Piroxicam

97 interactions 5 explained in plain English

Also sold as: Feldene Feldene®

About Piroxicam

Piroxicam is an NSAID pain reliever used to treat osteoarthritis and rheumatoid arthritis. Read the full Piroxicam drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Injection Ketorolac Ophthalmic Ketorolac Ketorolac Nasal Spray Pemetrexed Injection Hydrocortisone Injection

4 Contraindicated 63 Major 29 Moderate 1 Minor

All (97) Contraindicated (4) Major (63) Moderate (29) Minor (1)

Contraindicated

Piroxicam Ketorolac Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Piroxicam Ketorolac Injection Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Piroxicam Ketorolac Nasal Spray Sprix Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Piroxicam Ketorolac Ophthalmic Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details

Major

Piroxicam Amitriptyline Elavil Explained An increased risk of bleeding Details Piroxicam Sertraline Explained An increased risk of bleeding Details Piroxicam Apixaban Eliquis Explained An increased risk of bleeding Details Piroxicam Aspirin Acuprin® An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Piroxicam Aspirin Rectal Aspirin An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Piroxicam Betrixaban Bevyxxa® An increased risk of bleeding Details Piroxicam Anagrelide Agrylin An increased risk of bleeding Details Piroxicam Bromfenac Ophthalmic Bromday® Increased risk of bleeding Details Piroxicam Budesonide Entocort Increased risk of gastrointestinal ulcer or bleeding Details Piroxicam Budesonide Nasal Spray Rhinocort Increased risk of gastrointestinal ulcer or bleeding Details Piroxicam Budesonide Oral Inhalation Pulmicort Increased risk of gastrointestinal ulcer or bleeding Details Piroxicam Capecitabine Xeloda Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Piroxicam Clopidogrel Plavix An increased risk of bleeding Details Piroxicam Cyclosporine Injection Atopica An increased risk of cycloSPORINE nephrotoxicity Details Piroxicam Cyclosporine Ophthalmic Cequa An increased risk of cycloSPORINE nephrotoxicity Details Piroxicam Dabigatran Pradaxa® An increased risk of bleeding Details Piroxicam Dabigatran Etexilate An increased risk of bleeding Details Piroxicam Dalteparin Injection Fragmin An increased risk of bleeding Details Piroxicam Deflazacort Emflaza Increased risk of gastrointestinal ulcer or bleeding Details Piroxicam Dexamethasone Injection Decadron Increased risk of gastrointestinal ulcer or bleeding Details Piroxicam Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Increased risk of gastrointestinal ulcer or bleeding Details Piroxicam Diclofenac Ophthalmic Voltaren® Eye Drops Increased risk of bleeding Details Piroxicam Diclofenac Topical (Actinic Keratosis) Pennsaid Increased risk of bleeding Details Piroxicam Diclofenac Topical (Arthritis Pain) Pennsaid® Increased risk of bleeding Details Piroxicam Diclofenac Transdermal Patch Flector Increased risk of bleeding Details Piroxicam Digoxin Cardoxin® Increased digoxin exposure and prolonged half-life of digoxin Details Piroxicam Dipyridamole Permole® An increased risk of bleeding Details Piroxicam Edoxaban Savaysa An increased risk of bleeding Details Piroxicam Emtricitabine Emtriva Increased emtricitabine exposure and an increased risk of emtricitabine-related adverse effects Details Piroxicam Enoxaparin Lovenox An increased risk of bleeding Details Piroxicam Enoxaparin Injection Lovenox An increased risk of bleeding Details Piroxicam Epoprostenol Flolan An increased risk of bleeding Details Piroxicam Etodolac Lodine Increased risk of bleeding Details Piroxicam Fenoprofen Fenopron Increased risk of bleeding Details Piroxicam Fluorouracil Adrucil Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Piroxicam Fluorouracil Injection Adrucil Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.