Calming Ingredients & Drug Interactions
by Yogi
What is this page for?
First and foremost: checking Calming against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Calming is a dietary supplement by Yogi with 10 active ingredients. Its ingredients are commonly taken for anxiety and stress, sleep problems, relaxation and calming.Based on those ingredients, 1,333 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic Licorice, organic Fennel, organic Lemongrass. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Calming by Yogi
Ask about any prescription or over-the-counter medication and we check it for interactions with Calming by Yogi — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Calming by Yogi
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Yogi Calming is a 10-ingredient herbal tea blend. The active ingredients are organic chamomile, orange, rose hip, lavender, licorice, cardamom, lemongrass, fennel, hibiscus, and gotu kola, each contributing traditional calming or supportive properties.
The product also contains three inactive ingredients—organic toasted brown rice, organic natural plum flavor, and organic brown rice flavor—that serve as fillers and flavoring.
Does it work?
Not established
The effectiveness ratings for these ingredients are mixed. Lavender is rated possibly effective for dysmenorrhea (period pain).
Licorice is possibly effective for atopic dermatitis (eczema) and canker sores. Fennel is possibly effective for dysmenorrhea.
Gotu kola is possibly effective for venous insufficiency and burns. Most of the other conditions studied for these herbs—such as anxiety, fatigue, and cognitive function—either lack reliable evidence or showed insufficient or possibly ineffective results.
The data we hold does not establish a clear picture of this blend's effectiveness for general calming.
How safe is it?
Well-documented data
Most of these herbs are generally well tolerated in food amounts. However, licorice deserves special caution: overuse can cause serious problems, and it is unsafe in pregnancy and should be avoided while breastfeeding.
Lavender is generally well tolerated but should be used only with guidance from your doctor—essential oil is toxic if swallowed, and skin contact can irritate some people. Fennel is possibly unsafe in pregnancy and possibly unsafe while breastfeeding due to hormone-like effects.
Lemongrass is likely unsafe in pregnancy and should be avoided in medicinal amounts. Gotu kola is possibly safe in pregnancy but best avoided while breastfeeding due to insufficient data; there is also a rare concern about liver toxicity.
Cardamom is likely safe while breastfeeding but use only food amounts in pregnancy and lactation without medical advice. Common mild side effects reported with these herbs include headache, nausea, and gastrointestinal discomfort.
Meds to double-check
Moderate interaction found
Before taking Yogi Calming, check with your pharmacist if you take any heart medications (especially digoxin), blood thinners (especially warfarin), loop diuretics (water pills), sedatives or CNS depressants, birth control pills or hormone therapy, chemotherapy drugs (especially paclitaxel or cisplatin), the antibiotic ciprofloxacin, tamoxifen, or any drug metabolized by your liver's CYP3A4, CYP2B6, CYP2C19 enzymes, or glucuronidated drugs. The licorice content is the ingredient with the broadest interaction profile.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
Yogi Calming is an herbal tea with ingredients that have some traditional and limited clinical support for calming. However, if you take any prescription medications—especially heart drugs, blood thinners, sedatives, birth control, chemotherapy, or supplements—you need to check them against the interactions listed here before you brew a cup.
Talk to your pharmacist with your medication list in hand.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 6 of 10 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Calming, straight from the product label.
| Brand | Yogi |
|---|---|
| Net contents | 16 Tea Bag(s); 1.02 Oz(s); 29 Gram(s) |
| Market status | On market |
| Date entered into DSLD | Mar 24, 2020 |
| DSLD ID | 216292 |
| Product type | Botanical |
| Supplement form | Other (e.g. Tea Bag) |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Organic |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Calming by Yogi, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| organic Chamomile | 0 NP | -- |
| Proprietary Blend of Herbs | 1727 mg | -- |
| organic Orange | 0 NP | -- |
| organic Rose Hip | 0 NP | -- |
| organic Lavender | 0 NP | -- |
| organic Licorice | 0 NP | -- |
| organic Cardamom | 0 NP | -- |
| organic Lemongrass | 0 NP | -- |
| organic Fennel | 0 NP | -- |
| organic Hibiscus | 0 NP | -- |
| organic Gotu Kola | 0 NP | -- |
Other ingredients: organic toasted Brown Rice, organic natural Plum flavor, organic Brown Rice flavor
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Yoga to Set Your Tension Free Sit crossed-legged or in a chair with a straight spine. Place hands on your knees with your arms straight. Breathe long and deep and consciously. Understand your breath is for your being. Hold the pose for 3 minutes. Please ask your doctor if this exercise is suitable for you.
Our story began in 1969 when Yogi Bhajan, an inspirational teacher of holistic living, started teaching yoga in the West. While sharing his wisdom and knowledge of herbs and healthy living, he would serve his students an aromatic spiced tea they affectionately named "Yogi Tea".
Compostable tea bags
Relax with a delicious cup of our Calming tea - and discover a natural way to find calm, any time of day.
At Yogi, it's about more than creating deliciously purposeful teas. Learn about our efforts to do good at home and around the world at yogiproducts.com/doing-good.
Formulation
Helps soothe mild tension
Caffeine free
Certified Organic by QAI, Inc.
Vegan
Non GMO
FDA Statement of Identity
Herbal Supplement
Seals/Symbols
USDA Organic Non GMO Project Verified nongmoproject.org
Quality Assurance International Certified organic
OU (Kosher)
Certified B Corporation
Precautions
Warning: Consult your healthcare provider prior to use if you are pregnant or nursing.
Formula
OU (Kosher)
Find Serenity with Calming This soothing blend combines Chamomile, traditionally used by herbalists to help ease the mind and relax the body, with Lemongrass and Gotu Kola. Lavender Flower and Licorice add a pleasant, naturally sweet flavor.
FDA Disclaimer Statement
These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
Suggested/Recommended/Usage/Directions
Get the most out of every cup. Bring water to boiling and steep 7 minutes. For a stronger tea, use 2 tea bags.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Calming by Yogi label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Calming by Yogi
These are the 10 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Tea Bag(s) Dosage formOther (e.g. Tea Bag) Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Blend of Herbs
- › Organic Chamomile
- › Organic Orange
- › Organic Rose Hip
- › Organic Lavender
- › Organic Licorice
- › Organic Cardamom
- › Organic Lemongrass
- › Organic Fennel
- › Organic Hibiscus
- › Organic Gotu Kola
Other (inactive) ingredients: Organic toasted Brown Rice, Organic natural Plum flavor, Organic Brown Rice flavor. These complete the product’s ingredient list but are not active constituents.
Calming by Yogi Drug Interactions
HelloPharmacist Interaction Report
Yogi Calming contains several herbs with documented interactions.
The most serious concern involves licorice, which has Moderate interactions with digoxin (a heart medication), warfarin (a blood thinner), loop diuretics (water pills), and several chemotherapy and other drugs. Licorice can reduce how your body clears certain medications or interfere with their effects—for example, it may decrease warfarin's effectiveness or increase the risk of heart problems when combined with digoxin.
Read the full breakdown — every affected drug type, severity by severity
Lavender may increase the effects of CNS depressants (sedatives, sleep aids, pain relievers that work on the nervous system)—a Moderate concern. Lemongrass, fennel, and gotu kola each carry Moderate interactions with different drug categories: lemongrass affects how your body metabolizes certain drugs and can potentiate sedatives; fennel may interfere with birth control, hormone therapy, and blood thinners; and gotu kola may add to the sedative effects of CNS depressants or cause liver problems if combined with other liver-toxic drugs.
Cardamom was checked and has no documented interactions. We could not check chamomile, orange, rose hip, or hibiscus—no data is on file for those ingredients.
Although we hold no monograph data for four of the ten ingredients, the checked ones span a substantial number of medications. Use the search tool below to verify your exact prescriptions and over-the-counter drugs before starting this tea.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Calming?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Calming interact with 1,333 drugs. Click any drug to see the details.
5 of the 10 ingredients in Calming interact with drugs. Each result below shows which ingredient is responsible. organic Licorice organic Fennel organic Lemongrass organic Gotu Kola organic Lavender
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Calming — through 1 ingredient. Tap an ingredient for the detail:
Organic Gotu KolaHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking gotu kola with hepatotoxic drugs might have additive adverse effects.
Read the full Organic Gotu Kola + 6-mercaptopurine interactionAdo-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Calming — through 3 ingredients. Tap an ingredient for the detail:
Organic LicoriceCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Organic Licorice + Ado-trastuzumab Emtansine interactionOrganic LemongrassCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, lemongrass might decrease the metabolism of CYP3A4 substrates.
Read the full Organic Lemongrass + Ado-trastuzumab Emtansine interactionOrganic FennelCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
Read the full Organic Fennel + Ado-trastuzumab Emtansine interactionAbacavir Sulfate, Dolutegravir, LamivudineTriumeq
How Abacavir Sulfate, Dolutegravir, Lamivudine interacts with Calming — through 1 ingredient. Tap an ingredient for the detail:
Organic Gotu KolaHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking gotu kola with hepatotoxic drugs might have additive adverse effects.
Read the full Organic Gotu Kola + Abacavir Sulfate, Dolutegravir, Lamivudine interactionAbacavir, LamivudineEpzicom
How Abacavir, Lamivudine interacts with Calming — through 1 ingredient. Tap an ingredient for the detail:
Organic Gotu KolaHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking gotu kola with hepatotoxic drugs might have additive adverse effects.
Read the full Organic Gotu Kola + Abacavir, Lamivudine interactionAbciximabReoPro
How Abciximab interacts with Calming — through 1 ingredient. Tap an ingredient for the detail:
Organic FennelAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fennel might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Organic Fennel + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Calming — through 3 ingredients. Tap an ingredient for the detail:
Organic FennelCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
Read the full Organic Fennel + Abemaciclib interactionOrganic LemongrassCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, lemongrass might decrease the metabolism of CYP3A4 substrates.
Read the full Organic Lemongrass + Abemaciclib interactionOrganic LicoriceCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Organic Licorice + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Calming — through 4 ingredients. Tap an ingredient for the detail:
Organic LicoriceCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Organic Licorice + Abiraterone interactionOrganic Gotu KolaHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking gotu kola with hepatotoxic drugs might have additive adverse effects.
Read the full Organic Gotu Kola + Abiraterone interactionOrganic FennelCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
Read the full Organic Fennel + Abiraterone interactionOrganic LemongrassCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, lemongrass might decrease the metabolism of CYP3A4 substrates.
Read the full Organic Lemongrass + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Calming — through 4 ingredients. Tap an ingredient for the detail:
Organic FennelCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
Read the full Organic Fennel + Abiraterone Acetate interactionOrganic LemongrassCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, lemongrass might decrease the metabolism of CYP3A4 substrates.
Read the full Organic Lemongrass + Abiraterone Acetate interactionOrganic LicoriceCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Organic Licorice + Abiraterone Acetate interactionOrganic Gotu KolaHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking gotu kola with hepatotoxic drugs might have additive adverse effects.
Read the full Organic Gotu Kola + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Calming — through 2 ingredients. Tap an ingredient for the detail:
Organic LicoriceCytochrome P450 2c19 (cyp2c19) Substrates, Cytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, licorice might increase levels of drugs metabolized by CYP2C19.
Read the full Organic Licorice + Abrocitinib interactionOrganic FennelAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fennel might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Organic Fennel + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Calming — through 3 ingredients. Tap an ingredient for the detail:
Organic LemongrassCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, lemongrass might decrease the metabolism of CYP3A4 substrates.
Read the full Organic Lemongrass + Acalabrutinib interactionOrganic FennelCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
Read the full Organic Fennel + Acalabrutinib interactionOrganic LicoriceCytochrome P450 3a4 (cyp3a4) Substrates, P-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Organic Licorice + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Calming — through 1 ingredient. Tap an ingredient for the detail:
Organic Gotu KolaHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking gotu kola with hepatotoxic drugs might have additive adverse effects.
Read the full Organic Gotu Kola + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Calming — through 2 ingredients. Tap an ingredient for the detail:
Organic Gotu KolaHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking gotu kola with hepatotoxic drugs might have additive adverse effects.
Read the full Organic Gotu Kola + Acebutolol interactionOrganic LicoriceAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, licorice might reduce the effects of antihypertensive drugs.
Read the full Organic Licorice + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Calming — through 1 ingredient. Tap an ingredient for the detail:
Organic FennelAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fennel might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Organic Fennel + Acenocoumarol interactionAcepromazineAtravet
How Acepromazine interacts with Calming — through 2 ingredients. Tap an ingredient for the detail:
Organic Gotu KolaCns Depressants Moderate
Interaction Summary
Theoretically, taking gotu kola might increase the sedative effects of CNS depressants.
Read the full Organic Gotu Kola + Acepromazine interactionOrganic LavenderCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Organic Lavender + Acepromazine interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Calming — through 3 ingredients. Tap an ingredient for the detail:
Organic Gotu KolaHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking gotu kola with hepatotoxic drugs might have additive adverse effects.
Read the full Organic Gotu Kola + Acetaminophen interactionOrganic LemongrassGlucuronidated Drugs Moderate
Interaction Summary
Theoretically, lemongrass might increase the clearance and decrease the levels of glucuronidated drugs.
Read the full Organic Lemongrass + Acetaminophen interactionOrganic LicoriceCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Organic Licorice + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Calming — through 4 ingredients. Tap an ingredient for the detail:
Organic LemongrassGlucuronidated Drugs Moderate
Interaction Summary
Theoretically, lemongrass might increase the clearance and decrease the levels of glucuronidated drugs.
Read the full Organic Lemongrass + Acetaminophen, Aspirin interactionOrganic FennelAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fennel might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Organic Fennel + Acetaminophen, Aspirin interactionOrganic Gotu KolaHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking gotu kola with hepatotoxic drugs might have additive adverse effects.
Read the full Organic Gotu Kola + Acetaminophen, Aspirin interactionOrganic LicoriceCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Organic Licorice + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Calming — through 4 ingredients. Tap an ingredient for the detail:
Organic LicoriceCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Organic Licorice + Acetaminophen, Aspirin, Caffeine interactionOrganic FennelAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fennel might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Organic Fennel + Acetaminophen, Aspirin, Caffeine interactionOrganic LemongrassCytochrome P450 3a4 (cyp3a4) Substrates, Glucuronidated Drugs Moderate
Interaction Summary
Theoretically, lemongrass might decrease the metabolism of CYP3A4 substrates.
Read the full Organic Lemongrass + Acetaminophen, Aspirin, Caffeine interactionOrganic Gotu KolaHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking gotu kola with hepatotoxic drugs might have additive adverse effects.
Read the full Organic Gotu Kola + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Calming — through 3 ingredients. Tap an ingredient for the detail:
Organic Gotu KolaHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking gotu kola with hepatotoxic drugs might have additive adverse effects.
Read the full Organic Gotu Kola + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionOrganic LemongrassGlucuronidated Drugs Moderate
Interaction Summary
Theoretically, lemongrass might increase the clearance and decrease the levels of glucuronidated drugs.
Read the full Organic Lemongrass + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionOrganic LicoriceCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Organic Licorice + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Calming — through 3 ingredients. Tap an ingredient for the detail:
Organic LemongrassGlucuronidated Drugs Moderate
Interaction Summary
Theoretically, lemongrass might increase the clearance and decrease the levels of glucuronidated drugs.
Read the full Organic Lemongrass + Acetaminophen, Butalbital interactionOrganic Gotu KolaHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking gotu kola with hepatotoxic drugs might have additive adverse effects.
Read the full Organic Gotu Kola + Acetaminophen, Butalbital interactionOrganic LicoriceCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Organic Licorice + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Calming — through 4 ingredients. Tap an ingredient for the detail:
Organic LicoriceCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Organic Licorice + Acetaminophen, Butalbital, Caffeine interactionOrganic LemongrassGlucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, lemongrass might increase the clearance and decrease the levels of glucuronidated drugs.
Read the full Organic Lemongrass + Acetaminophen, Butalbital, Caffeine interactionOrganic FennelCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
Read the full Organic Fennel + Acetaminophen, Butalbital, Caffeine interactionOrganic Gotu KolaHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking gotu kola with hepatotoxic drugs might have additive adverse effects.
Read the full Organic Gotu Kola + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Calming — through 5 ingredients. Tap an ingredient for the detail:
Organic LicoriceCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Organic Licorice + Acetaminophen, Butalbital, Caffeine, Codeine interactionOrganic LavenderCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Organic Lavender + Acetaminophen, Butalbital, Caffeine, Codeine interactionOrganic Gotu KolaHepatotoxic Drugs, Cns Depressants Moderate
Interaction Summary
Theoretically, taking gotu kola with hepatotoxic drugs might have additive adverse effects.
Read the full Organic Gotu Kola + Acetaminophen, Butalbital, Caffeine, Codeine interactionOrganic LemongrassCytochrome P450 3a4 (cyp3a4) Substrates, Glucuronidated Drugs Moderate
Interaction Summary
Theoretically, lemongrass might decrease the metabolism of CYP3A4 substrates.
Read the full Organic Lemongrass + Acetaminophen, Butalbital, Caffeine, Codeine interactionOrganic FennelCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
Read the full Organic Fennel + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Calming — through 4 ingredients. Tap an ingredient for the detail:
Organic LemongrassGlucuronidated Drugs Moderate
Interaction Summary
Theoretically, lemongrass might increase the clearance and decrease the levels of glucuronidated drugs.
Read the full Organic Lemongrass + Acetaminophen, Butalbital, Codeine interactionOrganic Gotu KolaCns Depressants, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking gotu kola might increase the sedative effects of CNS depressants.
Read the full Organic Gotu Kola + Acetaminophen, Butalbital, Codeine interactionOrganic LavenderCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Organic Lavender + Acetaminophen, Butalbital, Codeine interactionOrganic LicoriceCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Organic Licorice + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Calming — through 4 ingredients. Tap an ingredient for the detail:
Organic LemongrassGlucuronidated Drugs Moderate
Interaction Summary
Theoretically, lemongrass might increase the clearance and decrease the levels of glucuronidated drugs.
Read the full Organic Lemongrass + Acetaminophen, Butalbital, Codeine Phosphate interactionOrganic LavenderCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Organic Lavender + Acetaminophen, Butalbital, Codeine Phosphate interactionOrganic Gotu KolaHepatotoxic Drugs, Cns Depressants Moderate
Interaction Summary
Theoretically, taking gotu kola with hepatotoxic drugs might have additive adverse effects.
Read the full Organic Gotu Kola + Acetaminophen, Butalbital, Codeine Phosphate interactionOrganic LicoriceCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Organic Licorice + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Calming — through 5 ingredients. Tap an ingredient for the detail:
Organic Gotu KolaCns Depressants, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking gotu kola might increase the sedative effects of CNS depressants.
Read the full Organic Gotu Kola + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionOrganic LicoriceCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Organic Licorice + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionOrganic LavenderCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Organic Lavender + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionOrganic LemongrassGlucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, lemongrass might increase the clearance and decrease the levels of glucuronidated drugs.
Read the full Organic Lemongrass + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionOrganic FennelCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
Read the full Organic Fennel + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Calming — through 5 ingredients. Tap an ingredient for the detail:
Organic FennelCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
Read the full Organic Fennel + Acetaminophen, Caffeine, Codeine interactionOrganic LemongrassGlucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, lemongrass might increase the clearance and decrease the levels of glucuronidated drugs.
Read the full Organic Lemongrass + Acetaminophen, Caffeine, Codeine interactionOrganic Gotu KolaHepatotoxic Drugs, Cns Depressants Moderate
Interaction Summary
Theoretically, taking gotu kola with hepatotoxic drugs might have additive adverse effects.
Read the full Organic Gotu Kola + Acetaminophen, Caffeine, Codeine interactionOrganic LicoriceCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Organic Licorice + Acetaminophen, Caffeine, Codeine interactionOrganic LavenderCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Organic Lavender + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Calming — through 5 ingredients. Tap an ingredient for the detail:
Organic LicoriceCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Organic Licorice + Acetaminophen, Caffeine, Codeine, Salicylamide interactionOrganic FennelCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
Read the full Organic Fennel + Acetaminophen, Caffeine, Codeine, Salicylamide interactionOrganic LemongrassGlucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, lemongrass might increase the clearance and decrease the levels of glucuronidated drugs.
Read the full Organic Lemongrass + Acetaminophen, Caffeine, Codeine, Salicylamide interactionOrganic Gotu KolaHepatotoxic Drugs, Cns Depressants Moderate
Interaction Summary
Theoretically, taking gotu kola with hepatotoxic drugs might have additive adverse effects.
Read the full Organic Gotu Kola + Acetaminophen, Caffeine, Codeine, Salicylamide interactionOrganic LavenderCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Organic Lavender + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Calming — through 5 ingredients. Tap an ingredient for the detail:
Organic LicoriceCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Organic Licorice + Acetaminophen, Caffeine, Dihydrocodeine interactionOrganic LavenderCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Organic Lavender + Acetaminophen, Caffeine, Dihydrocodeine interactionOrganic Gotu KolaHepatotoxic Drugs, Cns Depressants Moderate
Interaction Summary
Theoretically, taking gotu kola with hepatotoxic drugs might have additive adverse effects.
Read the full Organic Gotu Kola + Acetaminophen, Caffeine, Dihydrocodeine interactionOrganic LemongrassCytochrome P450 3a4 (cyp3a4) Substrates, Glucuronidated Drugs Moderate
Interaction Summary
Theoretically, lemongrass might decrease the metabolism of CYP3A4 substrates.
Read the full Organic Lemongrass + Acetaminophen, Caffeine, Dihydrocodeine interactionOrganic FennelCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
Read the full Organic Fennel + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Calming — through 4 ingredients. Tap an ingredient for the detail:
Organic FennelCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
Read the full Organic Fennel + Acetaminophen, Caffeine, Isometheptene interactionOrganic LemongrassGlucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, lemongrass might increase the clearance and decrease the levels of glucuronidated drugs.
Read the full Organic Lemongrass + Acetaminophen, Caffeine, Isometheptene interactionOrganic Gotu KolaHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking gotu kola with hepatotoxic drugs might have additive adverse effects.
Read the full Organic Gotu Kola + Acetaminophen, Caffeine, Isometheptene interactionOrganic LicoriceCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Organic Licorice + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Calming — through 4 ingredients. Tap an ingredient for the detail:
Organic LicoriceCytochrome P450 1a2 (cyp1a2) Substrates, Diuretic Drugs +1 Moderate
Interaction Summary
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Organic Licorice + Acetaminophen, Caffeine, Pyrilamine interactionOrganic LemongrassCytochrome P450 3a4 (cyp3a4) Substrates, Glucuronidated Drugs Moderate
Interaction Summary
Theoretically, lemongrass might decrease the metabolism of CYP3A4 substrates.
Read the full Organic Lemongrass + Acetaminophen, Caffeine, Pyrilamine interactionOrganic FennelCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
Read the full Organic Fennel + Acetaminophen, Caffeine, Pyrilamine interactionOrganic Gotu KolaHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking gotu kola with hepatotoxic drugs might have additive adverse effects.
Read the full Organic Gotu Kola + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Calming — through 4 ingredients. Tap an ingredient for the detail:
Organic LicoriceCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Organic Licorice + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionOrganic Gotu KolaHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking gotu kola with hepatotoxic drugs might have additive adverse effects.
Read the full Organic Gotu Kola + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionOrganic LemongrassGlucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, lemongrass might increase the clearance and decrease the levels of glucuronidated drugs.
Read the full Organic Lemongrass + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionOrganic FennelCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
Read the full Organic Fennel + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Calming with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
organic Licorice
Antihypertensive Drugs
Theoretically, licorice might reduce the effects of antihypertensive drugs.
In human research, licorice increases blood pressure in a dose-dependent manner.
Cisplatin (Platinol-Aq)
Theoretically, licorice might reduce the effects of cisplatin.
In animal research, licorice diminished the therapeutic efficacy of cisplatin.
Corticosteroids
Theoretically, concomitant use of licorice and corticosteroids might increase the side effects of corticosteroids.
Case reports suggest that concomitant use of licorice and oral corticosteroids, such as hydrocortisone, can potentiate the duration of activity and increase blood levels of corticosteroids. Additionally, in one case report, a patient with neurogenic orthostatic hypertension stabilized on fludrocortisone 0.1 mg twice daily developed pseudohyperaldosteronism after recent consumption of large amounts of black licorice.
Cytochrome P450 2B6 (Cyp2B6) Substrates
Theoretically, licorice might increase levels of drugs metabolized by CYP2B6.
In vitro research shows that licorice extract and glabridin, a licorice constituent, inhibit CYP2B6 isoenzymes. Licorice extract from the species G. uralensis seems to inhibit CYP2B6 isoenzymes to a greater degree than G. glabra extract in vitro. Theoretically, these species of licorice might increase levels of drugs metabolized by CYP2B6; however, these interactions have not yet been reported in humans.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, licorice might increase levels of drugs metabolized by CYP2C19.
In vitro, licorice extracts from the species G. glabra and G. uralensis inhibit CYP2C19 isoenzymes in vitro. Theoretically, these species of licorice might increase levels of drugs metabolized by CYP2C19; however, this interaction has not yet been reported in humans.
Cytochrome P450 2C8 (Cyp2C8) Substrates
Theoretically, licorice might increase levels of drugs metabolized by CYP2C8.
In vitro, licorice extract from the species G. glabra and G. uralensis inhibits CYP2C8 isoenzymes. Theoretically, these species of licorice might increase levels of drugs metabolized by CYP2C8; however, this interaction has not yet been reported in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP2C9.
There is conflicting evidence about the effect of licorice on CYP2C9 enzyme activity. In vitro research shows that extracts from the licorice species G. glabra and G. uralensis moderately inhibit CYP2C9 isoenzymes. However, evidence from an animal model shows that licorice extract from the species G. uralensis can induce hepatic CYP2C9 activity. Until more is known, licorice should be used cautiously in people taking CYP2C9 substrates.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Pharmacokinetic research shows that the licorice constituent glycyrrhizin, taken in a dosage of 150 mg orally twice daily for 14 days, modestly decreases the area under the concentration-time curve of midazolam by about 20%. Midazolam is a substrate of CYP3A4, suggesting that glycyrrhizin modestly induces CYP3A4 activity. Animal research also shows that licorice extract from the species G. uralensis induces CYP3A4 activity. However, licorice extract from G. glabra species appear to inhibit CYP3A4-induced metabolism of testosterone in vitro. It is thought that the G. glabra inhibits CYP3A4 due to its constituent glabridin, which is a moderate CYP3A4 inhibitor in vitro and not present in other licorice species. Until more is known, licorice should be used cautiously in people taking CYP3A4 substrates.
Digoxin (Lanoxin)
Theoretically, concomitant use of licorice with digoxin might increase the risk of cardiac toxicity.
Overuse or misuse of licorice with cardiac glycoside therapy might increase the risk of cardiac toxicity due to potassium loss.
Diuretic Drugs
Theoretically, concomitant use of licorice with diuretic drugs might increase the risk of hypokalemia.
Overuse of licorice might compound diuretic-induced potassium loss. In one case report, a 72-year-old male with a past medical history of hypertension, type 2 diabetes, hyperlipidemia, arrhythmia, stroke, and hepatic dysfunction was hospitalized with severe hypokalemia and uncontrolled hypertension due to pseudohyperaldosteronism. This was thought to be provoked by concomitant daily consumption of a product containing 225 mg of glycyrrhizin, a constituent of licorice, and hydrochlorothiazide 12.5 mg for 1 month.
Estrogens
Theoretically, licorice might increase or decrease the effects of estrogen therapy.
Theoretically, licorice might interfere with estrogen therapy due to estrogenic and anti-estrogenic effects.
Loop Diuretics
Theoretically, loop diuretics might increase the mineralocorticoid effects of licorice.
Theoretically, loop diuretics might enhance the mineralocorticoid effects of licorice by inhibiting the enzyme that converts cortisol to cortisone; however, bumetanide (Bumex) does not appear to have this effect.
Midazolam (Versed)
Theoretically, licorice might decrease levels of midazolam.
In humans, the licorice constituent glycyrrhizin appears to moderately induce the metabolism of midazolam. This is likely due to induction of cytochrome P450 3A4 by licorice. Until more is known, licorice should be used cautiously in people taking midazolam.
P-Glycoprotein Substrates
Theoretically, licorice might decrease the absorption of P-glycoprotein substrates.
In vitro research shows that licorice can increase P-glycoprotein activity.
Paclitaxel (Abraxane, Onxol)
Theoretically, licorice might decrease plasma levels and clinical effects of paclitaxel.
Multiple doses of licorice taken concomitantly with paclitaxel might reduce the effectiveness of paclitaxel. Animal research shows that licorice 3 grams/kg given orally for 14 days before intravenous administration of paclitaxel decreases the exposure to paclitaxel and increases its clearance. Theoretically, this occurs because licorice induces cytochrome P450 3A4 enzymes, which metabolize paclitaxel. Notably, a single dose of licorice did not affect exposure or clearance of paclitaxel.
Warfarin (Coumadin)
Theoretically, licorice might decrease plasma levels and clinical effects of warfarin.
Licorice seems to increase metabolism and decrease levels of warfarin in animal models. This is likely due to induction of cytochrome P450 2C9 (CYP2C9) metabolism by licorice. Advise patients taking warfarin to avoid taking licorice.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that licorice induces CYP1A2 enzymes.
Methotrexate (Trexall, Others)
Theoretically, licorice might increase levels of methotrexate.
Animal research suggests that intravenous administration of glycyrrhizin, a licorice constituent, and high-dose methotrexate may delay methotrexate excretion and increase systemic exposure, leading to transient elevations in liver enzymes and total bilirubin. This interaction has not yet been reported in humans.
organic Fennel
Anticoagulant/Antiplatelet Drugs
Theoretically, fennel might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Animal research suggests that fennel oil has antithrombotic and antiplatelet effects.
Ciprofloxacin (Cipro)
Theoretically, fennel might decrease the levels and clinical effects of ciprofloxacin.
Animal research shows that fennel reduces ciprofloxacin bioavailability by nearly 50%, possibly due to the metal cations such as calcium, iron, and magnesium contained in fennel. This study also found that fennel increased tissue distribution and slowed elimination of ciprofloxacin.
Contraceptive Drugs
Theoretically, taking large amounts of fennel might decrease the effects of contraceptive drugs due to competition for estrogen receptors.
Some constituents of fennel have estrogenic activity.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
In vitro research suggests that fennel inhibits CYP3A4 enzyme activity. This effect has not been reported in humans.
Estrogens
Theoretically, taking large amounts of fennel might interfere with hormone replacement therapy due to competition for estrogen receptors.
Some constituents of fennel have estrogenic activity.
Tamoxifen (Nolvadex)
Theoretically, taking large amounts of fennel might decrease the antiestrogenic effect of tamoxifen.
Some constituents of fennel have estrogenic activity, which may interfere with the antiestrogenic activity of tamoxifen.
organic Lemongrass
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, lemongrass might decrease the metabolism of CYP3A4 substrates.
Animal research shows that lemongrass and its constituent citral inhibit CYP3A4.
Glucuronidated Drugs
Theoretically, lemongrass might increase the clearance and decrease the levels of glucuronidated drugs.
Animal research shows that lemongrass and its constituent citral induce uridine diphosphoglucuronosyl transferase (UGT), the major phase 2 enzyme that is responsible for glucuronidation.
Pentobarbital (Nembutal)
Theoretically, lemongrass might increase the effects and adverse effects of pentobarbital.
Animal research shows that high doses of lemongrass essential oil increases sleep time and decreases time to fall asleep in animals administered pentobarbital.
organic Gotu Kola
Cns Depressants
Theoretically, taking gotu kola might increase the sedative effects of CNS depressants.
In vitro research suggests that gotu kola may have sedative effects via binding of GABA receptors.
Hepatotoxic Drugs
Theoretically, taking gotu kola with hepatotoxic drugs might have additive adverse effects.
There are at least four case reports of hepatotoxicity associated with the use of gotu kola. However, more information is needed to determine if gotu kola was the causative factor in these cases.
organic Lavender
Cns Depressants
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Laboratory research suggests that lavender has sedative effects. However, clinical studies in patients taking oral lavender oil (Silexan) 160 mg for 10 weeks or taking lavender flower powder 1 gram daily for 2 months have not reported side effects of drowsiness, sedation, or sleepiness. There is still some concern that higher doses or different preparations of lavender might have additive effects with CNS depressant medications.
Brand information
Manufacturer and brand details for Calming, from the product label.
Yogi
See all Yogi products- Name
- East West Tea Company, LLC
- City
- Eugene
- State
- OR
- ZipCode
- 97402
- Web Address
- yogiproducts.com/doing-good
Calming by Yogi: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Calming’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Lavender
Interacts with 248 drugsLavender is a fragrant herb most popular for promoting relaxation, easing anxiety, and supporting sleep, with some encouraging evidence for a standardized oral lavender oil product for anxie...
Read the full Lavender monograph → Herb & supplement monographLicorice
Interacts with 1,040 drugsLicorice root is a traditional remedy used for sore throats, coughs, and digestive complaints, but solid human evidence is limited for most uses. Regular licorice contains glycyrrhizin, whic...
Read the full Licorice monograph → Herb & supplement monographCardamom
Cardamom is a popular cooking spice that has long been used in traditional medicine for digestion and fresh breath. As a food, it is generally safe for most people, but high-dose supplements...
Read the full Cardamom monograph → Herb & supplement monographLemongrass
Interacts with 708 drugsLemongrass is a fragrant tropical grass widely used as a cooking herb, a tea, and an aromatherapy oil. It is generally considered safe in the small amounts used in food, but most of its clai...
Read the full Lemongrass monograph → Herb & supplement monographFennel
Interacts with 740 drugsFennel is a Mediterranean herb widely used as a food and spice, and traditionally taken for digestive complaints, colic, and menstrual cramps. Some small studies suggest possible benefit for...
Read the full Fennel monograph → Herb & supplement monographGotu Kola
Interacts with 579 drugsGotu kola is a traditional Ayurvedic and Asian herb that people use for wound healing, circulation, skin problems, and as a calming or memory-supporting herb. Some early studies suggest poss...
Read the full Gotu Kola monograph →Sources & How We Checked
Calming's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 151 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Lavender 20 references
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
- Akhondzadeh S, Kashani L, Fotouhi A, et al. Comparison of Lavandula angustifolia Mill. tincture and imipramine in the treatment of mild to moderate depression: a double-blind, randomized trial. Prog Neuropsychopharmacol Biol Psychiatry 2003;27:123-7. PubMed
- Varma S, Blackford S, Statham BN, Blackwell A. Combined contact allergy to tea tree oil and lavender oil complicating chronic vulvovaginitis. Contact Dermatitis 2000;42:309-10.
- Coulson IH and Khan AS. Facial 'pillow' dermatitis due to lavender oil allergy. Contact Dermatitis 1999;41(2):111. PubMed
- Woelk, H. and Schlafke, S. A multi-center, double-blind, randomised study of the Lavender oil preparation Silexan in comparison to Lorazepam for generalized anxiety disorder. Phytomedicine. 2010;17(2):94-99. PubMed
- Kasper, S., Gastpar, M., Muller, W. E., Volz, H. P., Moller, H. J., Dienel, A., and Schlafke, S. Silexan, an orally administered Lavandula oil preparation, is effective in the treatment of 'subsyndromal' anxiety disorder: a randomized, double-blind, plac
- Uehleke, B., Schaper, S., Dienel, A., Schlaefke, S., and Stange, R. Phase II trial on the effects of Silexan in patients with neurasthenia, post-traumatic stress disorder or somatization disorder. Phytomedicine. 6-15-2012;19(8-9):665-671. PubMed
- Brandao FM. Occupational allergy to lavender oil. Contact Dermatitis 1986;15(4):249-250. PubMed
- Rademaker M. Allergic contact dermatitis from lavender fragrance in Difflam gel. Contact Dermatitis 1994;31(1):58-59. PubMed
- Kasper S, Gastpar M, Müller WE, et al. Lavender oil preparation Silexan is effective in generalized anxiety disorder--a randomized, double-blind comparison to placebo and paroxetine. Int J Neuropsychopharmacol. 2014 Jun;17(6):859-69. PubMed
- Farshbaf-Khalili A, Kamalifard M, Namadian M. Comparison of the effect of lavender and bitter orange on anxiety in postmenopausal women: A triple-blind, randomized, controlled clinical trial. Complement Ther Clin Pract 2018;31:132-8. PubMed
- Bingham LJ, Tam MM, Palmer AM, Cahill JL, Nixon RL. Contact allergy and allergic contact dermatitis caused by lavender: A retrospective study from an Australian clinic. Contact Dermatitis. 2019;81(1):37-42. PubMed
- Donelli D, Antonelli M, Bellinazzi C, Gensini GF, Firenzuoli F. Effects of lavender on anxiety: A systematic review and meta-analysis. Phytomedicine. 2019;65:153099. PubMed
- Firoozeei TS, Feizi A, Rezaeizadeh H, Zargaran A, Roohafza HR, Karimi M. The antidepressant effects of lavender (Lavandula angustifolia Mill.): A systematic review and meta-analysis of randomized controlled clinical trials. Complement Ther Med 2021;59:102 PubMed
- Kodama T, Watanabe T, Mataki N, Kanoh S, Kichikawa Y. Acute eosinophilic pneumonia following aromatherapy with essential oil. Respir Med Case Rep 2022;37:101657. PubMed
- Barbaud A, Kurihara F, Raison-Peyron N, et al. Allergic contact dermatitis from essential oil in consumer products: Mode of uses and value of patch-tests with an essential oil series. Results of a French study of the DAG (dermato-allergy group of the Fren
- Ozer H, Sayan ZA, Baloglu I, Ozturk Y, Yonet F, Turkmen K. Unknown criminals for kidney: Acute interstitial nephritis due to lavender tea. Explore (NY) 2023. PubMed
- Kasper S, Volz HP, Möller HJ, et al. Lavender oil preparation Silexan is effective in mild-to-moderate major depression: a randomized, placebo- and reference-controlled trial. Eur Arch Psychiatry Clin Neurosci 2024. PubMed
- Simaei SR, Askari VR, Rostami M, et al. Lavender and metformin effectively propagate progesterone levels in patients with polycystic ovary syndrome: A randomized, double-blind clinical trial. Fitoterapia 2023;172:105720. PubMed
Licorice 92 references
- Farese RV Jr, Biglieri EG, Shackleton CH, et al. Licorice-induced hypermineralocorticoidism. N Engl J Med 1991;325:1223-7. PubMed
- Sigurjonsdottir HA, Ragnarsson J, Franzson L, Sigurdsson G. Is blood pressure commonly raised by moderate consumption of liquorice? J Hum Hypertens 1995;9:345-8.
- Armanini D, Lewicka S, Pratesi C, et al. Further studies on the mechanism of the mineralocorticoid action of licorice in humans. J Endocrinol Invest 1996;19:624-9. PubMed
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