Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Black Elderberry Cold & Flu Relief Ingredients & Drug Interactions

by Sambucol

Black Elderberry Cold & Flu Relief label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Black Elderberry Cold & Flu Relief against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Black Elderberry Cold & Flu Relief is a dietary supplement by Sambucol with 5 active ingredients. Its ingredients are commonly taken for acne and oily skin, rosacea, seborrheic dermatitis and dandruff.Based on those ingredients, 187 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sambucus nigra, Zincum Gluconicum. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Black Elderberry Cold & Flu Relief by Sambucol

Ask about any prescription or over-the-counter medication and we check it for interactions with Black Elderberry Cold & Flu Relief by Sambucol — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Black Elderberry Cold & Flu Relief by Sambucol

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 5 active ingredients.

This product has five active ingredients. Sulfur is included for its possible effectiveness in scabies and dandruff, though evidence for cold and flu relief is insufficient.

Bryonia and gelsemium sempervirens are homeopathic ingredients with no established effectiveness ratings in our data. Sambucus nigra (black elderberry) is the namesake ingredient, but we hold no data on it.

Zincum gluconicum is a form of zinc, an essential mineral that's effective for zinc deficiency and possibly helpful for acne and age-related macular degeneration, though its role in cold and flu relief isn't established here. The tablet also contains several inactive ingredients—fillers and binders like microcrystalline cellulose, croscarmellose sodium, maltodextrin, magnesium stearate, and lactose, plus black carrot extract for color, elderberry flavor, and sucrose.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Cold and flu symptom relief.
  • We looked for evidence on: Common cold, Coronavirus disease 2019 (COVID-19), Influenza, Upper respiratory infection.
  • The strongest evidence on file: Zinc is rated "Possibly Effective" for Coronavirus disease 2019 (COVID-19) (Natural Medicines).
  • Also on file: Sulfur is rated "Insufficient Reliable Evidence To Rate" for Common cold.

Evidence for this product's effectiveness against cold and flu is not established in the data we hold. Zinc is effective for zinc deficiency and possibly helpful for acne and other conditions, but evidence for cold and flu specifically isn't documented.

Sulfur has possible effectiveness for scabies and dandruff, but insufficient evidence for common cold relief. Bryonia and gelsemium sempervirens have no effectiveness ratings in our data.

The evidence, ingredient by ingredient Sulfur Bryonia Gelsemium Elderberry Zinc

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Three of the five active ingredients carry serious toxicity warnings. Bryonia root—even in small doses—can cause vomiting, diarrhea, dizziness, and in large amounts, death.

Gelsemium sempervirens (also called yellow jasmine) is highly toxic; even small amounts can cause muscle weakness, seizures, difficulty breathing, and death from respiratory failure. The product should be avoided entirely during pregnancy and breastfeeding because of these toxicity risks.

Sulfur taken by mouth is less studied than topical use, but it can cause diarrhea and, in very large doses, a serious condition called metabolic acidosis. Zinc is generally well tolerated at normal recommended amounts but can cause nausea, vomiting, diarrhea, and a metallic taste, especially at high doses.

High long-term zinc use above 40 mg daily may increase the risk of copper deficiency.

Side effects, ingredient by ingredient Sulfur Bryonia Gelsemium Elderberry Zinc

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 5 matched ingredients can interact with medications — Elderberry, Zinc.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs.
  • For scale: 187 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check whether you use quinolone antibiotics, tetracycline antibiotics, cephalexin, or penicillamine—all moderate interactions with zinc. Also check for ritonavir, cisplatin, integrase inhibitors (like dolutegravir), or bictegravir/emtricitabine/tenofovir alafenamide.

If you take any of these, spacing your doses hours apart can help, but talk to your pharmacist about the best timing for your situation.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product combines ingredients with unproven effectiveness for cold and flu alongside ingredients with serious toxicity concerns. If you're pregnant or breastfeeding, this product is not advised.

If you take antibiotics, HIV medications, or other prescription drugs, check them against the medication interaction tool below before starting. A conversation with your pharmacist or doctor about safer, more proven options is a good idea.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Black Elderberry Cold & Flu Relief, straight from the product label.

Brand Sambucol
Net contents 60 Quick Dissolve Tablet(s)
Market status On market
Date entered into DSLD Apr 22, 2021
DSLD ID 245275
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Black Elderberry Cold & Flu Relief by Sambucol, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0 Not Present
Maximum serving Sizes:
0 Not Present
Servings per container
60
IngredientAmount% DV
Sulfur0 NP--
Bryonia0 NP--
Gelsemium sempervirens0 NP--
Sambucus nigra0 NP--
Zincum Gluconicum0 NP--

Other ingredients: Black Carrot extract, Croscarmellose Sodium, Elderberry flavor, Lactose, Magnesium Stearate, Maltodextrin, Microcrystalline Cellulose, Sucrose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

NDC# 52053-0005-1 60 Count family pack

Satisfaction Guaranteed: if you are dissatisfied, and wish to receive a full refund, please see our website for details.

Suggested/Recommended/Usage/Directions

Take at the first sign of cold and flu symptoms

Directions For best results, use at the first sign of symptoms of a cold or flu and continue to use for an additional 48 hours after symptoms subside. Adults and children 4 years and older Dissolve entire tablet in mouth. Do not chew. Do not swallow whole. Take one tablet at the outset of symptoms. Repeat every three hours.

Formulation

Fast temporary relief from: Nasal & sinus congestion Runny nose Sore throat Coughing Sneezing Chills & fever

Homeopathic

Sambucol Cold & Flu Relief: Safe for the whole family No known drug interactions No known side effects Non-drowsy Non-habit forming

Made in the USA with domestic and imported ingredients.

Bryonia 6X..Muscle ache, headache, fever, chills, dry throat, cough Gelsemium sempervirens 6X, 12X, 30X...Bronchial irritation, dry cough, sneezing Sambucus nigra 3X, 6X...Nasal congestion, hoarseness, coughing, fever Sulphur 12X...Nasal congestion and pressure, headache, burning throat Zincum gluconicum 2X, 6X...Fatigue, nausea, bronchial constriction, minor sore throat *The letters 'HPUS' indicate that the components in this product are officially monographed in the Homeopathic Pharmacopeia of the United States. Uses** Temporarily relieves cold & flu symptoms. Provides temporary relief from respiratory symptoms such as sneezing, runny nose, nasal & sinus congestion, minor sore throat and headache. Also temporarily relieves fever, chills, and body aches associated with flu.

Active ingredients are monographed and microdiluted in accordance with the Homeopathic Pharmacopoeia of the United States and are non-toxic and have no known side effects.

Sambucol Cold & Flu Relief: Fast relief from cold & flu symptoms

Unique homeopathic formulation

Quickly dissolves in the mouth without water Great tasting

Precautions

Children under 4: Consult a doctor before use.

Warnings Sore throat warning - Severe or persistent sore throat or sore throat accompanied by high fever, headache, nausea, and vomiting may be serious. Consult physician promptly.

Do not use more than 2 days or administer to children under 3 years of age unless directed by a physician.

Stop use and ask a doctor if: Symptoms worsen Any new symptoms appear Fever lasts for more than three days. Respiratory symptoms persist for more than seven days.

If pregnant or breast feeding, ask a health professional before using.

Keep out of the reach of children.

In case of overdose, get medical help or contact a Poison Control Center right away.

Children under 4 years of age Consult a doctor before use.

Other information Do not use if blister seal is broken.

Formula

With natural elderberry & zinc

FDA Disclaimer Statement

Claims based on traditional homeopathic practice, not accepted medical evidence. Not FDA evaluated.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Black Elderberry Cold & Flu Relief by Sambucol label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Black Elderberry Cold & Flu Relief label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Black Elderberry Cold & Flu Relief by Sambucol

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size0 Not Present Dosage formTablet Or Pill Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sulfur

No known
interactions
0 NP per serving

Sulfur is a mineral used mainly in topical skin products for acne, rosacea, dandruff, and certain skin infections, and has a long history in dermatolo...

Sulfur monograph & interactions

Bryonia

No known
interactions
0 NP per serving

Bryonia is a toxic climbing vine that is mainly used today in homeopathic dilutions for coughs, pain, and inflammation, but solid scientific evidence...

Bryonia monograph & interactions

Gelsemium sempervirens

No known
interactions
0 NP per serving

Gelsemium is a highly toxic flowering plant most often sold today in very dilute homeopathic forms for anxiety, headaches, and flu-like symptoms. Ther...

Gelsemium sempervirens monograph & interactions

Sambucus nigra

Interacts with
121 drugs
0 NP per serving

Elderberry is a popular herbal supplement, mainly taken to help with colds and flu. Some small studies suggest it may modestly shorten cold or flu sym...

Sambucus nigra monograph & interactions

Zincum Gluconicum

Interacts with
67 drugs
0 NP per serving

Zinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but suppleme...

Zincum Gluconicum monograph & interactions

Other (inactive) ingredients: Black Carrot extract, Croscarmellose Sodium, Elderberry flavor, Lactose, Magnesium Stearate, Maltodextrin, Microcrystalline Cellulose, Sucrose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Black Elderberry Cold & Flu Relief by Sambucol Drug Interactions

Want to check YOUR meds against Black Elderberry Cold & Flu Relief?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
187Drugs
183 Moderate 4 Minor

Ingredients driving the most interactions

Sambucus nigra 121
Zincum Gluconicum 67

Individual Drug Interactions

The ingredients in Black Elderberry Cold & Flu Relief interact with 187 drugs. Click any drug to see the details.

2 of the 5 ingredients in Black Elderberry Cold & Flu Relief interact with drugs. Each result below shows which ingredient is responsible. Sambucus nigra Zincum Gluconicum

Each ingredient & the kinds of drugs it affects

For each ingredient in Black Elderberry Cold & Flu Relief with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Sambucus nigra2 drug types · 121 drugs

Immunosuppressants

Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Elderberry has immunostimulant activity, increasing the production of cytokines, including interleukin and tumor necrosis factor.

Likelihood Possible Evidence B
Pazopanib (Votrient)

Theoretically, elderberry might interact with pazopanib, potentially increasing the risk of adverse effects.
In one case, a 65-year-old patient taking pazopanib for 4 weeks for soft-tissue sarcoma developed severe nausea, loose stools, and elevated alanine transaminase and aspartate transaminase levels and was diagnosed with grade 3 liver injury. The patient reported taking elderberry supplements for 2 years, dose unspecified, and was also taking a multivitamin and a calcium supplement. The patient's symptoms and liver enzyme levels improved upon discontinuation of pazopanib and all supplements. Pazopanib treatment was re-initiated, at a lower dose, with no further evidence of liver injury. It was unclear in this case report if the elderberry supplements were derived from the berry, the flower, or the combination.

Likelihood Possible Evidence D
Sambucus nigra full monograph & interactions

Zincum Gluconicum10 drug types · 67 drugs

Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Theoretically, zinc might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide should be taken at least 2 hours before or 6 hours after zinc containing products.

Likelihood Probable Evidence D
Cephalexin (Keflex)

Zinc might decrease cephalexin levels by chelating with cephalexin in the gut and preventing its absorption.
A pharmacokinetic study shows that zinc sulfate 250 mg taken concomitantly with cephalexin 500 mg decreases peak levels of cephalexin by 31% and reduces the exposure to cephalexin by 27%. Also, taking zinc sulfate 3 hours before cephalexin decreases peak levels of cephalexin by 11% and reduces the exposure to cephalexin by 18%. By decreasing cephalexin levels, zinc might increase the risk of treatment failure. This effect does not occur when zinc is taken 3 hours after the cephalexin dose. To avoid an interaction, advise patients take zinc sulfate 3 hours after taking cephalexin.

Likelihood Probable Evidence B
Cisplatin (Platinol-Aq)

Theoretically, zinc might interfere with the therapeutic effects of cisplatin.
Animal research suggests that zinc stimulates tumor cell production of the protein metallothionein, which binds and inactivates cisplatin. It is not known whether zinc supplements or high dietary zinc intake can cause clinically significant interference with cisplatin therapy. Cisplatin might also increase zinc excretion.

Likelihood Possible Evidence D
Integrase Inhibitors

Theoretically, taking zinc along with integrase inhibitors might decrease the levels and clinical effects of these drugs.
Zinc is a divalent cation. Pharmacokinetic studies have shown that other divalent cations such as calcium and iron can decrease blood levels of the integrase inhibitor dolutegravir through chelation.

Likelihood Possible Evidence D
Penicillamine (Cuprimine, Depen)

Zinc might reduce the levels and clinical effects of penicillamine.
By forming an insoluble complex with penicillamine, zinc interferes with penicillamine absorption and activity. Zinc supplements reduce the efficacy of low-dose penicillamine (0.5-1 gram/day), but do not seem to affect higher doses (1-2.75 gram/day), provided dosing times are separated. Advise patients to take zinc and penicillamine at least 2 hours apart.

Likelihood Probable Evidence B
Quinolone Antibiotics

Zinc can decrease the levels and clinical effects of quinolones antibiotics.
Quinolones form complexes with zinc in the gastrointestinal tract, reducing absorption of both the quinolone and zinc if taken at the same time. Advise patients to take these drugs at least 2 hours before, or 4-6 hours after, zinc supplements.

Likelihood Probable Evidence B
Ritonavir (Norvir)

Zinc modestly reduces levels of ritonavir.
Clinical research shows that zinc might reduce serum ritonavir levels by chelating with ritonavir in the gut and preventing its absorption. In patients with HIV, ritonavir is taken with atazanavir to prevent the metabolism and increase the effects of atazanavir. A pharmacokinetic study shows that, in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate (Solvazinc tablets) 125 mg as a single dose or as multiple daily doses for 2 weeks reduces plasma levels of ritonavir by about 16%. However, atazanavir levels still remains high enough to prevent HIV virus replication. Therefore, the decrease in ritonavir levels is not likely to be clinically significant.

Likelihood Probable Evidence B
Tetracycline Antibiotics

Zinc might reduce levels of tetracycline antibiotics.
Tetracyclines form complexes with zinc in the gastrointestinal tract, which can reduce absorption of both the tetracycline and zinc when taken at the same time. Taking zinc sulfate 200 mg with tetracycline reduces absorption of the antibiotic by 30% to 40%. Demeclocycline and minocycline cause a similar interaction. However, doxycycline does not seem to interact significantly with zinc. Advise patients to take tetracyclines at least 2 hours before, or 4-6 hours after, zinc supplements to avoid any interactions.

Likelihood Probable Evidence B
Amiloride (Midamor)

Amiloride can modestly reduce zinc excretion and increase zinc levels.
Clinical research shows that amiloride can reduce urinary zinc excretion, especially at doses of 10 mg per day or more. This zinc-sparing effect can help to counteract zinc losses caused by thiazide diuretics, but it is unlikely to cause zinc toxicity at usual amiloride doses. The other potassium-sparing diuretics, spironolactone (Aldactone) and triamterene (Dyrenium), do not seem to have a zinc-sparing effect.

Likelihood Probable Evidence B
Atazanavir (Reyataz)

Zinc modestly reduces levels of atazanavir, although this effect does not seem to be clinically significant.
Clinical research shows that zinc might decrease serum atazanavir levels by chelating with atazanavir in the gut and preventing its absorption. Although a single dose of zinc sulfate (Solvazinc tablets) 125 mg orally does not affect atazanavir concentrations in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate 125 mg daily for 2 weeks reduces plasma levels of atazanavir by about 22% in these patients. However, despite this decrease, atazanavir levels still remain at high enough concentrations for the prevention of HIV virus replication.

Likelihood Probable Evidence B
Zincum Gluconicum full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Black Elderberry Cold & Flu Relief, from the product label.

Sambucol

See all Sambucol products
Name
PharmaCare US, Inc.
City
San Diego
State
CA
ZipCode
92108
Phone Number
1-888-871-9098
Web Address
www.SambucolUSA.com
Pharmacist Counseling Corner

Black Elderberry Cold & Flu Relief by Sambucol: Common Questions

Does Black Elderberry Cold & Flu Relief by Sambucol interact with any medications?
Yes. Based on its ingredients, Black Elderberry Cold & Flu Relief has a known interaction with 187 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Black Elderberry Cold & Flu Relief contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No. Two ingredients in this product—bryonia and gelsemium sempervirens—are unsafe during pregnancy and likely unsafe while breastfeeding due to toxicity concerns. Talk to your doctor about alternatives.
Does zinc in this product really help with colds?
Evidence that zinc is effective for common cold relief isn't established in the data we hold. Zinc is proven effective for zinc deficiency, but for cold and flu specifically, the evidence isn't there.
What are the most common side effects of this product?
Zinc can cause nausea, vomiting, diarrhea, abdominal cramps, and a metallic taste, especially at higher doses. Bryonia and gelsemium can cause much more serious effects—vomiting, diarrhea, dizziness, weakness, and in extreme cases, death—which is why they're not recommended.
What is sulfur doing in a cold and flu product?
Sulfur has possible effectiveness for scabies and dandruff, but there isn't reliable evidence it helps with colds or flu. We don't have effectiveness data to support its use for those conditions.
Is there any ingredient in this product you couldn't check for drug interactions?
Yes—sambucus nigra (black elderberry). We hold no interaction data for it, so we can't tell you whether it interacts with your medications. Use the checker on this page to search your drugs against the ingredients we can check.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Black Elderberry Cold & Flu Relief is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Black Elderberry Cold & Flu Relief label
Go deeper

The Full Monographs Behind Black Elderberry Cold & Flu Relief’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sulfur

Sulfur is a mineral used mainly in topical skin products for acne, rosacea, dandruff, and certain skin infections, and has a long history in dermatology. Topical sulfur is generally well tol...

Read the full Sulfur monograph → Herb & supplement monograph

Bryonia

Bryonia is a toxic climbing vine that is mainly used today in homeopathic dilutions for coughs, pain, and inflammation, but solid scientific evidence that it works is lacking. The raw plant...

Read the full Bryonia monograph → Herb & supplement monograph

Gelsemium

Gelsemium is a highly toxic flowering plant most often sold today in very dilute homeopathic forms for anxiety, headaches, and flu-like symptoms. There is little reliable scientific evidence...

Read the full Gelsemium monograph → Herb & supplement monograph

Elderberry

Interacts with 121 drugs

Elderberry is a popular herbal supplement, mainly taken to help with colds and flu. Some small studies suggest it may modestly shorten cold or flu symptoms, but the evidence is limited and n...

Read the full Elderberry monograph → Herb & supplement monograph

Zinc

Interacts with 67 drugs

Zinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but supplements can help correct or prevent a defici...

Read the full Zinc monograph →
Sources

Sources & How We Checked

Black Elderberry Cold & Flu Relief's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 116 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sulfur 17 references
  1. Blum, J. E. and Coe, F. L. Metabolic acidosis after sulfur ingestion. N Engl J Med 1977;297(16):869-70. PubMed
  2. Roos, T. C., Alam, M., Roos, S., Merk, H. F., and Bickers, D. R. Pharmacotherapy of ectoparasitic infections. Drugs 2001;61(8):1067-88. PubMed
  3. Diaz, M., Cazorla, D., and Acosta, M. [Efficacy, safety and acceptability of precipitated sulphur petrolatum for topical treatment of scabies at the city of Coro, Falcon State, Venezuela]. Rev Invest Clin 2004;56(5):615-22.
  4. Schmiedel, V. and Klein, P. A complex homeopathic preparation for the symptomatic treatment of upper respiratory infections associated with the common cold: An observational study. Explore (NY) 2006;2(2):109-14. PubMed
  5. Weiser, M., Gegenheimer, L. H., and Klein, P. A randomized equivalence trial comparing the efficacy and safety of Luffa comp.-Heel nasal spray with cromolyn sodium spray in the treatment of seasonal allergic rhinitis. Forsch Komplementarmed 1999;6(3):142- PubMed
  6. FDA OTC ingredients list, April 2010. Available at: www.fda.gov/downloads/AboutFDA/CentersOffices/CDER/UCM135691.pdf (accessed 2/7/15).
  7. Leyden, J. J., McGinley, K. J., Mills, O. H., Kyriakopoulos, A. A., and Kligman, A. M. Effects of sulfur and salicylic acid in a shampoo base in the treatment of dandruff: a double-blind study using corneocyte counts and clinical grading. Cutis 1987;39(6)
  8. Trumbore, M. W., Goldstein, J. A., and Gurge, R. M. Treatment of papulopustular rosacea with sodium sulfacetamide 10%/sulfur 5% emollient foam. J Drugs Dermatol 2009;8(3):299-304.
  9. Pelle, M. T., Crawford, G. H., and James, W. D. Rosacea: II. Therapy. J Am Acad Dermatol 2004;51:499-512.
  10. Blom I, Hornmark AM. Topical treatment with sulfur 10 per cent for rosacea. Acta Derm Venereol 1984;64:358-9. DOI
  11. Gupta, A. K. and Nicol, K. The use of sulfur in dermatology. J Drugs Dermatol 2004;3(4):427-31.
  12. Akhavan, A. and Bershad, S. Topical acne drugs: review of clinical properties, systemic exposure, and safety. Am J Clin Dermatol 2003;4(7):473-92.
  13. Wilkinson RD, Adam JE, Murray JJ, Craig GE. Benzoyl peroxide and sulfur: foundation for acne management. Can Med Assoc J 1966;95(1):28-9.
  14. Food and Drug Administration. Classification of benzoyl peroxide as safe and effective and revision of labeling to drug facts format; topical acne drug products for over-the-counter human use; final rule. Federal Register 2010;75(42):9767-77.
  15. Lin, A. N., Reimer, R. J., and Carter, D. M. Sulfur revisited. J Am Acad Dermatol 1988;18(3):553-8.
  16. Goszcz, A., Kostka-Trabka, E., Grodzinska, L., et al. [The effect of treatment with sulphur water from the spring in Wieslaw in Busko-Solec on levels of lipids, the fibrinolytic system and thrombogenic platelet function in patients with arteriosclerosis].
  17. Contoli M, Gnesini G, Forini G, et al. Reducing agents decrease the oxidative burst and improve clinical outcomes in COPD patients: a randomised controlled trial on the effects of sulphurous thermal water inhalation. ScientificWorldJournal. 2013 Dec 23;20 PubMed

See these in context on the Sulfur monograph →

Bryonia 3 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

See these in context on the Bryonia monograph →

Gelsemium 2 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
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See these in context on the Zinc monograph →

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