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Dietary supplement

Borage CP-240 Ingredients & Drug Interactions

by XYMOGEN

Borage CP-240 label
See full label image
Softgel Capsule Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Borage CP-240 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Borage CP-240 is a dietary supplement by XYMOGEN with 3 active ingredients. Its ingredients are commonly taken for eczema and dry skin, rheumatoid arthritis, inflammation.Based on those ingredients, 226 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Borage Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Borage CP-240 by XYMOGEN

Ask about any prescription or over-the-counter medication and we check it for interactions with Borage CP-240 by XYMOGEN — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Borage CP-240 by XYMOGEN

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Borage CP-240 contains 4 ingredients, including borage oil as the active component. Borage oil is rich in gamma-linolenic acid (GLA), an omega-6 fatty acid that's the main bioactive compound in the product.

The other listed ingredients — polyunsaturated fat, linoleic acid, and gamma-linolenic acid — support the oil's composition. The softgel capsule is an inactive ingredient used to deliver the oil.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: cardiovascular and antioxidant support.
  • We looked for evidence on: Cardiovascular disease (CVD).
  • The closest evidence on file: Borage is rated "Insufficient Reliable Evidence To Rate" for Cardiovascular disease (CVD) (Natural Medicines).

The evidence for borage oil in this product is mixed. For atopic dermatitis (eczema), the data suggests it's possibly ineffective.

For attention deficit-hyperactivity disorder (ADHD), acute respiratory distress syndrome (ARDS), and alcoholism, we don't have enough reliable evidence to say whether it works or not.

The evidence, ingredient by ingredient Borage

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Borage seed oil is generally well tolerated when taken by mouth, with the most common side effects being mild digestive ones: belching, bloating, soft stools, and diarrhea. However, borage contains compounds called pyrrolizidine alkaloids (PAs) that can damage the liver, especially if you're exposed over time.

This product should use borage oil certified to be PA-free, which is better tolerated, but other borage plant parts carry higher risk. During pregnancy and breastfeeding, borage is not recommended — the safety data advises against it because of concern about liver-toxic alkaloids and potential harm to the uterus.

Side effects, ingredient by ingredient Borage

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Borage.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 227 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Borage CP-240, double-check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (such as warfarin, clopidogrel, or aspirin) — moderate risk of increased bleeding. Also check if you're on antipsychotic medications called phenothiazines or drugs that induce CYP3A4 enzymes (such as rifampicin or St.

John's Wort).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Borage CP-240 is an option if you're looking at omega-6 supplementation, but it's not for everyone. If you take blood thinners, antipsychotics, or medications your liver processes quickly, talk with your doctor or pharmacist before starting — the interactions are real.

Pregnant or breastfeeding? Avoid this product.

Check your exact medications with the tool on this page.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Borage CP-240, straight from the product label.

Brand XYMOGEN
Barcode (UPC) 087114900136
Net contents 90 Softgel(s)
Market status On market
Date entered into DSLD Apr 25, 2014
DSLD ID 32065
Product type Botanical With Nutrients
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Borage CP-240 by XYMOGEN, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
90
UPC/BARCODE
087114900136
IngredientAmount% DV
Calories10 {Calories}--
Calories from Fat10 {Calories}--
Total Fat1 Gram(s)2%
Polyunsaturated Fat0.5 Gram(s)--
Borage Oil1 Gram(s)--
Linoleic Acid380 mg--
Gamma-Linolenic Acid240 mg--

Other ingredients: Softgel

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

DIRECTIONS: Take one softgel twice daily, or as directed by your healthcare practitioner.

Precautions

Consult your healthcare practitioner prior to use.

GLA-rich oils may be contraindicated in those who are pregnant or have a seizure disorder.

Do not use if tamper seal is damaged.

STORAGE: Keep tightly closed in a cool, dry place out of reach of children.

Formula

Borage CP-240(TM) softgels contain cold-pressed borage seed oil extracted from Borago officinalis, a blue-flowering plant. Borage seed oil is a rich source of gamma-linolenic acid (GLA), a unique omega-6 fatty acid found to support healthy skin, promote nerve health and function, and help balance the body's normal response to inflammation.

240 mg GLA from Fresh Cold-Pressed Borage Seed Oil

General Statements

Research suggests that GLA provides cardiovascular and antioxidant support as well.

Pharmaceutical Grade Professional Use Only

This package is completely recyclable

EXCLUSIVE PROFESSIONAL FORMULAS

Storage

STORAGE: Keep tightly closed in a cool, dry place out of reach of children.

Formulation

DOES NOT CONTAIN: Wheat, gluten, yeast, corn, soy, dairy products, fish, shellfish, peanuts, egg, ingredients from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or preservatives.

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

All XYMOGEN(R) Formulas Meet or Exceed cGMP Quality Standards.

(C) 2013 XYMOGEN

General

ZLB-BORAGE-01 REV. 061313

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Borage CP-240 by XYMOGEN label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Borage CP-240 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Borage CP-240 by XYMOGEN

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Borage Oil

Interacts with
226 drugs
1 Gram(s) per serving

Borage is a Mediterranean herb whose seed oil is rich in gamma-linolenic acid (GLA), an omega-6 fatty acid studied mostly for skin conditions and arth...

Borage Oil monograph & interactions

Linoleic Acid

380 mg per serving Form: Borage Oil

Gamma-Linolenic Acid

240 mg per serving Form: Borage Oil

Other (inactive) ingredients: Softgel. These complete the product’s ingredient list but are not active constituents.

Interaction report

Borage CP-240 by XYMOGEN Drug Interactions

Want to check YOUR meds against Borage CP-240?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
226Drugs
226 Moderate

Ingredients driving the most interactions

Borage Oil 226

Individual Drug Interactions

The ingredients in Borage CP-240 interact with 226 drugs. Click any drug to see the details.

1 of the 3 ingredients in Borage CP-240 interact with drugs. Each result below shows which ingredient is responsible. Borage Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in Borage CP-240 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Borage Oil3 drug types · 226 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, borage seed oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In healthy individuals, borage seed oil supplementation does not seem to affect platelet aggregation. However, gamma-linolenic acid, a constituent of borage seed oil, seems to decrease platelet aggregation by 45% and increase the risk of bleeding by 40% in animal and clinical research.

Likelihood Possible Evidence B
Cytochrome P450 3A4 (Cyp3A4) Inducers

Theoretically, taking borage with drugs that induce CYP3A4 might increase levels of pyrrolizidine alkaloid (PA) toxic metabolites.
Although borage seed oil contains little to no PAs, some borage plant parts, such as the leaf, flower, and seed, can contain hepatotoxic PAs. Hepatotoxic PAs are substrates of CYP3A4, which converts these chemicals into toxic metabolites. Tell patients to avoid borage preparations that are not certified and labeled as hepatotoxic PA-free.

Likelihood Possible Evidence D
Phenothiazines

Theoretically, taking borage sed oil with phenothiazines might increase the risk of seizures.
Borage seed oil contains gamma-linolenic acid (GLA). There is concern that taking supplements containing GLA might cause seizures, or lower the seizure threshold, when taken with phenothiazines. This is based on limited data from two reports published in the 1980s. In one report, three patients with schizophrenia who had received phenothiazines developed EEG changes suggestive of temporal lobe epilepsy after starting treatment with evening primrose, another source of GLA. However, none experienced an actual seizure. In the other report, two patients with schizophrenia who were stabilized on phenothiazines developed seizures when evening primrose 4 grams daily was added. One of these patients had a prior history of seizures. It is unclear whether evening primrose had any additive epileptogenic effects with the phenothiazines, but there is no evidence that taking GLA-containing supplements alone can cause seizures.

Likelihood Possible Evidence D
Borage Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Borage CP-240, from the product label.

XYMOGEN

See all XYMOGEN products
Name
XYMOGEN Exclusive Professional Formulas
Street Address
6900 Kingspointe Pkwy.
City
Orlando
State
FL
ZipCode
32819
Phone Number
800-647-6100
Web Address
www.xymogen.com
Pharmacist Counseling Corner

Borage CP-240 by XYMOGEN: Common Questions

Does Borage CP-240 by XYMOGEN interact with any medications?
Yes. Based on its ingredients, Borage CP-240 has a known interaction with 226 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Borage CP-240 contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm pregnant or nursing?
No — borage is rated as likely unsafe during pregnancy and breastfeeding because of concern about liver-toxic alkaloids and theoretical risk to the uterus. If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist before using this product.
What are the most common side effects?
The most common side effects are mild and digestive: belching, bloating, soft stools, and diarrhea. These tend to be well tolerated when the borage oil is certified free of pyrrolizidine alkaloids (hepatotoxic compounds).
Does borage oil actually work for eczema?
The evidence suggests it's possibly ineffective for atopic dermatitis (eczema), so it may not be a reliable choice for that condition.
Why is there a warning about liver damage?
Borage plant parts — the leaf, flower, and seed — can contain pyrrolizidine alkaloids, which are toxic to the liver. Borage seed oil contains little to none, but long-term exposure to these compounds from other sources has been linked to serious liver damage. That's why a certified PA-free product is safer.
Is this safe if I take blood thinners?
Not without checking first. Borage oil may increase bleeding risk when combined with blood thinners or antiplatelet drugs. Talk with your doctor or pharmacist before starting — they can advise whether it's safe for you and monitor you if you do take it together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Borage CP-240 is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Borage CP-240 label
Go deeper

The Full Monographs Behind Borage CP-240’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Borage

Interacts with 226 drugs

Borage is a Mediterranean herb whose seed oil is rich in gamma-linolenic acid (GLA), an omega-6 fatty acid studied mostly for skin conditions and arthritis with mixed results. The plant's le...

Read the full Borage monograph →
Sources

Sources & How We Checked

Borage CP-240's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Borage 11 references
  1. Guivernau M, Meza N, Barja P, Roman O. Clinical and experimental study on the long-term effect of dietary gamma-linolenic acid on plasma lipids, platelet aggregation, thromboxane formation, and prostacyclin production. Prostaglandins Leukot Essent Fatty A PubMed
  2. WHO working group. Pyrrolizidine alkaloids. Environmental Health Criteria, 80. WHO: Geneva, 1988.
  3. Fan YY, Chapkin RS. Importance of dietary gamma-linolenic acid in human health and nutrition. J Nutr 1998;128:1411-4.
  4. Takwale A, Tan E, Agarwal S, et al. Efficacy and tolerability of borage oil in adults and children with atopic eczema: randomised, double blind, placebo controlled, parallel group trial. BMJ 2003;327:1385. PubMed
  5. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
  6. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
  7. Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. PubMed
  8. Holman CP and Bell AF. A trial of evening primrose oil in the treatment of chronic schizophrenia. J Orhtomolecular Psych 1983;12:302-304.
  9. Vaddadi KS. The use of gamma-linolenic acid and linoleic acid to differentiate between temporal lobe epilepsy and schizophrenia. Prostaglandins Med 1981;6(4):375-379. PubMed
  10. Bard, J. M., Luc, G., Jude, B., Bordet, J. C., Lacroix, B., Bonte, J. P., Parra, H. J., and Duriez, P. A therapeutic dosage (3 g/day) of borage oil supplementation has no effect on platelet aggregation in healthy volunteers. Fundam.Clin.Pharmacol. 1997;1
  11. Puri BK. The safety of evening primrose oil in epilepsy. Prostaglandins Leukotrienes Essential Fatty Acids 2007;77:101-3. PubMed

See these in context on the Borage monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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