Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Blue Cohosh Ingredients & Drug Interactions

by Village Vitality

Blue Cohosh label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Blue Cohosh against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Blue Cohosh is a dietary supplement by Village Vitality with 1 active ingredient. Its ingredients are commonly taken for inducing labor or starting menstruation, menstrual cramps and irregular periods, symptoms of menopause.Based on those ingredients, 259 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are ethically wild harvested Blue Cohosh. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Blue Cohosh by Village Vitality

Ask about any prescription or over-the-counter medication and we check it for interactions with Blue Cohosh by Village Vitality — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Blue Cohosh by Village Vitality

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: ethically wild harvested Blue Cohosh, a plant whose compounds affect the heart and blood vessels. The liquid form also contains grain alcohol and deionized water as inactive ingredients.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: menstrual and menopausal health support.
  • We looked for evidence on: Menstrual irregularity, Menopause, Dysmenorrhea, Uterine health.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

We don't have effectiveness data on file for blue cohosh. What we do know is that it's a traditional herb used in folk medicine, but the strength of the evidence for any particular benefit isn't established in our data.

The evidence, ingredient by ingredient Blue Cohosh

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Blue cohosh carries serious safety concerns. It contains compounds that affect the heart and has been linked to significant adverse events — including chest pain (angina), high blood pressure, rapid heartbeat, stomach upset, diarrhea, cramping, nausea, and vomiting in people who take it orally.

The safety data advises against use during pregnancy and while breastfeeding. Blue cohosh may stimulate the uterus and has been linked to serious harm to newborns, including heart attacks, heart failure, heart damage, and shock in babies born to mothers who used it — even a month before delivery.

There isn't enough safety information to use it while nursing.

Side effects, ingredient by ingredient Blue Cohosh

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Blue Cohosh.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 259 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Blue Cohosh by Village Vitality, check with your doctor or pharmacist if you take blood pressure medications (captopril, enalapril, losartan, valsartan, or others) or angina drugs — blue cohosh may raise your blood pressure and weaken these drugs' effects. Also double-check if you take diabetes medications (insulin, glimepiride, glyburide, pioglitazone, rosiglitazone, or others) or use nicotine products, as this supplement may interfere with diabetes control and amplify nicotine effects.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Blue cohosh is not recommended during pregnancy or breastfeeding due to the risk of serious harm to your baby. If you take blood pressure medications, diabetes drugs, or use nicotine products, you need to talk with your doctor or pharmacist before starting this supplement — it could reduce how well your medications work or increase their effects.

The serious cardiac risks documented with this herb warrant a conversation with your healthcare provider before use.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Blue Cohosh, straight from the product label.

Brand Village Vitality
Barcode (UPC) 788332038013
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Mar 24, 2020
DSLD ID 215321
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Blue Cohosh by Village Vitality, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.167 mL
Maximum serving Sizes:
0.66 mL
Servings per container
30
UPC/BARCODE
788332038013
IngredientAmount% DV
ethically wild harvested Blue Cohosh333 mg--

Other ingredients: Grain Alcohol, deionized Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: 5-20 drops in water or juice, 2-3 times daily, or as needed. Shake well before using.

Precautions

Warnings: Do not take during pregnancy.

Keep out of the reach of children.

FDA Statement of Identity

Herbal Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Blue Cohosh by Village Vitality label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Blue Cohosh label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Blue Cohosh by Village Vitality

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.167 mL Dosage formLiquid Servings per container30 Amounts shown are per serving.

Ethically wild harvested Blue Cohosh

Interacts with
259 drugs
333 mg per serving

Blue cohosh is a traditional herb historically used by Native Americans and midwives to bring on labor or menstruation, but it carries serious safety...

Ethically wild harvested Blue Cohosh monograph & interactions

Other (inactive) ingredients: Grain Alcohol, Deionized Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Blue Cohosh by Village Vitality Drug Interactions

Want to check YOUR meds against Blue Cohosh?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
259Drugs
259 Moderate

Ingredients driving the most interactions

ethically wild harvested Blue Cohosh 259

Individual Drug Interactions

The ingredients in Blue Cohosh interact with 259 drugs. Click any drug to see the details.

1 of the 1 ingredient in Blue Cohosh interact with drugs. Each result below shows which ingredient is responsible. ethically wild harvested Blue Cohosh

Each ingredient & the kinds of drugs it affects

For each ingredient in Blue Cohosh with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

ethically wild harvested Blue Cohosh3 drug types · 259 drugs

Antidiabetes Drugs

There is some concern that blue cohosh might increase blood glucose levels. Theoretically, it might decrease the effectiveness of medicines used for diabetes. Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.

Likelihood Possible Evidence D
Antihypertensive Drugs

Constituents in blue cohosh might increase blood pressure by causing coronary vasoconstriction. Theoretically, concomitant use might decrease the effectiveness of drugs used for angina and high blood pressure; use with caution. Some antihypertensive drugs include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), Amlodipine (Norvasc), hydrochlorothiazide (HydroDiuril), furosemide (Lasix), and many others.

Likelihood Possible Evidence D
Nicotine

Blue cohosh can increase the effects of nicotine.

Likelihood Possible Evidence D
ethically wild harvested Blue Cohosh full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Blue Cohosh, from the product label.

Village Vitality

See all Village Vitality products
Name
Woodstock Apothecary
Street Address
79 Tinker Street
City
Woodstock
State
NY
ZipCode
12498
Pharmacist Counseling Corner

Blue Cohosh by Village Vitality: Common Questions

Does Blue Cohosh by Village Vitality interact with any medications?
Yes. Based on its ingredients, Blue Cohosh has a known interaction with 259 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Blue Cohosh contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I use blue cohosh if I'm pregnant or breastfeeding?
No. The safety data advises against it. Blue cohosh may stimulate the uterus and has been linked to serious harm to newborns, including heart attacks and heart failure. There also isn't enough safety information to use it while breastfeeding.
What side effects can blue cohosh cause?
Taken by mouth, blue cohosh can cause chest pain (angina), high blood pressure, rapid heartbeat, stomach upset with diarrhea and cramping, nausea, vomiting, and irritation of mucous membranes. More seriously, there are reports of heart attacks, heart failure, and shock in newborns following maternal use.
Why does blue cohosh interact with so many medications?
Blue cohosh contains compounds that affect your heart and blood vessels — raising blood pressure, tightening coronary vessels, and raising blood sugar. That's why it can weaken blood pressure and diabetes drugs, and amplify nicotine's effects.
Is blue cohosh safe to take?
Blue cohosh is linked to serious adverse events, including chest pain, high blood pressure, and dangerous effects on the heart. The safety data doesn't support its use, especially in pregnancy or breastfeeding. Talk with your doctor or pharmacist about whether it's right for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Blue Cohosh is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Blue Cohosh label
Go deeper

The Full Monographs Behind Blue Cohosh’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Blue Cohosh

Interacts with 259 drugs

Blue cohosh is a traditional herb historically used by Native Americans and midwives to bring on labor or menstruation, but it carries serious safety concerns, especially for the heart and d...

Read the full Blue Cohosh monograph →
Sources

Sources & How We Checked

Blue Cohosh's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Blue Cohosh 16 references
  1. Jones TK, Lawson BM. Profound neonatal congestive heart failure caused by maternal consumption of blue cohosh herbal medication. J Pediatr 1998;132:550-2. PubMed
  2. McFarlin BL, Gibson MH, O'Rear J, Harman P. A national survey of herbal preparation use by nurse-midwives for labor stimulation. Review of the literature and recommendations for practice. J Nurse Midwifery 1999;44:205-16. PubMed
  3. Wright IM. Neonatal effects of maternal consumption of blue cohosh. J Pediatr 1999;134:384-5. DOI
  4. Edmunds J. Blue cohosh and newborn myocardial infarction? Midwifery Today Int Midwife 1999;52:34-5.
  5. Fetrow CW, Avila JR. Professional's Handbook of Complementary & Alternative Medicines. 1st ed. Springhouse, PA: Springhouse Corp., 1999.
  6. Irikura B, Kennelly E. American Health Consultants. Blue Cohosh: a word of caution. 1999. Available at: http://www.ahcmedia.com/articles/50424-blue-cohosh-a-word-of-caution.
  7. Gunn TR, Wright IM. The use of black and blue cohosh in labour. N Z Med J 1996;109:410-1.
  8. Baillie N, Rasmussen P. Black and blue cohosh in labour. N Z Med J 1997;110:20-1.
  9. Finkel RS, Zarlengo KM. Blue cohosh and perinatal stroke. N Engl J Med 2004;351:302-3. PubMed
  10. Kennelly, E. J., Flynn, T. J., Mazzola, E. P., Roach, J. A., McCloud, T. G., Danford, D. E., and Betz, J. M. Detecting potential teratogenic alkaloids from blue cohosh rhizomes using an in vitro rat embryo culture. J.Nat.Prod. 1999;62(10):1385-1389. PubMed
  11. Rao, R. B. and Hoffman, R. S. Nicotinic toxicity from tincture of blue cohosh (Caulophyllum thalictroides) used as an abortifacient. Vet.Hum.Toxicol. 2002;44(4):221-222.
  12. Gunn, T. R. and Wright, I. M. The use of black and blue cohosh in labour. N.Z Med J 10-25-1996;109(1032):410-411.
  13. Scott, C. C. and Chen, K. K. The pharmacological action of N-methylcytisine. The Journal of Pharmacology and Experimental Therapuetics 1943;79:334-339. DOI
  14. Low, D. T. Blue cohosh and neonatal myocardial toxicity. Journal of the American Herbalists Guild 2001;2(2):9-10.
  15. Dugoua JJ, Perri D, Seely D, et al. Safety and efficacy of blue cohosh (Caulophyllum thalictroides) during pregnancy and lactation. Can J Clin Pharmacol. 2008;15(1):e66-73.
  16. Sirtori CR, Triolo M, Bosisio R, et al. Hypocholesterolaemic effects of lupin protein and pea protein/fibre combinations in moderately hypercholesterolaemic individuals. Br J Nutr 2012;107:1176-83. PubMed

See these in context on the Blue Cohosh monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team