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Dietary supplement

Chewable D-Ribose Natural Orange Flavor Ingredients & Drug Interactions

by Solgar

Chewable D-Ribose Natural Orange Flavor label
See full label image
Other (e.g. Tea Bag) Category: Fiber And Other Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Chewable D-Ribose Natural Orange Flavor against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Chewable D-Ribose Natural Orange Flavor is a dietary supplement by Solgar with 2 active ingredients. Its ingredients are commonly taken for energy and fatigue, athletic performance and recovery, fibromyalgia symptoms.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are D-Ribose. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Chewable D-Ribose Natural Orange Flavor by Solgar

Ask about any prescription or over-the-counter medication and we check it for interactions with Chewable D-Ribose Natural Orange Flavor by Solgar — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Chewable D-Ribose Natural Orange Flavor by Solgar

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: D-Ribose, a simple sugar your body makes naturally. The inactive ingredients are Florida Crystals, microcrystalline cellulose, stearic acid, silica, vegetable magnesium stearate, malic acid, natural orange flavor, and Luo Han Guo fruit concentrate — these are fillers, binders, and flavoring agents that give the chewable its texture and taste.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Ribose product and its label doesn't state a use — see Ribose's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for D-Ribose is mixed and often limited. It's rated possibly ineffective for athletic performance and McArdle disease.

For restless legs syndrome, muscle soreness, heart failure, and recovery after bypass surgery, there isn't enough reliable evidence yet to say whether it works. If you're considering this product for any of those reasons, talk with your doctor about whether the current evidence supports trying it.

The evidence, ingredient by ingredient Ribose

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

D-Ribose is generally well tolerated in the short term — up to about a month — but long-term safety hasn't been well studied. The most common side effects reported orally are diarrhea, stomach discomfort, headache, nausea, and low blood sugar.

Some people have also reported anxiety, lightheadedness, and increased appetite, though lowering the dose has resolved nausea and anxiety in some cases. There isn't enough safety information to recommend D-Ribose during pregnancy or while breastfeeding.

Talk with your doctor or pharmacist for personalized guidance if you're pregnant, planning to become pregnant, or nursing.

Side effects, ingredient by ingredient Ribose

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Ribose.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take insulin or any antidiabetes drugs (like metformin, sulfonylureas, or GLP-1 agonists). D-Ribose may lower your blood sugar further, raising the risk of hypoglycemia.

No other major medication interactions are documented for this ingredient.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

D-Ribose might appeal to you if you're exploring options for athletic performance or muscle recovery, though the evidence is limited. If you take insulin or any blood sugar medication, you'll want to check with your doctor or pharmacist before starting — low blood sugar is a real risk.

For pregnancy or breastfeeding, there's not enough safety data, so discuss it with your healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 26, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Chewable D-Ribose Natural Orange Flavor, straight from the product label.

Brand Solgar
Barcode (UPC) 033984009899
Net contents 90 Chewable Wafer(s)
Market status On market
Date entered into DSLD Feb 26, 2020
DSLD ID 214003
Product type Fiber And Other Nutrients
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses All Other
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Chewable D-Ribose Natural Orange Flavor by Solgar, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Wafer(s)
Maximum serving Sizes:
3 Wafer(s)
Servings per container
30
UPC/BARCODE
033984009899
IngredientAmount% DV
Calories20 Calorie(s)--
Total Carbohydrates5 Gram(s)2%
Sugar5 Gram(s)--
D-Ribose4.5 Gram(s)--

Other ingredients: Florida Crystals, Microcrystalline Cellulose, Stearic Acid, Silica, Vegetable Magnesium Stearate, Malic Acid, natural Orange flavor, Luo Han Guo fruit concentrate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Solgar's Chewable D-Ribose Wafers are free of corn, yeast, wheat, soy, dairy products and gluten and are formulated without the use of artificial preservatives, flavors or colors.

Suitable for vegetarians

Salt and starch free

Storage

To assure freshness and potency, store at room temperature 59 degrees-86 degrees F (15 degrees-30 degrees C). Store away from heat, light and moisture.

Formula

Solgar's KOF-K certification #K-1250

Precautions

Do not use if outer bottle seal is missing, torn or damaged in any way.

If you are pregnant, nursing, taking any medication or have a medical condition, please consult your healthcare practitioner before taking any dietary supplement.

Keep out of reach of children.

General Statements

For more information, call toll-free 1-877-SOLGAR 4 www.solgar.com Tastes great Solgar since 1947

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

K Parve (Kosher)

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement for adults, take three (3) wafers daily, with meals, or as directed by a healthcare practitioner.

Brand IP Statement(s)

Florida Crystals is a registered trademark of Florida Crystals Corporation.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Chewable D-Ribose Natural Orange Flavor by Solgar label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Chewable D-Ribose Natural Orange Flavor label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Chewable D-Ribose Natural Orange Flavor by Solgar

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Wafer(s) Dosage formOther (e.g. Tea Bag) Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

5 Gram(s) per serving

D-Ribose

Interacts with
86 drugs
4.5 Gram(s) per serving

Ribose (D-ribose) is a simple sugar your body makes naturally and uses to build energy molecules like ATP. Some people take it for fatigue, fibromyalg...

D-Ribose monograph & interactions

Other (inactive) ingredients: Florida Crystals, Microcrystalline Cellulose, Stearic Acid, Silica, Vegetable Magnesium Stearate, Malic Acid, Natural Orange flavor, Luo Han Guo fruit concentrate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Chewable D-Ribose Natural Orange Flavor by Solgar Drug Interactions

Want to check YOUR meds against Chewable D-Ribose Natural Orange Flavor?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

D-Ribose 86

Individual Drug Interactions

The ingredients in Chewable D-Ribose Natural Orange Flavor interact with 86 drugs. Click any drug to see the details.

1 of the 2 ingredients in Chewable D-Ribose Natural Orange Flavor interact with drugs. Each result below shows which ingredient is responsible. D-Ribose

Each ingredient & the kinds of drugs it affects

For each ingredient in Chewable D-Ribose Natural Orange Flavor with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

D-Ribose2 drug types · 86 drugs

Antidiabetes Drugs

Theoretically, taking ribose in combination with antidiabetes drugs might increase the risk of hypoglycemia.
In clinical research, ribose decreases serum glucose levels in a dose-dependent manner.

Likelihood Probable Evidence B
Insulin

Theoretically, taking ribose with insulin could increase the hypoglycemic effect of insulin.
In clinical pharmacokinetic studies, oral administration of ribose modestly increased serum insulin levels.

Likelihood Possible Evidence B
D-Ribose full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Chewable D-Ribose Natural Orange Flavor, from the product label.

Solgar

See all Solgar products
Name
Solgar Vitamin and Herb
City
Leonia
State
N.J.
ZipCode
07605
Phone Number
1-877-765-4274
Web Address
www.solgar.com
Pharmacist Counseling Corner

Chewable D-Ribose Natural Orange Flavor by Solgar: Common Questions

Does Chewable D-Ribose Natural Orange Flavor by Solgar interact with any medications?
Yes. Based on its ingredients, Chewable D-Ribose Natural Orange Flavor has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Chewable D-Ribose Natural Orange Flavor contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take D-Ribose if I have diabetes or use insulin?
Probably not without your doctor's guidance. D-Ribose can lower blood sugar levels, and combining it with insulin or antidiabetes drugs raises the risk of your blood sugar dropping too low. Talk with your doctor or pharmacist about your specific medications and whether this product is right for you.
Will this help with my muscle soreness or athletic performance?
The evidence isn't clear yet. D-Ribose is rated possibly ineffective for athletic performance, and there's not enough reliable evidence to say whether it helps muscle soreness. If you're interested in trying it anyway, discuss it with your doctor first, especially if you're on diabetes medication.
What are the most common side effects?
Diarrhea, stomach discomfort, headache, and nausea are reported most often. Some people also experience low blood sugar, anxiety, or lightheadedness. Lowering the dose has helped resolve nausea and anxiety in some cases.
Is it safe to take during pregnancy or while breastfeeding?
There isn't enough safety information to recommend D-Ribose during pregnancy or breastfeeding. Talk with your doctor or pharmacist — they can help you weigh the unknowns against your specific situation.
How long is it safe to take D-Ribose?
The data shows it's generally well tolerated for up to about a month. Long-term safety hasn't been well studied, so if you're considering using it longer than that, check in with your doctor or pharmacist first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Chewable D-Ribose Natural Orange Flavor is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Chewable D-Ribose Natural Orange Flavor label
Go deeper

The Full Monographs Behind Chewable D-Ribose Natural Orange Flavor’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Ribose

Interacts with 86 drugs

Ribose (D-ribose) is a simple sugar your body makes naturally and uses to build energy molecules like ATP. Some people take it for fatigue, fibromyalgia, exercise recovery, or heart conditio...

Read the full Ribose monograph →
Sources

Sources & How We Checked

Chewable D-Ribose Natural Orange Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Ribose 8 references
  1. Segal S, Foley J. The metabolism of D-ribose in man. J Clin Invest 1958;37:719-35. PubMed
  2. Perlmutter NS, Wilson RA, Angello DA, et al. Ribose facilitates thallium-201 redistribution in patients with coronary artery disease. J Nucl Med 1991;32:193-200.
  3. Hegewald MG, Palac RT, Angello DA, et al. Ribose infusion accelerates thallium redistribution with early imaging compared with late 24-hour imaging without ribose. J Am Coll Cardiol 1991;18:1671-81. PubMed
  4. Pliml W, von Arnim T, Stalein A, et al. Effects of ribose on excercise-induced ischaemia in stable coronary artery disease. Lancet 1992;340:507-10.
  5. Burke ER. D-Ribose What You Need To Know. Garden City Park, NY: Avery Publishing Group 1999;1-43.
  6. Gross M, Reiter S, Zollner N. Metabolism of D-ribose administered continuously to healthy persons and to patients with myoadenylate deaminase deficiency. Klin Wochenschr 1989;67:1205-13. PubMed
  7. Teitelbaum JE, Johnson C, St Cyr J. The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study. J Altern Complement Med 2006;12:857-62. PubMed
  8. Thompson J, Neutel J, Homer K, Tempero K, Shah A, Khankari R. Evaluation of D-ribose pharmacokinetics, dose proportionality, food effect, and pharmacodynamics after oral solution administration in healthy male and female subjects. J Clin Pharmacol 2014;54 PubMed

See these in context on the Ribose monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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