Drug & supplement interaction

Basil + Piroxicam

Piroxicam brand names: Feldene, Feldene Gel.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Basil has a moderate interaction with Piroxicam. Theoretically, basil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Basil and Piroxicam

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTICOAGULANT/ANTIPLATELET DRUGS

Why this applies to Piroxicam

Piroxicam falls under ANTICOAGULANT/ANTIPLATELET DRUGS — the group Basil interacts with.

Theoretically, basil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro and animal studies suggest that basil oils and extracts inhibit platelet aggregation.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the simple version. Piroxicam (Feldene) is an NSAID, and like other drugs in that family it can make your blood a little slower to clot, which is why stomach upset and bleeding are known concerns with it. Basil, in concentrated supplement or essential oil form, has shown in lab and animal studies that it may keep platelets from sticking together. Put those two together and, in theory, you could nudge up the bleeding risk a bit.

I want to be honest about the evidence here: this is theoretical and based mostly on test-tube and animal work, not solid human studies. Using basil as a kitchen herb in your cooking is very unlikely to matter. If you're thinking about basil capsules or essential oil while on piroxicam, just run it by your pharmacist or doctor first, and watch for easy bruising, dark stools, or unusual bleeding.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Tognolini, M., Barocelli, E., Ballabeni, V., Bruni, R., Bianchi, A., Chiavarini, M., and Impicciatore, M. Comparative screening of plant essential oils: phenylpropanoid moiety as basic core for antiplatelet activity. Life Sci. 2-23-2006;78(13):1419-1432. PubMed
  2. Tohti, I., Tursun, M., Umar, A., Turdi, S., Imin, H., and Moore, N. Aqueous extracts of Ocimum basilicum L. (sweet basil) decrease platelet aggregation induced by ADP and thrombin in vitro and rats arterio--venous shunt thrombosis in vivo. Thromb.Res 200 PubMed
  3. Amrani, S., Harnafi, H., Gadi, D., Mekhfi, H., Legssyer, A., Aziz, M., Martin-Nizard, F., and Bosca, L. Vasorelaxant and anti-platelet aggregation effects of aqueous Ocimum basilicum extract. J Ethnopharmacol. 8-17-2009;125(1):157-162. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Basil Also Interacts With Other Medications

Basil has 288 moderate known drug interactions in our database — the Piroxicam one above is one of them. If you take anything else, check it against the full list below.

Moderate 288 No known interaction 2,542 (incl. Piroxicam)
Taking anything else?

Check Another of Your Medications Against Basil

Covers the 2,830 medications we’ve checked against Basil. Pick one to open its full report.

From our Q&A

Questions About Basil or Piroxicam

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Basil or Piroxicam, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Piroxicam

This page covers Basil only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Piroxicam page lists 285 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Danshen (major) and Piracetam (major).

By severity: 7 major · 242 moderate · 36 minor.

From our pharmacist’s overview on the Piroxicam page

“Piroxicam (Feldene) is a potent, long-acting NSAID for arthritis pain, and since it already carries real stomach-bleeding risk on its own, my honest read is that this page calls for genuine caution rather than a quick skim. Most of the 285 interacting supplements share a single problem: they thin the blood or blunt platelets, stacking…”

Reviewed by 2 · Jul 18, 2026

Open the Piroxicam interaction page

One more smart check

Taking Basil as Part of a Dietary Supplement Product? Check It for Interactions

We hold 396 real supplement products containing Basil, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Basil. Your product may carry other ingredients that interact with Piroxicam too, on top of Basil — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Basil and Piroxicam Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Basil
Top 25%

#334 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Piroxicam
Steady interest

#1,717 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Basil

What is Basil?

Basil
  • Digestive upset and gas
  • Stress and anxiety
  • Antimicrobial support
  • Cold and cough symptoms
  • Headache
  • General antioxidant support

Basil is a popular cooking herb that is generally safe in the amounts used in food. While it has a long history of traditional medicinal use and contains antioxidant compounds, strong human evidence for most health claims is limited. Talk with your pharmacist or doctor before using concentrated supplements or essential oils.

Read the full Basil monograph & all interactions
Medication

About Piroxicam

What Is Piroxicam Used For?

Brand names: Feldene, Feldene Gel

Piroxicam capsules are used to relieve pain, swelling, and stiffness caused by osteoarthritis and rheumatoid arthritis. It targets inflammation at the source to help improve day-to-day comfort and movement.

Piroxicam is not a cure for either condition — it manages symptoms. Your prescriber will weigh the benefits against the risks and aim for the lowest effective dose for the shortest time needed.

See full Piroxicam drug information
Keep checking

Other Drugs & Basil

Browse every other medication we’ve checked against Basil — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
288Moderate
0Minor
2,541No known interaction
288 Moderate 2,541 No interaction
Moderate

288 interactions

Showing 60 of 288 moderate interactions — see all 288 on the Basil page.

No interaction 2,541 drugs checked — show the list

We also checked Basil against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,541 medications checked with no known interaction — see the full Basil list.

See the full Basil interactions page
See every supplement checked against Piroxicam, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Basil monograph › Uses, safety, and every drug interaction in one place Piroxicam supplement interactions › Every supplement checked against Piroxicam, ranked by severity Piroxicam drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Basil and Piroxicam Together: Common Questions

Can you take Basil with Piroxicam?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Basil and Piroxicam interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Piroxicam and Basil?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.