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Dietary supplement

Bulgarian Tribulus Ingredients & Drug Interactions

by Ultimate Nutrition

Bulgarian Tribulus label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Bulgarian Tribulus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Bulgarian Tribulus is a dietary supplement by Ultimate Nutrition with 1 active ingredient. Its ingredients are commonly taken for low libido and sexual function, athletic performance and muscle building, testosterone support.Based on those ingredients, 259 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Tribulus Blend. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Bulgarian Tribulus by Ultimate Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Bulgarian Tribulus by Ultimate Nutrition — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Bulgarian Tribulus by Ultimate Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Tribulus Blend” is a proprietary blend — the label gives one combined amount (750 mg) without saying how much of each component you get.

This product has 2 active ingredients, both forms of tribulus terrestris: a blend and a fruit extract. Tribulus is a plant used traditionally to support sexual function and athletic performance, though the evidence for those uses varies.

The inactive ingredients are gelatin, cellulose, dicalcium phosphate, and magnesium stearate, which are common capsule fillers and binders.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Tribulus's overall clinical evidence instead.

Moderate

Some clinical evidence supports Tribulus for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Sexual dysfunction — rated "Possibly Effective" (Natural Medicines).

Tribulus terrestris is rated possibly effective for sexual dysfunction based on clinical data. For athletic performance, the evidence points to possibly ineffective—the research doesn't support that claim.

For benign prostatic hyperplasia (enlarged prostate), we don't have enough reliable evidence to rate whether it works. If sexual function is your main goal, talk with your doctor about what the evidence actually shows and whether this is right for you.

The evidence, ingredient by ingredient Tribulus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Tribulus is generally well tolerated short-term in healthy adults, but quality and long-term safety data are limited, so we're cautious about recommending it long-term without more research. Serious side effects are rare but have been reported—liver and kidney injury, seizures, and in one case a patient drinking very large amounts experienced weakness, seizures, and kidney damage that improved only after stopping the supplement.

More common mild side effects are abdominal pain, cramping, nausea, vomiting, diarrhea, and constipation, though in one study these occurred at rates similar to placebo. Avoid this product during pregnancy because it may affect hormones and safety is not established.

Also avoid while breastfeeding due to lack of reliable safety information.

Side effects, ingredient by ingredient Tribulus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Tribulus.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; lithium.
  • For scale: 259 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, double-check with your pharmacist or doctor if you take blood pressure medications, diabetes medications, or lithium. Tribulus can lower blood pressure and blood sugar, raising the risk of hypotension and low blood sugar, and it may increase lithium levels.

These are all Moderate-severity interactions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Tribulus terrestris may help with sexual dysfunction, though the evidence is modest. If you take blood pressure medication, diabetes medication, or lithium, you'll need to check with your pharmacist or doctor before starting—the interactions are real and potentially serious.

Even if you don't take those drugs, keep in mind that long-term safety data are thin, and it's not advised in pregnancy or while breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Bulgarian Tribulus, straight from the product label.

Brand Ultimate Nutrition
Barcode (UPC) 099071004628
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Mar 22, 2023
DSLD ID 288075
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Bulgarian Tribulus by Ultimate Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
90
UPC/BARCODE
099071004628
IngredientAmount% DV
Tribulus Blend750 mg--
Tribulus terrestris Fruit Extract0 NP--
Tribulus terrestris0 NP--

Other ingredients: Gelatin, Cellulose, Dicalcium Phosphate, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Each Capsule Contains: 100% Bulgarian Tribulus 750 mg (Tribulus Terrestris L.). Naturally contains over 45% steroidal saponins.

750 mg of Bulgarian Tribulus Contains over 45% Steroidal Saponins

Suggested/Recommended/Usage/Directions

Directions: Take one or two capsules daily.

Daily

Precautions

Warning: If you have a medical condition or are using a prescription medicine, consult a health care professional before using this or any dietary supplement.

If you are a competitive athlete, check with your sports association before using this product.

Do not use this product if you are pregnant or nursing.

Not recommended for use by those under the age of 18.

Do not use if seal is broken or missing.

Keep out of reach of children

Storage

Protect from heat, light, and moisture Store in a cool, dry place; 15 - 30 degrees C (59 - 86 degrees F)

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

Platinum series

Pre During Post Night

FDA Statement of Identity

Herb Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Bulgarian Tribulus by Ultimate Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Bulgarian Tribulus label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Bulgarian Tribulus by Ultimate Nutrition

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Tribulus Blend

Interacts with
259 drugs
750 mg per serving

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims...

Tribulus Blend monograph & interactions

Other (inactive) ingredients: Gelatin, Cellulose, Dicalcium Phosphate, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Bulgarian Tribulus by Ultimate Nutrition Drug Interactions

Want to check YOUR meds against Bulgarian Tribulus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
259Drugs
259 Moderate

Ingredients driving the most interactions

Tribulus Blend 259

Individual Drug Interactions

The ingredients in Bulgarian Tribulus interact with 259 drugs. Click any drug to see the details.

1 of the 1 ingredient in Bulgarian Tribulus interact with drugs. Each result below shows which ingredient is responsible. Tribulus Blend

Each ingredient & the kinds of drugs it affects

For each ingredient in Bulgarian Tribulus with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Tribulus Blend3 drug types · 259 drugs

Antidiabetes Drugs

Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that Tribulus can lower blood glucose levels in adults with type 2 diabetes who are taking antidiabetes medications.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that tribulus can lower blood pressure by inhibiting angiotensin-converting enzyme (ACE). Tribulus has also demonstrated hypotensive effects in pre-hypertensive adults.

Likelihood Possible Evidence D
Lithium

Theoretically, tribulus might increase the levels and clinical effects of lithium.
Tribulus is thought to have diuretic properties. Due to these potential diuretic effects, tribulus might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Tribulus Blend full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Bulgarian Tribulus, from the product label.

Ultimate Nutrition

See all Ultimate Nutrition products
Name
Ultimate Nutrition, Inc.
Street Address
P.O. Box 643
City
Farmington
State
CT
ZipCode
06034
Web Address
www.UltimateNutrition.com
Pharmacist Counseling Corner

Bulgarian Tribulus by Ultimate Nutrition: Common Questions

Does Bulgarian Tribulus by Ultimate Nutrition interact with any medications?
Yes. Based on its ingredients, Bulgarian Tribulus has a known interaction with 259 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Bulgarian Tribulus contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does tribulus actually work for sexual dysfunction?
The evidence says possibly effective—clinical research supports some benefit, but it's not a slam-dunk. Your results may vary, and it's worth talking to your doctor about realistic expectations.
Can I take this if I'm trying to build muscle or improve athletic performance?
The research on athletic performance points to possibly ineffective, so tribulus isn't a proven sports supplement. If that's your goal, there are other approaches worth discussing with a trainer or doctor.
What side effects should I watch for?
Most people tolerate it fine, but you might experience abdominal pain, cramping, nausea, vomiting, diarrhea, or constipation. Serious side effects like liver or kidney injury are rare but have been reported. If you notice unusual symptoms, stop and talk to your pharmacist or doctor.
Is it safe to take long-term?
Long-term safety data are limited, so we're cautious. Short-term use in healthy adults is generally okay, but if you're thinking of taking it for months or longer, check with your doctor first.
Can I take this while I'm pregnant or breastfeeding?
No—avoid it during pregnancy because it may affect hormones and safety is not established. Also avoid while breastfeeding due to lack of reliable safety information. Talk to your doctor about what's safe for you and your baby.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Bulgarian Tribulus is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Bulgarian Tribulus label
Go deeper

The Full Monographs Behind Bulgarian Tribulus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tribulus

Interacts with 259 drugs

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims is weak and inconsistent. It is general...

Read the full Tribulus monograph →
Sources

Sources & How We Checked

Bulgarian Tribulus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tribulus 10 references
  1. Sharifi AM, Darabi R, Akbarloo N. Study of antihypertensive mechanism of Tribulus terrestris in 2K1C hypertensive rats: role of tissue ACE activity. Life Sci 2003;73:2963-71. PubMed
  2. Walker D, Bird A, Flora T, O'Sullivan B. Some effects of feeding Tribulus terrestris, Ipomoea lonchophylla and the seed of Abelmoschus ficulneus on fetal development and the outcome of pregnancy in sheep. Reprod Fertil Dev 1992;4:135-44. PubMed
  3. Al-Ali M, Wahbi S, Twaij H, Al-Badr A. Tribulus terrestris: preliminary study of its diuretic and contractile effects and comparison with Zea mays. J Ethnopharmacol 2003;85:257-60. PubMed
  4. Tabakova, P., Dimitrov, M., Ognyanov, K., and et al. Clinical study of Tribestan in females with endocrine sterility. Documentation for Registration (unpublished) 1999.
  5. Akhtari E, Raisi F, Keshavarz M, et al. Tribulus terrestris for treatment of sexual dysfunction in women: randomized double-blind placebo-controlled study. Daru 2014;22:40. PubMed
  6. Ryan M, Lazar I, Nadasdy GM, et al. Acute kidney injury and hyperbilirubinemia in a young male after ingestion of Tribulus terrestris. Clin Nephrol 2015;83(3):177-83. PubMed
  7. Postigo S, Lima SM, Yamada SS, et al. Assessment of the effects of Tribulus terrestris on sexual function of menopausal women. Rev Bras Ginecol Obstet 2016;38(3):140-6. PubMed
  8. Talasaz AH, Abbasi MR, Abkhiz S, Dashti-Khavidaki S. Tribulus terrestris-induced severe nephrotoxicity in a young healthy male. Nephrol Dial Tranplant 2010;25(11):3792-3. PubMed
  9. Samani NB, Jokar A, Soveid M, Heydari M, Mosavat SH. Efficacy of the hydroalcoholic extract of Tribulus terrestris on the serum glucose and lipid profile of women with diabetes mellitus: a double-blind randomized placebo-controlled clinical trial. J Evid
  10. Siddiqui MA, Itrat M, Mobeen A, Khan MI. Efficacy of khar-i-khasak (Tribulus terrestris Linn.) in prehypertension: a randomized, double-blind, placebo-controlled trial. J Complement Integr Med. 2021.

See these in context on the Tribulus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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