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Dietary supplement

Children's Probiotic Packets Ingredients & Drug Interactions

by up&up

Children's Probiotic Packets label
See full label image
Powder Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Children's Probiotic Packets against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Children's Probiotic Packets is a dietary supplement by up&up with 2 active ingredients. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus acidophilus. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Children's Probiotic Packets by up&up

Ask about any prescription or over-the-counter medication and we check it for interactions with Children's Probiotic Packets by up&up — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Children's Probiotic Packets by up&up

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Proprietary Probiotic Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

This product has 2 active ingredients: Lactobacillus acidophilus and Lactobacillus rhamnosus GG — both live beneficial bacteria meant to support digestive health. The powder also contains inactive ingredients (mannitol, inulin, and silicon dioxide) that help preserve and deliver the probiotics.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: digestive health and immune support.
  • We looked for evidence on: Antibiotic-associated diarrhea, Colic, Constipation, Irritable bowel syndrome (IBS), Lactose intolerance, Necrotizing enterocolitis (NEC) — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Irritable bowel syndrome (IBS).
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Respiratory tract infections, Constipation, Lactose intolerance, Necrotizing enterocolitis (NEC), and more.

Lactobacillus acidophilus is possibly effective for irritable bowel syndrome (IBS), Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis. The evidence is less clear for atopic disease (possibly ineffective) and acute respiratory distress syndrome (insufficient reliable evidence).

We don't have effectiveness data on file for Lactobacillus rhamnosus GG.

The evidence, ingredient by ingredient Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children. Gastrointestinal side effects — epigastric discomfort, abdominal pain, bloating, flatulence, diarrhea, vomiting, and burping — are uncommon but can occur when taking this with other probiotics.

Very rarely, the live organisms may cause infection in certain patients; most documented cases involved people with weakened immunity or pre-existing conditions. Since the data are limited, check with your doctor or pharmacist before starting.

Side effects, ingredient by ingredient Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist or doctor before combining this with antibiotic drugs — the antibiotic may reduce the probiotic's effectiveness, so you'll want to separate the doses. We don't have interaction data for all the ingredients in this product, so run your child's medications through the checker below.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This probiotic can help support digestive health in children, especially for antibiotic-associated diarrhea and IBS. If your child is on antibiotics, time the doses apart — don't give them together.

It's generally well tolerated, but talk to your pharmacist before starting, especially if your child has any health conditions.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 26, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Children's Probiotic Packets, straight from the product label.

Brand up&up
Barcode (UPC) 896095002247
Net contents 30 Single-Serving Packet(s)
Market status On market
Date entered into DSLD Dec 26, 2020
DSLD ID 240347
Product type Non-nutrient/non-botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Gluten Free, Dairy Free, Children more than 1 but less than 4
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Children's Probiotic Packets by up&up, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Stick Pack(s)
Maximum serving Sizes:
1 Stick Pack(s)
UPC/BARCODE
896095002247
IngredientAmount% DV
Lactobacillus acidophilus0 NP--
Lactobacillus rhamnosus GG0 NP--
Proprietary Probiotic Blend0 NP--

Other ingredients: Mannitol, Inulin, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Compare vs. Culturelle Kids Packets

100% satisfaction guaranteed or your money back. Each year we give 5% of our profit to communities, which adds up to more than $4 Million a week. See all the good we do together at Target.com/Community.

Formula

5 Billion active cultures per serving

Up & up children's probiotic packets contain Lactobacillus rhamnosus GG, one of the most studied probiotic strains, to help promote digestive and immune health and help alleviate occasional digestive discomfort.

Formulation

Digestive health Helps support children's natural defense systems Flavorless and easy to take Immune support

Keeping your child's defense system healthy and having healthy digestion is important. However, your child's intestinal balance can be disrupted by non-beneficial bacteria, causing digestive upset. When taken daily, up & up children's probiotic packets can help naturally build and restore the proper balance between good and non-beneficial bacteria in your child's intestinal tract.

This product does not contain any dairy, soy or gluten.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: For children 1 year and above: Empty entire contents of one (1) stick pack onto cool food or into a cool beverage and mix until dissolved. Do not add to warm or hot food or beverage. Take one (1) stick pack daily to promote a healthy digestive and immune system.

Precautions

This product is to be used under adult supervision only.

Keep out of reach of children. Not intended for children under one (1) year of age. Do not give this product to children with immune problems unless directed with unless directed by a physician.

We recommend you consult your physician or healthcare professional with any healthcare questions. Take this product only as directed.

Storage

Storage directions: Best if stored at 72 degrees F (22 degrees C) or below. Refrigeration not required, but may extend product shelf life. For best results, store this product in the original stick packaging.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

This product is not manufactured or distributed by i-Health, owner of the registered trademark of Culturelle Kids Packets.

TM & 2017 Target Brands, Inc.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Children's Probiotic Packets by up&up label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Children's Probiotic Packets label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Children's Probiotic Packets by up&up

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Stick Pack(s) Dosage formPowder Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Probiotic Blend

0 NP per serving

Other (inactive) ingredients: Mannitol, Inulin, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Children's Probiotic Packets by up&up Drug Interactions

Want to check YOUR meds against Children's Probiotic Packets?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Lactobacillus acidophilus 182

Individual Drug Interactions

The ingredients in Children's Probiotic Packets interact with 182 drugs. Click any drug to see the details.

1 of the 2 ingredients in Children's Probiotic Packets interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus acidophilus

Each ingredient & the kinds of drugs it affects

For each ingredient in Children's Probiotic Packets with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus acidophilus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Children's Probiotic Packets, from the product label.

up&up

See all up&up products
Name
Target Corporation
City
Minneapolis
State
MN
ZipCode
55403
Phone Number
1-800-910-6874
Pharmacist Counseling Corner

Children's Probiotic Packets by up&up: Common Questions

Does Children's Probiotic Packets by up&up interact with any medications?
Yes. Based on its ingredients, Children's Probiotic Packets has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Children's Probiotic Packets contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I give this to my child while they're on antibiotics?
You can use both, but don't give them at the same time. The antibiotic can kill the live probiotic organisms and make this product less effective. Ask your pharmacist how many hours to space them apart — typically a few hours does the job.
What are the side effects?
Most kids don't have problems, but some experience mild gas, bloating, stomach discomfort, or loose stools. These are uncommon and usually settle down. If your child has a weakened immune system, talk to your doctor first — serious infections from probiotics are very rare but have been reported in that group.
Is it safe during pregnancy or while breastfeeding?
Lactobacillus acidophilus is possibly safe in pregnancy, so it's reasonable to consider — but definitely talk with your doctor or pharmacist about it first. We don't have safety data on file for the other probiotic strain in this product, so get personalized advice before use.
Does this actually work for diarrhea?
Lactobacillus acidophilus is possibly effective for antibiotic-associated diarrhea — that's one of its stronger uses. It's also possibly effective for irritable bowel syndrome and a couple of other digestive issues, though the evidence isn't rock-solid for any of them.
What exactly are probiotics?
Probiotics are live beneficial bacteria. This product contains Lactobacillus acidophilus and Lactobacillus rhamnosus GG — strains meant to support your child's digestive health.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Children's Probiotic Packets is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Children's Probiotic Packets label
Go deeper

The Full Monographs Behind Children's Probiotic Packets’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

Children's Probiotic Packets's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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