Piroxicam

97 interactions 5 explained in plain English
Also sold as: Feldene Feldene®
About Piroxicam

Piroxicam is an NSAID pain reliever used to treat osteoarthritis and rheumatoid arthritis. Read the full Piroxicam drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Moderate

Piroxicam Lisinopril Prinivil Explained Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Piroxicam Atenolol Tenormin Explained Reduced antihypertensive effect Details Piroxicam Acebutolol Sectral® Reduced antihypertensive effect Details Piroxicam Benazepril Lotensin Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Piroxicam Azilsartan Edarbi Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Piroxicam Betaxolol Betoptic S Reduced antihypertensive effect Details Piroxicam Betaxolol Ophthalmic Betoptic® Reduced antihypertensive effect Details Piroxicam Bisoprolol Zebeta® Reduced antihypertensive effect Details Piroxicam Captopril Capoten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Piroxicam Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia Details Piroxicam Enalapril Epaned Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Piroxicam Eprosartan Teveten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Piroxicam Esmolol Brevibloc Reduced antihypertensive effect Details Piroxicam Fosinopril Monopril® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Piroxicam Irbesartan Avapro Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Piroxicam Labetalol Normodyne® Reduced antihypertensive effect Details Piroxicam Levobunolol Ophthalmic AKBeta® Reduced antihypertensive effect Details Piroxicam Levofloxacin Levaquin An increased risk of seizures Details Piroxicam Levofloxacin Injection Levaquin An increased risk of seizures Details Piroxicam Losartan Arbli Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Piroxicam Mitapivat Aqvesme Reduced CYP2C9 substrate exposure Details Piroxicam Moexipril Univasc® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Piroxicam Nadolol Corgard Reduced antihypertensive effect Details Piroxicam Nebivolol Bystolic Reduced antihypertensive effect Details Piroxicam Ofloxacin Floxin® An increased risk of seizures Details Piroxicam Ofloxacin Ophthalmic Ocuflox An increased risk of seizures Details Piroxicam Ofloxacin Otic Floxin® Otic An increased risk of seizures Details Piroxicam Penbutolol Levatol® Reduced antihypertensive effect Details Piroxicam Perindopril Aceon Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.