Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Black Elderberry 450 mg Ingredients & Drug Interactions

by HTP Hi-Tech Pharmaceuticals

Black Elderberry 450 mg label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Black Elderberry 450 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Black Elderberry 450 mg is a dietary supplement by HTP Hi-Tech Pharmaceuticals with 2 active ingredients. Its ingredients are commonly taken for colds, flu (influenza), other respiratory infections.Based on those ingredients, 121 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Black Elderberry extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Black Elderberry 450 mg by HTP Hi-Tech Pharmaceuticals

Ask about any prescription or over-the-counter medication and we check it for interactions with Black Elderberry 450 mg by HTP Hi-Tech Pharmaceuticals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Black Elderberry 450 mg by HTP Hi-Tech Pharmaceuticals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 2 active ingredients: black elderberry extract and black elderberry, both from the fruit of the elderberry plant. Together they make up the 450 mg dose.

The product also includes an inactive ingredient called Cyclosome Technology with Phospholipids, which is used to help the body absorb the active ingredients.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Elderberry's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: immune support and healthy antioxidant levels.
  • We looked for evidence on: Upper respiratory tract infection (URTI), Lower respiratory tract infections, Respiratory tract infections, Cold and flu support, Sinus health.
  • The closest evidence on file: Elderberry is rated "Insufficient Reliable Evidence To Rate" for Respiratory tract infections (Natural Medicines).
  • Also on file: Elderberry is rated "Insufficient Reliable Evidence To Rate" for Upper respiratory tract infection (URTI), Lower respiratory tract infections.

The evidence for black elderberry is insufficient to establish that it works for the conditions listed in our data — hay fever, heart disease, chronic fatigue, COPD, cognition, and respiratory tract infections. That doesn't mean it doesn't work; it means the studies we have aren't strong enough to say one way or the other.

If you're considering it for a specific condition, talk with your pharmacist about what the current research actually shows.

The evidence, ingredient by ingredient Elderberry

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Properly prepared (cooked) elderberry extracts are generally well tolerated. Raw or unripe berries, leaves, bark, and seeds contain compounds that can cause nausea, vomiting, severe diarrhea, weakness, dizziness, numbness, and confusion — cooking destroys these toxins.

There is one case report of autoimmune hepatitis (liver inflammation) in a person who took elderberry for years; the person recovered after stopping it. During pregnancy and breastfeeding, there isn't enough safety information, so it's best to avoid elderberry supplements — talk with your doctor or pharmacist if you're pregnant or nursing and want to use it.

Side effects, ingredient by ingredient Elderberry

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Elderberry.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs.
  • For scale: 121 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, double-check with your pharmacist if you take any immunosuppressants (medications that suppress your immune system, commonly used after transplant or for certain autoimmune conditions) or pazopanib (a cancer drug). Both carry Moderate interaction ratings with this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Black elderberry is generally well tolerated when prepared from ripe fruit, but it's not your choice if you take immunosuppressants or pazopanib — those interactions are real. The evidence for what it actually treats is too thin to call it proven.

If you're healthy and taking no medications in those categories, this may be worth a try, but check your exact prescriptions with a pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Black Elderberry 450 mg, straight from the product label.

Brand HTP Hi-Tech Pharmaceuticals
Barcode (UPC) 811836024432
Net contents 120 Tablet(s)
Market status On market
Date entered into DSLD Jul 23, 2020
DSLD ID 229390
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Black Elderberry 450 mg by HTP Hi-Tech Pharmaceuticals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
120
UPC/BARCODE
811836024432
IngredientAmount% DV
Black Elderberry extract250 mg--
Black Elderberry200 mg--

Other ingredients: Cyclosome Technology with Phospholipids

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Hi-Tech's Black Elderberry delivers the benefits of elderberries in convenient concentrated tablet form so you don't have to consume large amounts of the fruit. Despite the accumulating evidence supporting the health effects of anthocyanins, their plasma concentrations were found to be very low. Hi-Tech's Sambuca Black Elderberry Extract provides a minimum of 15% anthocyanins and 10% polyphenols - the naturally-occurring, active constituents of elderberries.

Black Elderberry 450 mg per tablet

Formulation

Recent research has confirmed elderberry's traditional use to support a healthy immune response and promote healthy antioxidant levels. For centuries European elderberry have been used to help support the body's natural defenses thus making it extremely useful during seasonal change and winter months. According to the United States Department of Agriculture, the antioxidant capacity of black elderberries is superior to strawberries, cranberries and blueberries. Black elderberry possesses antioxidant properties that can help protect cells from free radical damage and may support healthy immune function.

Hi-Tech's Elderberry extracts are manufactured from premium European Sambucus nigra fruit, processed without solvents via physical membrane separation, and provides 15% anthocyanins and 10% polyphenols - the beneficial phytonutrients.

Elderberry has one of the highest ORAC antioxidant values compared to other fruit. Sambuca Black Elderberry extract, provides strong immune system support to help you and your family stay healthy throughout the year. Sambuca Black Elderberry extract conveniently arms you with some of the best protection nature has to offer.

Cyclosome Delivery for Enhanced Bioavailability

Supports a healthy immune response Promotes healthy antioxidant levels

(Non-GMO)

Seals/Symbols

Good Manufacturing Practice Sourced from a GMP Certified Facility Quality Assured

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Take one (1) tablet 1-3 times daily or as directed by a qualified health care professional.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Black Elderberry 450 mg by HTP Hi-Tech Pharmaceuticals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Black Elderberry 450 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Black Elderberry 450 mg by HTP Hi-Tech Pharmaceuticals

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container120 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Black Elderberry extract

Interacts with
121 drugs
250 mg per serving Form: Sambucus nigra

Elderberry is a popular herbal supplement, mainly taken to help with colds and flu. Some small studies suggest it may modestly shorten cold or flu sym...

Black Elderberry extract monograph & interactions

Black Elderberry

Interacts with
121 drugs
200 mg per serving Form: Anthocyanins, Flavonoids

Elderberry is a popular herbal supplement, mainly taken to help with colds and flu. Some small studies suggest it may modestly shorten cold or flu sym...

Black Elderberry monograph & interactions

Other (inactive) ingredients: Cyclosome Technology with Phospholipids. These complete the product’s ingredient list but are not active constituents.

Interaction report

Black Elderberry 450 mg by HTP Hi-Tech Pharmaceuticals Drug Interactions

Want to check YOUR meds against Black Elderberry 450 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
121Drugs
121 Moderate

Ingredients driving the most interactions

Black Elderberry extract 121

Individual Drug Interactions

The ingredients in Black Elderberry 450 mg interact with 121 drugs. Click any drug to see the details.

1 of the 2 ingredients in Black Elderberry 450 mg interact with drugs. Each result below shows which ingredient is responsible. Black Elderberry extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Black Elderberry 450 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Black Elderberry extract2 drug types · 121 drugs

Immunosuppressants

Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Elderberry has immunostimulant activity, increasing the production of cytokines, including interleukin and tumor necrosis factor.

Likelihood Possible Evidence B
Pazopanib (Votrient)

Theoretically, elderberry might interact with pazopanib, potentially increasing the risk of adverse effects.
In one case, a 65-year-old patient taking pazopanib for 4 weeks for soft-tissue sarcoma developed severe nausea, loose stools, and elevated alanine transaminase and aspartate transaminase levels and was diagnosed with grade 3 liver injury. The patient reported taking elderberry supplements for 2 years, dose unspecified, and was also taking a multivitamin and a calcium supplement. The patient's symptoms and liver enzyme levels improved upon discontinuation of pazopanib and all supplements. Pazopanib treatment was re-initiated, at a lower dose, with no further evidence of liver injury. It was unclear in this case report if the elderberry supplements were derived from the berry, the flower, or the combination.

Likelihood Possible Evidence D
Black Elderberry extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Black Elderberry 450 mg, from the product label.

HTP Hi-Tech Pharmaceuticals

See all HTP Hi-Tech Pharmaceuticals products
Name
Hi-Tech Pharmaceuticals, Inc.
Street Address
6015-B Unity Dr.
City
Norcross
State
GA
ZipCode
30071
Phone Number
1-888-855-7919
Web Address
www.hitechpharma.com
Pharmacist Counseling Corner

Black Elderberry 450 mg by HTP Hi-Tech Pharmaceuticals: Common Questions

Does Black Elderberry 450 mg by HTP Hi-Tech Pharmaceuticals interact with any medications?
Yes. Based on its ingredients, Black Elderberry 450 mg has a known interaction with 121 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Black Elderberry 450 mg contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take if I'm pregnant or nursing?
There isn't enough reliable safety information to know either way. It's best to avoid elderberry supplements during pregnancy and breastfeeding. Talk with your doctor or pharmacist for personalized advice if you're pregnant, trying to conceive, or nursing.
Can raw elderberries be toxic?
Yes. Raw or unripe berries, seeds, leaves, and bark contain compounds (cyanogenic glycosides) that can cause nausea, vomiting, diarrhea, weakness, dizziness, and numbness. This product is made from properly prepared (cooked) elderberry extract, so it should be safe from that angle — but always make sure you're buying a reputable, processed product.
What does elderberry do?
According to our data, the evidence isn't strong enough to say it reliably treats hay fever, heart disease, fatigue, lung disease, memory, or colds. That doesn't mean people don't use it for those reasons — it just means the science isn't solid yet.
Are there any common side effects?
Properly prepared elderberry extract is well tolerated and most people don't report side effects. In rare cases, nausea and vomiting have been reported, though it's unclear whether that was from the elderberry or other ingredients in the product.
What's Cyclosome Technology with Phospholipids?
That's an inactive ingredient designed to help your body absorb the active elderberry ingredients more effectively. It's not the active part — the black elderberry is what you're taking this for.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Black Elderberry 450 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Black Elderberry 450 mg label
Go deeper

The Full Monographs Behind Black Elderberry 450 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Elderberry

Interacts with 121 drugs

Elderberry is a popular herbal supplement, mainly taken to help with colds and flu. Some small studies suggest it may modestly shorten cold or flu symptoms, but the evidence is limited and n...

Read the full Elderberry monograph →
Sources

Sources & How We Checked

Black Elderberry 450 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Elderberry 6 references
  1. Barak V, Halperin T, Kalickman I. The effect of Sambucol, a black elderberry-based, natural product, on the production of human cytokines: I. Inflammatory cytokines. Eur Cytokine Netw 2001;12:290-6..
  2. Elderberry (Sambucus species). The Poison Plant Patch, Novia Scotia Museum, 2007. Available at: http://museum.gov.ns.ca/poison/?section=species&id=117 (Accessed 16 October 2009).
  3. European elder. Canadian Poisonous Plants Information System. Available at: http://www.cbif.gc.ca/pls/pp/ppack.jump?p_null=all&p_psn=121&p_type=all&p_sci=comm&p_x=px (Accessed 16 October 2009).
  4. Raus K, Pleschka S, Klein P, Schoop R, Fisher P. Effect of an echinacea-based hot drink versus oseltamivir in Influenza treatment: a randomized, double-blind, double-dummy, multicenter, noninferiority clinical trial. . Curr Ther Res Clin Exp. 2015;20;77:6 PubMed
  5. Ramachandran A, Antala D, Pudasainee P, Panginikkod S, Gupta H. A Plausible Association Between the Use of Elderberry and Autoimmune Hepatitis. Cureus 2022;14(4):e24250. PubMed
  6. Agarwal N, Mangla A. Elderberry interaction with pazopanib in a patient with soft-tissue sarcoma: A case report and literature review. Mol Clin Oncol 2024;20(5):36. PubMed

See these in context on the Elderberry monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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