Blue-Green Algae 500 mg Ingredients & Drug Interactions
by Thompson
What is this page for?
First and foremost: checking Blue-Green Algae 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Blue-Green Algae 500 mg is a dietary supplement by Thompson with 3 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 511 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Blue-Green Algae, Sodium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Blue-Green Algae 500 mg by Thompson
Ask about any prescription or over-the-counter medication and we check it for interactions with Blue-Green Algae 500 mg by Thompson — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Blue-Green Algae 500 mg by Thompson
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains 2 active ingredients: sodium and blue-green algae. The tablet also includes cellulose and stearic acid as inactive ingredients (binders and fillers).
Does it work?
Strong evidence
The sodium in this product is rated likely effective for cystic fibrosis and possibly effective for reducing kidney damage from the drug amphotericin B. For the blue-green algae component, there is possibly effective evidence for high blood pressure (hypertension), but for other uses we hold — including acne, hay fever, iron deficiency anemia, and arsenic poisoning — the evidence is not established in our data.
How safe is it?
Well-documented data
Sodium is well tolerated when used in normal dietary amounts, but excess intake is linked to high blood pressure, heart strain, and kidney disease. The safety notes advise against sodium supplements or very high intake without medical guidance.
Blue-green algae are generally well tolerated, though the most common side effects reported are abdominal cramps, bloating, diarrhea, dizziness, fatigue, flatulence, headache, nausea, and vomiting. Rare allergic reactions including rashes, severe swelling, and anaphylaxis have been reported.
A key safety concern is that quality varies and some blue-green algae products can be contaminated with toxins or heavy metals. The pregnancy and lactation data for sodium rates it likely safe in pregnancy but possibly unsafe in lactation; no data is on file for blue-green algae in pregnancy or lactation.
Meds to double-check
Moderate interaction found
If you take blood pressure medications (antihypertensives), corticosteroids, lithium, didanosine, sodium phosphates, tolvaptan, or other sodium-containing medications, check with your doctor or pharmacist before using this product — the sodium content can affect how these drugs work or increase the risk of high sodium levels. If you're on blood thinners or antiplatelet drugs, immunosuppressants, or diabetes medications, the blue-green algae component may interact, so check your specific medications with the tool on this page.
The bottom line
Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
This product may appeal to people looking for support with high blood pressure, but the sodium content and broad interaction profile make it something to discuss with your doctor or pharmacist first — especially if you take blood pressure medications, lithium, diabetes drugs, blood thinners, or immunosuppressants. The blue-green algae component also carries a contamination risk that's worth weighing.
Talk it over with your own healthcare provider before starting.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 26, 2014.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Blue-Green Algae 500 mg, straight from the product label.
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Blue-Green Algae 500 mg by Thompson, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 2 {Calories} | -- |
| Total Carbohydrates | 1 Gram(s) | 1% |
| Protein | 1 Gram(s) | 1% |
| Sodium | 5 mg | 1% |
| Blue-Green Algae | 1 Gram(s) | -- |
Other ingredients: Cellulose, Stearic Acid
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
Our own laboratory analysis guarantees purity and freshness of all Thompson(R) products.
(C)2008
General
7223238 1107
General Statements
SINCE 1932
GREEN SUPPLEMENT
FRESH HEALTHY
Keep your licensed health care practitioner informed when using this product.
TWICE DAILY
FDA Statement of Identity
DIETARY SUPPLEMENT
Precautions
WARNING: Do not use if safety seal is broken or missing.
Keep out of reach of children.
Suggested/Recommended/Usage/Directions
Directions: Use only as directed. Take two tablets up to two times daily, preferably on an empty stomach.
Storage
Store in a cool, dry place.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Blue-Green Algae 500 mg by Thompson label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Blue-Green Algae 500 mg by Thompson
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Protein
Sodium
Interacts with205 drugs
Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...
Sodium monograph & interactionsBlue-Green Algae
Interacts with327 drugs
Blue-green algae are nutrient-rich aquatic microorganisms (such as spirulina and Klamath Lake algae) taken as a supplement for energy, nutrition, and...
Blue-Green Algae monograph & interactionsOther (inactive) ingredients: Cellulose, Stearic Acid. These complete the product’s ingredient list but are not active constituents.
Blue-Green Algae 500 mg by Thompson Drug Interactions
HelloPharmacist Interaction Report
Thompson's Blue-Green Algae 500 mg contains sodium and blue-green algae, both of which have documented interactions with medications.
The sodium in this product is the primary concern — it can reduce the effectiveness of blood pressure medications (antihypertensives) and may increase the risk of dangerously high sodium levels (hypernatremia) if you're taking corticosteroids, lithium, didanosine, sodium phosphates, tolvaptan, or other sodium-containing drugs.
Read the full breakdown — every affected drug type, severity by severity
Blue-green algae itself carries separate moderate-severity interactions. It may theoretically increase bleeding risk if combined with blood thinners or antiplatelet drugs, though this is considered unlikely based on limited evidence.
It can also interfere with immunosuppressant medications and might increase the risk of low blood sugar (hypoglycemia) if you're taking diabetes medications.
Altogether, these interactions span 511 individual medications. Because of the sodium content and the range of drug interactions documented, you'll want to check your exact medications with the search tool on this page before starting this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Blue-Green Algae 500 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Blue-Green Algae 500 mg interact with 511 drugs. Click any drug to see the details.
2 of the 3 ingredients in Blue-Green Algae 500 mg interact with drugs. Each result below shows which ingredient is responsible. Blue-Green Algae Sodium
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Blue-Green Algae 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Blue-green AlgaeImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of blue-green algae might interfere with immunosuppressive therapy.
Read the full Blue-green Algae + 6-mercaptopurine interactionAbciximabReoPro
How Abciximab interacts with Blue-Green Algae 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Blue-green AlgaeAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, spirulina blue-green algae might increase the risk of bleeding if used with other anticoagulant or antiplatelet drugs.
Read the full Blue-green Algae + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Blue-Green Algae 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Blue-green AlgaeAnticoagulant/antiplatelet Drugs, Immunosuppressants Moderate
Interaction Summary
Theoretically, spirulina blue-green algae might increase the risk of bleeding if used with other anticoagulant or antiplatelet drugs.
Read the full Blue-green Algae + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Blue-Green Algae 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Blue-green AlgaeAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking blue-green algae with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Blue-green Algae + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Blue-Green Algae 500 mg — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Blue-Green Algae 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Blue-green AlgaeAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, spirulina blue-green algae might increase the risk of bleeding if used with other anticoagulant or antiplatelet drugs.
Read the full Blue-green Algae + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Blue-Green Algae 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Blue-green AlgaeAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, spirulina blue-green algae might increase the risk of bleeding if used with other anticoagulant or antiplatelet drugs.
Read the full Blue-green Algae + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Blue-Green Algae 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Blue-green AlgaeAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, spirulina blue-green algae might increase the risk of bleeding if used with other anticoagulant or antiplatelet drugs.
Read the full Blue-green Algae + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Blue-Green Algae 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Blue-green AlgaeAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, spirulina blue-green algae might increase the risk of bleeding if used with other anticoagulant or antiplatelet drugs.
Read the full Blue-green Algae + Acetaminophen, Ibuprofen interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Blue-Green Algae 500 mg — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Acetazolamide interactionAcetohexamideDymelor
How Acetohexamide interacts with Blue-Green Algae 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Blue-green AlgaeAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking blue-green algae with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Blue-green Algae + Acetohexamide interactionAcetylsalicylic AcidEntrophen
How Acetylsalicylic Acid interacts with Blue-Green Algae 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Blue-green AlgaeAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, spirulina blue-green algae might increase the risk of bleeding if used with other anticoagulant or antiplatelet drugs.
Read the full Blue-green Algae + Acetylsalicylic Acid interactionAdalimumabHumira
How Adalimumab interacts with Blue-Green Algae 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Blue-green AlgaeImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of blue-green algae might interfere with immunosuppressive therapy.
Read the full Blue-green Algae + Adalimumab interactionAdalimumab-adazHyrimoz
How Adalimumab-adaz interacts with Blue-Green Algae 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Blue-green AlgaeImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of blue-green algae might interfere with immunosuppressive therapy.
Read the full Blue-green Algae + Adalimumab-adaz interactionAdalimumab-adbmCyltezo
How Adalimumab-adbm interacts with Blue-Green Algae 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Blue-green AlgaeImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of blue-green algae might interfere with immunosuppressive therapy.
Read the full Blue-green Algae + Adalimumab-adbm interactionAdalimumab-afzbAbrilada
How Adalimumab-afzb interacts with Blue-Green Algae 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Blue-green AlgaeImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of blue-green algae might interfere with immunosuppressive therapy.
Read the full Blue-green Algae + Adalimumab-afzb interactionAdalimumab-attoAmjevita
How Adalimumab-atto interacts with Blue-Green Algae 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Blue-green AlgaeImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of blue-green algae might interfere with immunosuppressive therapy.
Read the full Blue-green Algae + Adalimumab-atto interactionAdalimumab-bwwdHadlima
How Adalimumab-bwwd interacts with Blue-Green Algae 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Blue-green AlgaeImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of blue-green algae might interfere with immunosuppressive therapy.
Read the full Blue-green Algae + Adalimumab-bwwd interactionAdalimumab-fkjpHulio
How Adalimumab-fkjp interacts with Blue-Green Algae 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Blue-green AlgaeImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of blue-green algae might interfere with immunosuppressive therapy.
Read the full Blue-green Algae + Adalimumab-fkjp interactionAlbiglutideTanzeum
How Albiglutide interacts with Blue-Green Algae 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Blue-green AlgaeAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking blue-green algae with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Blue-green Algae + Albiglutide interactionAlefaceptAmevive
How Alefacept interacts with Blue-Green Algae 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Blue-green AlgaeImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of blue-green algae might interfere with immunosuppressive therapy.
Read the full Blue-green Algae + Alefacept interactionAlemtuzumabCampath
How Alemtuzumab interacts with Blue-Green Algae 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Blue-green AlgaeImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of blue-green algae might interfere with immunosuppressive therapy.
Read the full Blue-green Algae + Alemtuzumab interactionAliskirenTekturna
How Aliskiren interacts with Blue-Green Algae 500 mg — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Aliskiren interactionAlogliptinNesina
How Alogliptin interacts with Blue-Green Algae 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Blue-green AlgaeAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking blue-green algae with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Blue-green Algae + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Blue-Green Algae 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Blue-green AlgaeAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking blue-green algae with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Blue-green Algae + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Blue-Green Algae 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Blue-green AlgaeAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking blue-green algae with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Blue-green Algae + Alogliptin, Pioglitazone interactionAlteplase, TpaActilyse, Activase
How Alteplase, Tpa interacts with Blue-Green Algae 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Blue-green AlgaeAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, spirulina blue-green algae might increase the risk of bleeding if used with other anticoagulant or antiplatelet drugs.
Read the full Blue-green Algae + Alteplase, Tpa interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Blue-Green Algae 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Blue-green AlgaeAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, spirulina blue-green algae might increase the risk of bleeding if used with other anticoagulant or antiplatelet drugs.
Read the full Blue-green Algae + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Blue-Green Algae 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Blue-green AlgaeAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, spirulina blue-green algae might increase the risk of bleeding if used with other anticoagulant or antiplatelet drugs.
Read the full Blue-green Algae + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with Blue-Green Algae 500 mg — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Ambrisentan interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Blue-Green Algae 500 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Blue-Green Algae
Anticoagulant/Antiplatelet Drugs
Theoretically, spirulina blue-green algae might increase the risk of bleeding if used with other anticoagulant or antiplatelet drugs. However, this is unlikely.
Spirulina blue-green algae have shown antiplatelet and anticoagulant effects in vitro. However, one preliminary study in 24 patients receiving spirulina blue-green algae 2.3 grams daily for 2 weeks showed no effect on platelet activation or measures of clotting time.
Antidiabetes Drugs
Theoretically, taking blue-green algae with antidiabetes drugs might increase the risk of hypoglycemia.
Human research shows that spirulina blue-green algae can have hypoglycemic effects in patients with diabetes, at least some of whom were using antidiabetes drugs. However, blue-green algae does not seem to improve glycated hemoglobin (HbA1c) levels in patients with diabetes. A meta-analysis of animal studies also suggests that spirulina blue-green algae have hypoglycemic effects.
Immunosuppressants
Theoretically, concurrent use of blue-green algae might interfere with immunosuppressive therapy.
Blue-green algae have been shown to stimulate the immune system.
Sodium
Antihypertensive Drugs
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.
Corticosteroids
Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.
Didanosine (Videx)
Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.
Lithium
Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.
Sodium Phosphates
Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.
Sodium-Containing Drugs
Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.
Tolvaptan (Samsca)
Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.
Brand information
Manufacturer and brand details for Blue-Green Algae 500 mg, from the product label.
Blue-Green Algae 500 mg by Thompson: Common Questions
Does Blue-Green Algae 500 mg by Thompson interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does this product actually help with high blood pressure?
What are the most common side effects I might experience?
Is it safe to take during pregnancy or while breastfeeding?
What's the contamination risk with blue-green algae?
Can I take this with my blood thinner?
Will this affect my diabetes medication?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Blue-Green Algae 500 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Blue-Green Algae 500 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sodium
Interacts with 205 drugsSodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...
Read the full Sodium monograph → Herb & supplement monographBlue-green Algae
Interacts with 327 drugsBlue-green algae are nutrient-rich aquatic microorganisms (such as spirulina and Klamath Lake algae) taken as a supplement for energy, nutrition, and general wellness. Evidence for most heal...
Read the full Blue-green Algae monograph →Sources & How We Checked
Blue-Green Algae 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 60 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Sodium 38 references
- Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. Am Fam Physician 1986;33:165-74.
- Food and Drug Administration Science Background: Safety of Sodium Phosphates Oral Solution. September 17, 2001. Available at: http://www.fda.gov/cder/drug/safety/sodiumphospate.htm
- Coton T, Mallaret C, Coilliot C, Carre D, Guisset M. Severe acute ulcerated gastritis induced by salt. Presse Med 2009;38(3):499-500. PubMed
- Frings-Meuthen P, Buehlmeier J, Baecker N, et al. High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. J Appl Physiol 2011;111(2):537-542. PubMed
- Frings-Meuthen P, Baecker N, Heer M. Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorption. J Bone Miner Res 2008;23(4):517-524. PubMed
- Alam S, Johnson AG. A meta-analysis of randomised controlled trials (RCT) among healthy normotensive and essential hypertensive elderly patients to determine the effect of high salt (NaCl) diet of blood pressure. J Hum Hypertens 1999;13(6):367-74.
- Boudville N, Ward S, Benaroia M, House AA. Increased sodium intake correlates with greater use of antihypertensive agents by subjects with chronic kidney disease. Am J Hypertens 2005;18(10):1300-5. PubMed
- Bennett WM. Drug interactions and consequences of sodium restriction. Am J Clin Nutr 1997;65(2 Suppl):678S-681S. PubMed
- Okusa MD, Crystal LJ. Clinical manifestations and management of acute lithium intoxication. Am J Med 1994;97(4):383-9. PubMed
- Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for water, potassium, sodium, chloride, and sulfate. Washington, DC: National Academy Press, 2005. Available at: http://www.nap.edu/openbook.php?record_id=10925. DOI
- D'Elia L, Rossi G, Ippolito R, Cappuccio FP, Strazzullo P. Habitual salt intake and risk of gastric cancer: a meta-analysis of prospective studies. Clin Nutr 2012;31(4):489-98. PubMed
- Goldsmith SR. Hyponatremia in heart failure: time for a trial. J Card Fail 2013;19(6):398-400. PubMed
- Willocks L, Brettle R, Keen J, Valentine C, Pinching AJ. Formulations of didanosine (ddI) and salt overload. Lancet 1992;339(8786):190.
- Chen L, Zhang Z, Chen W, Whelton PK, Appel LJ. Lower Sodium Intake and Risk of Headaches: Results From the Trial of Nonpharmacologic Interventions in the Elderly. Am J Public Health. 2016;106(7):1270-5. PubMed
- Cook NR, Appel LJ, Whelton PK. Lower levels of sodium intake and reduced cardiovascular risk. Circulation. 2014;129(9):981-9. PubMed
- Cook NR, Appel LJ, Whelton PK. Sodium Intake and All-Cause Mortality Over 20 Years in the Trials of Hypertension Prevention. J Am Coll Cardiol. 2016;68(15):1609-1617. PubMed
- Mente A, O'Donnell M, Rangarajan S, et al. Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension: a pooled analysis of data from four studies. Lancet. 2016;388(10043):465-75. PubMed
- Moosavian SP, Haghighatdoost F, Surkan PJ, Azadbakht L. Salt and obesity: a systematic review and meta-analysis of observational studies. Int J Food Sci Nutr. 2017;68(3):265-277. PubMed
- O'Donnell M, Mente A, Rangarajan S, et al. Urinary sodium and potassium excretion, mortality, and cardiovascular events. N Engl J Med. 2014;371(7):612-23. DOI
- Poggio R, Gutierrez L, Matta MG, Elorriaga N, Irazola V, Rubinstein A. Daily sodium consumption and CVD mortality in the general population: systematic review and meta-analysis of prospective studies. Public Health Nutr. 2015;18(4):695-704. PubMed
- Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad
- Mahtani KR, Heneghan C, Onakpoya I, et al. Reduced Salt Intake for Heart Failure: A Systematic Review. JAMA Intern Med. 2018 Dec 1;178(12):1693-1700. PubMed
- Yancy CW. Sodium Restriction in Heart Failure: Too Much Uncertainty-Do the Trials. JAMA Intern Med. 2018 Dec 1;178(12):1700-1701. PubMed
- He FJ, Campbell NRC, Ma Y, MacGregor GA, Cogswell ME, Cook NR. Errors in estimating usual sodium intake by the Kawasaki formula alter its relationship with mortality: implications for public health. Int J Epidemiol. 2018;47(6):1784-1795. PubMed
- Murthy K, Ondrey GJ, Malkani N, et al. THE EFFECTS OF HYPONATREMIA ON BONE DENSITY AND FRACTURES: A SYSTEMATIC REVIEW AND META-ANALYSIS. Endocr Pract. 2019;25(4):366-378. PubMed
- Messerli FH, Hofstetter L, Syrogiannouli L, et al. Sodium intake, life expectancy, and all-cause mortality. Eur Heart J 2021;42(21):2103-2112. PubMed
- Graudal NA, Hubeck-Graudal T, Jurgens G. Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol, and triglyceride. Cochrane Database Syst Rev 2020;12(12):CD004022. PubMed
- Giatti S, Santos RB, Aielo AN, et al. Association of sodium with obstructive sleep apnea. The ELSA-Brasil study. Ann Am Thorac Soc 2021;18(3):502-510. PubMed
- Nan X, Lu H, Wu J, et al. The interactive association between sodium intake, alcohol consumption and hypertension among elderly in northern China: a cross-sectional study. BMC Geriatr 2021;21(1):135. PubMed
- Kyozuka H, Fukusda T, Murata T, et al. Impact of preconception sodium intake on hypertensive disorders of pregnancy: The Japan Environment and Children's study. Pregnancy Hypertens 2021;23:66-72. PubMed
- Zhao L, Ogden CL, Yang Q, et al. Association of usual sodium intake with obesity among US children and adolescents, NHANES 2009-2016. Obesity (Silver Spring) 2021;29(3):587-594. PubMed
- Ma Y, He FJ, Sun Q, et al. 24-Hour urinary sodium and potassium excretion and cardiovascular risk. N Engl J Med 2022;386(3):252-263. PubMed
- Liu J, Yang X, Zhang P, et al. Association of urinary sodium excretion and left ventricular hypertrophy in people with type 2 diabetes mellitus: A cross-sectional study. Front Endocrinol (Lausanne) 2021;12:728493. PubMed
- Filippini T, Malavolti M, Whelton PK, Vinceti M. Sodium intake and risk of hypertension: A systematic review and dose-response meta-analysis of observational cohort studies. Curr Hypertens Rep 2022;24(5):133-144. PubMed
- Wang DD, Li Y, Nguyen XT, et al. Dietary sodium and potassium intake and risk of non-fatal cardiovascular diseases: The million veteran program. Nutrients 2022;14(5):1121. PubMed
- Kwak JH, Park CH, Eun CS, et al. The associations of dietary intake of high sodium and low zinc with gastric cancer mortality: A prospective cohort study in Korea. Nutr Cancer 2022;74(10):3501-3508. PubMed
- George S, Maiti R, Mishra BR, Jena M, Mohapatra D. Effect of regulated add-on sodium chloride intake on stabilization of serum lithium concentration in bipolar disorder: A randomized controlled trial. Bipolar Disord 2023;25(1):66-75. PubMed
- Zhou TL, Schütten MTJ, Kroon AA, et al. Urinary Sodium Excretion and Salt Intake Are Not Associated With Blood Pressure Variability in a White General Population. J Am Heart Assoc 2023;12(1):e026578. PubMed
Blue-green Algae 22 references
- Jensen GS, Ginsberg DJ, Huerta P, et al. Consumption of Aphanizomenon flos-aquae has rapid effects on the circulation and function of immune cells in humans. A novel approach to nutritional mobilization of the immune system. JANA 2000;2:50-6.
- Iwasa M, Yamamoto M, Tanaka Y, et al. Spirulina-associated hepatotoxicity. Am J Gastroenterol 2002;97:3212-13. PubMed
- Hayashi O, Katoh T, Okuwaki Y. Enhancement of antibody production in mice by dietary Spirulina platensis. J Nutr Sci Vitaminol (Tokyo) 1994;40:431-41.. PubMed
- Vitale S, Miller NR, Mejico LJ, et al. A randomized, placebo-controlled, crossover clinical trial of super blue-green algae in patients with essential blepharospasm or Meige syndrome. Am J Ophthalmol 2004;138:18-32. PubMed
- Mani UV, Desai S, Iyer U. Studies on the long-term effect of spirulina supplementation on serum lipid profile and glycated proteins in NIDDM patients. J Nutraceut 2000;2(3):25-32. DOI
- Chiu HF, Yang SP, Kuo YL, et al. Mechanisms involved in the antiplatelet effect of C-phycocyanin. Br J Nutr 2006;95:435-40. PubMed
- Hsiao G, Chou PH, Shen MY, et al. C-phycocyanin, a very potent and novel platelet aggregation inhibitor from Spirulina platensis. J Agric Food Chem 2005;53:7734-40.
- Katz M, Levine AA, Kol-Degani H, Kav-Venaki L. A compound herbal preparation (CHP) in the treatment of children with ADHD: a randomized controlled trial. J Atten Disord 2010;14:281-91. PubMed
- Madhyastha, H. K., Radha, K. S., Sugiki, M., Omura, S., and Maruyama, M. Purification of c-phycocyanin from Spirulina fusiformis and its effect on the induction of urokinase-type plasminogen activator from calf pulmonary endothelial cells. Phytomedicine PubMed
- Mazokopakis, E. E., Karefilakis, C. M., Tsartsalis, A. N., Milkas, A. N., and Ganotakis, E. S. Acute rhabdomyolysis caused by Spirulina (Arthrospira platensis). Phytomedicine. 2008;15(6-7):525-527. PubMed
- Halidou, Doudou M., Degbey, H., Daouda, H., Leveque, A., Donnen, P., Hennart, P., and Dramaix-Wilmet, M. [The effect of spiruline during nutritional rehabilitation: systematic review]. Rev.Epidemiol.Sante Publique 2008;56(6):425-431.
- Konno, T., Umeda, Y., Umeda, M., Kawachi, I., Oyake, M., and Fujita, N. [A case of inflammatory myopathy with widely skin rash following use of supplements containing Spirulina]. Rinsho Shinkeigaku 2011;51(5):330-333. PubMed
- Le TM, Knulst AC, Röckmann H. Anaphylaxis to Spirulina confirmed by skin prick test with ingredients of Spirulina tablets. Food Chem Toxicol 2014;74:309-10. PubMed
- Rzymski P, Niedzielski P, Kaczmarek N, Jurczak T, Klimaszyk P. The multidisciplinary approach to safety and toxicity assessment of microalgae-based food supplements following clinical cases of poisoning. Harmful Algae 2015;46:34-42. DOI
- Petrus M, Culerrier R, Campistron M, et al. First case report of anaphylaxis to spirulin: identification of phycocyanin as responsible allergen. Allergy 2010;65(7):924-5. PubMed
- Marles RJ, Barrett ML, Barnes J, et al. United States Pharmacopeia safety evaluation of spirulina. Crit Rev Food Sci Nutr 2011;51(7):593-604. PubMed
- Majdoub H, Ben Mansour M, Chaubet F, et al. Anticoagulant activity of a sulfated polysaccharide from the green alga Arthrospira platensis. Biochim Biophys Acta 2009;1790(10):1377-81. PubMed
- Cha BG, Kwak HW, Park AR, et al. Structural characteristics and biological performance of silk fibroin nanofiber containing microalgae spirulina extract. Biopolymers 2014;101(4):307-18. PubMed
- Jensen GS, Drapeau C, Lenninger M, Benson KF. Clinical safety of a high dose of phycocyanin-enriched aqueous extract from Arthrospira (Spirulina) platensis: results from a randomized, double-Blind, placebo-controlled study with a focus on anticoagulant ac
- Hamedifard Z, Milajerdi A, Reiner Z, Taghizadeh M, Kolahdooz F, Asemi Z. The effects of spirulina on glycemic control and serum lipoproteins in patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized con
- Moradi S, Zobeiri M, Feizi A, Clark CCT, Entezari MH. The effects of spirulina (Arthrospira platensis) supplementation on anthropometric indices, blood pressure, sleep quality, mental health, fatigue status and quality of life in patients with ulcerative
- Ghanbari F, Amerizadeh A, Behshood P, Moradi S, Asgary S. Effect of microalgae arthrospira on biomarkers of glycemic control and glucose metabolism: a systematic Review and meta-analysis. Curr Probl Cardiol 2022;47(10):100942. PubMed
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