Drug & supplement interaction

Basil + Amiloride

Amiloride brand names: Midamor, Amilamont.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Basil has a moderate interaction with Amiloride. Theoretically, basil might increase the risk of hypotension when taken with antihypertensive drugs.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Basil and Amiloride

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIHYPERTENSIVE DRUGS

Why this applies to Amiloride

Amiloride falls under ANTIHYPERTENSIVE DRUGS — the group Basil interacts with.

Theoretically, basil might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that basil extract can reduce systolic and diastolic blood pressure.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist: amiloride is a potassium-sparing water pill that helps lower blood pressure. In animal studies, concentrated basil extract also nudged blood pressure down a bit. So in theory, pairing the two could push your pressure a little lower than you intend. If that happened, you might notice things like dizziness, lightheadedness when you stand up, or feeling tired or washed out.

I want to be honest about the evidence though. This is only lab and animal research, not solid human studies, so it's a fairly weak signal. The basil in your pasta sauce or pesto isn't the concern. The bigger question would be concentrated basil capsules or essential oils. If you're considering those, check with your pharmacist or doctor first, and let them know amiloride can already raise potassium.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Umar, A., Imam, G., Yimin, W., Kerim, P., Tohti, I., Berke, B., and Moore, N. Antihypertensive effects of Ocimum basilicum L. (OBL) on blood pressure in renovascular hypertensive rats. Hypertens.Res 5-7-2010; PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Basil Also Interacts With Other Medications

Basil has 288 moderate known drug interactions in our database — the Amiloride one above is one of them. If you take anything else, check it against the full list below.

Moderate 288 No known interaction 2,542 (incl. Amiloride)
Taking anything else?

Check Another of Your Medications Against Basil

Covers the 2,830 medications we’ve checked against Basil. Pick one to open its full report.

From our Q&A

Questions About Basil or Amiloride

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Basil or Amiloride, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Amiloride

This page covers Basil only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Amiloride page lists 143 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Tyramine (major) and Adrafinil (moderate).

By severity: 4 major · 116 moderate · 23 minor.

From our pharmacist’s overview on the Amiloride page

“Amiloride (Midamor) is a water pill that lowers blood pressure while holding onto potassium, and both of those jobs give supplements openings to cause trouble, so I would read this list with real care. Four of the 143 ingredients on file carry a major rating, including tyramine and American mistletoe, which can push blood pressure up a…”

Reviewed by 2 · Jul 18, 2026

Open the Amiloride interaction page

One more smart check

Taking Basil as Part of a Dietary Supplement Product? Check It for Interactions

We hold 396 real supplement products containing Basil, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Basil. Your product may carry other ingredients that interact with Amiloride too, on top of Basil — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Basil and Amiloride Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Basil
Top 25%

#340 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Amiloride
Top 25%

#695 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Basil

What is Basil?

Basil
  • Digestive upset and gas
  • Stress and anxiety
  • Antimicrobial support
  • Cold and cough symptoms
  • Headache
  • General antioxidant support

Basil is a popular cooking herb that is generally safe in the amounts used in food. While it has a long history of traditional medicinal use and contains antioxidant compounds, strong human evidence for most health claims is limited. Talk with your pharmacist or doctor before using concentrated supplements or essential oils.

Read the full Basil monograph & all interactions
Medication

About Amiloride

What Is Amiloride Used For?

Brand names: Midamor, Amilamont

Amiloride is used together with other diuretics (water pills) to treat congestive heart failure and high blood pressure (hypertension). It is added to a thiazide or similar diuretic to either restore low potassium levels or prevent them from dropping dangerously in the first place.

It is especially useful for people who are at particular risk if their potassium falls too low — for example, those taking digoxin or those with significant heart rhythm problems. Amiloride is rarely used on its own, as its diuretic and blood-pressure-lowering effects are weak compared with other diuretics.

See full Amiloride drug information
Keep checking

Other Drugs & Basil

Browse every other medication we’ve checked against Basil — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
288Moderate
0Minor
2,541No known interaction
288 Moderate 2,541 No interaction
Moderate

288 interactions

Showing 60 of 288 moderate interactions — see all 288 on the Basil page.

No interaction 2,541 drugs checked — show the list

We also checked Basil against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,541 medications checked with no known interaction — see the full Basil list.

See the full Basil interactions page
See every supplement checked against Amiloride, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Basil monograph › Uses, safety, and every drug interaction in one place Amiloride supplement interactions › Every supplement checked against Amiloride, ranked by severity Amiloride drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Basil and Amiloride Together: Common Questions

Can you take Basil with Amiloride?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Basil and Amiloride interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Amiloride and Basil?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.