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Dietary supplement

Chewable Acidophilus 20 Million CFU Ingredients & Drug Interactions

by Mason Natural

Chewable Acidophilus 20 Million CFU label
See full label image
Other (e.g. Tea Bag) Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Chewable Acidophilus 20 Million CFU against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Chewable Acidophilus 20 Million CFU is a dietary supplement by Mason Natural with 1 active ingredient. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus acidophilus. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Chewable Acidophilus 20 Million CFU by Mason Natural

Ask about any prescription or over-the-counter medication and we check it for interactions with Chewable Acidophilus 20 Million CFU by Mason Natural — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Chewable Acidophilus 20 Million CFU by Mason Natural

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This supplement contains one active ingredient: Lactobacillus acidophilus at 20 million colony-forming units (CFU) per dose. L. acidophilus is a beneficial live bacterium that naturally lives in the human gut and helps support digestive health.

The other ingredients—modified cellulose gum, vegetable stearates, and natural banana and vanilla flavors—are inactive excipients that help form and flavor the chewable tablet.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Digestive health and intestinal balance.
  • We looked for evidence on: Antibiotic-associated diarrhea, Bacterial vaginosis, Clostridioides difficile infection, Colic, Constipation, Inflammatory bowel disease (IBD) — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Bacterial vaginosis, Irritable bowel syndrome (IBS).
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Constipation, Inflammatory bowel disease (IBD), Lactose intolerance, Necrotizing enterocolitis (NEC).

The evidence for L. acidophilus is strongest for irritable bowel syndrome (IBS), Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis—all rated Possibly Effective based on available research. For atopic disease (like eczema and allergies), the data suggest it's possibly ineffective.

For acute respiratory distress syndrome (ARDS), there isn't enough reliable evidence yet to know whether it helps or doesn't.

The evidence, ingredient by ingredient Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L. acidophilus is generally well tolerated in healthy adults and children. Gastrointestinal side effects like bloating, gas, abdominal pain, and diarrhea can occur when taking it with other probiotics, but these are uncommon.

Very rarely, in people with compromised immunity or certain underlying conditions, L. acidophilus organisms have been linked to serious infections like sepsis or endocarditis; this is thought to happen when bacteria move from the gut into the bloodstream. Because data are limited, check with your doctor or pharmacist before starting, especially if you have a weakened immune system or a central line or other medical device.

Side effects, ingredient by ingredient Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Antibiotic drugs are the one medication type documented to interact with this product (Moderate severity). Separating the timing of doses can reduce the interaction.

Check your exact antibiotic with the search tool on this page, and ask your pharmacist for a dosing schedule that works.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This probiotic may help with IBS, antibiotic-related diarrhea, and a few other digestive or bacterial concerns if you have those conditions. The main thing to watch is timing: don't take it at the same moment as an antibiotic—space them out.

Talk to your pharmacist about the best schedule for your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 22, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Chewable Acidophilus 20 Million CFU, straight from the product label.

Brand Mason Natural
Barcode (UPC) 311845168917
Net contents 100 Wafer(s)
Market status On market
Date entered into DSLD Dec 22, 2019
DSLD ID 211875
Product type Non-nutrient/non-botanical
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Chewable Acidophilus 20 Million CFU by Mason Natural, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Chewable Wafer(s)
Maximum serving Sizes:
2 Chewable Wafer(s)
Servings per container
50
UPC/BARCODE
311845168917
IngredientAmount% DV
Calories5 Calorie(s)--
Total Carbohydrates2 Gram(s)1%
Added Sugars2 Gram(s)4%
Total Sugars2 Gram(s)--
Lactobacillus acidophilus2 mg--

Other ingredients: modified Cellulose Gum, Vegetable Stearates, natural Banana and Vanilla flavors

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

Mason guarantee Laboratory tested cGMP Certified Good Manufacturing Practice

General Statements

N

Certified Est. 1967

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Adults - Chew two wafers, two to four times daily, preferably with food, as a dietary supplement.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

Guaranteed no added: Starch, yeast, soy, corn, wheat, dairy, egg, fragrance, artifical color and preservatives.

Soy free

May support healthy digestion

Precautions

Warning: If you are pregnant, nursing, taking any medications or planning any medical procedure, consult your physician before use.

Discontinue use and consult your physician if any adverse reactions occur.

Keep out of reach of children.

Tamper-evident seal: Do no use product if seal appears tampered.

Storage

Store in a dry place under controlled room temperature: 20 degrees - 25 degrees C (68 degrees - 77 degrees F).

Brand IP Statement(s)

Mason Natural is a registered trademark and does not refer to any product or ingredient claim.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Chewable Acidophilus 20 Million CFU by Mason Natural label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Chewable Acidophilus 20 Million CFU label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Chewable Acidophilus 20 Million CFU by Mason Natural

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Chewable Wafer(s) Dosage formOther (e.g. Tea Bag) Servings per container50 Amounts shown are per serving.

Lactobacillus acidophilus

Interacts with
182 drugs
2 mg per serving

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy p...

Lactobacillus acidophilus monograph & interactions

Other (inactive) ingredients: Modified Cellulose Gum, Vegetable Stearates, Natural Banana and Vanilla flavors. These complete the product’s ingredient list but are not active constituents.

Interaction report

Chewable Acidophilus 20 Million CFU by Mason Natural Drug Interactions

Want to check YOUR meds against Chewable Acidophilus 20 Million CFU?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Lactobacillus acidophilus 182

Individual Drug Interactions

The ingredients in Chewable Acidophilus 20 Million CFU interact with 182 drugs. Click any drug to see the details.

1 of the 1 ingredient in Chewable Acidophilus 20 Million CFU interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus acidophilus

Each ingredient & the kinds of drugs it affects

For each ingredient in Chewable Acidophilus 20 Million CFU with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus acidophilus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Chewable Acidophilus 20 Million CFU, from the product label.

Mason Natural

See all Mason Natural products
Name
Mason Vitamins, Inc.
City
Miami Lakes
State
FL
ZipCode
33014
Phone Number
1-888-860-5376
Web Address
www.MasonVitamins.com
Pharmacist Counseling Corner

Chewable Acidophilus 20 Million CFU by Mason Natural: Common Questions

Does Chewable Acidophilus 20 Million CFU by Mason Natural interact with any medications?
Yes. Based on its ingredients, Chewable Acidophilus 20 Million CFU has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Chewable Acidophilus 20 Million CFU contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm on antibiotics?
Not at the exact same time. Antibiotics can kill the live L. acidophilus in this supplement, making it less effective. Your pharmacist can help you space out the doses—for example, taking the probiotic several hours before or after your antibiotic—so both work as intended.
What is Lactobacillus acidophilus, and what does it do?
L. acidophilus is a beneficial live bacterium that naturally lives in your gut. It's included in this supplement to support digestive health and may help with conditions like IBS, antibiotic-related diarrhea, and bacterial vaginosis.
Is this safe if I have a weak immune system?
Most healthy people tolerate L. acidophilus well, but if your immune system is compromised—whether from medication, illness, or a medical device—there's a small risk the bacteria could cause a serious infection. Talk to your doctor before starting.
Can I take this while pregnant?
The safety data rate this as possibly safe during pregnancy, but the information is limited. Since you're making a decision for two, it's best to check with your doctor or pharmacist for personalized advice before starting.
What side effects might I experience?
Most people have no side effects. When taken with other probiotics, some people report bloating, gas, abdominal discomfort, or diarrhea, but these are uncommon. In rare cases, rashes or itching have been reported, though it's unclear if they were due to this ingredient or something else.
Does this product contain fillers?
Yes—the inactive ingredients are modified cellulose gum, vegetable stearates, and natural banana and vanilla flavors. These help form and flavor the chewable tablet.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Chewable Acidophilus 20 Million CFU is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Chewable Acidophilus 20 Million CFU label
Go deeper

The Full Monographs Behind Chewable Acidophilus 20 Million CFU’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

Chewable Acidophilus 20 Million CFU's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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