Major interaction on record — check this product against your medications before combining. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

Calcium + D3 Ingredients & Drug Interactions

by L'il Critters

Calcium + D3 label
See full label image
Gummy Or Jelly Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Calcium + D3 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Calcium + D3 is a dietary supplement by L'il Critters with 3 active ingredients. Its ingredients are commonly taken for bone health and osteoporosis, correcting vitamin d deficiency, immune system support.Based on those ingredients, 778 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Vitamin D, Calcium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Calcium + D3 by L'il Critters

Ask about any prescription or over-the-counter medication and we check it for interactions with Calcium + D3 by L'il Critters — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Calcium + D3 by L'il Critters

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

L'il Critters Calcium + D3 contains 3 active ingredients: calcium, vitamin D, and phosphorus. Calcium and vitamin D work together to support bone health and strength — calcium provides the mineral your bones need, and vitamin D helps your body absorb and use it.

The product also contains several inactive ingredients like sugar, gelatin, and fruit concentrates for taste and texture.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Bone and teeth support.
  • We looked for evidence on: Fractures, Fall prevention, Corticosteroid-induced osteoporosis, Hyperparathyroidism-related bone loss, Kidney transplant-related bone loss, Fetal bone mineralization — and 4 related terms.
  • The strongest evidence on file: Calcium is rated "Likely Effective" for Corticosteroid-induced osteoporosis (Natural Medicines).
  • Also on file: Calcium is rated "Likely Effective" for Hyperparathyroidism, Osteoporosis.
  • Also on file: Vitamin D is rated "Likely Effective" for Corticosteroid-induced osteoporosis.

Vitamin D is established as effective for several conditions where the body struggles to use or produce it: familial hypophosphatemia, osteomalacia (soft bones from vitamin D deficiency), renal osteodystrophy (bone disease from kidney failure), rickets (children's bone disease), and hypoparathyroidism. Calcium is likely effective for osteoporosis and is also effective for low blood calcium (hypercalcemia), certain kidney problems, and high potassium.

We hold no effectiveness data for phosphorus in this product.

The evidence, ingredient by ingredient Vitamin D Calcium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin D is generally well tolerated at recommended doses, though very high doses over time can cause toxicity — symptoms include high blood calcium levels (hypercalcemia), kidney problems, and in children, poor growth. Calcium is generally well tolerated and most people experience only mild stomach upset, constipation, or gas.

Both ingredients are considered likely safe during pregnancy and breastfeeding at recommended amounts, though vitamin D use in pregnancy should be guided by your doctor. There is some long-term concern from epidemiological studies linking very high calcium intake (over 1500–2000 mg daily) to increased prostate cancer risk in men, though the evidence is mixed and debated.

Side effects, ingredient by ingredient Vitamin D Calcium

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Calcium, Vitamin D.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: heart-rhythm medications; lithium.
  • For scale: 779 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with us before starting if your child takes dolutegravir or elvitegravir (HIV medications) — calcium significantly lowers their levels. Also flag verapamil, diltiazem, or digoxin (heart medications); levothyroxine (thyroid); sotalol (beta-blocker); ceftriaxone (antibiotic); calcipotriene (psoriasis); or raltegravir (HIV).

High-dose vitamin D with these drugs carries Moderate to Major risk. For any other prescription, run it through the checker on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product is designed for kids who need a boost in calcium and vitamin D, typically for bone development and strength. If your child takes any prescription medications — especially HIV drugs, heart medications, or thyroid medicine — check with us first: calcium and vitamin D can interfere with how these drugs work.

Talk to your pharmacist or pediatrician before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Calcium + D3, straight from the product label.

Brand L'il Critters
Barcode (UPC) 027917014173
Net contents 150 Gummy(ies)
Market status On market
Date entered into DSLD Jun 16, 2022
DSLD ID 271820
Product type Other Combinations
Supplement form Gummy Or Jelly
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Gluten Free, Dairy Free, Children more than 1 but less than 4
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Calcium + D3 by L'il Critters, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Gummy Bear(s)
Maximum serving Sizes:
2 Gummy Bear(s)
Servings per container
75
UPC/BARCODE
027917014173
IngredientAmount% DV
Calories15 Calorie(s), 10 Calorie(s)--
Total Carbohydrates4 Gram(s), 2 Gram(s)1%, 1%
Vitamin D11 mcg, 5.5 mcg55%, 37%
Added Sugars3 Gram(s), 2 Gram(s)6%, 8%
Total Sugars3 Gram(s), 2 Gram(s)--
Calcium220 mg, 110 mg17%, 16%
Phosphorus100 mg, 50 mg8%, 11%

Other ingredients: Sugar, Glucose Syrup, Water, Gelatin, Canola Lecithin, Citric Acid, Annatto Extract, Blueberry concentrate, Carrot Concentrate, Purple Carrot juice concentrate, Fumaric Acid, Lactic Acid, Medium Chain Triglyceride, Natural Flavors, Pectin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Americas #1 gummy vitamin brand Growing Communities with Fruitful Planting Our L'il Critters team believes in holistic wellness and realizes that it's more than just taking good vitamins. That's why we teamed up with the Fruit Tree Planting Foundation with the goal to plant 200,000 fruit trees by 2020 in underserved communities. Together we are committed to producing nutrient-rich fresh fruit, sustainable lifestyles and happy, healthy communities now and for generations to come. Join our mission Lilcritters.com

Questions, comments? Call 1-888-334-5389 M - F 9am-5pm ET

This product may settle during shipping.

The ChefsBest excellence award is awarded to brands that surpass quality standards established by independent professional chefs.

L'il Critters Powered by vitafusion

Servings per bottle 150 for 2-3 years, 75 for 4 years and older

An individual's need for this product may be met through a varied and well balanced diet.

Discard, Seal, Empty & Replace Cap Plastic bottle Bottle Not Recyclable Unless Label Removed Plastic label How2recycle.info

Brand IP Statement(s)

Kids love 'em. Parents trust them.

Seals/Symbols

Made in the USA with US and international ingredients American Culinary ChefsBest ChefsBest.com 2019 Chefs Best Award excellence

Manufactured with 100% Certified Renewable Energy Certified Renewable Energy Green-e

Formulation

Bone support Doctor tested Proven nutrient absorption

The No-nos No artificial flavors or sweeteners No synthetic (FD&C) dyes No high fructose corn syrup No gluten or dairy

To ensure quality and potency through expiration this dietary supplement is manufactured with higher active ingredient levels than the indicated Amount Per Serving.

Colors will fade over time. This does not alter the potency of the product.

FDA Statement of Identity

Dietary Supplement

Formula

Award-winning taste! Flavors Black cherry Orange Strawberry

What's in our gummies: Ca Calcium bone & teeth support D3 Vitamin D3 helps promote calcium absorption Two gummies contain as much calcium as a 6 oz. glass of milk For Vitamin D

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, parents may give each child, two to three years old, one (1) gummy bear per day. Parents may give each child, four years old or older, two (2) gummy bears per day. Instruct child to chew each gummy thoroughly.

Precautions

Processed in a facility with products that contain egg, fish, shellfish, soy and tree nuts.

Keep out of the reach of children

Take only as directed. Do not exceed suggested dosage.

If your child has a medical condition or is on medication, please consult a physician before using this product. Not recommended for children under two years of age due to choking.

Do not use if inner seal is broken or missing.

Storage

Do not expose to excessive heat or moisture.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Calcium + D3 by L'il Critters label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Calcium + D3 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Calcium + D3 by L'il Critters

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Gummy Bear(s) Dosage formGummy Or Jelly Servings per container75 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin D

Interacts with
715 drugs
11 mcg per serving Form: Cholecalciferol

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people,...

Vitamin D monograph & interactions

Calcium

Interacts with
168 drugs
220 mg per serving Form: Tricalcium Phosphate

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet f...

Calcium monograph & interactions

Phosphorus

100 mg per serving Form: Tricalcium Phosphate

Other (inactive) ingredients: Sugar, Glucose Syrup, Water, Gelatin, Canola Lecithin, Citric Acid, Annatto Extract, Blueberry concentrate, Carrot Concentrate, Purple Carrot juice concentrate, Fumaric Acid, Lactic Acid, Medium Chain Triglyceride, Natural Flavors, Pectin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Calcium + D3 by L'il Critters Drug Interactions

Want to check YOUR meds against Calcium + D3?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
778Drugs
7 Major 146 Moderate 625 Minor

Ingredients driving the most interactions

Vitamin D 715
Calcium 168

Individual Drug Interactions

The ingredients in Calcium + D3 interact with 778 drugs. Click any drug to see the details.

2 of the 3 ingredients in Calcium + D3 interact with drugs. Each result below shows which ingredient is responsible. Vitamin D Calcium

Each ingredient & the kinds of drugs it affects

For each ingredient in Calcium + D3 with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin D8 drug types · 715 drugs

Aluminum

Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
The protein that transports calcium across the intestinal wall can also bind and transport aluminum. This protein is stimulated by vitamin D, which may therefore increase aluminum absorption. This mechanism may contribute to increased aluminum levels and toxicity in people with renal failure, when they take vitamin D and aluminum-containing phosphate binders chronically.

Likelihood Probable Evidence B
Atorvastatin (Lipitor)

Vitamin D might reduce absorption of atorvastatin.
A small, low-quality clinical study shows that taking vitamin D reduces levels of atorvastatin and its active metabolites by up to 55%. However, while atorvastatin levels decreased, total cholesterol, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol levels did not substantially change. Atorvastatin is metabolized in the gut by CYP3A4 enzymes, and researchers theorized that vitamin D might induce CYP3A4, causing reduced levels of atorvastatin. However, this proposed mechanism was not specifically studied.

Likelihood Probable Evidence B
Calcipotriene (Dovonex)

Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with vitamin D supplements might increase the risk of hypercalcemia.

Likelihood Probable Evidence D
Digoxin (Lanoxin)

Theoretically, hypercalcemia induced by high-dose vitamin D can increase the risk of arrhythmia from digoxin.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and digoxin concurrently.

Likelihood Possible Evidence D
Diltiazem (Cardizem, Others)

Theoretically, hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of diltiazem for arrhythmia.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically this could also occur with diltiazem. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and diltiazem concurrently.

Likelihood Probable Evidence B
Thiazide Diuretics

Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Thiazide diuretics decrease urinary calcium excretion, which could lead to hypercalcemia if vitamin D supplements are taken concurrently. This has been reported in people being treated with vitamin D for hypoparathyroidism, and also in elderly people with normal parathyroid function who were taking a thiazide, vitamin D, and calcium-containing antacids daily.

Likelihood Probable Evidence D
Verapamil (Calan, Others)

Hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of verapamil for arrhythmia.
Hypercalcemia due to high doses of vitamin D can reduce the effectiveness of verapamil in atrial fibrillation. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and verapamil concurrently.

Likelihood Probable Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
There is some concern that vitamin D might induce CYP3A4. In vitro research suggests that vitamin D induces CYP3A4 transcription. Additionally, observational research has found that increased UV light exposure and serum vitamin D levels are associated with decreased serum levels of CYP3A4 substrates such as tacrolimus and sirolimus, while no association between UV light exposure or vitamin D levels and levels of mycophenolic acid, a non-CYP3A4 substrate, was found. A small, low-quality clinical study shows that taking vitamin D reduces levels of the CYP3A4 substrate atorvastatin and its active metabolites by up to 55%; however, the clinical effects of atorvastatin were not reduced. While researchers theorized that vitamin D might induce CYP3A4, this proposed mechanism was not specifically studied.

Likelihood Possible Evidence D
Vitamin D full monograph & interactions

Calcium18 drug types · 168 drugs

Ceftriaxone (Rocephin)

Co-administration of intravenous calcium and ceftriaxone can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys.
Avoid administering intravenous calcium in any form, such as parenteral nutrition or Lactated Ringers, within 48 hours of intravenous ceftriaxone. Case reports in neonates show that administering intravenous ceftriaxone and calcium can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys. In several cases, neonates have died as a result of this interaction. So far there are no reports in adults; however, there is still concern that this interaction might occur in adults.

Likelihood Probable Evidence D
Dolutegravir (Tivicay)

Calcium seems to reduce levels of dolutegravir.
Advise patients to take dolutegravir either 2 hours before or 6 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium carbonate 1200 mg concomitantly with dolutegravir 50 mg reduces plasma levels of dolutegravir by almost 40%. Calcium appears to decrease levels of dolutegravir through chelation.

Likelihood Probable Evidence B
Elvitegravir (Vitekta)

Calcium seems to reduce levels of elvitegravir.
Advise patients to take elvitegravir either 2 hours before or 2 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium along with elvitegravir can reduce blood levels of elvitegravir through chelation.

Likelihood Probable Evidence B
Aluminum

Calcium citrate might increase aluminum absorption and toxicity. Other types of calcium do not increase aluminum absorption.
Calcium citrate can increase the absorption of aluminum when taken with aluminum hydroxide. The increase in aluminum levels may become toxic, particularly in individuals with kidney disease. However, the effect of calcium citrate on aluminum absorption is due to the citrate anion rather than calcium cation. Calcium acetate does not appear to increase aluminum absorption.

Likelihood Possible Evidence B
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Calcium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and calcium can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, calcium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Calcium reduces the absorption of bisphosphonates.
Advise patients to take bisphosphonates at least 30 minutes before calcium, but preferably at a different time of day. Calcium supplements decrease absorption of bisphosphonates.

Likelihood Probable Evidence C
Calcipotriene (Dovonex)

Taking calcipotriene with calcium might increase the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with calcium supplements might increase the risk of hypercalcemia.

Likelihood Possible Evidence B
Digoxin (Lanoxin)

Using intravenous calcium with digoxin might increase the risk of fatal cardiac arrhythmias.
Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. However, one retrospective analysis of clinical data suggests that intravenous calcium does not increase the risk of dysrhythmias or mortality in patients receiving digoxin.

Likelihood Possible Evidence B
Diltiazem (Cardizem, Others)

Theoretically, calcium may reduce the therapeutic effects of diltiazem.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, calcium might increase this risk of hypercalcemia and reduce the effectiveness of diltiazem.

Likelihood Probable Evidence D
Levothyroxine (Synthroid, Others)

Calcium seems to reduce the absorption and effectiveness of levothyroxine.
Advise patients to take levothyroxine and calcium supplements at least 4 hours apart. Calcium reduces levothyroxine absorption, probably by forming insoluble complexes. Calcium carbonate supplements reduce effectiveness of levothyroxine in patients with hypothyroidism.

Likelihood Probable Evidence B
Lithium

Theoretically, concomitant use of calcium and lithium may increase this risk of hypercalcemia.
Clinical research suggests that long-term use of lithium may cause hypercalcemia in 10% to 60% of patients. Theoretically, concomitant use of lithium and calcium supplements may further increase this risk.

Likelihood Possible Evidence B
Quinolone Antibiotics

Calcium seems to reduce the absorption of quinolone antibiotics.
Advise patients to take oral quinolones at least 2 hours before or 4-6 hours after calcium supplements or calcium-fortified foods. Taking calcium at the same time as oral quinolones can reduce quinolone absorption. Calcium binds to quinolones in the gut.

Likelihood Probable Evidence B
Raltegravir (Isentress)

Calcium may reduce levels of raltegravir.
Pharmacokinetic research shows that taking a single dose of calcium carbonate 3000 mg along with raltegravir 400 mg twice daily modestly decreases the mean area under the curve of raltegravir, but the decrease does not necessitate a dose adjustment of raltegravir. However, a case of elevated HIV-1 RNA levels and documented resistance to raltegravir has been reported for a patient taking calcium carbonate 1 gram three times daily plus vitamin D3 (cholecalciferol) 400 IU three times daily in combination with raltegravir 400 mg twice daily for 11 months. It is thought that calcium reduced raltegravir levels by chelation, leading to treatment failure.

Likelihood Possible Evidence B
Sotalol (Betapace)

Calcium seems to reduce the absorption of sotalol.
Advise patients to separate doses by at least 2 hours before or 4-6 hours after calcium. Calcium appears to reduce the absorption of sotalol, probably by forming insoluble complexes.

Likelihood Possible Evidence B
Tetracycline Antibiotics

Calcium seems to reduce the absorption of tetracycline antibiotics.
Advise patients to take oral tetracyclines at least 2 hours before, or 4-6 hours after calcium supplements. Taking calcium at the same time as oral tetracyclines can reduce tetracycline absorption. Calcium binds to tetracyclines in the gut.

Likelihood Probable Evidence C
Thiazide Diuretics

Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Thiazides reduce calcium excretion by the kidneys. Using thiazides along with moderately large amounts of calcium carbonate increases the risk of milk-alkali syndrome (hypercalcemia, metabolic alkalosis, renal failure). Patients may need to have their serum calcium levels and/or parathyroid function monitored regularly.

Likelihood Probable Evidence C
Verapamil (Calan, Others)

Theoretically, calcium may reduce the therapeutic effects of verapamil.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, use of calcium supplements may increase this risk of hypercalcemia and reduce the effectiveness of verapamil.

Likelihood Probable Evidence D
Calcium Channel Blockers

Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.
Intravenous calcium is used to decrease the effects of calcium channel blockers in the management of overdose. Intravenous calcium gluconate has been used before intravenous verapamil (Isoptin) to prevent or reduce the hypotensive effects without affecting the antiarrhythmic effects. But there is no evidence that dietary or supplemental calcium when taken orally interacts with calcium channel blockers.

Likelihood Unlikely Evidence D
Calcium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Calcium + D3, from the product label.

L'il Critters

See all L'il Critters products
Name
Church & Dwight Co., Inc.
City
Ewing
State
NJ
ZipCode
08628
Phone Number
1-888-334-5389
Web Address
www.lilcritters.com
Pharmacist Counseling Corner

Calcium + D3 by L'il Critters: Common Questions

Does Calcium + D3 by L'il Critters interact with any medications?
Yes. Based on its ingredients, Calcium + D3 has a known interaction with 778 medications, including 7 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Calcium + D3 contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I give this to my child if they take levothyroxine for low thyroid?
Not without talking to your pharmacist or doctor first. Calcium in this product reduces how much levothyroxine your child's body absorbs. If your child does take it, separate the timing by at least 4 hours — give the thyroid medicine and the gummy at different times of day.
Is vitamin D in this product safe for pregnancy?
Vitamin D is generally considered likely safe in pregnancy at recommended amounts, but there are some cautions listed in the data. Use only under the guidance of your doctor, who can recommend the right dose for you and your baby.
What does phosphorus do in this gummy?
Phosphorus is one of the three active ingredients, but we don't have data on its specific role or effectiveness in this product. Your pediatrician or pharmacist can explain why it's included.
Will this cause constipation?
Calcium can cause constipation, belching, gas, or diarrhea in some people. Most children tolerate it well at recommended doses, but if your child has a sensitive stomach, mention it to your pharmacist.
Can this raise calcium too high in my child's blood?
At recommended doses, no. But if your child takes a psoriasis medicine called calcipotriene (Dovonex) or a vitamin D prescription, combining them with this gummy could raise calcium levels too high. Check with your pharmacist.
Are there any fillers or other stuff in these gummies?
Yes — these gummies contain sugar, gelatin, fruit concentrates, and other inactive ingredients for taste, texture, and shelf life. The active ingredients are calcium, vitamin D, and phosphorus.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Calcium + D3 is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Calcium + D3 label
Go deeper

The Full Monographs Behind Calcium + D3’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin D

Interacts with 715 drugs

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people, especially those with low sun exposure,...

Read the full Vitamin D monograph → Herb & supplement monograph

Calcium

Interacts with 168 drugs

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet falls short. Most people do best getting...

Read the full Calcium monograph →
Sources

Sources & How We Checked

Calcium + D3's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 88 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin D 26 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Tatro DS, ed. Drug Interactions Facts. Facts and Comparisons Inc., St. Louis, MO. 1999.
  3. Koutkia P, Chen TC, Holick MF. Vitamin D intoxication associated with an over-the-counter supplement. N Engl J Med 2001;345:66-7. PubMed
  4. Bar-Or D, Yoel G. Calcium and calciferol antagonize effect of verapamil in atrial fibrillation. Br Med J 1981;282:1585-6.
  5. Demontis R, Leflon A, Fournier A, et al. 1 alpha(OH) vitamin D3 increases plasma aluminum in hemodialyzed patients taking AI(OH)3. Clin Nephrol 1986;26:146-9.
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See these in context on the Calcium monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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