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Dietary supplement

Carnosine Supreme Ingredients & Drug Interactions

by Designs for Health

Carnosine Supreme label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Carnosine Supreme against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Carnosine Supreme is a dietary supplement by Designs for Health with 2 active ingredients. Its ingredients are commonly taken for diabetic nerve pain (neuropathy), supporting healthy nerve function, thiamine deficiency.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Carnosine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Carnosine Supreme by Designs for Health

Ask about any prescription or over-the-counter medication and we check it for interactions with Carnosine Supreme by Designs for Health — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Carnosine Supreme by Designs for Health

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Carnosine Supreme contains two active ingredients. Benfotiamine is a form of vitamin B1 (thiamine) that your body absorbs more readily than standard thiamine.

Carnosine is a naturally occurring compound made from two amino acids (alanine and histidine) that your muscle and nerve cells produce on their own. The product also includes microcrystalline cellulose and vegetable stearate as inactive ingredients to hold the capsule together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Diabetic neuropathy — rated "Possibly Effective" (Benfotiamine) (Natural Medicines).

The evidence for this product's ingredients is mixed and limited. Benfotiamine may help with diabetic nerve pain (neuropathy) but appears ineffective for diabetic kidney damage (nephropathy).

For carnosine, we don't have enough reliable evidence to say whether it works for age-related cognitive decline, Alzheimer disease, athletic performance, cataracts, or general cognitive impairment — the research just isn't established yet in our data.

The evidence, ingredient by ingredient Benfotiamine Carnosine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both ingredients are generally well tolerated in short-term studies, but long-term safety data are limited. With benfotiamine, a small number of trial participants reported allergic skin reactions or mild stomach discomfort, though these rates matched placebo.

Carnosine can cause decreased appetite, dry mouth, minor weight changes, foot and joint pain, and in rare cases pneumonia has been reported. For pregnancy and breastfeeding: the safety data advises against using carnosine — there isn't enough information to know it's safe.

Benfotiamine safety during breastfeeding hasn't been well studied, so caution is advised. Talk with your doctor or pharmacist about either ingredient if you're pregnant or nursing.

Side effects, ingredient by ingredient Benfotiamine Carnosine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Carnosine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antidiabetes drugs — like metformin, insulin, sulfonylureas, or GLP-1 agonists — check with your doctor or pharmacist before adding this product. Carnosine may increase your low blood sugar risk, and you may need dose adjustments or closer monitoring.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Carnosine Supreme might interest you if you're exploring options for nerve pain or cognitive support, but the evidence for most uses is still uncertain. If you take any diabetes medications, you'll need to check those carefully with your doctor or pharmacist first — carnosine may lower your blood sugar further.

Pregnant or breastfeeding? The safety data on these ingredients don't support use, so discuss it with your healthcare provider before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Carnosine Supreme, straight from the product label.

Brand Designs for Health
Barcode (UPC) 879452001282
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jul 25, 2013
DSLD ID 22380
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Carnosine Supreme by Designs for Health, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
879452001282
IngredientAmount% DV
Benfotiamine100 mg--
Carnosine450 mg--

Other ingredients: Microcrystalline Cellulose, Vegetable Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Notice: Color, size or shape may appear different between lots.

For Professional Use Only

Formulation

Does not contain gluten.

General

CNS060

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Recommended Use: As a dietary supplement, take one capsule daily, or as directed by your health care practitioner.

Seals/Symbols

Manufactured in a GMP CERTIFIED Facility

Storage

STORE IN A COOL, DRY PLACE.

Precautions

KEEP OUT OF REACH OF CHILDREN.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Carnosine Supreme by Designs for Health label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Carnosine Supreme label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Carnosine Supreme by Designs for Health

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Benfotiamine

No known
interactions
100 mg per serving

Benfotiamine is a man-made, fat-soluble form of vitamin B1 (thiamine) that the body may absorb more easily than regular thiamine. It is mostly studied...

Benfotiamine monograph & interactions

Carnosine

Interacts with
86 drugs
450 mg per serving

Carnosine is a naturally occurring dipeptide (made of beta-alanine and histidine) that acts as an antioxidant and buffer in muscle and brain. It is so...

Carnosine monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Vegetable Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Carnosine Supreme by Designs for Health Drug Interactions

Want to check YOUR meds against Carnosine Supreme?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Carnosine 86

Individual Drug Interactions

The ingredients in Carnosine Supreme interact with 86 drugs. Click any drug to see the details.

1 of the 2 ingredients in Carnosine Supreme interact with drugs. Each result below shows which ingredient is responsible. Carnosine

Each ingredient & the kinds of drugs it affects

For each ingredient in Carnosine Supreme with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Carnosine1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking carnosine with antidiabetes drugs might increase the risk of hypoglycemia.
Some, but not all, preliminary clinical research shows that carnosine might reduce fasting blood glucose levels.

Likelihood Possible Evidence D
Carnosine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Carnosine Supreme, from the product label.

Designs for Health

See all Designs for Health products
Name
Designs for Health, Inc.
Street Address
980 South Street
City
Suffield
State
CT
ZipCode
06078
Web Address
www.designsforhealth.com
Pharmacist Counseling Corner

Carnosine Supreme by Designs for Health: Common Questions

Does Carnosine Supreme by Designs for Health interact with any medications?
Yes. Based on its ingredients, Carnosine Supreme has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Carnosine Supreme contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I have diabetes?
If you're already on diabetes medication, you need to talk with your doctor or pharmacist first. Carnosine in this product may lower blood sugar further, raising the risk of it dropping too low. Your doses or monitoring may need to change.
What side effects might I experience?
The most common are decreased appetite, dry mouth, foot or joint pain, and minor weight changes. In studies, allergic skin reactions and mild stomach discomfort were reported with benfotiamine, though at the same rate as placebo. Pneumonia has been reported with carnosine, though it's rare.
Is it safe to take while pregnant or breastfeeding?
No — the safety data advise against carnosine during pregnancy and breastfeeding. Benfotiamine safety while breastfeeding hasn't been well studied, so caution is advised during that time. Talk with your doctor or pharmacist if you're pregnant or nursing.
How long can I safely take this?
We don't have long-term safety data for either ingredient. Both are generally well tolerated in short-term studies, but if you're thinking of using this regularly for weeks or months, run that by your doctor or pharmacist first.
Will this help with memory or brain fog?
The evidence isn't established in our data. We don't have enough reliable research yet to say whether carnosine or benfotiamine actually improve age-related memory loss, Alzheimer disease, or general cognitive impairment.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Carnosine Supreme is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Carnosine Supreme label
Go deeper

The Full Monographs Behind Carnosine Supreme’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Benfotiamine

Benfotiamine is a man-made, fat-soluble form of vitamin B1 (thiamine) that the body may absorb more easily than regular thiamine. It is mostly studied for diabetic nerve problems, but the ev...

Read the full Benfotiamine monograph → Herb & supplement monograph

Carnosine

Interacts with 86 drugs

Carnosine is a naturally occurring dipeptide (made of beta-alanine and histidine) that acts as an antioxidant and buffer in muscle and brain. It is sold as an anti-aging and performance supp...

Read the full Carnosine monograph →
Sources

Sources & How We Checked

Carnosine Supreme's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Benfotiamine 1 reference
  1. Stracke H, Gaus W, Achenbach U, Federlin K, Bretzel RG. Benfotiamine in diabetic polyneuropathy (BENDIP): results of a randomised, double blind, placebo-controlled clinical study. Exp Clin Endocrinol Diabetes 2008;116(10):600-5. PubMed

See these in context on the Benfotiamine monograph →

Carnosine 5 references
  1. Chengappa KN, Turkin SR, DeSanti S, et al. A preliminary, randomized, double-blind, placebo-controlled trial of L-carnosine to improve cognition in schizophrenia. Schizophr Res 2012;142(1-3):145-52. PubMed
  2. Karkabounas S, Papadopoulos N, Anastasiadou C, et al. Effects of a-lipoic Acid, carnosine, and thiamine supplementation in obese patients with type 2 diabetes mellitus: A randomized, double-blind study. J Med Food. 2018;21(12):1197-1203.
  3. Peng W, Mao P, Liu L, et al. Effect of carnosine supplementation on lipid profile, fasting blood glucose, HbA1C and insulin resistance: a systematic review and meta-analysis of long-term randomized controlled trials. Complement Ther Med 2020;48:102241. PubMed
  4. Siriwattanasit N, Satirapoj B, Supasyndh O. Effect of oral carnosine supplementation on urinary TGF-ß in diabetic nephropathy: a randomized controlled trial. BMC Nephrol 2021;22(1):236. PubMed
  5. Sureshkumar K, Durairaj M, Srinivasan K, et al. Effect of L-Carnosine in Patients with Age-Related Diseases: A Systematic Review and Meta-Analysis. Front Biosci (Landmark Ed) 2023;28(1):18. PubMed

See these in context on the Carnosine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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