Fruit Full Anti-Oxidant Extracts Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Fruit Full Anti-Oxidant Extracts against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Fruit Full Anti-Oxidant Extracts is a dietary supplement by ProCaps Laboratories with 16 active ingredients. Its ingredients are commonly taken for common cold and immune support, antioxidant support, skin health and collagen formation.Based on those ingredients, 1,322 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Pomegranate extract blend, Grape Seed Extract, Resveratrol. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Fruit Full Anti-Oxidant Extracts by ProCaps Laboratories
Ask about any prescription or over-the-counter medication and we check it for interactions with Fruit Full Anti-Oxidant Extracts by ProCaps Laboratories — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Fruit Full Anti-Oxidant Extracts by ProCaps Laboratories
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Fruit Full Anti-Oxidant Extracts contains 16 active ingredients: vitamin C, resveratrol, cranberry fruit extract, grape seed extract, black elder extract, grape skin extract, pomegranate extract blend, chokeberry extract blend, raspberry powder, strawberry powder, blackberry powder, apple fruit extract, acai berry extract blend, acai berry 4:1 concentrate, bilberry extract blend, and cherry extract/powder blend. Together they deliver a range of fruit and plant compounds—mostly antioxidants from berries, grapes, and pomegranate—meant to support your body's defense against free radicals.
The product contains no inactive fillers or added ingredients beyond these actives.
Does it work?
Strong evidence
The evidence for most ingredients in this product is limited or mixed. Vitamin C is effective for preventing vitamin C deficiency and possibly effective for anemia of chronic disease, atrial fibrillation, cataracts, and exercise-induced respiratory infections.
Resveratrol is possibly effective for obesity and allergic rhinitis (hay fever) but possibly ineffective for cardiovascular disease and high cholesterol. Cranberry is possibly effective for urinary tract infections but has insufficient evidence for cognitive decline, prostate health, cancer, and other conditions.
Grape extracts are possibly effective for chronic venous insufficiency (poor circulation in the legs) but possibly ineffective for nausea from chemotherapy, hay fever, and obesity. Pomegranate is possibly effective for high blood pressure but possibly ineffective for cholesterol and diabetes.
Black elder extract, chokeberry, strawberry, apple, acai, bilberry, and blueberry have insufficient evidence or lack established effectiveness ratings for their claimed uses. If you're taking this product for a specific health goal, check the ingredient you're relying on—most of these lack strong proof of benefit.
How safe is it?
Well-documented data
Vitamin C is generally well tolerated at normal dietary doses but can cause abdominal cramps, heartburn, osmotic diarrhea, nausea, and vomiting at high doses (above 2 grams daily); kidney stones may occur in susceptible people. Resveratrol is generally well tolerated at typical supplement doses but may cause diarrhea and gastrointestinal discomfort at higher doses; long-term safety is not fully known, and it should be avoided in pregnancy and breastfeeding due to insufficient safety data.
Cranberry, both grape extracts, pomegranate, and blueberry are generally well tolerated as foods and supplements, with diarrhea and mild gastrointestinal upset being the most common effects. Black elder extract (when properly prepared from ripe berries) is generally well tolerated, but raw or unripe berries, leaves, and seeds contain toxic compounds that cause nausea, vomiting, and severe diarrhea; the safety data advises avoiding it in pregnancy and breastfeeding.
Chokeberry is generally well tolerated as a food but supplement safety is less studied; avoid during pregnancy and breastfeeding due to insufficient data. Strawberry and apple are safe as foods; rare allergic reactions including anaphylaxis have been reported.
Acai is generally well tolerated but high-dose effects and supplement quality are not well studied; use caution in pregnancy and breastfeeding. Bilberry fruit is generally safe but concentrated supplements lack safety data in pregnancy and breastfeeding.
Blackberry has insufficient data for concentrated supplements during pregnancy and breastfeeding. Raspberry and cherry powder safety data are not on file.
Meds to double-check
Major interaction found
Before taking this product, check with your doctor or pharmacist if you take any of the following: blood thinners and antiplatelet drugs (aspirin, warfarin, clopidogrel) — multiple ingredients may increase bleeding risk; organic anion-transporting polypeptide (OATP) substrates like fexofenadine, atenolol, and aliskiren — apple fruit extract significantly reduces their blood levels; blood pressure medications and antihypertensive drugs — apple and pomegranate may interfere with control; blood sugar medications (antidiabetes drugs) — several ingredients may affect glucose levels; warfarin specifically — vitamin C, cranberry, grape extracts, and pomegranate all may increase levels or bleeding risk; chemotherapy drugs — vitamin C's antioxidant effects could theoretically reduce effectiveness of alkylating agents and antitumor antibiotics. No interactions are documented for the raspberry powder and cherry extract we could not check.
The bottom line
Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.
This product is a blend of fruit and plant extracts marketed for antioxidant support, but the evidence that any of them prevent disease or improve health is weak or incomplete. More importantly, several ingredients—especially apple fruit extract, vitamin C, and the grape extracts—interact significantly with common blood pressure medications, blood thinners, and other drugs.
If you take any prescription medications, especially blood thinners, heart medications, or drugs for blood pressure or diabetes, check your exact medications with your doctor or pharmacist before starting this product. The product is generally well tolerated for short-term use, but long-term safety for many ingredients is unknown.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 14 of 16 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 23, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Fruit Full Anti-Oxidant Extracts, straight from the product label.
| Brand | ProCaps Laboratories |
|---|---|
| Barcode (UPC) | 730985 |
| Net contents | 9.96 Ounce(s); 0.62 Pound(s); 282.6 Gram(s) |
| Market status | On market |
| Date entered into DSLD | Jun 23, 2021 |
| DSLD ID | 250524 |
| Product type | Other Combinations |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Fruit Full Anti-Oxidant Extracts by ProCaps Laboratories, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Vitamin C | 30 mg | 33% |
| Resveratrol | 20 mg | -- |
| Cranberry Fruit Extract | 40 mg | -- |
| Grape Seed Extract | 20 mg | -- |
| Black Elder extract | 40 mg | -- |
| Grape Skin Extract | 40 mg | -- |
| Pomegranate extract blend | 40 mg | -- |
| Chokeberry extract blend | 20 mg | -- |
| Raspberry powder | 20 mg | -- |
| Strawberry powder | 20 mg | -- |
| Blackberry powder | 10 mg | -- |
| Apple Fruit Extract | 10 mg | -- |
| Acai berry extract blend | 40 mg | -- |
| Acai berry 4:1 concentrate | 15 mg | -- |
| Bilberry extract blend | 40 mg | -- |
| Blueberry extract/powder blend | 20 mg | -- |
| Cherry extract/powder blend | 20 mg | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested Use Each level scoop (approximately 1/4 teaspoon) contains the equivalent of one capsule of the encapsulated version of Fruit Full Anti-Oxidant Extracts. Consume one or more scoops daily or as recommended by your health care professional. You can add the benefits of this product to water, smoothies or a beverage of your choosing. It can also be used to enhance the nutrient content of yogurt, applesauce, oatmeal or more. As with any dietary supplement, this product is most effective as part of a healthy diet and active lifestyle. For questions about the use of this product call 800.332.7799.
General Statements
This package is sold by weight, not by volume. It contains the full weight indicated on the label. Settling of contents can occur during shipment.
Unsurpassed. Purity. Quality. Integrity. Effectiveness. Andrew Lessman - Founder of ProCaps Labs www.HSN.com - 800.944.9999 www.QVC.com - 800.345.1515
All-solar manufactuing
Brand IP Statement(s)
Copyright 2020 ProCaps Labs
Formula
Acai - Bilberry - Cranberry - Blueberry - Raspberry Grape - Elderberry - Cherry - Chokeberry - Blackberry Pomegranate - Resveratrol - Apple - Strawberry
Andrew Lessman's Fruit Full Anti-Oxidant Extracts is a unique blend of Mother Nature's healthiest fruits and berries. It is well-established that rich-colored fruits and berries deliver a multitude of powerful protective compounds called polyphenols. Our Fruit Full Anti-Oxidant Extracts combines standardized extracts from 14 of the most well-researched fruits and berries to provide a broad spectrum of powerful natural protection.
We add our unique extracts from exotic super-fruits, such as pomegranate and acai berry, to extracts of well-known berries, such as blackberry, elderberry, raspberry, strawberry, chokeberry and blueberry. Each of these remarkably-rich extracts owes their protective properties to the deep, rich colors and pigments of their skins and pulp. We also add resveratrol - the key beneficial molecule in red wine, grapes and grape skin, because of its central role in the Mediterranean diet. All the ingredients in Fruit Full Anti-Oxidant Extracts are standardized, so you are assured of the quality and consistency of its contents from the healthiest foods that are so rarely a part of our modern diet.
FDA Statement of Identity
Dietary Supplement
Formulation
The anthocyanins in our bilberry extract protect the retina and its macular region while also supporting night vision. The fruit acids and anthocyanins in our cranberry extract support the health of the bladder and kidneys while the proanthocyanidins and polyphenols in our grape seed, grape skin and apple extracts offer extensive cardiovascular and circulatory benefits.
Contains no milk, soy, yeast, wheat, gluten, sodium, salt, sugar, fat, cholesterol, color, preservative, common allergens or manufacturing additives. Contains no additives of any kind.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Fruit Full Anti-Oxidant Extracts by ProCaps Laboratories label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Fruit Full Anti-Oxidant Extracts by ProCaps Laboratories
These are the 16 active ingredients this product is made of. Select any to open its full monograph.
Serving size471 mg Dosage formPowder Servings per container600 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Vitamin C
Interacts with207 drugs
Vitamin C (ascorbic acid) is an essential nutrient your body needs but cannot make, so you must get it from food or supplements. It's important for im...
Vitamin C monograph & interactionsResveratrol
Interacts with822 drugs
Resveratrol is a plant compound found in red grapes, berries, and peanuts that is popular for heart health, anti-aging, and antioxidant support. While...
Resveratrol monograph & interactionsCranberry Fruit Extract
Interacts with712 drugs
Cranberry is best known for helping to prevent repeated urinary tract infections (UTIs) in some people, and the evidence here is moderate but mixed. I...
Cranberry Fruit Extract monograph & interactionsGrape Seed Extract
Interacts with910 drugs
Grapes and grape products like grape seed extract contain antioxidant compounds such as resveratrol and proanthocyanidins that may support heart and b...
Grape Seed Extract monograph & interactionsBlack Elder extract
Interacts with121 drugs
Elderberry is a popular herbal supplement, mainly taken to help with colds and flu. Some small studies suggest it may modestly shorten cold or flu sym...
Black Elder extract monograph & interactionsGrape Skin Extract
Interacts with910 drugs
Grapes and grape products like grape seed extract contain antioxidant compounds such as resveratrol and proanthocyanidins that may support heart and b...
Grape Skin Extract monograph & interactionsPomegranate extract blend
Interacts with922 drugs
Pomegranate is a nutrient-rich fruit that is high in antioxidants and is widely enjoyed as food and juice. Early research suggests it may support hear...
Pomegranate extract blend monograph & interactionsChokeberry extract blend
Interacts with811 drugs
Chokeberry (aronia) is a dark berry rich in antioxidants called polyphenols, and it's widely eaten as juice, jam, and supplements. Early research hint...
Chokeberry extract blend monograph & interactionsRaspberry powder
Strawberry powder
Interacts with316 drugs
Strawberry is a popular, nutrient-rich fruit that supplies vitamin C, fiber, and antioxidant plant compounds. Eating strawberries as part of a balance...
Strawberry powder monograph & interactionsBlackberry powder
No knowninteractions
Blackberry is a common edible berry that is safe and nutritious as a food, rich in vitamin C, fiber, and antioxidant plant compounds. The leaves and r...
Blackberry powder monograph & interactionsApple Fruit Extract
Interacts with300 drugs
Apples are a nutritious whole food that provides fiber, vitamins, and antioxidant plant compounds, and eating them regularly fits well into a healthy...
Apple Fruit Extract monograph & interactionsAcai berry extract blend
Interacts with86 drugs
Acai is a nutritious Amazonian berry rich in antioxidants and healthy fats, and it is fine to enjoy as a food. However, strong human evidence is lacki...
Acai berry extract blend monograph & interactionsBilberry extract blend
Interacts with275 drugs
Bilberry is a blueberry-like fruit rich in antioxidant plant compounds called anthocyanins, and it has a long history of traditional use for eye healt...
Bilberry extract blend monograph & interactionsBlueberry extract/powder blend
Interacts with88 drugs
Blueberries are a nutritious fruit rich in antioxidants called anthocyanins, and eating them as part of a balanced diet is healthy and safe for most p...
Blueberry extract/powder blend monograph & interactionsCherry extract/powder blend
Fruit Full Anti-Oxidant Extracts by ProCaps Laboratories Drug Interactions
HelloPharmacist Interaction Report
Fruit Full Anti-Oxidant Extracts by ProCaps Laboratories has documented interactions with medications through its vitamin C, resveratrol, cranberry fruit extract, grape seed extract, black elder extract, grape skin extract, pomegranate extract blend, chokeberry extract blend, strawberry powder, apple fruit extract, acai berry 4:1 concentrate, and bilberry extract blend.
The most serious interaction is a Major-severity effect: apple fruit extract can significantly reduce blood levels and effectiveness of organic anion-transporting polypeptide (OATP) substrates—drugs that rely on a specific transport system to be absorbed—including fexofenadine (an allergy medication), atenolol (a blood pressure medication), and aliskiren (another blood pressure drug).
Read the full breakdown — every affected drug type, severity by severity
Vitamin C carries the most moderate-severity interactions, affecting estrogens (oral contraceptives and hormone replacement therapy may have increased blood levels), chemotherapy drugs like alkylating agents and antitumor antibiotics (where antioxidants could theoretically reduce their effectiveness), warfarin (a blood thinner, where high doses might reduce effectiveness), and several others. Resveratrol, cranberry, both grape extracts, pomegranate, chokeberry, strawberry, and bilberry all interact with anticoagulants and antiplatelet drugs (blood thinners and aspirin-like medications), raising bleeding risk.
Several ingredients also affect how your liver processes drugs: resveratrol and bilberry with CYP2E1 substrates, resveratrol with CYP3A4 and CYP1A2 and CYP2C19 substrates, cranberry and both grape extracts with CYP3A4, and apple with antihypertensive and antidiabetes drugs.
Additionally, your liver metabolizes many common medications through a system called the cytochrome P450 pathway—resveratrol, cranberry, grape seed extract, grape skin extract, and chokeberry all theoretically affect enzymes in this system, potentially changing how drugs like certain statins, HIV protease inhibitors, and immunosuppressants work. Apple fruit extract also reduces absorption of blood pressure medications atenolol and aliskiren by 58–82% depending on dose.
Altogether, these interactions span 1,323 individual medications.
Raspberry powder and cherry extract/powder blend could not be checked because we hold no monograph data for them. Use the medication checker on this page to verify your exact prescriptions and over-the-counter medications before taking this product, and talk with your doctor or pharmacist about timing and dosing if any of these categories apply to you.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Fruit Full Anti-Oxidant Extracts?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Fruit Full Anti-Oxidant Extracts interact with 1,322 drugs. Click any drug to see the details.
12 of the 16 ingredients in Fruit Full Anti-Oxidant Extracts interact with drugs. Each result below shows which ingredient is responsible. Pomegranate extract blend Grape Seed Extract Resveratrol Chokeberry extract blend Cranberry Fruit Extract Strawberry powder Apple Fruit Extract Bilberry extract blend Vitamin C Black Elder extract Blueberry extract/powder blend Acai berry extract blend
AtorvastatinAtorvaliq
How Atorvastatin interacts with Fruit Full Anti-Oxidant Extracts — through 6 ingredients. Tap an ingredient for the detail:
Apple Fruit ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Fruit Extract + Atorvastatin interactionGrape Skin ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.
Read the full Grape Skin Extract + Atorvastatin interactionResveratrolCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
Read the full Resveratrol + Atorvastatin interactionChokeberry Extract BlendCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, chokeberry might increase levels of drugs metabolized by CYP3A4.
Read the full Chokeberry Extract Blend + Atorvastatin interactionCranberry Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Atorvastatin (lipitor) Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Fruit Extract + Atorvastatin interactionPomegranate Extract BlendCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Pomegranate Extract Blend + Atorvastatin interactionAtorvastatin CalciumLipitor
How Atorvastatin Calcium interacts with Fruit Full Anti-Oxidant Extracts — through 6 ingredients. Tap an ingredient for the detail:
Apple Fruit ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Fruit Extract + Atorvastatin Calcium interactionCranberry Fruit ExtractAtorvastatin (lipitor), Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase levels and adverse effects of atorvastatin.
Read the full Cranberry Fruit Extract + Atorvastatin Calcium interactionChokeberry Extract BlendCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, chokeberry might increase levels of drugs metabolized by CYP3A4.
Read the full Chokeberry Extract Blend + Atorvastatin Calcium interactionGrape Skin ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.
Read the full Grape Skin Extract + Atorvastatin Calcium interactionResveratrolCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
Read the full Resveratrol + Atorvastatin Calcium interactionPomegranate Extract BlendCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Pomegranate Extract Blend + Atorvastatin Calcium interactionBosentanTracleer
How Bosentan interacts with Fruit Full Anti-Oxidant Extracts — through 6 ingredients. Tap an ingredient for the detail:
Apple Fruit ExtractOrganic Anion-transporting Polypeptide Substrates (oatp), Antihypertensive Drugs Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Fruit Extract + Bosentan interactionPomegranate Extract BlendCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2c9 (cyp2c9) Substrates +1 Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Pomegranate Extract Blend + Bosentan interactionResveratrolCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
Read the full Resveratrol + Bosentan interactionChokeberry Extract BlendCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, chokeberry might increase levels of drugs metabolized by CYP3A4.
Read the full Chokeberry Extract Blend + Bosentan interactionCranberry Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Fruit Extract + Bosentan interactionGrape Skin ExtractCytochrome P450 2c9 (cyp2c9) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
Read the full Grape Skin Extract + Bosentan interactionBrincidofovirTembexa
How Brincidofovir interacts with Fruit Full Anti-Oxidant Extracts — through 1 ingredient. Tap an ingredient for the detail:
Apple Fruit ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Fruit Extract + Brincidofovir interactionCeliprololCelicard
How Celiprolol interacts with Fruit Full Anti-Oxidant Extracts — through 3 ingredients. Tap an ingredient for the detail:
Apple Fruit ExtractOrganic Anion-transporting Polypeptide Substrates (oatp), Antihypertensive Drugs Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Fruit Extract + Celiprolol interactionPomegranate Extract BlendAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Read the full Pomegranate Extract Blend + Celiprolol interactionStrawberry PowderP-glycoprotein Substrates Moderate
Interaction Summary
In vitro research suggests that strawberry extract can inhibit p-glycoprotein efflux.
Read the full Strawberry Powder + Celiprolol interactionCerivastatin SodiumBaycol
How Cerivastatin Sodium interacts with Fruit Full Anti-Oxidant Extracts — through 1 ingredient. Tap an ingredient for the detail:
Apple Fruit ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Fruit Extract + Cerivastatin Sodium interactionCinoxacinCinobac
How Cinoxacin interacts with Fruit Full Anti-Oxidant Extracts — through 1 ingredient. Tap an ingredient for the detail:
Apple Fruit ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Fruit Extract + Cinoxacin interactionCiprofloxacinCiloxan, Cipro, Cipro IV, Cipro XR, Ciprobay, Otiprio
How Ciprofloxacin interacts with Fruit Full Anti-Oxidant Extracts — through 1 ingredient. Tap an ingredient for the detail:
Apple Fruit ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Fruit Extract + Ciprofloxacin interactionCiprofloxacin, HydrocortisoneCipro HC Otic
How Ciprofloxacin, Hydrocortisone interacts with Fruit Full Anti-Oxidant Extracts — through 1 ingredient. Tap an ingredient for the detail:
Apple Fruit ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Fruit Extract + Ciprofloxacin, Hydrocortisone interactionClinafloxacinClinafloxacin
How Clinafloxacin interacts with Fruit Full Anti-Oxidant Extracts — through 1 ingredient. Tap an ingredient for the detail:
Apple Fruit ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Fruit Extract + Clinafloxacin interactionEnoxacinPenetrex
How Enoxacin interacts with Fruit Full Anti-Oxidant Extracts — through 1 ingredient. Tap an ingredient for the detail:
Apple Fruit ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Fruit Extract + Enoxacin interactionEtoposideEtopophos, VePesid, VP16
How Etoposide interacts with Fruit Full Anti-Oxidant Extracts — through 7 ingredients. Tap an ingredient for the detail:
Apple Fruit ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Fruit Extract + Etoposide interactionResveratrolCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
Read the full Resveratrol + Etoposide interactionStrawberry PowderP-glycoprotein Substrates Moderate
Interaction Summary
In vitro research suggests that strawberry extract can inhibit p-glycoprotein efflux.
Read the full Strawberry Powder + Etoposide interactionCranberry Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Fruit Extract + Etoposide interactionChokeberry Extract BlendCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, chokeberry might increase levels of drugs metabolized by CYP3A4.
Read the full Chokeberry Extract Blend + Etoposide interactionGrape Skin ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.
Read the full Grape Skin Extract + Etoposide interactionPomegranate Extract BlendCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Pomegranate Extract Blend + Etoposide interactionEzetimibe, AtorvastatinLiptruzet
How Ezetimibe, Atorvastatin interacts with Fruit Full Anti-Oxidant Extracts — through 6 ingredients. Tap an ingredient for the detail:
Apple Fruit ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Fruit Extract + Ezetimibe, Atorvastatin interactionResveratrolCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
Read the full Resveratrol + Ezetimibe, Atorvastatin interactionChokeberry Extract BlendCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, chokeberry might increase levels of drugs metabolized by CYP3A4.
Read the full Chokeberry Extract Blend + Ezetimibe, Atorvastatin interactionCranberry Fruit ExtractAtorvastatin (lipitor), Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase levels and adverse effects of atorvastatin.
Read the full Cranberry Fruit Extract + Ezetimibe, Atorvastatin interactionGrape Skin ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.
Read the full Grape Skin Extract + Ezetimibe, Atorvastatin interactionPomegranate Extract BlendCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Pomegranate Extract Blend + Ezetimibe, Atorvastatin interactionFexofenadineAllegra
How Fexofenadine interacts with Fruit Full Anti-Oxidant Extracts — through 7 ingredients. Tap an ingredient for the detail:
Apple Fruit ExtractOrganic Anion-transporting Polypeptide Substrates (oatp), Fexofenadine (allegra) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Fruit Extract + Fexofenadine interactionStrawberry PowderP-glycoprotein Substrates Moderate
Interaction Summary
In vitro research suggests that strawberry extract can inhibit p-glycoprotein efflux.
Read the full Strawberry Powder + Fexofenadine interactionGrape Skin ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.
Read the full Grape Skin Extract + Fexofenadine interactionResveratrolCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
Read the full Resveratrol + Fexofenadine interactionChokeberry Extract BlendCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, chokeberry might increase levels of drugs metabolized by CYP3A4.
Read the full Chokeberry Extract Blend + Fexofenadine interactionCranberry Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Fruit Extract + Fexofenadine interactionPomegranate Extract BlendCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Pomegranate Extract Blend + Fexofenadine interactionFexofenadine, PseudoephedrineAllegra D
How Fexofenadine, Pseudoephedrine interacts with Fruit Full Anti-Oxidant Extracts — through 7 ingredients. Tap an ingredient for the detail:
Apple Fruit ExtractOrganic Anion-transporting Polypeptide Substrates (oatp), Fexofenadine (allegra) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Fruit Extract + Fexofenadine, Pseudoephedrine interactionCranberry Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Fruit Extract + Fexofenadine, Pseudoephedrine interactionChokeberry Extract BlendCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, chokeberry might increase levels of drugs metabolized by CYP3A4.
Read the full Chokeberry Extract Blend + Fexofenadine, Pseudoephedrine interactionGrape Skin ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.
Read the full Grape Skin Extract + Fexofenadine, Pseudoephedrine interactionStrawberry PowderP-glycoprotein Substrates Moderate
Interaction Summary
In vitro research suggests that strawberry extract can inhibit p-glycoprotein efflux.
Read the full Strawberry Powder + Fexofenadine, Pseudoephedrine interactionResveratrolCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
Read the full Resveratrol + Fexofenadine, Pseudoephedrine interactionPomegranate Extract BlendCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Pomegranate Extract Blend + Fexofenadine, Pseudoephedrine interactionFluvastatinLescol, Lescol XL
How Fluvastatin interacts with Fruit Full Anti-Oxidant Extracts — through 4 ingredients. Tap an ingredient for the detail:
Apple Fruit ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Fruit Extract + Fluvastatin interactionPomegranate Extract BlendCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2C9.
Read the full Pomegranate Extract Blend + Fluvastatin interactionCranberry Fruit ExtractCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry Fruit Extract + Fluvastatin interactionGrape Skin ExtractCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
Read the full Grape Skin Extract + Fluvastatin interactionGatifloxacinTequin, Tequin Injection
How Gatifloxacin interacts with Fruit Full Anti-Oxidant Extracts — through 1 ingredient. Tap an ingredient for the detail:
Apple Fruit ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Fruit Extract + Gatifloxacin interactionGemifloxacinFactive
How Gemifloxacin interacts with Fruit Full Anti-Oxidant Extracts — through 1 ingredient. Tap an ingredient for the detail:
Apple Fruit ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Fruit Extract + Gemifloxacin interactionGlyburideAlbert Glyburide, Diabeta, Glycron, Glynase, Glynase PresTab, Micronase +1 more
How Glyburide interacts with Fruit Full Anti-Oxidant Extracts — through 8 ingredients. Tap an ingredient for the detail:
Apple Fruit ExtractAntidiabetes Drugs, Organic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Theoretically, consuming apple juice with antidiabetes drugs might interfere with blood glucose control.
Read the full Apple Fruit Extract + Glyburide interactionChokeberry Extract BlendAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chokeberry might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Chokeberry Extract Blend + Glyburide interactionAcai Berry 4:1 ConcentrateAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking acai with antidiabetes drugs might interfere with glycemic control.
Read the full Acai Berry 4:1 Concentrate + Glyburide interactionBilberry Extract BlendAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, bilberry leaf or fruit extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Bilberry Extract Blend + Glyburide interactionBlueberry Extract/powder BlendAntidiabetes Drugs Minor
Interaction Summary
Theoretically, blueberries or blueberry leaf extracts might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Blueberry Extract/powder Blend + Glyburide interactionCranberry Fruit ExtractCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry Fruit Extract + Glyburide interactionGrape Skin ExtractCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
Read the full Grape Skin Extract + Glyburide interactionPomegranate Extract BlendCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2C9.
Read the full Pomegranate Extract Blend + Glyburide interactionGlyburide, MetforminGlucovance
How Glyburide, Metformin interacts with Fruit Full Anti-Oxidant Extracts — through 8 ingredients. Tap an ingredient for the detail:
Apple Fruit ExtractAntidiabetes Drugs, Organic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Theoretically, consuming apple juice with antidiabetes drugs might interfere with blood glucose control.
Read the full Apple Fruit Extract + Glyburide, Metformin interactionBilberry Extract BlendAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, bilberry leaf or fruit extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Bilberry Extract Blend + Glyburide, Metformin interactionAcai Berry 4:1 ConcentrateAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking acai with antidiabetes drugs might interfere with glycemic control.
Read the full Acai Berry 4:1 Concentrate + Glyburide, Metformin interactionChokeberry Extract BlendAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chokeberry might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Chokeberry Extract Blend + Glyburide, Metformin interactionPomegranate Extract BlendCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2C9.
Read the full Pomegranate Extract Blend + Glyburide, Metformin interactionBlueberry Extract/powder BlendAntidiabetes Drugs Minor
Interaction Summary
Theoretically, blueberries or blueberry leaf extracts might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Blueberry Extract/powder Blend + Glyburide, Metformin interactionGrape Skin ExtractCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
Read the full Grape Skin Extract + Glyburide, Metformin interactionCranberry Fruit ExtractCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry Fruit Extract + Glyburide, Metformin interactionGrepafloxacinRaxar
How Grepafloxacin interacts with Fruit Full Anti-Oxidant Extracts — through 3 ingredients. Tap an ingredient for the detail:
Apple Fruit ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Fruit Extract + Grepafloxacin interactionGrape Skin ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, grape juice might reduce the levels of CYP1A2 substrates.
Read the full Grape Skin Extract + Grepafloxacin interactionResveratrolCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP1A2.
Read the full Resveratrol + Grepafloxacin interactionIrinotecanCamptosar, Onivyde
How Irinotecan interacts with Fruit Full Anti-Oxidant Extracts — through 6 ingredients. Tap an ingredient for the detail:
Apple Fruit ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Fruit Extract + Irinotecan interactionGrape Skin ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.
Read the full Grape Skin Extract + Irinotecan interactionCranberry Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Fruit Extract + Irinotecan interactionChokeberry Extract BlendCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, chokeberry might increase levels of drugs metabolized by CYP3A4.
Read the full Chokeberry Extract Blend + Irinotecan interactionResveratrolCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
Read the full Resveratrol + Irinotecan interactionPomegranate Extract BlendCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Pomegranate Extract Blend + Irinotecan interactionIrinotecan Hydrochloride
How Irinotecan Hydrochloride interacts with Fruit Full Anti-Oxidant Extracts — through 6 ingredients. Tap an ingredient for the detail:
Apple Fruit ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Fruit Extract + Irinotecan Hydrochloride interactionResveratrolCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
Read the full Resveratrol + Irinotecan Hydrochloride interactionGrape Skin ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.
Read the full Grape Skin Extract + Irinotecan Hydrochloride interactionCranberry Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Fruit Extract + Irinotecan Hydrochloride interactionChokeberry Extract BlendCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, chokeberry might increase levels of drugs metabolized by CYP3A4.
Read the full Chokeberry Extract Blend + Irinotecan Hydrochloride interactionPomegranate Extract BlendCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Pomegranate Extract Blend + Irinotecan Hydrochloride interactionIsoniazid, Pyrazinamide, RifampinRifater
How Isoniazid, Pyrazinamide, Rifampin interacts with Fruit Full Anti-Oxidant Extracts — through 1 ingredient. Tap an ingredient for the detail:
Apple Fruit ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Fruit Extract + Isoniazid, Pyrazinamide, Rifampin interactionIsoniazid, RifampinRifamate
How Isoniazid, Rifampin interacts with Fruit Full Anti-Oxidant Extracts — through 1 ingredient. Tap an ingredient for the detail:
Apple Fruit ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Fruit Extract + Isoniazid, Rifampin interactionLevofloxacinLeva-pak, Levaquin, Levaquin Injection
How Levofloxacin interacts with Fruit Full Anti-Oxidant Extracts — through 1 ingredient. Tap an ingredient for the detail:
Apple Fruit ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Fruit Extract + Levofloxacin interactionLevofloxacin (ophthalmic)Levofloxacin
How Levofloxacin (ophthalmic) interacts with Fruit Full Anti-Oxidant Extracts — through 1 ingredient. Tap an ingredient for the detail:
Apple Fruit ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Fruit Extract + Levofloxacin (ophthalmic) interactionLomefloxacinMaxaquin
How Lomefloxacin interacts with Fruit Full Anti-Oxidant Extracts — through 1 ingredient. Tap an ingredient for the detail:
Apple Fruit ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Fruit Extract + Lomefloxacin interactionLovastatinAltocor, Mevacor
How Lovastatin interacts with Fruit Full Anti-Oxidant Extracts — through 6 ingredients. Tap an ingredient for the detail:
Apple Fruit ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Fruit Extract + Lovastatin interactionCranberry Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Fruit Extract + Lovastatin interactionChokeberry Extract BlendCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, chokeberry might increase levels of drugs metabolized by CYP3A4.
Read the full Chokeberry Extract Blend + Lovastatin interactionGrape Skin ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.
Read the full Grape Skin Extract + Lovastatin interactionResveratrolCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
Read the full Resveratrol + Lovastatin interactionPomegranate Extract BlendCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Pomegranate Extract Blend + Lovastatin interactionMethotrexateOtrexup, Rasuvo, Reditrex, Rheumatrex
How Methotrexate interacts with Fruit Full Anti-Oxidant Extracts — through 1 ingredient. Tap an ingredient for the detail:
Apple Fruit ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Fruit Extract + Methotrexate interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Fruit Full Anti-Oxidant Extracts with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Pomegranate extract blend
Ace Inhibitors (Aceis)
Theoretically, taking pomegranate with ACEIs might increase the risk of adverse effects.
Pomegranate juice is thought to have ACE inhibitor-like effects.
Antihypertensive Drugs
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Consuming pomegranate juice can modestly lower blood pressure.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
In vitro, pomegranate juice inhibits CYP2D6. However, the clinical significance of this potential interaction in humans is not known.
Rosuvastatin (Crestor)
Theoretically, taking pomegranate with rosuvastatin might increase the risk of adverse effects.
In one case, a patient taking rosuvastatin 5 mg every other day in combination with ezetimibe 10 mg daily developed rhabdomyolysis after drinking pomegranate juice 200 mL twice weekly for 3 weeks. This patient had a history of elevated creatine kinase levels while not receiving any statin treatment. This suggests a possible underlying myopathy and predisposition to rhabdomyolysis.
Warfarin (Coumadin)
Theoretically, pomegranate might increase warfarin levels and increase the risk of bleeding. Also, discontinuing regular consumption of pomegranate juice might decrease warfarin levels.
In one case report, a patient had a stable, therapeutic bleeding time, as measured by international normalized ratio (INR), while taking warfarin in combination with pomegranate juice 2-3 times per week. The patient became subtherapeutic within about 10 days after discontinuing pomegranate juice, which required a warfarin dose increase. In another case report, a patient with a stable INR for over one year presented with an INR of 14. The patient noted no changes to medications or diet but did report consuming around 3 liters of pomegranate juice over the previous week. The patient's INR stabilized upon moderation of pomegranate juice consumption. The mechanism of this potential interaction is unclear.
Carbamazepine (Tegretol)
Theoretically, taking pomegranate with carbamazepine might increase the risk of adverse effects, although research suggests this interaction is unlikely to be clinically significant.
Animal research shows that pomegranate juice may inhibit cytochrome P450 3A4 (CYP3A4) metabolism of carbamazepine and increase levels of carbamazepine by 1.5 times without prolonging the elimination half-life. This suggests that pomegranate juice inhibits intestinal CYP3A4, but might not inhibit hepatic CYP3A4. However, some human research suggests that pomegranate does not significantly inhibit CYP3A4 drug metabolism in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2C9.
Some animal and in vitro research shows that pomegranate juice inhibits intestinal, but not hepatic, CYP2C9 isoenzyme activity. However, clinical research shows that neither pomegranate juice nor pomegranate extract have a significant effect on CYP2C9 activity in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Pomegranate contains several polyphenols that have individually been shown to inhibit CYP3A4. However, there is contradictory evidence about the effect of whole pomegranate juice on CYP3A4 activity. In vitro, pomegranate juice significantly inhibits the CYP3A4 enzyme, with comparable inhibition to grapefruit juice. In an animal model, pomegranate juice inhibits CYP3A4 metabolism of carbamazepine and increases levels of carbamazepine by 1.5 times; however, in human volunteers, drinking a single glass of pomegranate juice 240 mL or taking 200 mL daily for 2 weeks does not significantly affect levels of the CYP3A4 substrate midazolam after oral or intravenous administration. Another study in healthy volunteers shows that consuming pomegranate juice 300 mL three times daily for three days also does not significantly affect levels of simvastatin, a CYP3A4 substrate This suggests that pomegranate is unlikely to significantly affect levels of CYP3A4 substrates in humans.
Tolbutamide (Orinase)
Theoretically, pomegranate might increase levels of tolbutamide, although research suggests this interaction is unlikely to be clinically significant.
Animal research shows that pomegranate juice inhibits the cytochrome P450 2C9 (CYP2C9) metabolism of tolbutamide. Pomegranate juice increased tolbutamide levels by 1.2 times without prolonging the elimination half-life. This suggests that pomegranate juice inhibits intestinal CYP2C9, but might not inhibit hepatic CYP2C9. Despite this evidence, clinical research shows that neither pomegranate juice nor pomegranate extract have a significant effect on CYP2C9 activity in humans. This interaction does not appear to be clinically significant in humans.
Grape Seed Extract
Anticoagulant/Antiplatelet Drugs
Theoretically, grape extracts may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro evidence suggests that grape extracts might decrease platelet aggregation.
Cyclosporine (Neoral, Sandimmune)
Ingesting grape juice with cyclosporine can reduce cyclosporine absorption.
A small pharmacokinetic study in healthy young adults shows that intake of purple grape juice 200 mL along with cyclosporine can decrease the absorption of cyclosporine by up to 30% when compared with water. Separate doses of grape juice and cyclosporine by at least 2 hours to avoid this interaction.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, grape juice might reduce the levels of CYP1A2 substrates.
A small pharmacokinetic study in healthy adults shows that ingestion of 200 mL of grape juice decreases phenacetin plasma levels. This is thought to be due to induction of CYP1A2.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, grape seed extract may increase the levels of CYP2D6 substrates.
In vitro evidence suggests that grape seed extract might inhibit CYP2D6 enzymes. However, this interaction has not been reported in humans.
Cytochrome P450 2E1 (Cyp2E1) Substrates
Theoretically, grape seed extract might increase the levels of CYP2E1 substrates.
In vitro and animal research suggests that grape seed proanthocyanidin extract inhibits CYP2E1 enzymes. However, this interaction has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.
In vitro evidence suggests that grape seed extract might inhibit CYP3A4 enzymes. However, evidence from animal research shows that grape seed extract may induce CYP3A4 in the liver. So far, these interactions have not been reported in humans.
Midazolam (Versed)
Theoretically, long-term intake of grape seed extract might decrease the effects of midazolam.
Animal research shows that subchronic ingestions of grape seed extract can increase the elimination of intravenous midazolam by increasing hepatic CYP3A4 activity. Single doses of grape seed extract do not appear to affect midazolam elimination.
Phenacetin
Grape juice might decrease phenacetin absorption.
A small pharmacokinetic study in healthy adults shows that ingestion of 200 mL of grape juice decreases phenacetin plasma levels. This is thought to be due to induction of cytochrome P450 1A2 (CYP1A2).
Cytochrome P450 2C9 (Cyp2C9) Substrates
It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
In vitro evidence shows that grape seed extract or grape juice might inhibit CYP2C9 enzymes. However, a small pharmacokinetic study in healthy adults shows that drinking 8 ounces of grape juice once does not affect the clearance of flurbiprofen, a probe-drug for CYP2C9 metabolism. The effects of continued grape juice consumption are unclear.
Resveratrol
Anticoagulant/Antiplatelet Drugs
Resveratrol may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Resveratrol seems to have antiplatelet effects.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, resveratrol might increase levels of drugs metabolized by CYP1A2.
In vitro research shows that resveratrol can inhibit CYP1A2 enzymes. However, this interaction has not been reported in humans.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, resveratrol might increase levels of drugs metabolized by CYP2C19.
In vitro research shows that resveratrol can inhibit CYP2C19 enzymes. However, this interaction has not been reported in humans.
Cytochrome P450 2E1 (Cyp2E1) Substrates
Resveratrol might increase levels of drugs metabolized by CYP2E1.
In vitro research suggests that resveratrol inhibits CYP2E1 isoenzyme. Also, a pharmacokinetic study shows that taking resveratrol 500 mg daily for 10 days prior to taking a single dose of chlorzoxazone 250 mg increases the maximum concentration of chlorzoxazone by about 54%, the area under the curve of chlorzoxazone by about 72%, and the half-life of chlorzoxazone by about 35%. Chlorzoxazone is used as a probe drug for CYP2E1.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
In vitro research shows that resveratrol can inhibit the CYP3A4 enzyme. However, clinical research shows that taking resveratrol 3000 mg daily for 8 weeks does not necessitate dose adjustments to medications metabolized by CYP3A4.
Chokeberry extract blend
Anticoagulant/Antiplatelet Drugs
Theoretically, chokeberry might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Clinical and in vitro research suggests that chokeberry extract can temporarily inhibit platelet aggregation and decrease clot formation.
Antidiabetes Drugs
Theoretically, chokeberry might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Some clinical research shows that chokeberry decreases levels of blood glucose in some patients with diabetes. However, other clinical research suggests that chokeberry has no significant effect on blood glucose levels.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, chokeberry might increase levels of drugs metabolized by CYP3A4.
In vitro research shows that chokeberry inhibits CYP3A4. In humans, there is one case report of a drug interaction with trabectedin, a CYP3A4 substrate, which is hypothesized to have been caused by chokeberry inhibition of CYP3A4.
Trabectedin (Yondelis)
Theoretically, chokeberry might increase the effects and adverse effects of trabectedin.
In one case report, a patient drinking chokeberry juice developed rhabdomyolysis induced by trabectedin, a cytochrome P450 3A4 (CYP3A4) substrate. It is possible that inhibition of CYP3A4 by chokeberry juice might have inhibited the metabolism of trabectedin and increased trabectedin levels in this patient.
Cranberry Fruit Extract
Atorvastatin (Lipitor)
Theoretically, cranberry might increase levels and adverse effects of atorvastatin.
In one case report, a patient taking atorvastatin experienced upper back pain, rhabdomyolysis, and abnormal liver function after drinking cranberry juice 16 ounces daily for 2 weeks. Theoretically, this may have been caused by inhibition of cytochrome P450 3A4 (CYP3A4) enzymes by cranberry juice, as atorvastatin is a CYP3A4 substrate. Creatinine kinase and liver enzymes normalized within 2 weeks of stopping cranberry juice. Patients taking atorvastatin should avoid large quantities of cranberry juice.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
A case of upper back pain, rhabdomyolysis, and abnormal liver function has been reported for a patient taking atorvastatin, a CYP3A4 substrate, in combination with cranberry juice 16 ounces daily for 2 weeks. Creatinine kinase and liver enzymes normalized within 2 weeks of stopping cranberry juice. Also, animal research suggests that cranberry juice, administered intraduodenally 30 minutes prior to nifedipine, a CYP3A4 substrate, inhibits nifedipine metabolism and increases the area under the concentration-time curve by 1.6-fold compared to control.
Nifedipine (Procardia)
Theoretically, cranberry might increase the levels and adverse effects of nifedipine.
Animal research suggests that cranberry juice, administered intraduodenally 30 minutes prior to nifedipine treatment, inhibits nifedipine metabolism and increases the area under the concentration-time curve by 1.6-fold compared to control. This interaction has not been reported in humans.
Warfarin (Coumadin)
Theoretically, cranberry might increase the levels and adverse effects of warfarin. However, research is conflicting.
There is contradictory evidence about the effect of cranberry juice on warfarin. Case reports have linked cranberry juice consumption to increases in the international normalized ratio (INR) in patients taking warfarin, resulting in severe spontaneous bleeding and excessive postoperative bleeding. Daily consumption of cranberry sauce for one week has also been linked to an increase in INR in one case report. In a small study in healthy young males, taking a high dose of 3 grams of cranberry juice concentrate capsules, equivalent to 57 grams of fruit daily, for 2 weeks produced a 30% increase in the area under the INR-time curve after a single 25-mg dose of warfarin. However, 3 very small clinical studies in patients stabilized on warfarin reported that cranberry juice 250 mL once or twice daily for 7 days (27% cranberry juice or pure cranberry juice) or 240 mL once daily for 14 days does not significantly increase INR or affect plasma warfarin levels. The reasons for these discrepant findings are unclear. It is possible that the form and dose of cranberry may play a role, as cranberry extracts and juices contain different constituents. Additionally, an in vitro study evaluating 5 different cranberry juices found varying effects, with only a cranberry concentrate, and not diluted cranberry juices, inhibiting CYP2C9. However, this concentrate did not inhibit CYP2C9 activity in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates. However, research is conflicting.
There is contradictory evidence about the effect of cranberry on CYP2C9 enzymes. In vitro evidence suggests that flavonoids in cranberry inhibit CYP2C9 enzymes. However, clinical research shows that cranberry juice does not significantly affect the levels, metabolism, or elimination of the CYP2C9 substrates flurbiprofen or diclofenac. Also, in patients stabilized on warfarin, drinking cranberry juice 250 mL daily for 7 days does not significantly increase the anticoagulant activity of warfarin, a CYP2C9 substrate. Additional pharmacokinetic research shows that cranberry juice does not increase peak plasma concentrations or area under the concentration-time curve of warfarin.
Diclofenac (Voltaren, Others)
Theoretically, cranberry might modestly increase the levels and adverse effects of diclofenac.
In vitro evidence suggests that cranberry juice inhibits diclofenac metabolism by human liver microsomes. However, drinking cranberry juice does not seem to affect diclofenac metabolism in humans.
Strawberry powder
Anticoagulant/Antiplatelet Drugs
In vitro and animal research suggests that strawberry extract can inhibit platelet aggregation due to its phenolic content. Theoretically, strawberry might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Some anticoagulant or antiplatelet drugs include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.
P-Glycoprotein Substrates
In vitro research suggests that strawberry extract can inhibit p-glycoprotein efflux. Theoretically, strawberry might inhibit p-glycoprotein mediated drug efflux and potentially increase levels of drugs that are substrates of p-glycoprotein. Until more is known, strawberry should be used cautiously in people taking p-glycoprotein substrates.
Drugs that might be affected include some chemotherapeutic agents (etoposide, paclitaxel, vinblastine, vincristine, vindesine), antifungals (ketoconazole, itraconazole), protease inhibitors (amprenavir, indinavir, nelfinavir, saquinavir), H2 antagonists (cimetidine, ranitidine), some calcium channel blockers (diltiazem, verapamil), corticosteroids, erythromycin, cisapride (Propulsid), fexofenadine (Allegra), cyclosporine, loperamide (Imodium), quinidine, and others.
Apple Fruit Extract
Organic Anion-Transporting Polypeptide Substrates (Oatp)
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Research shows that consuming apple juice inhibits OATP, which reduces bioavailability of oral drugs that are substrates of OATP. Fexofenadine, atenolol, and aliskiren are substrates of OATP. Clinical research shows that coadministration of apple juice decreases bioavailability of fexofenadine by up to 78%, aliskiren by 63%, and atenolol by up to 82%. These effects appear to increase with larger quantities of apple juice. It is thought that apple juice might affect OATP for only a short time. Therefore, separating drug administration and consumption of apple juice by at least 4 hours might avoid this interaction.
Aliskiren (Tekturna, Rasilez)
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of aliskiren.
Pharmacokinetic research shows that coadministration of apple juice 200 mL along with aliskiren 150 mg decreases the bioavailability of aliskiren by 63%. Apple juice seems to inhibit organic anion transporting polypeptide (OATP), which is involved in drug uptake in the gut, liver, and kidney. It is thought that apple juice might affect OATP for only a short time. Therefore, separating drug administration and consumption of apple juice by at least 4 hours might avoid this interaction.
Antidiabetes Drugs
Theoretically, consuming apple juice with antidiabetes drugs might interfere with blood glucose control.
Clinical research suggests that consuming apples or drinking apple juice can raise blood glucose levels, with the effects of drinking apple juice being more significant than consuming apples.
Antihypertensive Drugs
Consuming apple juice with antihypertensive drugs might interfere with blood pressure control.
Some clinical evidence suggests that consuming apple and cherry juice can increase blood pressure in elderly patients.
Atenolol (Tenormin)
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of atenolol.
Pharmacokinetic research shows that coadministration of apple juice 600-1200 mL decreases levels of atenolol by 58% to 82% in a dose-dependent manner. Apple juice seems to inhibit organic anion transporting polypeptide (OATP), which is involved in drug uptake in the gut, liver, and kidney. It is thought that apple juice might affect OATP for only a short time. Therefore, separating drug administration and consumption of apple juice by at least 4 hours might avoid this interaction.
Fexofenadine (Allegra)
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of fexofenadine.
Pharmacokinetic research shows that coadministration of apple juice 400-1200 mL along with fexofenadine 60-120 mg decreases bioavailability of fexofenadine by up to 78%. Coadministration with smaller quantities of apple juice (150 mL or less) does not appear to affect the bioavailability of fexofenadine. Apple juice seems to inhibit organic anion transporting polypeptide (OATP), which is involved in drug uptake in the gut, liver, and kidney. It is thought that apple juice might affect OATP for only a short time. Therefore, separating drug administration and consumption of apple juice by at least 4 hours might avoid this interaction.
Lithium
There is some concern that concomitant consumption of apple juice might decrease oral absorption and blood levels of lithium.
In one case report, a patient had an undetectable serum lithium level when lithium citrate was administered with apple juice. When lithium was administered with an alternative beverage, the lithium level became detectable and the patient demonstrated clinical improvement.
Bilberry extract blend
Anticoagulant/Antiplatelet Drugs
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro, animal, and clinical research suggest that anthocyanidin extracts from bilberry can inhibit platelet aggregation.
Antidiabetes Drugs
Theoretically, bilberry leaf or fruit extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research suggests that bilberry leaf extract might have blood glucose-lowering activity. Also, one small clinical trial in patients with type 2 diabetes shows that taking bilberry fruit extract 470 mg as a single dose prior to an oral glucose tolerance test lowers plasma glucose levels when compared with placebo.
Cytochrome P450 2E1 (Cyp2E1) Substrates
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Animal research shows that exposure to small concentrations of bilberry extract in drinking water for around one month increased CYP2E1 activity by 31%. However, exposure over a 2-month period did not increase CYP2E1 activity. This effect has not been reported in humans.
Erlotinib (Tarceva)
Theoretically, bilberry fruit extract might reduce the efficacy of erlotinib.
In vitro research suggests that bilberry fruit extract and its constituents, delphinidin and delphinidin-3-O-glucoside, inhibit the activity of erlotinib. This interaction has not been reported in humans.
Vitamin C
Alkylating Agents
Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.
The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin C have on chemotherapy.
Aluminum
Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Research in animals and humans shows that vitamin C increases aluminum absorption, theoretically by chelating aluminum and keeping it in solution where it is available for absorption. In people with normal renal function, urinary excretion of aluminum will likely increase, making aluminum retention and toxicity unlikely. Patients with renal failure who take aluminum-containing compounds such as phosphate binders should avoid vitamin C supplements in doses above the recommended dietary allowances.
Antitumor Antibiotics
Theoretically, the antioxidant effects of vitamin C might reduce the effectiveness of antitumor antibiotics.
The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs which generate free radicals, such as doxorubicin. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effects, if any, antioxidants such as vitamin C have on chemotherapy.
Estrogens
Vitamin C might increase blood levels of estrogens.
Increases in plasma estrogen levels of up to 55% occur under some circumstances when vitamin C is taken concurrently with oral contraceptives or hormone replacement therapy, including topical products. It is suggested that vitamin C prevents oxidation of estrogen in the tissues, regenerates oxidized estrogen, and reduces sulfate conjugation of estrogen in the gut wall. When tissue levels of vitamin C are high, these processes are already maximized and supplemental vitamin C does not have any effect on estrogen levels. Increases in plasma estrogen levels may occur when patients who are deficient in vitamin C take supplements. Monitor these patients for estrogen-related side effects.
Fluphenazine (Prolixin)
Theoretically, vitamin C might decrease levels of fluphenazine.
In one patient there was a clinically significant decrease in fluphenazine levels when vitamin C (500 mg twice daily) was started. The mechanism is not known, and there is no further data to confirm this interaction.
Indinavir (Crixivan)
Vitamin C can modestly reduce indinavir levels.
One pharmacokinetic study shows that taking vitamin C 1 gram orally once daily along with indinavir 800 mg orally three times daily reduces the area under the concentration-time curve of indinavir by 14%. The mechanism of this interaction is unknown, but it is unlikely to be clinically significant in most patients. The effect of higher doses of vitamin C on indinavir levels is unknown.
Levothyroxine (Synthroid, Others)
Vitamin C can increase levothyroxine absorption.
Two clinical studies in adults with poorly controlled hypothyroidism show that swallowing levothyroxine with a glass of water containing vitamin C 500-1000 mg in solution reduces thyroid stimulating hormone (TSH) levels and increases thyroxine (T4) levels when compared with taking levothyroxine alone. This suggests that vitamin C increases the oral absorption of levothyroxine, possibly due to a reduction in pH.
Warfarin (Coumadin)
High-dose vitamin C might reduce the levels and effectiveness of warfarin.
Vitamin C in high doses may cause diarrhea and possibly reduce warfarin absorption. There are reports of two people who took up to 16 grams daily of vitamin C and had a reduction in prothrombin time. Lower doses of 5-10 grams daily can also reduce warfarin absorption. In many cases, this does not seem to be clinically significant. However, a case of warfarin resistance has been reported for a patient who took vitamin C 500 mg twice daily. Cessation of vitamin C supplementation resulted in a rapid increase in international normalized ratio (INR). Tell patients taking warfarin to avoid taking vitamin C in excessively high doses (greater than 10 grams daily). Lower doses may be safe, but the anticoagulation activity of warfarin should be monitored. Patients who are stabilized on warfarin while taking vitamin C should avoid adjusting vitamin C dosage to prevent the possibility of warfarin resistance.
Acetaminophen (Tylenol, Others)
High-dose vitamin C might slightly prolong the clearance of acetaminophen.
A small pharmacokinetic study in healthy volunteers shows that taking high-dose vitamin C (3 grams) 1.5 hours after taking acetaminophen 1 gram slightly increases the apparent half-life of acetaminophen from around 2.3 hours to 3.1 hours. Ascorbic acid competitively inhibits sulfate conjugation of acetaminophen. However, to compensate, elimination of acetaminophen glucuronide and unconjugated acetaminophen increases. This effect is not likely to be clinically significant.
Aspirin
Acidification of the urine by vitamin C might increase aspirin levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction is not clinically significant.
Choline Magnesium Trisalicylate (Trilisate)
Acidification of the urine by vitamin C might increase choline magnesium trisalicylate levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction probably is not clinically significant.
Niacin
Vitamin C might decrease the beneficial effects of niacin on high-density lipoprotein (HDL) cholesterol levels.
A combination of niacin and simvastatin (Zocor) effectively raises HDL cholesterol levels in patients with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50% in patients with coronary disease. It is not known whether this adverse effect is due to a single antioxidant such as vitamin C, or to the combination. It also is not known whether it will occur in other patient populations.
Salsalate (Disalcid)
Acidification of the urine by vitamin C might increase salsalate levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams/day vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction probably is not clinically significant.
Black Elder extract
Immunosuppressants
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Elderberry has immunostimulant activity, increasing the production of cytokines, including interleukin and tumor necrosis factor.
Pazopanib (Votrient)
Theoretically, elderberry might interact with pazopanib, potentially increasing the risk of adverse effects.
Blueberry extract/powder blend
Antidiabetes Drugs
Theoretically, blueberries or blueberry leaf extracts might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal and in vitro research suggests that blueberry and/or blueberry leaf extracts can lower blood glucose levels.
Buspirone (Buspar)
Theoretically, blueberry juice might increase blood levels of buspirone.
In vitro research shows that blueberry juice can inhibit the metabolism of buspirone, possibly by inhibiting cytochrome P450 3A (CYP3A) enzymes. However, pharmacokinetic research in humans shows that drinking 300 mL of blueberry juice 30 minutes before taking buspirone hydrochloride 10 mg does not significantly affect the concentration or clearance of buspirone.
Flurbiprofen (Ansaid, Others)
Theoretically, blueberry juice might increase blood levels of flurbiprofen.
In vitro research shows that blueberry juice can inhibit the metabolism of flurbiprofen, possibly by inhibiting cytochrome P450 2C9 (CYP2C9) enzymes. However, pharmacokinetic research in humans shows that drinking 300 mL of blueberry juice 30 minutes before taking flurbiprofen 100 mg does not significantly affect the concentration or clearance of flurbiprofen.
Acai berry extract blend
Antidiabetes Drugs
Theoretically, taking acai with antidiabetes drugs might interfere with glycemic control.
Preliminary clinical research in healthy adults has shown that taking acai may increase or decrease levels of fasting blood glucose.
Brand information
Manufacturer and brand details for Fruit Full Anti-Oxidant Extracts, from the product label.
ProCaps Laboratories
See all ProCaps Laboratories products- Name
- ProCaps Laboratories
- City
- Henderson
- State
- NV
- ZipCode
- 89011
- Phone Number
- 800.800.1200
- Web Address
- www.ProCapsLabs.com
Fruit Full Anti-Oxidant Extracts by ProCaps Laboratories: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Fruit Full Anti-Oxidant Extracts’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Vitamin C
Interacts with 207 drugsVitamin C (ascorbic acid) is an essential nutrient your body needs but cannot make, so you must get it from food or supplements. It's important for immune function, collagen, and acts as an...
Read the full Vitamin C monograph → Herb & supplement monographResveratrol
Interacts with 822 drugsResveratrol is a plant compound found in red grapes, berries, and peanuts that is popular for heart health, anti-aging, and antioxidant support. While lab and animal studies are promising, s...
Read the full Resveratrol monograph → Herb & supplement monographCranberry
Interacts with 712 drugsCranberry is best known for helping to prevent repeated urinary tract infections (UTIs) in some people, and the evidence here is moderate but mixed. It is not a reliable treatment for an act...
Read the full Cranberry monograph → Herb & supplement monographGrape
Interacts with 910 drugsGrapes and grape products like grape seed extract contain antioxidant compounds such as resveratrol and proanthocyanidins that may support heart and blood vessel health. While the food is he...
Read the full Grape monograph → Herb & supplement monographElderberry
Interacts with 121 drugsElderberry is a popular herbal supplement, mainly taken to help with colds and flu. Some small studies suggest it may modestly shorten cold or flu symptoms, but the evidence is limited and n...
Read the full Elderberry monograph → Herb & supplement monographPomegranate
Interacts with 922 drugsPomegranate is a nutrient-rich fruit that is high in antioxidants and is widely enjoyed as food and juice. Early research suggests it may support heart health and blood pressure, but the evi...
Read the full Pomegranate monograph → Herb & supplement monographChokeberry
Interacts with 811 drugsChokeberry (aronia) is a dark berry rich in antioxidants called polyphenols, and it's widely eaten as juice, jam, and supplements. Early research hints it may support heart health, blood pre...
Read the full Chokeberry monograph → Herb & supplement monographStrawberry
Interacts with 316 drugsStrawberry is a popular, nutrient-rich fruit that supplies vitamin C, fiber, and antioxidant plant compounds. Eating strawberries as part of a balanced diet is healthy for most people, but c...
Read the full Strawberry monograph → Herb & supplement monographBlackberry
Blackberry is a common edible berry that is safe and nutritious as a food, rich in vitamin C, fiber, and antioxidant plant compounds. The leaves and root have a long history of traditional u...
Read the full Blackberry monograph → Herb & supplement monographApple
Interacts with 300 drugsApples are a nutritious whole food that provides fiber, vitamins, and antioxidant plant compounds, and eating them regularly fits well into a healthy diet. While research suggests apples may...
Read the full Apple monograph → Herb & supplement monographAcai
Interacts with 86 drugsAcai is a nutritious Amazonian berry rich in antioxidants and healthy fats, and it is fine to enjoy as a food. However, strong human evidence is lacking for the bold health claims often atta...
Read the full Acai monograph → Herb & supplement monographBilberry
Interacts with 275 drugsBilberry is a blueberry-like fruit rich in antioxidant plant compounds called anthocyanins, and it has a long history of traditional use for eye health, circulation, and mild diarrhea. While...
Read the full Bilberry monograph → Herb & supplement monographBlueberry
Interacts with 88 drugsBlueberries are a nutritious fruit rich in antioxidants called anthocyanins, and eating them as part of a balanced diet is healthy and safe for most people. Concentrated supplements are mark...
Read the full Blueberry monograph →Sources & How We Checked
Fruit Full Anti-Oxidant Extracts's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 241 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Vitamin C 51 references
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- Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
- Dwyer JH, Merz NB, Shirocre AM, et al. Progression of early atherosclerosis and intake of vitamin C and vitamin E from supplements and food. The Los Angeles Atherosclerosis Study. 41st Annual Conference on Cardiovascular Disease Epidemiology and Prevent
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- Domingo JL, Gomez M, Llobet JM, Corbella J. Influence of some dietary constituents on aluminum absorption and retention in rats. Kidney Int 1991;39:598-601. PubMed
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- Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
- Slain D, Amsden JR, Khakoo RA, et al. Effect of high-dose vitamin C on the steady-state pharmacokinetics of the protease inhibitor indinavir in healthy volunteers. Pharmacotherapy 2005;25:165-70. PubMed
- Cheung MC, Zhao XQ, Chait A, et al. Antioxidant supplements block the response of HDL to simvastatin-niacin therapy in patients with coronary artery disease and low HDL. Arterioscler Thromb Vasc Biol 2001;21:1320-6. PubMed
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- Rahimi, R., Nikfar, S., Rezaie, A., and Abdollahi, M. A meta-analysis on the efficacy and safety of combined vitamin C and E supplementation in preeclamptic women. Hypertens.Pregnancy. 2009;28(4):417-434. PubMed
- Einerson, B., Nathorn, C., Kitiyakara, C., Sirada, M., and Thamlikitkul, V. The efficacy of ascorbic acid in suboptimal responsive anemic hemodialysis patients receiving erythropoietin: a meta-analysis. J Med.Assoc.Thai. 2011;94 Suppl 1:S134-S146.
- Li, G., Li, L., Yu, C., and Chen, L. Effect of vitamins C and E supplementation on Helicobacter pylori eradication: a meta-analysis. Br.J Nutr 2011;106(11):1632-1637.
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- Yaich S, Chaabouni Y, Charfeddine K, et al. Secondary oxalosis due to excess vitamin C intake: a cause of graft loss in a renal transplant recipient. Saudi J Kidney Dis Transpl. 2014;25(1):113-6. PubMed
- Jalloh MA, Gregory PJ, Hein D, et al. Dietary supplement interactions with antiretrovirals: a systematic review. Int J STD AIDS. 2017 Jan;28(1):4-15. PubMed
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- Seo MS, Kim JK, Shim JY. High-dose vitamin C promotes regression of multiple pulmonary metastases originating from hepatocellular carcinoma. Yonsei Med J. 2015;56(5):1449-52. PubMed
- Skelin M, Lucijanic T, Amidzic Klaric D, et al. Factors Affecting Gastrointestinal Absorption of Levothyroxine: A Review. Clin Ther. 2017 Feb;39(2):378-403. PubMed
- Jiang K, Tang K, Liu H, Xu H, Ye Z, Chen Z. Ascorbic acid supplements and kidney stones incidence among men and women: a systematic review and meta-analysis. Urol J. 2019;16(2):115-120.
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Apple 16 references
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Bilberry 14 references
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Blueberry 7 references
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