Interactions on record — worth a quick check against your medications. Based on 2 of 6 ingredients. Check your meds →
Dietary supplement

CholestaCare plus Fibermucil Ingredients & Drug Interactions

by ProCaps Laboratories

CholestaCare plus Fibermucil label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking CholestaCare plus Fibermucil against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

CholestaCare plus Fibermucil is a dietary supplement by ProCaps Laboratories with 6 active ingredients. Its ingredients are commonly taken for constipation, diarrhea, high cholesterol.Based on those ingredients, 2,083 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Dietary Fiber, Lactobacillus sporogenes. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against CholestaCare plus Fibermucil by ProCaps Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with CholestaCare plus Fibermucil by ProCaps Laboratories — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of CholestaCare plus Fibermucil by ProCaps Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 5 of its 6 active ingredients.

CholestaCare plus Fibermucil contains five active ingredients. Psyllium powder and soluble and insoluble fiber are bulk-forming agents that add water-holding material to your stool to help move things along.

The CholestaCare Proprietary Sterol Blend — a blend of plant stanols and sterols — is designed to help support cholesterol levels already in a healthy range. Lactobacillus sporogenes (a probiotic) adds beneficial bacteria meant to support digestive and intestinal health.

The capsule also contains inactive ingredients: gelatin, leucine, and silicon dioxide — standard excipients that help hold the capsule together and keep the powder flowing.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: naturally reduce total and LDL cholesterol levels.
  • We looked for evidence on: Hypercholesterolemia, Coronary heart disease (CHD), cholesterol management, lipid metabolism.
  • The strongest evidence on file: Black Psyllium is rated "Likely Effective" for Coronary heart disease (CHD) (Natural Medicines).
  • Also on file: Bacillus Coagulans is rated "Insufficient Reliable Evidence To Rate" for Hypercholesterolemia.

For constipation and irritable bowel syndrome (IBS), Bacillus coagulans is rated possibly effective — meaning there's some evidence it may help, but it's not definitive. For antibiotic-associated diarrhea, athletic performance, cancer, and nonalcoholic fatty liver disease, the evidence we hold is insufficient to rate whether it works.

We have no effectiveness data on file for the fiber components or the sterol blend in this product.

The evidence, ingredient by ingredient Black Psyllium Bacillus Coagulans

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bacillus coagulans is generally well tolerated in healthy adults, but the evidence and quality of probiotic products vary widely. The safety data overall is limited, and there isn't enough reliable information to say how safe this supplement is for everyone — talk to your doctor or pharmacist first, especially if you have a weakened immune system, an indwelling catheter, or a serious illness.

In rare cases, live probiotic organisms have caused infection (bacteremia and sepsis) in severely ill or immunocompromised patients, including preterm infants. Pregnancy and lactation safety data are not on file for this product.

Side effects, ingredient by ingredient Black Psyllium Bacillus Coagulans

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Black Psyllium, Bacillus Coagulans.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: heart-rhythm medications; lithium.
  • For scale: 2,084 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Antibiotics are the main medication type documented to interact with this product — specifically, taking them at the same time can reduce the probiotic's effectiveness. Separate your antibiotic dose from this supplement by several hours.

We couldn't check the four fiber and sterol ingredients for interactions, so use the search tool on this page to verify your specific drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This supplement may help with constipation or IBS symptoms if you're otherwise healthy, but the evidence isn't strong. The main thing to watch is taking it with antibiotics — space them out a few hours apart so the antibiotic doesn't kill off the probiotic.

If you're immunocompromised, have a central line, or are seriously ill, check with your doctor before starting. Run your medications through our checker to be sure.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about CholestaCare plus Fibermucil, straight from the product label.

Brand ProCaps Laboratories
Barcode (UPC) 397922
Net contents 60 Perma-Fresh Packets(s); 240 Easy-To-Swallow Capsule(s)
Market status On market
Date entered into DSLD Apr 22, 2021
DSLD ID 248410
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Approved Health, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for CholestaCare plus Fibermucil by ProCaps Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 Capsule(s)
Maximum serving Sizes:
4 Capsule(s)
Servings per container
60
UPC/BARCODE
397922
IngredientAmount% DV
Calories0 Calorie(s)--
Total Carbohydrates1 Gram(s)1%
Psyllium powder1.3 Gram(s)--
CholestaCare Proprietary Sterol Blend800 mg--
Dietary Fiber1.1 Gram(s)4%
Soluble Fiber0.9 Gram(s)--
Insoluble Fiber0.2 Gram(s)--
Lactobacillus sporogenes0 NP--

Other ingredients: Gelatin Capsule, Leucine, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use Each packet contains the optimum combination of water-soluble fiber and plant sterols to naturally reduce total and LDL cholesterol levels. Consume the contents of one packet daily with the largest meal of the day. Always consume with adequate fluid. CholestaCare Plus Fibermucil is intended to be taken immediately before, during of within 60 minutes of finishing eating. As with any dietary supplement, this product is most effective when used as part of a healthy diet low in saturated fat and cholesterol and an active lifestyle, along with a daily multi-vitamin-mineral formula. For questions about the use of this product call 800.332.7799.

Precautions

Notice All fiber products should be taken with a full glass of liquid. Consuming any fiber product without adequate fluid may cause choking. Do not use this or any fiber product if you have difficulty swallowing. If you feel abdominal pain or unexpected gastrointestinal discomfort when using this product, discontinue use and consult a physician. Initially, when using this product, evacuations may not occur until the second day, hence you may experience a temporary feeling of fullness.

As with any grain product, inhaled or ingested psyllium husk may cause allergic reactions in some individuals.

If you are taking prescription medicine by mouth, take this product 2 hours before or 2 hours after the prescribed medicine.

Formulation

Unsurpassed. Purity. Quality. Integrity. Effectiveness.

Natural cholesterol management

All-solar manufacturing

Andrew Lessman's CholestaCare plus Fibermucil is specifically formulated to safely and naturally lower total and LDL cholesterol using two all-natural active ingredients approved by the US Government for the reduction of cholesterol and heart disease risk. The active ingredients in both CholestaCare and Fibermucil are supported by decades of extensive clinical studies, which have unequivocally proven their ability to support heart health by safely lowering total cholesterol and LDL cholesterol (the "bad" cholesterol). The research on CholestaCare is so convincing that its active ingredient is the first natural ingredient actually recognized by the US Food and Drug Administration (FDA) to lower your total and LDL cholesterol. By adding Fibermucil to CholestaCare we increase its cholesterol-lowering power with a natural ingredient that is supported by clinical studies going back over 50 years. The combination of CholestaCare and Fibermucil delivers heart health and cholesterol-lowering benefits far greater than either can provide on their own.

Both of these active ingredients have been an important part of healthy vegetarian diets for centuries and in recent decades have been included in nutritional supplements for their heart health benefits.

Contains no milk, soy, yeast, wheat, gluten, sodium, salt, sugar, starch, fat, cholesterol, oil, emulsifier, wax, binder, filler, coating, diluent, common allergens, color, flavor, sweetener or preservative.

General Statements

Andrew Lessman Founder of ProCaps Labs HSN 800.944.9999 www.HSN.com www.QVC.com 800.345.1515

The perfect packet. The Perma-Fresh Purple Packet. The only packet worthy of our 100% pure products. Our Purple Packet is our most advanced packet ever, offering even more protection than our original foil packet. To retain potency, vitamins must be protected from light, moisture and oxygen and the ordinary clear packets used with typical vitamins cannot do so. Our unique Purple Packets are constructed from multiple layers of specialized materials to safeguard your vitamins from damaging light, moisture and oxygen. For decades, our foil packets set the standard for vitamin protection and today, our Perma-Fresh Purple Packet takes that protection to the highest levels, giving your vitamins the special protection they deserve.

Brand IP Statement(s)

2020 ProCaps Laboratories

Formula

Natural plant sterols Natural psyllium fiber Bulk and water soluble fiber

CholestaCare plus Fibermucil provides a natural means of lowering cholesterol that is entirely derived from the edible plants. CholestaCare is our specially balanced blend of plant sterols, while Fibermucil is our all-natural, 100% pure, encapsulated psyllium husk powder from the high-fiber Indian plant Plantago ovata. Both of these active ingredients have been an important part of healthy vegetarian diets for centuries and in recent decades have been included in nutritional supplements for their heart health benefits.

Beyond centuries of safely realized health benefits, both of these active ingredients are now FDA-approved to support heart health by lowering total and LDL cholesterol. In fact, according to the US Food and Drug Administration, consuming at least 400 mg per serving of CholestaCare twice daily with meals for a daily total intake of at least 800 mg of CholestaCare, as part of a diet low in saturated fat and cholesterol, may reduce the risk of heart disease. One packet of CholestaCare plus Fibermucil provides 800 mg of this FDA-approved active ingredient. To further enhance the proven cholesterol-lowering properties of CholestaCare, we have added Fibermucil, our all-natural, mild and non-abrasive, 100% pure psyllium husk powder. Dietary fiber is generally considered the most overlooked component in the American diet, which is unfortunate since it is well established that dietary fiber can naturally support heart health by safely reducing total and LDL cholesterol. Nowadays, heart health seems to be synonymous with lower cholesterol and as a result, millions of Americans are taking cholesterol-lowering "statin" drugs, which come with a very long list of dangerous side effects. If you and your physician would prefer a clinically proven, safe and natural method for achieving healthy cholesterol levels that contains two natural ingredients, then CholestaCare plus Fibermucil is the perfect choice. When used in conjunction with the appropriate diet, CholestaCare plus Fibermucil can reduce or even eliminate the need for cholesterol-lowering "statin" drugs by delivering reductions in cholesterol previously only thought to be achievable with drugs. Of course, partner with your physician to determine how CholestaCare plus Fibermucil can best accomplish your cholesterol and "statin" drug reduction goals.

The Western diet tends to increase our cholesterol levels and clinical studies have consistently proven that including the active ingredients from CholestaCare plus Fibermucil in your diet can help to lower total and LDL cholesterol levels, providing a safe and easy way to help reduce your risk of heart disease. Despite the powerful, proven benefits of CholestaCare plus Fibermucil, it is important to never underestimate the profound and long-term benefits of a healthy diet and active lifestyle. By adding CholestaCare plus Fibermucil to such a diet and lifestyle, you and your doctor are assured of getting the very best results from your efforts. Despite CholestaCare's proven effectiveness, it should never provide an excuse to ignore one's diet. In fact, CholestaCare plus Fibermucil works best when taken with meals that contain less "bad" hydrogenated and saturated fat and cholesterol, and when you try to avoid simple sugars or convertible carbohydrates, such as potatoes, pasta, rice and bread.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

CholestaCare plus Fibermucil by ProCaps Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

CholestaCare plus Fibermucil label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in CholestaCare plus Fibermucil by ProCaps Laboratories

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size4 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Psyllium powder

1.3 Gram(s) per serving

CholestaCare Proprietary Sterol Blend

800 mg per serving

Dietary Fiber

Interacts with
2,025 drugs
1.1 Gram(s) per serving

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. I...

Dietary Fiber monograph & interactions

Soluble Fiber

0.9 Gram(s) per serving

Insoluble Fiber

0.2 Gram(s) per serving

Lactobacillus sporogenes

Interacts with
182 drugs
0 NP per serving

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, a...

Lactobacillus sporogenes monograph & interactions

Other (inactive) ingredients: Gelatin Capsule, Leucine, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

CholestaCare plus Fibermucil by ProCaps Laboratories Drug Interactions

Want to check YOUR meds against CholestaCare plus Fibermucil?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,083Drugs
205 Moderate 1,878 Minor

Ingredients driving the most interactions

Dietary Fiber 2,025
Lactobacillus sporogenes 182

Individual Drug Interactions

The ingredients in CholestaCare plus Fibermucil interact with 2,083 drugs. Click any drug to see the details.

2 of the 6 ingredients in CholestaCare plus Fibermucil interact with drugs. Each result below shows which ingredient is responsible. Dietary Fiber Lactobacillus sporogenes

Each ingredient & the kinds of drugs it affects

For each ingredient in CholestaCare plus Fibermucil with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Dietary Fiber7 drug types · 2,025 drugs

Carbamazepine (Tegretol)

Theoretically, black psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Theoretically, black psyllium might reduce carbamazepine absorption. A preliminary study using blond psyllium reported decreased carbamazepine bioavailability due to binding of the drug to psyllium, as well as reduction of available fluid in the gut for dissolution of the drug. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Lithium

Theoretically, taking black psyllium at the same time as lithium might reduce lithium absorption.
The fiber in black psyllium might reduce lithium absorption and plasma levels. Some case reports describe a reduction in plasma lithium levels with concomitant administration of blond psyllium. This was reversed when psyllium was stopped. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Metformin (Glucophage)

Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Animal research shows that concurrent consumption of blond psyllium with metformin slows and increases the absorption of metformin. This interaction may also occur with black psyllium. To avoid changes in absorption, take psyllium 30-60 minutes after metformin.

Likelihood Possible Evidence D
Olanzapine (Zyprexa)

Theoretically, taking black psyllium at the same time as olanzapine might reduce olanzapine absorption.
The fiber in black psyllium might decrease the absorption of olanzapine. A single case report describes a reduction in the effectiveness of olanzapine when it was concomitantly administered with an unspecified type of psyllium 3 grams orally twice daily. This effect was reversed when psyllium was stopped.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, taking black psyllium at the same time as digoxin might reduce digoxin absorption and decrease digoxin levels.
Psyllium might bind digoxin in the gut. However, some clinical evidence suggests that psyllium does not impact digoxin absorption.

Likelihood Unlikely Evidence B
Ethinyl Estradiol

Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Concurrent use of blond psyllium with ethinyl estradiol results in a slight increase in the extent of ethinyl estradiol absorption and a slower rate of absorption. This is unlikely to be clinically significant.

Likelihood Unlikely Evidence D
Oral Drugs

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol. Case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine. Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin. Although many of these studies evaluated blond psyllium, the fiber content in black psyllium may have similar effects.

Likelihood Possible Evidence B
Dietary Fiber full monograph & interactions

Lactobacillus sporogenes1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B. coagulans.
B. coagulans preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. coagulans preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus sporogenes full monograph & interactions
The maker

Brand information

Manufacturer and brand details for CholestaCare plus Fibermucil, from the product label.

ProCaps Laboratories

See all ProCaps Laboratories products
Name
ProCaps Laboratories
City
Henderson
State
NV
ZipCode
89011
Phone Number
800.800.1200
Web Address
ProCapsLabs.com
Pharmacist Counseling Corner

CholestaCare plus Fibermucil by ProCaps Laboratories: Common Questions

Does CholestaCare plus Fibermucil by ProCaps Laboratories interact with any medications?
Yes. Based on its ingredients, CholestaCare plus Fibermucil has a known interaction with 2,083 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
CholestaCare plus Fibermucil contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does Bacillus coagulans actually do?
It's a probiotic — a live beneficial bacterium meant to support your digestive and intestinal health. The evidence shows it's possibly effective for constipation and irritable bowel syndrome, but for other uses like antibiotic-related diarrhea or athletic performance, there isn't enough data yet.
I'm on an antibiotic. Can I take this at the same time?
No — take them separately. Since the probiotic contains live organisms, the antibiotic can kill them off and make the supplement less effective. Space your doses a few hours apart, ideally taking your antibiotic at one time of day and this supplement at another.
What are all these fiber ingredients for?
They're bulk-forming agents that absorb water and add bulk to your stool, which helps move things through your digestive system and can ease constipation. Both soluble and insoluble fiber work in slightly different ways, and together they're meant to support digestive regularity.
Is this safe during pregnancy or breastfeeding?
We don't have safety data on file for this product during pregnancy or lactation. Talk with your doctor or pharmacist before using it if you're pregnant or nursing — they can give you personalized advice based on your situation.
Are there any side effects I should know about?
In healthy people with intact immune systems, this probiotic is generally well tolerated. However, in very rare cases — mainly in severely ill, immunocompromised, or preterm patients — live probiotic organisms have caused serious infections. If you have a weakened immune system or a central catheter, check with your doctor first.
What's the plant sterol blend supposed to do?
The CholestaCare Proprietary Sterol Blend is designed to help support cholesterol levels that are already in a healthy range. We don't have specific effectiveness data on file for this particular blend.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

CholestaCare plus Fibermucil label
Go deeper

The Full Monographs Behind CholestaCare plus Fibermucil’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Black Psyllium

Interacts with 2,025 drugs

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. It is best known and most studied for rel...

Read the full Black Psyllium monograph → Herb & supplement monograph

Bacillus Coagulans

Interacts with 182 drugs

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, and certain types of diarrhea. The eviden...

Read the full Bacillus Coagulans monograph →
Sources

Sources & How We Checked

CholestaCare plus Fibermucil's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 38 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Black Psyllium 18 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
  4. Etman M. Effect of a bulk forming laxative on the bioavailablility of carbamazepine in man. Drug Dev Ind Pharm 1995;21:1901-6.
  5. Perlman BB. Interaction between lithium salts and ispaghula husk. Lancet 1990;335:416.
  6. Vaswani SK, Hamilton RG, Valentine MD, Adkinson NF. Psyllium laxative-induced anaphylaxis, asthma, and rhinitis. Allergy 1996;51:266-8. PubMed
  7. Lantner RR, Espiritu BR, Zumerchik P, Tobin MC. Anaphylaxis following ingestion of a psyllium-containing cereal. JAMA 1990;264:2534-6. DOI
  8. Kaplan MJ. Anaphylactic reaction to "Heartwise." N Engl J Med 1990;323:1072-3. DOI
  9. Nordstrom M, Melander A, Robertsson E, Steen B. Influence of wheat bran and of a bulk-forming ispaghula cathartic on the bioavailability of digoxin in geriatric in-patients. Drug Nutr Interact 1987;5:67-9..
  10. Robinson DS, Benjamin DM, McCormack JJ. Interaction of warfarin and nonsystemic gastrointestinal drugs. Clin Pharmacol Ther 1971;12:491-5. PubMed
  11. Garcia JJ, Fernandez N, Diez MJ, et al. Influence of two dietary fibers in the oral bioavailability and other pharmacokinetic parameters of ethinyloestradiol. Contraception 2000;62:253-7. PubMed
  12. Fernandez N, Lopez C, Díez R, et al. Drug interactions with the dietary fiber Plantago ovata husk. Expert Opin Drug Metab Toxicol 2012;8(11):1377-86.
  13. Semen plantaginis in: WHO Monographs on Selected Medicinal Plants, volume 1. World Health Organization, Geneva, 1999. Available at http://apps.who.int/medicinedocs/en/d/Js2200e/. Accessed November 26, 1026.
  14. Code of Federal Regulations, Title 21 (21CFR 101.17). Food labeling warning, notice, and safe handling statements. Available at www.ecfr.gov/cgi-bin/text-idx?SID=20f647d3b74161501f46564b915b4048&mc=true&node=se21.2.101_117&rgn=div8. Accessed December 3, 2
  15. Code of Federal Regulations, Title 21 (21CFR 201.319). Specific labeling requirements - water-soluble gums, hydrophilic gums, and hydrophilic mucilloids. Available at www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=201.319. Accessed Dece
  16. Diez R, Garcia JJ, Diez MJ, Sierra M, Sahagun AM, Fernandez N. Influence of Plantago ovata husk (dietary fiber) on the bioavailability and other pharmacokinetic parameters of metformin in diabetic rabbits. BMC Complement Altern Med. 2017 Jun 7;17(1):298. PubMed
  17. Chiu AC, Sherman SI. Effects of pharmacological fiber supplements on levothyroxine absorption. Thyroid. 1998;8(8):667-71. PubMed
  18. Merrick C, Madden CA, Capurso NA. A Case of Blunted Orally Disintegrating Olanzapine Effect Due to Coadministered Psyllium. J Clin Psychiatry 2021;82(2):20cr13633. PubMed

See these in context on the Black Psyllium monograph →

Bacillus Coagulans 20 references
  1. Saxelin M, Chuang NH, Chassy B, et al. Lactobacilli and bacteremia in southern Finland 1989-1992. Clin Infect Dis 1996;22:564-6. PubMed
  2. Tynkkynen S, Singh KV, Varmanen P. Vancomycin resistance factor of Lactobacillus rhamnosus GG in relation to enterococcal vancomycin resistance (van) genes. Int J Food Microbiol 1998;41:195-204. PubMed
  3. Klein G, Zill E, Schindler R, et al. Peritonitis associated with vancomycin-resistant Lactobacillus rhamnosus in a continuous ambulatory peritoneal dialysis patient; organism identification, antibiotic therapy, and case report. J Clin Microbiol 1998;36:
  4. Kalima P, Masterton RG, Roddie PH, et al. Lactobacillus rhamnosus infection in a child following bone marrow transplant. J Infect 1996;32:165-7. PubMed
  5. Goldin BR. Health Benefits of probiotics. Br J Nutr 1998;80:S203-7. DOI
  6. Rautio M, Jousimies-Somer H, Kauma H, et al. Liver abscess due to Lactobacillus rhamnosus strain indistinguishable from L. rhamnosus strain GG. Clin Infect Dis 1999;28:1159-60.
  7. MacGregor G, Smith AJ, Thakker B, Kinsella J. Yoghurt biotherapy: contraindicated in immunosuppressed patients? Postgrad Med J 2002;78:366-7. PubMed
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See these in context on the Bacillus Coagulans monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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