrafted Apple Extract by Dr. Mercola, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Polyphenols | 360 mg | -- |
| Apple Fruit Extract | 600 mg | -- |
Other ingredients: Hydroxypropyl Methylcellulose, Rice Bran
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested use: Adults, as a dietary supplement, take two (2) capsules daily.
Precautions
Keep out of reach of children.
Do not use if safety seal is broken.
If you are nursing, pregnant, taking medication or have a medical condition, consult your physician before taking this product.
Formula
360 mg polyphenols per serving
FDA Statement of Identity
Dietary Supplement
Brand IP Statement(s)
Dr. Mercola Providing quality products since 2001.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Biothin Wildcrafted Apple Extract by Dr. Mercola label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Biothin Wildcrafted Apple Extract by Dr. Mercola
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Apple Fruit Extract
Interacts with300 drugs
Apples are a nutritious whole food that provides fiber, vitamins, and antioxidant plant compounds, and eating them regularly fits well into a healthy...
Apple Fruit Extract monograph & interactions- › Polyphenols
Other (inactive) ingredients: Hydroxypropyl Methylcellulose, Rice Bran. These complete the product’s ingredient list but are not active constituents.
Biothin Wildcrafted Apple Extract by Dr. Mercola Drug Interactions
Biothin Wildcrafted Apple Extract contains a single active ingredient, and it has known interactions with 300 medications. Here’s the picture, then you can look up your own drug.
Want to check YOUR meds against Biothin Wildcrafted Apple Extract?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Biothin Wildcrafted Apple Extract interact with 300 drugs. Click any drug to see the details.
1 of the 1 ingredient in Biothin Wildcrafted Apple Extract interact with drugs. Each result below shows which ingredient is responsible. Apple Fruit Extract
AcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Biothin Wildcrafted Apple Extract — through 1 ingredient. Tap an ingredient for the detail:
Apple Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, consuming apple juice with antidiabetes drugs might interfere with blood glucose control.
Read the full Apple Fruit Extract + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Biothin Wildcrafted Apple Extract — through 1 ingredient. Tap an ingredient for the detail:
Apple Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Consuming apple juice with antihypertensive drugs might interfere with blood pressure control.
Read the full Apple Fruit Extract + Acebutolol interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Biothin Wildcrafted Apple Extract — through 1 ingredient. Tap an ingredient for the detail:
Apple Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Consuming apple juice with antihypertensive drugs might interfere with blood pressure control.
Read the full Apple Fruit Extract + Acetazolamide interactionAcetohexamideDymelor
How Acetohexamide interacts with Biothin Wildcrafted Apple Extract — through 1 ingredient. Tap an ingredient for the detail:
Apple Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, consuming apple juice with antidiabetes drugs might interfere with blood glucose control.
Read the full Apple Fruit Extract + Acetohexamide interactionAlbiglutideTanzeum
How Albiglutide interacts with Biothin Wildcrafted Apple Extract — through 1 ingredient. Tap an ingredient for the detail:
Apple Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, consuming apple juice with antidiabetes drugs might interfere with blood glucose control.
Read the full Apple Fruit Extract + Albiglutide interactionAliskirenTekturna
How Aliskiren interacts with Biothin Wildcrafted Apple Extract — through 1 ingredient. Tap an ingredient for the detail:
Apple Fruit ExtractAntihypertensive Drugs, Aliskiren (tekturna, Rasilez) Moderate
Interaction Summary
Consuming apple juice with antihypertensive drugs might interfere with blood pressure control.
Read the full Apple Fruit Extract + Aliskiren interactionAlogliptinNesina
How Alogliptin interacts with Biothin Wildcrafted Apple Extract — through 1 ingredient. Tap an ingredient for the detail:
Apple Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, consuming apple juice with antidiabetes drugs might interfere with blood glucose control.
Read the full Apple Fruit Extract + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Biothin Wildcrafted Apple Extract — through 1 ingredient. Tap an ingredient for the detail:
Apple Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, consuming apple juice with antidiabetes drugs might interfere with blood glucose control.
Read the full Apple Fruit Extract + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Biothin Wildcrafted Apple Extract — through 1 ingredient. Tap an ingredient for the detail:
Apple Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, consuming apple juice with antidiabetes drugs might interfere with blood glucose control.
Read the full Apple Fruit Extract + Alogliptin, Pioglitazone interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with Biothin Wildcrafted Apple Extract — through 1 ingredient. Tap an ingredient for the detail:
Apple Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Consuming apple juice with antihypertensive drugs might interfere with blood pressure control.
Read the full Apple Fruit Extract + Ambrisentan interactionAmilorideAmilamont, Midamor
How Amiloride interacts with Biothin Wildcrafted Apple Extract — through 1 ingredient. Tap an ingredient for the detail:
Apple Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Consuming apple juice with antihypertensive drugs might interfere with blood pressure control.
Read the full Apple Fruit Extract + Amiloride interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with Biothin Wildcrafted Apple Extract — through 1 ingredient. Tap an ingredient for the detail:
Apple Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Consuming apple juice with antihypertensive drugs might interfere with blood pressure control.
Read the full Apple Fruit Extract + Amiloride, Hydrochlorothiazide interactionAmlodipineNorliqva
How Amlodipine interacts with Biothin Wildcrafted Apple Extract — through 1 ingredient. Tap an ingredient for the detail:
Apple Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Consuming apple juice with antihypertensive drugs might interfere with blood pressure control.
Read the full Apple Fruit Extract + Amlodipine interactionAmlodipine BenzoateKaterzia
How Amlodipine Benzoate interacts with Biothin Wildcrafted Apple Extract — through 1 ingredient. Tap an ingredient for the detail:
Apple Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Consuming apple juice with antihypertensive drugs might interfere with blood pressure control.
Read the full Apple Fruit Extract + Amlodipine Benzoate interactionAmlodipine BesilateIstin
How Amlodipine Besilate interacts with Biothin Wildcrafted Apple Extract — through 1 ingredient. Tap an ingredient for the detail:
Apple Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Consuming apple juice with antihypertensive drugs might interfere with blood pressure control.
Read the full Apple Fruit Extract + Amlodipine Besilate interactionAmlodipine BesylateNorvasc
How Amlodipine Besylate interacts with Biothin Wildcrafted Apple Extract — through 1 ingredient. Tap an ingredient for the detail:
Apple Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Consuming apple juice with antihypertensive drugs might interfere with blood pressure control.
Read the full Apple Fruit Extract + Amlodipine Besylate interactionAmlodipine Besylate, BenazeprilLotrel
How Amlodipine Besylate, Benazepril interacts with Biothin Wildcrafted Apple Extract — through 1 ingredient. Tap an ingredient for the detail:
Apple Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Consuming apple juice with antihypertensive drugs might interfere with blood pressure control.
Read the full Apple Fruit Extract + Amlodipine Besylate, Benazepril interactionAmlodipine, CelecoxibConsensi
How Amlodipine, Celecoxib interacts with Biothin Wildcrafted Apple Extract — through 1 ingredient. Tap an ingredient for the detail:
Apple Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Consuming apple juice with antihypertensive drugs might interfere with blood pressure control.
Read the full Apple Fruit Extract + Amlodipine, Celecoxib interactionAmmonium ChlorideAmmonium Chloride
How Ammonium Chloride interacts with Biothin Wildcrafted Apple Extract — through 1 ingredient. Tap an ingredient for the detail:
Apple Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Consuming apple juice with antihypertensive drugs might interfere with blood pressure control.
Read the full Apple Fruit Extract + Ammonium Chloride interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with Biothin Wildcrafted Apple Extract — through 1 ingredient. Tap an ingredient for the detail:
Apple Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, consuming apple juice with antidiabetes drugs might interfere with blood glucose control.
Read the full Apple Fruit Extract + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionAprocitentanTryvio
How Aprocitentan interacts with Biothin Wildcrafted Apple Extract — through 1 ingredient. Tap an ingredient for the detail:
Apple Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Consuming apple juice with antihypertensive drugs might interfere with blood pressure control.
Read the full Apple Fruit Extract + Aprocitentan interactionAtenololAtenix, Tenormin
How Atenolol interacts with Biothin Wildcrafted Apple Extract — through 1 ingredient. Tap an ingredient for the detail:
Apple Fruit ExtractAntihypertensive Drugs, Atenolol (tenormin) Moderate
Interaction Summary
Consuming apple juice with antihypertensive drugs might interfere with blood pressure control.
Read the full Apple Fruit Extract + Atenolol interactionAtenolol, ChlortalidoneAtenixCo, Tenoret 50, Totaretic
How Atenolol, Chlortalidone interacts with Biothin Wildcrafted Apple Extract — through 1 ingredient. Tap an ingredient for the detail:
Apple Fruit ExtractAntihypertensive Drugs, Atenolol (tenormin) Moderate
Interaction Summary
Consuming apple juice with antihypertensive drugs might interfere with blood pressure control.
Read the full Apple Fruit Extract + Atenolol, Chlortalidone interactionAtenolol, ChlorthalidoneTenoretic
How Atenolol, Chlorthalidone interacts with Biothin Wildcrafted Apple Extract — through 1 ingredient. Tap an ingredient for the detail:
Apple Fruit ExtractAntihypertensive Drugs, Atenolol (tenormin) Moderate
Interaction Summary
Consuming apple juice with antihypertensive drugs might interfere with blood pressure control.
Read the full Apple Fruit Extract + Atenolol, Chlorthalidone interactionAzilsartanEdarbi
How Azilsartan interacts with Biothin Wildcrafted Apple Extract — through 1 ingredient. Tap an ingredient for the detail:
Apple Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Consuming apple juice with antihypertensive drugs might interfere with blood pressure control.
Read the full Apple Fruit Extract + Azilsartan interactionAzilsartan, ChlorthalidoneEdarbyclor
How Azilsartan, Chlorthalidone interacts with Biothin Wildcrafted Apple Extract — through 1 ingredient. Tap an ingredient for the detail:
Apple Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Consuming apple juice with antihypertensive drugs might interfere with blood pressure control.
Read the full Apple Fruit Extract + Azilsartan, Chlorthalidone interactionBenazeprilLotensin
How Benazepril interacts with Biothin Wildcrafted Apple Extract — through 1 ingredient. Tap an ingredient for the detail:
Apple Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Consuming apple juice with antihypertensive drugs might interfere with blood pressure control.
Read the full Apple Fruit Extract + Benazepril interactionBenazepril, HydrochlorothiazideLotensin HCT
How Benazepril, Hydrochlorothiazide interacts with Biothin Wildcrafted Apple Extract — through 1 ingredient. Tap an ingredient for the detail:
Apple Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Consuming apple juice with antihypertensive drugs might interfere with blood pressure control.
Read the full Apple Fruit Extract + Benazepril, Hydrochlorothiazide interactionBendroflumethiazideAprinox, Naturetin, Neo-NaClex
How Bendroflumethiazide interacts with Biothin Wildcrafted Apple Extract — through 1 ingredient. Tap an ingredient for the detail:
Apple Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Consuming apple juice with antihypertensive drugs might interfere with blood pressure control.
Read the full Apple Fruit Extract + Bendroflumethiazide interactionBendroflumethiazide, NadololCorzide
How Bendroflumethiazide, Nadolol interacts with Biothin Wildcrafted Apple Extract — through 1 ingredient. Tap an ingredient for the detail:
Apple Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Consuming apple juice with antihypertensive drugs might interfere with blood pressure control.
Read the full Apple Fruit Extract + Bendroflumethiazide, Nadolol interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Biothin Wildcrafted Apple Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Apple Fruit Extract
Organic Anion-Transporting Polypeptide Substrates (Oatp)
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Research shows that consuming apple juice inhibits OATP, which reduces bioavailability of oral drugs that are substrates of OATP. Fexofenadine, atenolol, and aliskiren are substrates of OATP. Clinical research shows that coadministration of apple juice decreases bioavailability of fexofenadine by up to 78%, aliskiren by 63%, and atenolol by up to 82%. These effects appear to increase with larger quantities of apple juice. It is thought that apple juice might affect OATP for only a short time. Therefore, separating drug administration and consumption of apple juice by at least 4 hours might avoid this interaction.
Aliskiren (Tekturna, Rasilez)
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of aliskiren.
Pharmacokinetic research shows that coadministration of apple juice 200 mL along with aliskiren 150 mg decreases the bioavailability of aliskiren by 63%. Apple juice seems to inhibit organic anion transporting polypeptide (OATP), which is involved in drug uptake in the gut, liver, and kidney. It is thought that apple juice might affect OATP for only a short time. Therefore, separating drug administration and consumption of apple juice by at least 4 hours might avoid this interaction.
Antidiabetes Drugs
Theoretically, consuming apple juice with antidiabetes drugs might interfere with blood glucose control.
Clinical research suggests that consuming apples or drinking apple juice can raise blood glucose levels, with the effects of drinking apple juice being more significant than consuming apples.
Antihypertensive Drugs
Consuming apple juice with antihypertensive drugs might interfere with blood pressure control.
Some clinical evidence suggests that consuming apple and cherry juice can increase blood pressure in elderly patients.
Atenolol (Tenormin)
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of atenolol.
Pharmacokinetic research shows that coadministration of apple juice 600-1200 mL decreases levels of atenolol by 58% to 82% in a dose-dependent manner. Apple juice seems to inhibit organic anion transporting polypeptide (OATP), which is involved in drug uptake in the gut, liver, and kidney. It is thought that apple juice might affect OATP for only a short time. Therefore, separating drug administration and consumption of apple juice by at least 4 hours might avoid this interaction.
Fexofenadine (Allegra)
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of fexofenadine.
Pharmacokinetic research shows that coadministration of apple juice 400-1200 mL along with fexofenadine 60-120 mg decreases bioavailability of fexofenadine by up to 78%. Coadministration with smaller quantities of apple juice (150 mL or less) does not appear to affect the bioavailability of fexofenadine. Apple juice seems to inhibit organic anion transporting polypeptide (OATP), which is involved in drug uptake in the gut, liver, and kidney. It is thought that apple juice might affect OATP for only a short time. Therefore, separating drug administration and consumption of apple juice by at least 4 hours might avoid this interaction.
Lithium
There is some concern that concomitant consumption of apple juice might decrease oral absorption and blood levels of lithium.
In one case report, a patient had an undetectable serum lithium level when lithium citrate was administered with apple juice. When lithium was administered with an alternative beverage, the lithium level became detectable and the patient demonstrated clinical improvement.
Brand information
Manufacturer and brand details for Biothin Wildcrafted Apple Extract, from the product label.
Dr. Mercola
See all Dr. Mercola products- Name
- NHP
- Street Address
- 125 SW 3rd Place
- City
- Cape Coral
- State
- FL
- ZipCode
- 33991
- Phone Number
- (877) 985-2696
Biothin Wildcrafted Apple Extract by Dr. Mercola: Common Questions
Does Biothin Wildcrafted Apple Extract by Dr. Mercola interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Biothin Wildcrafted Apple Extract is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Biothin Wildcrafted Apple Extract’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Biothin Wildcrafted Apple Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 16 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Apple 16 references
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Bailey DG, Dresser GK, Munoz C, et al. Reduction of fexofenadine bioavailability by fruit juices. Clin Pharmacol Ther 2001;69:P21.
- Rodriguez J, Crespo JF, Lopez-Rubio A, et al. Clinical cross-reactivity among foods of the Rosaceae family. J Allergy Clin Immunol 2000;106:183-189. PubMed
- Greenblatt DJ. Analysis of drug interactions involving fruit beverages and organic anion-transporting polypeptides. J Clin Pharmacol 2009;49:1403-7. PubMed
- Bailey DG. Fruit juice inhibition of uptake transport: a new type of food-drug interaction. Br J Clin Pharmacol 2010;70:645-55. PubMed
- Kamath AV, Yao M, Zhang Y, Chong S. Effect of fruit juices on the oral bioavailability of fexofenadine in rats. J Pharm Sci 2005;94:233-9. PubMed
- Tapaninen T, Neuvonen PJ, Niemi M. Orange and apple juice greatly reduce the plasma concentrations of the OATP2B1 substrate aliskiren. Br J Clin Pharmacol 2011;71:718-26. PubMed
- Jeon H, Jang IJ, Lee S, et al. Apple juice greatly reduces systemic exposure to atenolol. Br J Clin Pharmacol 2012 May 11. doi: 10.1111/j.1365-2125.2012.04324.x. [Epub ahead of print]. PubMed
- Visvanathan, R., Chen, R., Horowitz, M., and Chapman, I. Blood pressure responses in healthy older people to 50 g carbohydrate drinks with differing glycaemic effects. Br J Nutr 2004;92(2):335-340. PubMed
- Asp, N. G., Agardh, C. D., Ahren, B., Dencker, I., Johansson, C. G., Lundquist, I., Nyman, M., Sartor, G., and Schersten, B. Dietary fibre in type II diabetes. Acta Med Scand Suppl 1981;656:47-50. PubMed
- Akamine Y, Miura M, Komori H, et al. Effects of one-time apple juice ingestion on the pharmacokinetics of fexofenadine enantiomers. Eur J Clin Pharmacol. 2014 Sep;70(9):1087-95. PubMed
- Luo J, Imai H, Ohyama T, et al. The Pharmacokinetic Exposure to Fexofenadine is Volume-Dependently Reduced in Healthy Subjects Following Oral Administration With Apple Juice. Clin Transl Sci. 2016 Aug;9(4):201-6. PubMed
- Tsiougkos N, Vovolis V. Repeated anaphylactic episodes to orange and apple. Eur Ann Allergy Clin Immunol. 2013 May;45(3):113-5.
- Rubido S, García-Caballero L, Abeleira MT, Limeres J, García M, Diz P. Effect of chewing an apple on dental plaque removal and on salivary bacterial viability. PLoS One. 2018;13(7):e0199812. PubMed
- Krishnasamy S, Lomer MCE, Marciani L, et al. Processing apples to puree or juice speeds gastric emptying and reduces postprandial intestinal volumes and satiety in healthy adults. J Nutr 2020;150(11):2890-9. PubMed
- Awan S, Abelleira A, Khehra L, Hieber R. Undetectable serum lithium concentrations after coadministration of liquid lithium citrate and apple juice: A case report. Ment Health Clin. 2021;11(1):27-30. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC