Brilliant Berberine 1000 mg Ingredients & Drug Interactions
by AgeImmune
What is this page for?
First and foremost: checking Brilliant Berberine 1000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Brilliant Berberine 1000 mg is a dietary supplement by AgeImmune with 2 active ingredients. Its ingredients are commonly taken for polycystic ovary syndrome (pcos), anxiety and panic, depression and mood.Based on those ingredients, 1,160 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Berberine Hydrochloride, Inositol. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Brilliant Berberine 1000 mg by AgeImmune
Ask about any prescription or over-the-counter medication and we check it for interactions with Brilliant Berberine 1000 mg by AgeImmune — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Brilliant Berberine 1000 mg by AgeImmune
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Brilliant Berberine contains 2 active ingredients: berberine hydrochloride and inositol. Berberine is a plant alkaloid studied for blood sugar and cholesterol support, while inositol is a carbohydrate your body uses to manage glucose and reproductive health.
The capsule also contains cellulose and organic rice concentrate as inactive ingredients.
Does it work?
Moderate evidence
The data shows berberine is possibly effective for high cholesterol, PCOS, high blood pressure, Helicobacter pylori infection, and diabetes. Inositol is possibly effective for PCOS, metabolic syndrome, and preterm labor.
Neither ingredient has sufficient evidence for anxiety, depression, or diabetic nerve damage—the research doesn't support those uses.
How safe is it?
Well-documented data
Berberine is generally well tolerated short-term but commonly causes digestive upset: abdominal pain, bloating, constipation, diarrhea, nausea, and vomiting. You may also feel dizzy, drowsy, or fatigued.
Inositol's most common side effects are milder—diarrhea, gas, and nausea. Berberine is likely unsafe in pregnancy and lactation; it can cross the placenta and pass into breast milk, with documented risk to newborns.
Inositol is possibly safe in pregnancy but only under medical supervision since full safety data isn't established; lactation data isn't on file. If you're pregnant, breastfeeding, or planning either, talk with your doctor before taking this product.
Meds to double-check
Major interaction found
Before you take this, double-check with your pharmacist if you're on cyclosporine (Major risk—berberine can raise its levels dangerously). Also flag any blood thinners (warfarin, aspirin, clopidogrel), blood pressure drugs, sedatives or sleep aids, diabetes medications, or any drugs your doctor says are metabolized by your liver.
If you take statins, beta-blockers, or antiarrhythmics, those need checking too.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.
If you take cyclosporine, blood thinners, blood pressure drugs, sedatives, or medications metabolized by liver enzymes CYP3A4, CYP2D6, or CYP2C9—or if you take diabetes drugs—you need to check your exact medications with your pharmacist before starting. Anyone pregnant or breastfeeding should avoid berberine and confirm inositol safety with their doctor.
If you're looking for PCOS or cholesterol support and have no medication conflicts, this product warrants a conversation with your pharmacist.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Brilliant Berberine 1000 mg, straight from the product label.
| Brand | AgeImmune |
|---|---|
| Barcode (UPC) | X001Q8NG7Z |
| Net contents | 60 Vegetarian Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jun 16, 2022 |
| DSLD ID | 268712 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Brilliant Berberine 1000 mg by AgeImmune, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Inositol | 10 mg | -- |
| Berberine Hydrochloride | 1000 mg | -- |
Other ingredients: Cellulose, organic Rice concentrate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
GMP Quality Product Made in a FDA registered facility
Non GMO
Yeast-free Non-GMO No preservatives Magnesium stearate free Corn-free Soy-free
Vegan
Doctor formulated
Advanced immune and metabolism support
Made in the USA.
Precautions
Keep out of reach of children.
Do not use if safety seal is broken.
Warnings: Consult a physician before taking this or any dietary supplement if you are pregnant, nursing, taking any medications or have a medical condition.
Storage
Store in a cool, dark place.
Suggested/Recommended/Usage/Directions
Recommended use: As a dietary supplement for adults, take 2 capsules once daily, preferably at mealtime, or as directed by a physician.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Seals/Symbols
Made In USA
Formula
Berberine with Inulin
1000 mg berberine HCL per serving
FDA Statement of Identity
Dietary Supplement
General Statements
Superior Quality Guarantee More info at www.AgeImmune.com
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Brilliant Berberine 1000 mg by AgeImmune label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Brilliant Berberine 1000 mg by AgeImmune
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Inositol
Interacts with86 drugs
Inositol is a sugar alcohol made naturally in the body and found in many foods, and it is sold as a supplement (often myo-inositol) mainly for PCOS, m...
Inositol monograph & interactionsBerberine Hydrochloride
Interacts with1,160 drugs
Berberine is a yellow plant compound that has shown promise for lowering blood sugar and cholesterol in some studies, but the quality of research vari...
Berberine Hydrochloride monograph & interactionsOther (inactive) ingredients: Cellulose, Organic Rice concentrate. These complete the product’s ingredient list but are not active constituents.
Brilliant Berberine 1000 mg by AgeImmune Drug Interactions
HelloPharmacist Interaction Report
Brilliant Berberine by AgeImmune carries significant interactions we need to talk through.
The most serious is berberine with cyclosporine (Neoral, Sandimmune)—a Major interaction. Berberine can slow how your body clears cyclosporine, raising its levels in your bloodstream and risking toxicity.
If you take an immunosuppressant like cyclosporine, this product isn't safe without close medical oversight.
Read the full breakdown — every affected drug type, severity by severity
Berberine also has Moderate interactions with several medication groups: blood thinners and antiplatelet drugs (aspirin, warfarin, clopidogrel)—it may boost bleeding risk; blood pressure drugs—it can lower pressure further; CNS depressants like benzodiazepines and opioids—it might add sedation; and drugs metabolized by your liver's CYP3A4, CYP2D6, and CYP2C9 enzymes (a large group including certain statins, beta-blockers, and antiarrhythmics)—berberine can raise their levels and side effects. Inositol also pairs with diabetes medications: both ingredients may lower blood sugar further, raising hypoglycemia risk.
Altogether, these interactions span 1,148 individual medications. Use the interaction checker below with your exact prescriptions before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Brilliant Berberine 1000 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Brilliant Berberine 1000 mg interact with 1,160 drugs. Click any drug to see the details.
2 of the 2 ingredients in Brilliant Berberine 1000 mg interact with drugs. Each result below shows which ingredient is responsible. Berberine Hydrochloride Inositol
CyclosporineCequa, Ciclosporine, Gengraf, Neoral, Sandimmune, Verkazia +1 more
How Cyclosporine interacts with Brilliant Berberine 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberine HydrochlorideCytochrome P450 3a4 (cyp3a4) Substrates, Cyclosporine (neoral, Sandimmune) Major
Interaction Summary
Theoretically, berberine might increase serum levels of drugs metabolized by CYP3A4.
Read the full Berberine Hydrochloride + Cyclosporine interactionAdo-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Brilliant Berberine 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberine HydrochlorideCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, berberine might increase serum levels of drugs metabolized by CYP3A4.
Read the full Berberine Hydrochloride + Ado-trastuzumab Emtansine interactionAbciximabReoPro
How Abciximab interacts with Brilliant Berberine 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberine HydrochlorideAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, berberine might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Berberine Hydrochloride + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Brilliant Berberine 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberine HydrochlorideCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, berberine might increase serum levels of drugs metabolized by CYP3A4.
Read the full Berberine Hydrochloride + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Brilliant Berberine 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberine HydrochlorideCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, berberine might increase serum levels of drugs metabolized by CYP3A4.
Read the full Berberine Hydrochloride + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Brilliant Berberine 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberine HydrochlorideCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, berberine might increase serum levels of drugs metabolized by CYP3A4.
Read the full Berberine Hydrochloride + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Brilliant Berberine 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberine HydrochlorideAnticoagulant/antiplatelet Drugs, Cytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, berberine might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Berberine Hydrochloride + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Brilliant Berberine 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberine HydrochlorideCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, berberine might increase serum levels of drugs metabolized by CYP3A4.
Read the full Berberine Hydrochloride + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Brilliant Berberine 1000 mg — through 2 ingredients. Tap an ingredient for the detail:
Berberine HydrochlorideAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, berberine may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Berberine Hydrochloride + Acarbose interactionInositolAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking inositol with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Inositol + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Brilliant Berberine 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberine HydrochlorideAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, berberine might have additive effects with antihypertensive drugs.
Read the full Berberine Hydrochloride + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Brilliant Berberine 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberine HydrochlorideAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, berberine might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Berberine Hydrochloride + Acenocoumarol interactionAcepromazineAtravet
How Acepromazine interacts with Brilliant Berberine 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberine HydrochlorideCns Depressants Moderate
Interaction Summary
Theoretically, berberine might increase the sedative effects of CNS depressants.
Read the full Berberine Hydrochloride + Acepromazine interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Brilliant Berberine 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberine HydrochlorideAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, berberine might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Berberine Hydrochloride + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Brilliant Berberine 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberine HydrochlorideAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, berberine might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Berberine Hydrochloride + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Brilliant Berberine 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberine HydrochlorideCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, berberine might increase serum levels of drugs metabolized by CYP3A4.
Read the full Berberine Hydrochloride + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Brilliant Berberine 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberine HydrochlorideCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants +1 Moderate
Interaction Summary
Theoretically, berberine might increase serum levels of drugs metabolized by CYP3A4.
Read the full Berberine Hydrochloride + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Brilliant Berberine 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberine HydrochlorideCytochrome P450 2d6 (cyp2d6) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, berberine might increase serum levels of drugs metabolized by CYP2D6.
Read the full Berberine Hydrochloride + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Brilliant Berberine 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberine HydrochlorideCns Depressants, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, berberine might increase the sedative effects of CNS depressants.
Read the full Berberine Hydrochloride + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Brilliant Berberine 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberine HydrochlorideCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, berberine might increase serum levels of drugs metabolized by CYP2D6.
Read the full Berberine Hydrochloride + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Brilliant Berberine 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberine HydrochlorideCns Depressants, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, berberine might increase the sedative effects of CNS depressants.
Read the full Berberine Hydrochloride + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Brilliant Berberine 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberine HydrochlorideCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, berberine might increase the sedative effects of CNS depressants.
Read the full Berberine Hydrochloride + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Brilliant Berberine 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberine HydrochlorideCytochrome P450 2d6 (cyp2d6) Substrates, Cns Depressants +1 Moderate
Interaction Summary
Theoretically, berberine might increase serum levels of drugs metabolized by CYP2D6.
Read the full Berberine Hydrochloride + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Brilliant Berberine 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberine HydrochlorideCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, berberine might increase serum levels of drugs metabolized by CYP3A4.
Read the full Berberine Hydrochloride + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Brilliant Berberine 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberine HydrochlorideCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, berberine might increase serum levels of drugs metabolized by CYP3A4.
Read the full Berberine Hydrochloride + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Brilliant Berberine 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberine HydrochlorideDextromethorphan (robitussin Dm, Others), Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, berberine may increase serum levels of dextromethorphan.
Read the full Berberine Hydrochloride + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Brilliant Berberine 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberine HydrochlorideCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, berberine might increase the sedative effects of CNS depressants.
Read the full Berberine Hydrochloride + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Brilliant Berberine 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberine HydrochlorideCytochrome P450 2d6 (cyp2d6) Substrates, Dextromethorphan (robitussin Dm, Others) +1 Moderate
Interaction Summary
Theoretically, berberine might increase serum levels of drugs metabolized by CYP2D6.
Read the full Berberine Hydrochloride + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Brilliant Berberine 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberine HydrochlorideCytochrome P450 3a4 (cyp3a4) Substrates, Dextromethorphan (robitussin Dm, Others) +1 Moderate
Interaction Summary
Theoretically, berberine might increase serum levels of drugs metabolized by CYP3A4.
Read the full Berberine Hydrochloride + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Brilliant Berberine 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberine HydrochlorideCytochrome P450 2d6 (cyp2d6) Substrates, Dextromethorphan (robitussin Dm, Others) +1 Moderate
Interaction Summary
Theoretically, berberine might increase serum levels of drugs metabolized by CYP2D6.
Read the full Berberine Hydrochloride + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Brilliant Berberine 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberine HydrochlorideCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, berberine might increase serum levels of drugs metabolized by CYP3A4.
Read the full Berberine Hydrochloride + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Brilliant Berberine 1000 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Berberine Hydrochloride
Cyclosporine (Neoral, Sandimmune)
Berberine can increase serum levels of cyclosporine.
Berberine can reduce metabolism and increase serum levels of cyclosporine. Berberine might inhibit cytochrome P450 3A4 (CYP3A4), which metabolizes cyclosporine.
Anticoagulant/Antiplatelet Drugs
Theoretically, berberine might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
In vitro and in vivo research suggest that berberine can inhibit platelet aggregation. Theoretically, berberine might have additive effects when used with anticoagulant and antiplatelet drugs and increase the risk of bleeding.
Antidiabetes Drugs
Theoretically, berberine may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Clinical research shows that berberine may lower blood glucose levels. Theoretically, berberine might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia.
Antihypertensive Drugs
Theoretically, berberine might have additive effects with antihypertensive drugs.
Animal research suggests that berberine can have hypotensive effects. Also, a clinical study suggests that taking berberine in combination with amlodipine can lower systolic and diastolic blood pressure when compared with amlodipine alone.
Cns Depressants
Theoretically, berberine might increase the sedative effects of CNS depressants.
Animal research suggests that berberine may have sedative effects. Theoretically, use of berberine along with CNS depressants might produce additive therapeutic and adverse effects.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, berberine might increase serum levels of drugs metabolized by CYP2C9.
Preliminary clinical research shows that berberine can inhibit CYP2C9. Theoretically, taking berberine with drugs metabolized by CYP2C9 might increase drug levels and increase the risk of adverse effects.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, berberine might increase serum levels of drugs metabolized by CYP2D6.
In vitro research and preliminary clinical evidence show that berberine can inhibit CYP2D6. Theoretically, use of berberine with drugs metabolized by CYP2D6 might increase drug levels and increase the risk of adverse effects.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, berberine might increase serum levels of drugs metabolized by CYP3A4.
In vitro research and preliminary clinical research show that berberine moderately inhibits CYP3A4. Theoretically, use of berberine with drugs metabolized by CYP3A4 might increase drug levels and increase the risk of adverse effects.
Dextromethorphan (Robitussin Dm, Others)
Theoretically, berberine may increase serum levels of dextromethorphan.
Preliminary clinical research shows that berberine can inhibit cytochrome P450 2D6 (CYP2D6) activity and reduce the metabolism of dextromethorphan. This may increase the effects and side effects of dextromethorphan.
Losartan (Cozaar)
Berberine might reduce the therapeutic effects of losartan by decreasing its conversion to its active form.
Preliminary clinical research suggests that berberine can inhibit cytochrome P450 2C9 (CYP2C9) activity and reduce metabolism of losartan.
Metformin (Glucophage)
Theoretically, berberine might increase the therapeutic and adverse effects of metformin.
In vitro and animal studies show that berberine can increase the systemic exposure and half-life of metformin, potentially increasing metformin's effects and side effects. This interaction seems to be most apparent when berberine is administered 2 hours prior to metformin. Taking berberine and metformin at the same time does not appear to increase systemic exposure to metformin.
Midazolam (Versed)
Berberine can reduce metabolism of midazolam, which might increase the risk of severe adverse effects.
Preliminary clinical research shows that berberine can inhibit cytochrome P450 3A4 (CYP3A4) activity and reduce metabolism of midazolam.
Pentobarbital (Nembutal)
Berberine might increase the sedative effect of pentobarbital.
Evidence from animal research shows that berberine can prolong pentobarbital-induced sleeping time. Theoretically, combining berberine and pentobarbital might increase the sedative effects of pentobarbital.
Tacrolimus (Prograf)
Berberine has been associated with increased blood levels of tacrolimus.
In a 16-year-old patient with idiopathic nephrotic syndrome who was being treated with tacrolimus 6.5 mg twice daily, intake of berberine 200 mg three times daily increased the blood concentration of tacrolimus from 8 to 22 ng/mL. Following a reduction of the tacrolimus dose to 3 mg daily, blood levels of tacrolimus decreased to 12 ng/mL.
Acetazolamide
Laboratory studies and initial clinical findings suggest that berberine has the potential to increase acetazolamide concentrations in the body. More research is needed to confirm this interaction.
Inositol
Antidiabetes Drugs
Theoretically, taking inositol with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that inositol lowers blood glucose levels and glycated hemoglobin (HbA1c) levels in patients with diabetes.
Brand information
Manufacturer and brand details for Brilliant Berberine 1000 mg, from the product label.
AgeImmune
See all AgeImmune products- Name
- Age Immune, LLC
- City
- New York
- State
- NY
- Web Address
- www.AgeImmune.com
Brilliant Berberine 1000 mg by AgeImmune: Common Questions
Does Brilliant Berberine 1000 mg by AgeImmune interact with any medications?
How can one product interact with so many drugs?
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What's the difference between berberine and inositol in this product?
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Is this safe to take with my blood pressure medication?
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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The Full Monographs Behind Brilliant Berberine 1000 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Inositol
Interacts with 86 drugsInositol is a sugar alcohol made naturally in the body and found in many foods, and it is sold as a supplement (often myo-inositol) mainly for PCOS, mood, and metabolic concerns. The stronge...
Read the full Inositol monograph → Herb & supplement monographBerberine
Interacts with 1,160 drugsBerberine is a yellow plant compound that has shown promise for lowering blood sugar and cholesterol in some studies, but the quality of research varies and it is not a replacement for presc...
Read the full Berberine monograph →Sources & How We Checked
Brilliant Berberine 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 55 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Inositol 14 references
- Palatnik A, Frolov K, Fux M, Benjamin J. Double-blind, controlled, crossover trial of inositol versus fluvoxamine for the treatment of panic disorder. J Clin Psychopharmacol 2001;21:335-9.. PubMed
- Allan SJ, Kavanagh GM, Herd RM, Savin JA. The effect of inositol supplements on the psoriasis of patients taking lithium: a randomized, placebo-controlled trial. Br J Dermatol 2004;150:966-9. PubMed
- Machado-Vieira R, Viale CI, Kapczinski F. Mania associated with an energy drink: the possible role of caffeine, taurine, and inositol. Can J Psychiatry 2001;46:454-5. PubMed
- Kamenov Z, Kolarov G, Gateva A, Carlomagno G, Genazzani AD. Ovulation induction with myo-inositol alone and in combination with clomiphene citrate in polycystic ovarian syndrome patients with insulin resistance. Gynecol Endocrinol 2015;31(2):131-5. PubMed
- Matarrelli B, Vitacolonna E, D'Angelo M, et al. Effect of dietary myo-inositol supplementation in pregnancy on the incidence of maternal gestational diabetes mellitus and fetal outcomes: a randomized controlled trial. J Matern Fetal Neonatal Med 2013;26(1 PubMed
- Mukai T, Kishi T, Matsuda Y, Iwata N. A meta-analysis of inositol for depression and anxiety disorders. Hum Psychopharmacol 2014;29(1):55-63. PubMed
- Farren M, Daly N, McKeating A, Kinsley B, Turner MJ, Daly S. The Prevention of Gestational Diabetes Mellitus With Antenatal Oral Inositol Supplementation: A Randomized Controlled Trial. Diabetes Care. 2017;40(6):759-63. PubMed
- Zheng X, Liu Z, Zhang Y, et al. Relationship Between Myo-Inositol Supplementary and Gestational Diabetes Mellitus: A Meta-Analysis. Medicine (Baltimore). 2015;94(42):e1604. PubMed
- Crawford TJ, Crowther CA, Alsweiler J, Brown J. Antenatal dietary supplementation with myo-inositol in women during pregnancy for preventing gestational diabetes. Cochrane Database Syst Rev. 2015;(12):CD011507. PubMed
- Maurizi AR, Menduni M, Del Toro R, et al. A pilot study of D-chiro-inositol plus folic acid in overweight patients with type 1 diabetes. Acta Diabetol. 2017;54(4):361-65. PubMed
- Leppink EW, Redden SA, Grant JE. A double-blind, placebo-controlled study of inositol in trichotillomania. Int Clin Psychopharmacol. 2017;32(2):107-14. PubMed
- Lam S, Mandrekar SJ, Gesthalter Y. A Randomized Phase IIb Trial of myo-Inositol in Smokers with Bronchial Dysplasia. Cancer Prev Res (Phila). 2016;9(12):906-14.
- Wozniak J, Faraone SV, Chan J, et al. A randomized clinical trial of high eicosapentaenoic acid omega-3 fatty acids and inositol as monotherapy and in combination in the treatment of pediatric bipolar spectrum disorders: a pilot study. J Clin Psychiatry. PubMed
- Vitale SG, Corrado F, Caruso S, et al. Myo-inositol supplementation to prevent gestational diabetes in overweight non-obese women: bioelectrical impedance analysis, metabolic aspects, obstetric and neonatal outcomes - a randomized and open-label, placebo-
Berberine 41 references
- Chan E. Displacement of bilirubin from albumin by berberine. Biol Neonate 1993;63:201-8. PubMed
- Janbaz KH, Gilani AH. Studies on preventive and curative effects of berberine on chemical-induced hepatotoxicity in rodents. Fitoterapia 2000;71:25-33.. PubMed
- Wu X, Li Q, Xin H, Yu A, Zhong M. Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study. Eur J Clin Pharmacol 2005;61:567-72. PubMed
- Zhang Y, Li X, Zou D, et al. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. J Clin Endocrinol Metab 2008;93:2559-65. PubMed
- Huang XS, Yang GF, Pan YC. Effect of berberin hydrochloride on blood concentration of cyclosporine A in cardiac transplanted patients. Zhongguo Zhong Xi Yi Jie He Za Zhi 2008;28:702-4.
- Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
- Chatterjee P, Franklin MR. Human cytochrome p450 inhibition and metabolic-intermediate complex formation by goldenseal extract and its methylenedioxyphenyl components. Drug Metab Dispos 2003;31:1391-7. PubMed
- Marin-Neto, J. A., Maciel, B. C., Secches, A. L., and Gallo, Junior L. Cardiovascular effects of berberine in patients with severe congestive heart failure. Clin.Cardiol. 1988;11(4):253-260. PubMed
- Choudhry, V. P., Sabir, M., and Bhide, V. N. Berberine in giardiasis. Indian Pediatr. 1972;9(3):143-146.
- Shanbhag, S. M., Kulkarni, H. J., and Gaitonde, B. B. Pharmacological actions of berberine on the central nervous system. Jpn.J Pharmacol 1970;20(4):482-487. PubMed
- Wu, J. F. and Liu, T. P. [Effects of berberine on platelet aggregation and plasma levels of TXB2 and 6-keto-PGF1 alpha in rats with reversible middle cerebral artery occlusion]. Yao Xue.Xue.Bao. 1995;30(2):98-102.
- Peng, W. H., Hsieh, M. T., and Wu, C. R. Effect of long-term administration of berberine on scopolamine-induced amnesia in rats. Jpn J Pharmacol 1997;74(3):261-266. DOI
- Sharda DC. Berberine in the treatment of diarrhoea of infancy and childhood. J Indian M A 1970;54(1):22-24.
- Sabir M and Bhide NK. Study of some pharmacological actions of berberine. Ind J Physiol & Pharmac 1971;15(3):111-132.
- Tripathi YB and Shukla SD. Berberis artistata inhibits PAF induced aggregation of rabbit platelets. Phytotherapy Research 1996;10:628-630.
- Seery TM and Bieter RN. A contribution to the pharmacology of berberine. J Pharmacol Exp Ther 1940;69:64-67. DOI
- Xin, H. W., Wu, X. C., Li, Q., Yu, A. R., Zhong, M. Y., and Liu, Y. Y. The effects of berberine on the pharmacokinetics of cyclosporin A in healthy volunteers. Methods Find.Exp.Clin Pharmacol 2006;28(1):25-29.
- Zhang, Y., Li, X., Zou, D., Liu, W., Yang, J., Zhu, N., Huo, L., Wang, M., Hong, J., Wu, P., Ren, G., and Ning, G. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. J Clin Endocrinol.Metab 2008;93(7):2559-2565. PubMed
- Yin, J., Xing, H., and Ye, J. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism 2008;57(5):712-717. PubMed
- Zhang, H., Wei, J., Xue, R., Wu, J. D., Zhao, W., Wang, Z. Z., Wang, S. K., Zhou, Z. X., Song, D. Q., Wang, Y. M., Pan, H. N., Kong, W. J., and Jiang, J. D. Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin re
- Guo, Y., Chen, Y., Tan, Z. R., Klaassen, C. D., and Zhou, H. H. Repeated administration of berberine inhibits cytochromes P450 in humans. Eur J Clin Pharmacol 2012;68(2):213-217. PubMed
- Wei, W., Zhao, H., Wang, A., Sui, M., Liang, K., Deng, H., Ma, Y., Zhang, Y., Zhang, H., and Guan, Y. A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndro
- Marazzi, G., Cacciotti, L., Pelliccia, F., Iaia, L., Volterrani, M., Caminiti, G., Sposato, B., Massaro, R., Grieco, F., and Rosano, G. Long-term effects of nutraceuticals (berberine, red yeast rice, policosanol) in elderly hypercholesterolemic patients. PubMed
- Meng, S., Wang, L. S., Huang, Z. Q., Zhou, Q., Sun, Y. G., Cao, J. T., Li, Y. G., and Wang, C. Q. Berberine ameliorates inflammation in patients with acute coronary syndrome following percutaneous coronary intervention. Clin Exp.Pharmacol Physiol 2012;39 PubMed
- Hermann, R. and von, Richter O. Clinical evidence of herbal drugs as perpetrators of pharmacokinetic drug interactions. Planta Med 2012;78(13):1458-1477. PubMed
- Chun YT, Yip TT, Lau KL, and et al. A biochemical study on the hypotensive effect of berberine in rats. Gen Pharmac 1979;10:177-182. PubMed
- Saksena HC, Tomar VN, and Soangra MR. Efficacy of a new salt of Berberine Uni-Berberine in oriental sore. Current Medical Practice 1970;14:247-252.
- Abascal K, Yarnell E. Recent clinical advances with berberine. Altern Complement Ther 2010;16(5):281-7. DOI
- Dong H, Zhao Y, Zhao L, Lu F. The effects of berberine on blood lipids: a systemic review and meta-analysis of randomized controlled trials. Planta Med 2013;79(6):437-46. PubMed
- Hou Q, Han W, Fu X. Pharmacokinetic interaction between tacrolimus and berberine in a child with idiopathic nephrotic syndrome. Eur J Clin Pharmacol 2013;69(10):1861-2. PubMed
- Lan J, Zhao Y, Dong F, et al. Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension. J Ethnopharmacol. 2015;161:69-81. PubMed
- Li G, Zhao M, Qiu F, Sun Y, Zhao L. Pharmacokinetic interactions and tolerability of berberine chloride with simvastatin and fenofibrate: an open-label, randomized, parallel study in healthy Chinese subjects. Drug Des Devel Ther. 2018;13:129-139. PubMed
- Ju J, Li J, Lin Q, Xu H. Efficacy and safety of berberine for dyslipidaemias: A systematic review and meta-analysis of randomized clinical trials. Phytomedicine. 2018;50:25-34. PubMed
- Xu L, Zhang Y, Xue X, et al. A phase I trial of berberine in Chinese with ulcerative colitis. Cancer Prev Res (Phila). 2020;13(1):117-26. PubMed
- Lyu Y, Zhang Y, Yang M, et al. Pharmacokinetic interactions between metformin and berberine in rats: Role of oral administration sequences and microbiota. Life Sci. 2019;235:116818. PubMed
- Chen YX, Gao QY, Zou TH, et al. Berberine versus placebo for the prevention of recurrence of colorectal adenoma: a multicentre, double-blinded, randomised controlled study. Lancet Gastroenterol Hepatol. 2020;5(3):267-75. PubMed
- Zhang J, Wang Y, Jiang H, et al. Preventive effect of berberine on postoperative atrial fibrillation. Circ Arrhythm Electrophysiol 2022;15(10):e011160. PubMed
- Blais JE, Huang X, Zhao JV. Overall and Sex-Specific Effect of Berberine for the Treatment of Dyslipidemia in Adults: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials. Drugs 2023;83(5):403-427. PubMed
- Panigrahi A, Mohanty S. Efficacy and safety of HIMABERB® Berberine on glycemic control in patients with prediabetes: double-blind, placebo-controlled, and randomized pilot trial. BMC Endocr Disord 2023;23(1):190. PubMed
- Nie Q, Li M, Huang C, et al. The clinical efficacy and safety of berberine in the treatment of non-alcoholic fatty liver disease: a meta-analysis and systematic review. J Transl Med 2024;22(1):225. PubMed
- Koperska A, Moszak M, Seraszek-Jaros A, Bogdanski P, Szulinska M. Does berberine impact anthropometric, hepatic, and metabolic parameters in patients with metabolic dysfunction-associated fatty liver disease? Randomized, double-blind placebo-controlled tr
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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