Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Blue-Green Algae Ingredients & Drug Interactions

by Pure Synergy

Blue-Green Algae label
See full label image
Powder Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Blue-Green Algae against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Blue-Green Algae is a dietary supplement by Pure Synergy with 2 active ingredients. Its ingredients are commonly taken for general nutrition and energy, antioxidant support, cholesterol and metabolic health.Based on those ingredients, 327 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic Klamath Lake Blue-Green Algae. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Blue-Green Algae by Pure Synergy

Ask about any prescription or over-the-counter medication and we check it for interactions with Blue-Green Algae by Pure Synergy — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Blue-Green Algae by Pure Synergy

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: organic Klamath Lake blue-green algae, delivered as a powder. There are no inactive ingredients listed.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Blue-green Algae's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Energy clarity and mental focus support.
  • We looked for evidence on: Mental alertness, Memory, Cognitive Impairment, Stress, Anxiety, Mental fatigue — and 1 related terms.
  • The closest evidence on file: Blue-green Algae is rated "Insufficient Reliable Evidence To Rate" for Anxiety (Natural Medicines).
  • Also on file: Blue-green Algae is rated "Insufficient Reliable Evidence To Rate" for Cognitive Impairment, Memory, Mental alertness, Stress.

The evidence for blue-green algae is mixed. It's rated possibly effective for high blood pressure (hypertension).

For acne, allergic rhinitis (hay fever), iron deficiency anemia, and arsenic poisoning, the evidence isn't established enough to rate — there's insufficient reliable data on file. So if you're considering it for blood pressure support, there's some backing; for other uses, we don't have solid evidence to point to.

The evidence, ingredient by ingredient Blue-green Algae

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Blue-green algae is generally well tolerated when taken by mouth. The most common side effects are digestive — abdominal cramps, bloating, diarrhea, nausea, and vomiting — along with dizziness, fatigue, headache, and flatulence.

Allergic reactions, including rashes, itching, and in rare cases severe reactions like anaphylaxis, have been reported. A few people taking the algae have experienced mild gum bleeding or bruising.

The biggest safety concern is quality control: some blue-green algae products can be contaminated with toxins or heavy metals, and contamination risk is real enough that the data advises caution when choosing a product.

Side effects, ingredient by ingredient Blue-green Algae

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Blue-green Algae.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 327 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your own doctor or pharmacist if you take anticoagulants or antiplatelet drugs (like warfarin or aspirin), immunosuppressants, or antidiabetes medications. The algae may increase bleeding risk with blood thinners, interfere with immune-suppressing drugs, and lower blood sugar more than expected with diabetes medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Blue-Green Algae by Pure Synergy may help with high blood pressure, but it's not established for other common uses. It's generally well tolerated, but quality varies — pick carefully to avoid contamination.

If you take blood thinners, immunosuppressants, or diabetes drugs, check with your doctor or pharmacist before starting, since interactions are possible.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Blue-Green Algae, straight from the product label.

Brand Pure Synergy
Barcode (UPC) 852971004262
Net contents 3.2 oz; 90 Gram(s)
Market status On market
Date entered into DSLD Apr 22, 2021
DSLD ID 247468
Product type Non-nutrient/non-botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Organic, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Blue-Green Algae by Pure Synergy, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tsp(s)
Maximum serving Sizes:
1 Tsp(s)
Servings per container
60
UPC/BARCODE
852971004262
IngredientAmount% DV
Calories5 Calorie(s)--
Total Carbohydrates1 Gram(s)1%
Protein1 Gram(s)2%
organic Klamath Lake Blue-Green Algae1500 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Energy clarity boost

For more recipe ideas, visit our website and follow us @pure_synergy.

Packaged by weight, not volume. Contents may settle.

Formula

Blue-Green Algae is one of nature's most cleansing, nourishing, and chlorophyll-rich superfoods. The unique, pristine growing environment of Upper Klamath Lake where our algae grows ensures unparalleled purity and mineral content.

OU (Kosher) Certified Kosher

Organic pure Klamath Crystals

Formulation

Cold-dried to perfection and third party tested for purity, our organic Blue-Green Algae supports healthy energy, mental clarity and focus.

Oregon Tilth Certified Organic (OTCO)

Non GMO

No GMO's, dairy or gluten.

Suggested/Recommended/Usage/Directions

Suggested use: Mix 1 tsp with 4-6 oz filtered water or juice in a lidded jar and shake briskly, or add to your favorite smoothie.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Oregon Tilth Certified Organic (OTCO) OU (Kosher) Certified Kosher

USDA Organic

FDA Statement of Identity

Dietary Supplement

Storage

For optimal freshness, use a dry spoon and close lid tightly after each use. If some caking should occur from natural humidity, not to worry, the powder's benefits will not be compromised.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Blue-Green Algae by Pure Synergy label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Blue-Green Algae label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Blue-Green Algae by Pure Synergy

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tsp(s) Dosage formPowder Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Protein

1 Gram(s) per serving

Organic Klamath Lake Blue-Green Algae

Interacts with
327 drugs
1500 mg per serving

Blue-green algae are nutrient-rich aquatic microorganisms (such as spirulina and Klamath Lake algae) taken as a supplement for energy, nutrition, and...

Organic Klamath Lake Blue-Green Algae monograph & interactions
Interaction report

Blue-Green Algae by Pure Synergy Drug Interactions

Want to check YOUR meds against Blue-Green Algae?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
327Drugs
327 Moderate

Ingredients driving the most interactions

organic Klamath Lake Blue-Green Algae 327

Individual Drug Interactions

The ingredients in Blue-Green Algae interact with 327 drugs. Click any drug to see the details.

1 of the 2 ingredients in Blue-Green Algae interact with drugs. Each result below shows which ingredient is responsible. organic Klamath Lake Blue-Green Algae

Each ingredient & the kinds of drugs it affects

For each ingredient in Blue-Green Algae with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

organic Klamath Lake Blue-Green Algae3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, spirulina blue-green algae might increase the risk of bleeding if used with other anticoagulant or antiplatelet drugs. However, this is unlikely.
Spirulina blue-green algae have shown antiplatelet and anticoagulant effects in vitro. However, one preliminary study in 24 patients receiving spirulina blue-green algae 2.3 grams daily for 2 weeks showed no effect on platelet activation or measures of clotting time.

Likelihood Unlikely Evidence D
Antidiabetes Drugs

Theoretically, taking blue-green algae with antidiabetes drugs might increase the risk of hypoglycemia.
Human research shows that spirulina blue-green algae can have hypoglycemic effects in patients with diabetes, at least some of whom were using antidiabetes drugs. However, blue-green algae does not seem to improve glycated hemoglobin (HbA1c) levels in patients with diabetes. A meta-analysis of animal studies also suggests that spirulina blue-green algae have hypoglycemic effects.

Likelihood Possible Evidence B
Immunosuppressants

Theoretically, concurrent use of blue-green algae might interfere with immunosuppressive therapy.
Blue-green algae have been shown to stimulate the immune system.

Likelihood Possible Evidence D
organic Klamath Lake Blue-Green Algae full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Blue-Green Algae, from the product label.

Pure Synergy

See all Pure Synergy products
Name
The Synergy Company
City
Moab
State
Utah
ZipCode
84532
Phone Number
800-723-0277
Web Address
thesynergycompany.com
Pharmacist Counseling Corner

Blue-Green Algae by Pure Synergy: Common Questions

Does Blue-Green Algae by Pure Synergy interact with any medications?
Yes. Based on its ingredients, Blue-Green Algae has a known interaction with 327 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Blue-Green Algae contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
We don't have safety data on file for blue-green algae in pregnancy or lactation. Talk with your doctor or pharmacist about whether it's right for you in those situations — they can weigh your individual circumstances.
What are the most common side effects?
Digestive upset is most typical: abdominal cramps, bloating, diarrhea, nausea, and vomiting. You may also notice dizziness, fatigue, headache, or gas. These are usually mild, but if they're bothersome or don't settle, stop and let your pharmacist know.
Is it really just algae, or does it have fillers?
Yes — this product contains only the algae itself, with no added inactive ingredients listed.
How do I know if my product is contaminated?
You can't tell by looking. The safety data warns that quality varies and contamination with toxins or heavy metals can happen, so buy from a trusted brand and supplier. If you have concerns about a specific batch, contact the manufacturer.
Does this really help with high blood pressure?
It's rated possibly effective for hypertension based on the evidence we have. It's not a replacement for blood pressure medication, but it may offer some support — talk with your doctor about whether it fits into your plan.
Can I take this if I'm allergic to seafood?
Although blue-green algae aren't fish, allergic reactions to the algae itself have been reported, including severe ones in rare cases. If you have a shellfish or seafood allergy, mention this product to your doctor or pharmacist before trying it, since cross-reactivity is possible.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Blue-Green Algae is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Blue-Green Algae label
Go deeper

The Full Monographs Behind Blue-Green Algae’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Blue-green Algae

Interacts with 327 drugs

Blue-green algae are nutrient-rich aquatic microorganisms (such as spirulina and Klamath Lake algae) taken as a supplement for energy, nutrition, and general wellness. Evidence for most heal...

Read the full Blue-green Algae monograph →
Sources

Sources & How We Checked

Blue-Green Algae's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 22 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Blue-green Algae 22 references
  1. Jensen GS, Ginsberg DJ, Huerta P, et al. Consumption of Aphanizomenon flos-aquae has rapid effects on the circulation and function of immune cells in humans. A novel approach to nutritional mobilization of the immune system. JANA 2000;2:50-6.
  2. Iwasa M, Yamamoto M, Tanaka Y, et al. Spirulina-associated hepatotoxicity. Am J Gastroenterol 2002;97:3212-13. PubMed
  3. Hayashi O, Katoh T, Okuwaki Y. Enhancement of antibody production in mice by dietary Spirulina platensis. J Nutr Sci Vitaminol (Tokyo) 1994;40:431-41.. PubMed
  4. Vitale S, Miller NR, Mejico LJ, et al. A randomized, placebo-controlled, crossover clinical trial of super blue-green algae in patients with essential blepharospasm or Meige syndrome. Am J Ophthalmol 2004;138:18-32. PubMed
  5. Mani UV, Desai S, Iyer U. Studies on the long-term effect of spirulina supplementation on serum lipid profile and glycated proteins in NIDDM patients. J Nutraceut 2000;2(3):25-32. DOI
  6. Chiu HF, Yang SP, Kuo YL, et al. Mechanisms involved in the antiplatelet effect of C-phycocyanin. Br J Nutr 2006;95:435-40. PubMed
  7. Hsiao G, Chou PH, Shen MY, et al. C-phycocyanin, a very potent and novel platelet aggregation inhibitor from Spirulina platensis. J Agric Food Chem 2005;53:7734-40.
  8. Katz M, Levine AA, Kol-Degani H, Kav-Venaki L. A compound herbal preparation (CHP) in the treatment of children with ADHD: a randomized controlled trial. J Atten Disord 2010;14:281-91. PubMed
  9. Madhyastha, H. K., Radha, K. S., Sugiki, M., Omura, S., and Maruyama, M. Purification of c-phycocyanin from Spirulina fusiformis and its effect on the induction of urokinase-type plasminogen activator from calf pulmonary endothelial cells. Phytomedicine PubMed
  10. Mazokopakis, E. E., Karefilakis, C. M., Tsartsalis, A. N., Milkas, A. N., and Ganotakis, E. S. Acute rhabdomyolysis caused by Spirulina (Arthrospira platensis). Phytomedicine. 2008;15(6-7):525-527. PubMed
  11. Halidou, Doudou M., Degbey, H., Daouda, H., Leveque, A., Donnen, P., Hennart, P., and Dramaix-Wilmet, M. [The effect of spiruline during nutritional rehabilitation: systematic review]. Rev.Epidemiol.Sante Publique 2008;56(6):425-431.
  12. Konno, T., Umeda, Y., Umeda, M., Kawachi, I., Oyake, M., and Fujita, N. [A case of inflammatory myopathy with widely skin rash following use of supplements containing Spirulina]. Rinsho Shinkeigaku 2011;51(5):330-333. PubMed
  13. Le TM, Knulst AC, Röckmann H. Anaphylaxis to Spirulina confirmed by skin prick test with ingredients of Spirulina tablets. Food Chem Toxicol 2014;74:309-10. PubMed
  14. Rzymski P, Niedzielski P, Kaczmarek N, Jurczak T, Klimaszyk P. The multidisciplinary approach to safety and toxicity assessment of microalgae-based food supplements following clinical cases of poisoning. Harmful Algae 2015;46:34-42. DOI
  15. Petrus M, Culerrier R, Campistron M, et al. First case report of anaphylaxis to spirulin: identification of phycocyanin as responsible allergen. Allergy 2010;65(7):924-5. PubMed
  16. Marles RJ, Barrett ML, Barnes J, et al. United States Pharmacopeia safety evaluation of spirulina. Crit Rev Food Sci Nutr 2011;51(7):593-604. PubMed
  17. Majdoub H, Ben Mansour M, Chaubet F, et al. Anticoagulant activity of a sulfated polysaccharide from the green alga Arthrospira platensis. Biochim Biophys Acta 2009;1790(10):1377-81. PubMed
  18. Cha BG, Kwak HW, Park AR, et al. Structural characteristics and biological performance of silk fibroin nanofiber containing microalgae spirulina extract. Biopolymers 2014;101(4):307-18. PubMed
  19. Jensen GS, Drapeau C, Lenninger M, Benson KF. Clinical safety of a high dose of phycocyanin-enriched aqueous extract from Arthrospira (Spirulina) platensis: results from a randomized, double-Blind, placebo-controlled study with a focus on anticoagulant ac
  20. Hamedifard Z, Milajerdi A, Reiner Z, Taghizadeh M, Kolahdooz F, Asemi Z. The effects of spirulina on glycemic control and serum lipoproteins in patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized con
  21. Moradi S, Zobeiri M, Feizi A, Clark CCT, Entezari MH. The effects of spirulina (Arthrospira platensis) supplementation on anthropometric indices, blood pressure, sleep quality, mental health, fatigue status and quality of life in patients with ulcerative
  22. Ghanbari F, Amerizadeh A, Behshood P, Moradi S, Asgary S. Effect of microalgae arthrospira on biomarkers of glycemic control and glucose metabolism: a systematic Review and meta-analysis. Curr Probl Cardiol 2022;47(10):100942. PubMed

See these in context on the Blue-green Algae monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team