Chemical Four Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Chemical Four against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Chemical Four is a dietary supplement by Chaos and Pain with 4 active ingredients. Its ingredients are commonly taken for muscle building, strength and athletic performance, boosting testosterone.Based on those ingredients, 8 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are 4-DHEA Blend. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Chemical Four by Chaos and Pain
Ask about any prescription or over-the-counter medication and we check it for interactions with Chemical Four by Chaos and Pain — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Chemical Four by Chaos and Pain
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Partial disclosure
Chemical Four contains 6 active ingredients, most of them related to androgens — compounds that mimic or are converted to testosterone in the body. Two of the androsterone forms here (4 Androstene-3b-Ol, 17-One and 4 androstene-3b-0l, 17-one Caprylate) are purportedly metabolized into anabolic compounds.
The product also includes Fadogia agrestis, an herbal ingredient, and Epicatechin, a plant compound. One ingredient — 6,7 Dihydroxybergamottin — we could not check against our data.
The tablet also contains inactive ingredients (fillers, binders, and capsule material) including microcrystalline cellulose, phosphatidylcholine, starch, magnesium stearate, and colorants.
Does it work?
Couldn't assess
For the ingredients we have evidence on, the data don't support their use yet. Fadogia agrestis is promoted for athletic performance, erectile dysfunction, and malaria, but we hold insufficient reliable evidence to rate it for any of these.
The other active ingredients in this product don't have effectiveness ratings in our data — meaning the evidence isn't established in what we hold.
How safe is it?
Well-documented data
This product carries real safety concerns. Both androsterone forms are prohormones — they can disrupt your natural hormone balance, strain your liver, and affect your cholesterol levels.
Safety data are limited, and in theory, serious side effects similar to anabolic steroids — including stroke, kidney failure, and liver injury — are possible. Fadogia agrestis adds another worry: human safety data don't exist, and animal studies flag possible damage to the testicles, liver, and kidneys.
Do not use this product if you're pregnant — androgenic hormones harm a developing baby. Avoid it while breastfeeding too; hormonal effects on a nursing infant are unknown and potentially harmful.
If you're considering this for any reason, talk it through with your doctor or pharmacist first.
Meds to double-check
Moderate interaction found
If you're on testosterone or testosterone replacement therapy, hold on before starting Chemical Four — the androsterone compounds in it may add to testosterone's effects and raise your risk of mood changes, heart strain, kidney stress, or liver damage. No interactions are documented for the other ingredients we could check, but we don't have data on three of them.
Check your exact medications on this page first, or ask your doctor or pharmacist to confirm it's safe for you.
The bottom line
Scorecard at a glancePartially disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Chemical Four is a prohormone supplement with limited safety data and no proven effectiveness in our evidence base. It's marketed toward people seeking muscle or athletic gains, but prohormones carry real risks to your liver, kidneys, heart, and hormones — and those risks are not fully understood.
If you're taking testosterone or any hormone therapy, this product can interact. Before you take it, check your full medication list with your doctor or pharmacist.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Chemical Four, straight from the product label.
| Brand | Chaos and Pain |
|---|---|
| Net contents | 60 Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Jun 16, 2022 |
| DSLD ID | 267070 |
| Product type | Other Combinations |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years), Women (not pregnant or lactating) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Chemical Four by Chaos and Pain, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| 6,7 Dihydroxybergamottin | 50 mg | -- |
| 4-DHEA Blend | 75 mg | -- |
| 4 Androstene-3b-Ol, 17-One | 0 NP | -- |
| 4 Androstene-3b-ol, 17-one Undecanoate | 0 NP | -- |
| 4 androstene-3b-0l,17-one Caprylate | 0 NP | -- |
| Fadogia agrestis | 150 mg | -- |
| Epicatechin | 150 mg | -- |
Other ingredients: Microcrystalline, Phosphatidylcholine, Hydroxypropyl-Beta-Cyclodextrin, Phytosterol, Stearic Acid, Magnesium Stearate, Starch, Titanium Dioxide, Silica, FD&C Red #40
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Directions: Take one (1) tablet in the morning and one (1) tablet in the evening preferably twelve (12) hours apart. Do not exceed two (2) tablets per day. Visit our website for additional information and guidance.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Precautions
Warning: This product is only intended for use by healthy adults over 18 years of age. Do not take this product with any product containing caffeine or other ingredients that have a known stimulant effect. Discontinue use and consult your health care professional if you experience an adverse reaction to this product. Do not exceed recommended serving size or suggested use. Do not use if safety seal is broken or missing.
Consult your physician before using this if you are taking any prescription or over the counter medications or supplements. Do not use this product if you are pregnant, expect to become pregnant or are nursing.
Keep out of reach of children & pets.
Storage
Store in a cool dry place.
General Statements
The most powerful supplements in the world.
FDA Statement of Identity
Dietary Supplement
Formulation
DHEA product
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Chemical Four by Chaos and Pain label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Chemical Four by Chaos and Pain
These are the 4 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
6,7 Dihydroxybergamottin
4-DHEA Blend
Interacts with8 drugs
4-Androsterone (sometimes called 4-DHEA) is a lab-made prohormone marketed to bodybuilders as a way to raise testosterone and build muscle, but human...
4-DHEA Blend monograph & interactions- › 4 Androstene-3b-Ol, 17-One
- › 4 Androstene-3b-ol, 17-one Undecanoate
- › 4 androstene-3b-0l,17-one Caprylate
Fadogia agrestis
No knowninteractions
Fadogia agrestis is a West African shrub marketed as a testosterone booster, but human evidence is essentially nonexistent and what we know comes most...
Fadogia agrestis monograph & interactionsEpicatechin
Other (inactive) ingredients: Microcrystalline, Phosphatidylcholine, Hydroxypropyl-Beta-Cyclodextrin, Phytosterol, Stearic Acid, Magnesium Stearate, Starch, Titanium Dioxide, Silica, FD&C Red #40. These complete the product’s ingredient list but are not active constituents.
Chemical Four by Chaos and Pain Drug Interactions
HelloPharmacist Interaction Report
Chemical Four by Chaos and Pain contains two ingredients with documented interactions with medications: both 4 Androstene-3b-Ol, 17-One and 4 androstene-3b-0l, 17-one Caprylate are purportedly converted to testosterone in the body.
If you're taking testosterone or testosterone replacement therapy, combining this product with those treatments may increase the risk of additive effects — mood swings, cardiovascular strain, kidney stress, or liver problems — and this is rated Moderate severity.
Read the full breakdown — every affected drug type, severity by severity
Altogether, these interactions span 8 individual medications.
We could not check three other ingredients in this product: 6,7 Dihydroxybergamottin, 4 Androstene-3b-Ol, 17-One Undecanoate, and Epicatechin. No data are on file for them, so we can't tell you whether they interact with anything.
Before you start, run your exact medications through the search tool on this page, or confirm the full list with your doctor or pharmacist.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Chemical Four?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Chemical Four interact with 8 drugs. Click any drug to see the details.
1 of the 4 ingredients in Chemical Four interact with drugs. Each result below shows which ingredient is responsible. 4-DHEA Blend
Conjugated Estrogens, MethyltestosteronePremarin with Methyltestosterone
How Conjugated Estrogens, Methyltestosterone interacts with Chemical Four — through 1 ingredient. Tap an ingredient for the detail:
4 Androstene-3b-0l,17-one CaprylateTestosterone Moderate
Interaction Summary
4-Androsterone is purportedly converted to testosterone and other androgens upon ingestion.
Read the full 4 Androstene-3b-0l,17-one Caprylate + Conjugated Estrogens, Methyltestosterone interactionDiethylstilbestrol, MethyltestosteroneTylosterone
How Diethylstilbestrol, Methyltestosterone interacts with Chemical Four — through 1 ingredient. Tap an ingredient for the detail:
4 Androstene-3b-0l,17-one CaprylateTestosterone Moderate
Interaction Summary
4-Androsterone is purportedly converted to testosterone and other androgens upon ingestion.
Read the full 4 Androstene-3b-0l,17-one Caprylate + Diethylstilbestrol, Methyltestosterone interactionEsterified Estrogens, MethyltestosteroneEstratest
How Esterified Estrogens, Methyltestosterone interacts with Chemical Four — through 1 ingredient. Tap an ingredient for the detail:
4 Androstene-3b-0l,17-one CaprylateTestosterone Moderate
Interaction Summary
4-Androsterone is purportedly converted to testosterone and other androgens upon ingestion.
Read the full 4 Androstene-3b-0l,17-one Caprylate + Esterified Estrogens, Methyltestosterone interactionMethyltestosteroneAndroid 10, Android 25, Metandren, Methitest, Oreton, Testred +1 more
How Methyltestosterone interacts with Chemical Four — through 1 ingredient. Tap an ingredient for the detail:
4 Androstene-3b-0l,17-one CaprylateTestosterone Moderate
Interaction Summary
4-Androsterone is purportedly converted to testosterone and other androgens upon ingestion.
Read the full 4 Androstene-3b-0l,17-one Caprylate + Methyltestosterone interactionMethyltestosterone BuccalAndroid 5, Oreton Buccal
How Methyltestosterone Buccal interacts with Chemical Four — through 1 ingredient. Tap an ingredient for the detail:
4 Androstene-3b-0l,17-one CaprylateTestosterone Moderate
Interaction Summary
4-Androsterone is purportedly converted to testosterone and other androgens upon ingestion.
Read the full 4 Androstene-3b-0l,17-one Caprylate + Methyltestosterone Buccal interactionTestosteroneAndrogel, Andropatch, Delatestryl, Intrinsa, Natesto, Nebido +3 more
How Testosterone interacts with Chemical Four — through 1 ingredient. Tap an ingredient for the detail:
4 Androstene-3b-0l,17-one CaprylateTestosterone Moderate
Interaction Summary
4-Androsterone is purportedly converted to testosterone and other androgens upon ingestion.
Read the full 4 Androstene-3b-0l,17-one Caprylate + Testosterone interactionTestosterone EnanthateXyosted
How Testosterone Enanthate interacts with Chemical Four — through 1 ingredient. Tap an ingredient for the detail:
4 Androstene-3b-0l,17-one CaprylateTestosterone Moderate
Interaction Summary
4-Androsterone is purportedly converted to testosterone and other androgens upon ingestion.
Read the full 4 Androstene-3b-0l,17-one Caprylate + Testosterone Enanthate interactionTestosterone UndecanoateAndriol, Aveed, Jatenzo, Kyzatrex
How Testosterone Undecanoate interacts with Chemical Four — through 1 ingredient. Tap an ingredient for the detail:
4 Androstene-3b-0l,17-one CaprylateTestosterone Moderate
Interaction Summary
4-Androsterone is purportedly converted to testosterone and other androgens upon ingestion.
Read the full 4 Androstene-3b-0l,17-one Caprylate + Testosterone Undecanoate interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Chemical Four with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
4-DHEA Blend
Testosterone
4-Androsterone is purportedly converted to testosterone and other androgens upon ingestion. Theoretically, taking 4-androsterone with testosterone may increase the risk for additive adverse effects such as mood disturbances and cardiovascular, kidney, or liver problems.
Brand information
Manufacturer and brand details for Chemical Four, from the product label.
Chaos and Pain
See all Chaos and Pain products- Name
- Chaos and Pain
- City
- Birmingham
- State
- AL
- ZipCode
- 35238
- Web Address
- www.chaosandpain.com
Chemical Four by Chaos and Pain: Common Questions
Does Chemical Four by Chaos and Pain interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What are prohormones, and why is this product made of them?
Can I take this if I'm pregnant or breastfeeding?
What side effects might I get from Chemical Four?
Does this product actually improve athletic performance or muscle growth?
Why can't you check all the ingredients for interactions?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Chemical Four is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Chemical Four’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
4-androsterone
Interacts with 8 drugs4-Androsterone (sometimes called 4-DHEA) is a lab-made prohormone marketed to bodybuilders as a way to raise testosterone and build muscle, but human studies are very limited and it carries...
Read the full 4-androsterone monograph → Herb & supplement monographFadogia Agrestis
Fadogia agrestis is a West African shrub marketed as a testosterone booster, but human evidence is essentially nonexistent and what we know comes mostly from a few small rat studies. Animal...
Read the full Fadogia Agrestis monograph →Sources & How We Checked
Chemical Four's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 5 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
4-androsterone 3 references
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC