Basil - Ziac (Bisoprolol, Hydrochlorothiazide) Interaction
Herbal: Basil
Also Known As: Ocimum basilicum, Albahaca, Basilic, Basilic Commun, Basilic Grand, Basilic Grand Vert, Basilic Romain, Basilic aux Sauces, Basilici Herba, Common Basil, Garden Basil, Munjariki, St. Josephwort, St. Joseph's Wort, Surasa, Sweet Basil, Vanatulasi, Varvara
Drug: Bisoprolol, Hydrochlorothiazide
Brand names:
Ziac
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 04, 2025
Interaction Details
Bisoprolol, Hydrochlorothiazide is classified as belonging to the following category: Antihypertensive Drugs
Theoretically, basil might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that basil extract can reduce systolic and diastolic blood pressure.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Umar, A., Imam, G., Yimin, W., Kerim, P., Tohti, I., Berke, B., and Moore, N. Antihypertensive effects of Ocimum basilicum L. (OBL) on blood pressure in renovascular hypertensive rats. Hypertens.Res 5-7-2010;
Basil Overview
Basil is an herb that is native to tropical regions of Asia and Africa and is commonly used in cooking to add flavor to a variety of dishes. It is a member of the mint family (Lamiaceae) and is known for its fragrant, sweet, and slightly spicy aroma. Basil also has a history of medicinal use and has been used for headache, stomach spasms, flatulence, diarrhea, constipation, peptic ulcers, kidney conditions, the common cold, warts, and parasite infections. Studies of basil show it is a rich source of vitamin C, carotenoids, calcium, magnesium, potassium, and iron. It is also used as an essential oil, which contains linalool, estragole (methyl chavicol), eugenol, methyl cinnamate, o-cymene, citral, alpha-pinene, camphene, beta-pinene, gamma-terpinene, cineole, menthol, rosmarinic acid, geraniol, and geranial.
Basil - More Interactions
Basil interacts with 286 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
Return to the main supplement interaction checker page
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
Ask A Pharmacist About Your Herbal Questions!
Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
Ask A Pharmacist