Interactions on record — worth a quick check against your medications. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

Calm Essentials Ingredients & Drug Interactions

by Terry Naturally

Calm Essentials label
See full label image
Softgel Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Calm Essentials against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Calm Essentials is a dietary supplement by Terry Naturally with 3 active ingredients. Its ingredients are commonly taken for source of vitamin c, digestive support, aromatherapy and relaxation.Based on those ingredients, 871 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Mandarin (Citrus reticulata) peel oil, Basil (Ocimum basilicum) flower oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Calm Essentials by Terry Naturally

Ask about any prescription or over-the-counter medication and we check it for interactions with Calm Essentials by Terry Naturally — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Calm Essentials by Terry Naturally

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “Proprietary Formula” is a proprietary blend — the label gives one combined amount (125 mg) without saying how much of each component you get.

Calm Essentials has three active ingredients: mandarin (citrus reticulata) peel oil, basil (Ocimum basilicum) flower oil, and exotic verbena (Litsea citrata) fruit oil. The product also contains inactive ingredients — extra virgin olive oil, gelatin, glycerin, and water — that serve as the softgel base and carrier.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: reduce stress, irritability, agitation, and tension.
  • We looked for evidence on: Headache, anxiety, mood, stress.
  • The closest evidence on file: Basil is rated "Insufficient Reliable Evidence To Rate" for Headache (Natural Medicines).

The effectiveness of these ingredients isn't well established in the data we hold. Mandarin peel shows insufficient reliable evidence for cancer.

Basil has insufficient reliable evidence for acne, headache, common cold, constipation, diarrhea, and flatulence. We have no effectiveness data on file for exotic verbena.

The evidence, ingredient by ingredient Tangerine Basil

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Tangerine fruit is generally safe as food, but concentrated extracts and essential oils should be used cautiously and with medical advice — safety hasn't been thoroughly studied at supplement doses. Basil is safe in food amounts, but concentrated supplements and essential oils are less studied; avoid medicinal doses.

Very few adverse effects have been reported with medicinal tangerine use, though contact dermatitis from tangerine essential oil has been documented in at least one case. One report links occupational basil exposure to allergic contact dermatitis.

For pregnancy and breastfeeding, basil is rated both "likely safe" and "possibly unsafe" in the data — the conflicting ratings mean you should talk with your doctor or pharmacist for personalized advice. We have no pregnancy or breastfeeding data on file for mandarin or exotic verbena.

Side effects, ingredient by ingredient Tangerine Basil

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Basil, Tangerine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 872 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist if you take blood thinners or antiplatelet drugs (like warfarin, clopidogrel, or aspirin) — basil may increase bleeding risk. Also flag any blood pressure medications you're on, since basil might lower blood pressure further.

If you take midazolam or other sedatives metabolized by the liver, mention those too.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Calm Essentials is worth discussing with your pharmacist if you're on blood thinners, blood pressure medications, or liver-metabolized drugs — especially before you start. If you're pregnant, breastfeeding, or have a history of bleeding problems, run it by your doctor first.

The effectiveness of these oils isn't proven, so be clear on what you're hoping it'll do.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 25, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Calm Essentials, straight from the product label.

Brand Terry Naturally
Barcode (UPC) 367703390044
Net contents 45 Softgel(s)
Market status On market
Date entered into DSLD Nov 25, 2014
DSLD ID 39351
Product type Botanical
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Calm Essentials by Terry Naturally, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
45
UPC/BARCODE
367703390044
IngredientAmount% DV
Proprietary Formula125 mg--
Mandarin (Citrus reticulata) peel oil0 NP--
Basil (Ocimum basilicum) flower oil0 NP--
Exotic Verbena (Litsea citrata) Fruit Oil0 NP--

Other ingredients: extra virgin Olive Oil, Gelatin, Glycerin, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

NON-GMO

Product of Belgium

UNCONDITIONALLY GUARANTEED

This highly effective formula naturally reduces stress, irritability, agitation, and tension.

All three of these plant oils have relaxing and calming effects. The unique combination helps reduce tension and improve mood.*

Bio-Typed Plant Oils are 75 to 100 times more concentrated than herbal extracts.

Supports Relaxation and Calmness* For Your Good Health

{signature} Terry

Formula

It contains mandarin oil, also known as “happy oil,” oil of basil, and oil of exotic verbena.

Suggested/Recommended/Usage/Directions

Recommendations: 1 softgel daily, may increase to 2 softgels, if desired.

Precautions

If pregnant or nursing, consult a healthcare practitioner before using.

FDA Disclaimer Statement

* THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE OR PREVENT ANY DISEASE.

General

JC 34 91 + 3(5,6)EP L39004.05

Seals/Symbols

Terry Naturally(R)

Terry Naturally EuroPharma(R)

FDA Statement of Identity

DIETARY SUPPLEMENT

Formulation

No sugar, salt, yeast, wheat, gluten, corn, soy, dairy products, artificial coloring, artificial flavoring, or artificial preservatives.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Calm Essentials by Terry Naturally label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Calm Essentials label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Calm Essentials by Terry Naturally

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container45 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Formula

125 mg per serving

Other (inactive) ingredients: Extra virgin Olive Oil, Gelatin, Glycerin, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Calm Essentials by Terry Naturally Drug Interactions

Want to check YOUR meds against Calm Essentials?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
871Drugs
289 Moderate 582 Minor

Ingredients driving the most interactions

Mandarin (Citrus reticulata) peel oil 645
Basil (Ocimum basilicum) flower oil 289

Individual Drug Interactions

The ingredients in Calm Essentials interact with 871 drugs. Click any drug to see the details.

2 of the 3 ingredients in Calm Essentials interact with drugs. Each result below shows which ingredient is responsible. Mandarin (Citrus reticulata) peel oil Basil (Ocimum basilicum) flower oil

Each ingredient & the kinds of drugs it affects

For each ingredient in Calm Essentials with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Mandarin (Citrus reticulata) peel oil2 drug types · 645 drugs

Cytochrome P450 3A4 (Cyp3A4) Substrates

In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4). This suggests that tangeretin may stimulate CYP3A4 activity. However, in humans, drinking tangerine juice 200 mL slightly delayed the absorption, but did not affect the metabolism, of midazolam, a CYP3A4 substrate. Theoretically, tangerine juice might increase CYP3A4 activity and decrease levels of drugs metabolized by this enzyme. However, this effect is unlikely.
Some drugs metabolized by CYP3A4 include amitriptyline (Elavil), amiodarone (Cordarone), citalopram (Celexa), felodipine (Plendil), lansoprazole (Prevacid), ondansetron (Zofran), prednisone (Deltasone, Orasone), sertraline (Zoloft), sibutramine (Meridia), and many others.

Likelihood Unlikely Evidence B
Midazolam (Versed)

In vitro, tangeretin, a constituent of tangerine, appears to increase the metabolism of midazolam in human liver microsomes by up to 52%. However, in humans, drinking tangerine juice 200 mL slightly delayed the absorption, but did not affect the metabolism, of midazolam. Theoretically, tangerine juice might increase the metabolism and reduce the effects of midazolam. However, this effect is unlikely.

Likelihood Unlikely Evidence B
Mandarin (Citrus reticulata) peel oil full monograph & interactions

Basil (Ocimum basilicum) flower oil2 drug types · 289 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, basil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro and animal studies suggest that basil oils and extracts inhibit platelet aggregation.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, basil might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that basil extract can reduce systolic and diastolic blood pressure.

Likelihood Possible Evidence D
Basil (Ocimum basilicum) flower oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Calm Essentials, from the product label.

Terry Naturally

See all Terry Naturally products
Name
EuroPharma, Inc.
City
Green Bay
State
WI
ZipCode
54311
Phone Number
(866) 807-2731
Web Address
www.EuroPharmaUSA.com
Pharmacist Counseling Corner

Calm Essentials by Terry Naturally: Common Questions

Does Calm Essentials by Terry Naturally interact with any medications?
Yes. Based on its ingredients, Calm Essentials has a known interaction with 871 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Calm Essentials contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help me sleep or calm anxiety?
We don't have effectiveness data on file showing that mandarin oil, basil oil, or exotic verbena work for sleep or anxiety. Talk with your pharmacist about what you're trying to achieve — there may be better-studied options.
Is it okay to take this with my blood thinner?
No — don't start this without checking first. Basil in this product may increase your bleeding risk if you're on a blood thinner like warfarin or clopidogrel. Text or call your pharmacist with the name of your medication before you buy.
Can I take this while pregnant?
The data on basil in pregnancy is mixed — it's rated both likely safe and possibly unsafe, which means we don't have a clear answer. Talk with your doctor or pharmacist about whether it's right for you. We have no pregnancy data on file for the other ingredients.
What does mandarin oil do in this formula?
Mandarin peel oil is one of the three active ingredients, but we don't have established effectiveness data showing what it's supposed to do in a supplement formula.
Are there any side effects?
Very few adverse effects have been reported with medicinal tangerine use. Basil can rarely cause allergic contact dermatitis. Both tangerine and basil oils have caused skin reactions in some cases, though that's more common with direct skin contact.
What's the olive oil in the ingredients?
That's an inactive ingredient — it's the carrier that makes the softgel. Gelatin, glycerin, and water are also there to form and fill the capsule.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Calm Essentials is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Calm Essentials label
Go deeper

The Full Monographs Behind Calm Essentials’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tangerine

Interacts with 645 drugs

Tangerine is a sweet citrus fruit that is a good source of vitamin C and other nutrients, and is widely enjoyed as food. While the peel and essential oil are used in traditional medicine and...

Read the full Tangerine monograph → Herb & supplement monograph

Basil

Interacts with 289 drugs

Basil is a popular cooking herb that is generally safe in the amounts used in food. While it has a long history of traditional medicinal use and contains antioxidant compounds, strong human...

Read the full Basil monograph →
Sources

Sources & How We Checked

Calm Essentials's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tangerine 3 references
  1. Yuan, J. M., Wang, X. L., Xiang, Y. B., Gao, Y. T., Ross, R. K., and Yu, M. C. Preserved foods in relation to risk of nasopharyngeal carcinoma in Shanghai, China. Int J Cancer 2000;85(3):358-363. DOI
  2. Backman, J. T., Maenpaa, J., Belle, D. J., Wrighton, S. A., Kivisto, K. T., and Neuvonen, P. J. Lack of correlation between in vitro and in vivo studies on the effects of tangeretin and tangerine juice on midazolam hydroxylation. Clin Pharmacol Ther 2000; PubMed
  3. Vilaplana, J. and Romaguera, C. Contact dermatitis from the essential oil of tangerine in fragrance. Contact Dermatitis 2002;46(2):108. PubMed

See these in context on the Tangerine monograph →

Basil 7 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Tognolini, M., Barocelli, E., Ballabeni, V., Bruni, R., Bianchi, A., Chiavarini, M., and Impicciatore, M. Comparative screening of plant essential oils: phenylpropanoid moiety as basic core for antiplatelet activity. Life Sci. 2-23-2006;78(13):1419-1432. PubMed
  4. Tohti, I., Tursun, M., Umar, A., Turdi, S., Imin, H., and Moore, N. Aqueous extracts of Ocimum basilicum L. (sweet basil) decrease platelet aggregation induced by ADP and thrombin in vitro and rats arterio--venous shunt thrombosis in vivo. Thromb.Res 200 PubMed
  5. Amrani, S., Harnafi, H., Gadi, D., Mekhfi, H., Legssyer, A., Aziz, M., Martin-Nizard, F., and Bosca, L. Vasorelaxant and anti-platelet aggregation effects of aqueous Ocimum basilicum extract. J Ethnopharmacol. 8-17-2009;125(1):157-162. PubMed
  6. Umar, A., Imam, G., Yimin, W., Kerim, P., Tohti, I., Berke, B., and Moore, N. Antihypertensive effects of Ocimum basilicum L. (OBL) on blood pressure in renovascular hypertensive rats. Hypertens.Res 5-7-2010; PubMed
  7. Kiec-Swierczynska M, Krecisz B, Chomiczewska D, et al. Occupational allergic contact dermatitis caused by basil (Ocimum basilicum). Contact Dermatitis 2010;63(6):365-7.

See these in context on the Basil monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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