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Dietary supplement

Clovanol Ingredients & Drug Interactions

by North American Herb & Spice

Clovanol label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Clovanol against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Clovanol is a dietary supplement by North American Herb & Spice with 1 active ingredient. Its ingredients are commonly taken for toothache and oral pain, digestive upset, antimicrobial and antifungal.Based on those ingredients, 977 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Clove Bud Oil Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Clovanol by North American Herb & Spice

Ask about any prescription or over-the-counter medication and we check it for interactions with Clovanol by North American Herb & Spice — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Clovanol by North American Herb & Spice

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.
  • “Proprietary Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

Clovanol is a single-ingredient liquid supplement: clove bud oil extract in a proprietary blend. Clove has been used traditionally for its flavor and possible health effects, and the extract concentrates its active compounds, mainly eugenol.

There are no inactive ingredients listed.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Clove's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: healthy support for teeth, gums and digestion.
  • We looked for evidence on: Dental plaque, Gingivitis, Halitosis, Oral mucositis, Dyspepsia, Flatulence — and 4 related terms.
  • The closest evidence on file: Clove is rated "Insufficient Reliable Evidence To Rate" for Dental plaque (Natural Medicines).
  • Also on file: Clove is rated "Insufficient Reliable Evidence To Rate" for Diarrhea, Dyspepsia, Flatulence, Gingivitis, and more.

The evidence for clove is mixed. For ventilator-associated pneumonia (a serious lung infection in hospitalized patients), clove is possibly effective based on available research.

For cough, pain, and indigestion, the data we hold shows insufficient reliable evidence to rate whether it works. If you're considering this for one of those uses, talk with your doctor about what the science actually supports and whether it's the right choice for you.

The evidence, ingredient by ingredient Clove

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Clove is generally well tolerated when used as a food spice. However, concentrated clove oil and medicinal doses can be irritating or toxic, especially in large amounts or in children — even 5–10 mL of clove oil has caused toxicity in kids.

Topical clove may cause burning, contact dermatitis, itching, or mucous membrane irritation. Inhaled clove and inhalation of clove cigarettes carry risks including high blood pressure, rapid heart rate, and in rare cases, serious lung injury.

Oral doses in excess can rarely cause liver failure. Because the safety data on medicinal doses is limited, avoid medicinal or essential-oil doses unless your provider has cleared it.

Side effects, ingredient by ingredient Clove

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Clove.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 978 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Clovanol, check with your doctor or pharmacist if you take antidiabetes drugs (insulin or oral diabetes medications), since clove may lower blood sugar. Also double-check any medications processed by your liver's CYP2D6, CYP1A2, CYP3A4, or CYP2C9 enzymes — clove may raise their levels.

If you take blood thinners (anticoagulants) or antiplatelet drugs, mention clove as well.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Clovanol may be worth considering if you're interested in clove extract and your medications don't interact with it — but you'll need to check your exact drugs first. If you take diabetes medications, blood thinners, or drugs processed by your liver's CYP enzymes, talk with your doctor or pharmacist before starting.

Keep doses within food-spice range unless your healthcare provider has advised otherwise.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 21, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Clovanol, straight from the product label.

Brand North American Herb & Spice
Barcode (UPC) 635824000761
Net contents 1 Fluid Ounce(s); 30 Milliliter(s)
Market status On market
Date entered into DSLD Jul 21, 2022
DSLD ID 269614
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Clovanol by North American Herb & Spice, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Drop(s)
Maximum serving Sizes:
3 Drop(s)
Servings per container
318
UPC/BARCODE
635824000761
IngredientAmount% DV
Proprietary Blend0 NP--
Clove Bud Oil Extract0 NP--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Take three drops under the tongue as needed. Also, apply directly on teeth and/or gums or on cotton wedged between the gums.

Formula

Clovanol is unique, pure clove oil made from the flowering buds. This steam-extracted oil is a highly concentrated source of natural eugenol.

Oil of clove buds

CRC Kosher 748

Formulation

Clove is used by dentists to support tooth and gum health.

Healthy support for teeth & gums Healthy digestive support

Non-GMO

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

CRC Kosher 748

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Clovanol by North American Herb & Spice label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Clovanol label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Clovanol by North American Herb & Spice

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size3 Drop(s) Dosage formLiquid Servings per container318 Amounts shown are per serving.

Proprietary Blend

0 NP per serving Form: Extra Virgin Olive Oil
Interaction report

Clovanol by North American Herb & Spice Drug Interactions

Want to check YOUR meds against Clovanol?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
977Drugs
917 Moderate 60 Minor

Ingredients driving the most interactions

Clove Bud Oil Extract 977

Individual Drug Interactions

The ingredients in Clovanol interact with 977 drugs. Click any drug to see the details.

1 of the 1 ingredient in Clovanol interact with drugs. Each result below shows which ingredient is responsible. Clove Bud Oil Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Clovanol with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Clove Bud Oil Extract7 drug types · 977 drugs

Antidiabetes Drugs

Theoretically, concomitant use of clove extracts with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical and laboratory research suggest that polyphenol extracts from clove flower buds might lower blood glucose levels. Dosing adjustments for insulin or oral hypoglycemic agents may be necessary when taken with clove. Monitor blood glucose levels closely.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP1A2.
In vitro research shows that eugenol, the principal constituent of clove, can inhibit CYP1A2 in a dose-dependent manner,. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP2C9.
In vitro research shows that eugenol, the principal constituent of clove, inhibits CYP2C9 in a dose-dependent manner. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP2D6.
In vitro research shows that eugenol, the principal constituent of clove, can inhibit CYP2D6 in a dose-dependent manner. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP3A4.
In vitro research shows that eugenol, the principal constituent of clove, can inhibit CYP3A4 in a dose-dependent manner. This effect has not been reported in humans.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, clove oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Laboratory research suggests that eugenol, a constituent of clove, has antiplatelet activity. This interaction has not been reported in humans.

Likelihood Unlikely Evidence D
Ibuprofen (Advil, Others)

Theoretically, topical application of clove oil with ibuprofen might increase the absorption and side effects of topical ibuprofen.
Laboratory research shows that topical application of clove oil increases the absorption of topical ibuprofen. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Clove Bud Oil Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Clovanol, from the product label.

North American Herb & Spice

See all North American Herb & Spice products
Name
North American Herb & Spice
Street Address
13900 W. Polo Trail Drive
City
Lake Forest
State
IL
ZipCode
60045
Phone Number
1-800-243-5242
Web Address
www.oreganol.com
Pharmacist Counseling Corner

Clovanol by North American Herb & Spice: Common Questions

Does Clovanol by North American Herb & Spice interact with any medications?
Yes. Based on its ingredients, Clovanol has a known interaction with 977 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Clovanol contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is clove oil safe to take by mouth?
Clove is well tolerated as a food spice, but concentrated clove oil is a different story — even small amounts (5–10 mL) can be toxic, especially in children. Stick to food-spice doses unless your doctor has cleared a higher dose for you.
Can I use Clovanol while I'm pregnant or breastfeeding?
According to the safety data, clove is likely safe in pregnancy and lactation. That said, this is a concentrated extract, not a food spice, so check with your doctor or midwife before taking it to be sure it's right for your situation.
What is clove bud oil extract actually used for?
Clove extract has possibly effective evidence for ventilator-associated pneumonia in hospitalized patients. For cough, pain, and indigestion, there isn't enough reliable evidence yet to say whether it works. Your doctor can advise whether it's appropriate for your needs.
Does clove affect blood sugar?
Yes — research suggests clove may lower blood glucose levels. If you take diabetes medications, this could increase your risk of low blood sugar. Talk with your doctor about dosing adjustments or monitoring before you add clove.
What are the most common side effects?
When applied to skin, clove may cause burning, itching, or irritation. When inhaled (like in clove cigarettes), it can raise blood pressure and heart rate. Serious side effects are rare but can include liver damage with high oral doses.
Is there anything in this product besides clove?
No — Clovanol contains only clove bud oil extract in a proprietary blend, with no other active or inactive ingredients listed.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Clovanol label
Go deeper

The Full Monographs Behind Clovanol’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Clove

Interacts with 977 drugs

Clove is a common cooking spice that is also used in traditional medicine, especially as a topical numbing agent for tooth pain thanks to its main compound, eugenol. Food amounts are general...

Read the full Clove monograph →
Sources

Sources & How We Checked

Clovanol's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 26 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Clove 26 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  3. Kanerva L, Estlander T, Jolanki R. Occupational allergic contact dermatitis from spices. Contact Dermatitis 1996;35:157-62. PubMed
  4. Chen SJ, Wang MH, Chen IJ. Antiplatelet and calcium inhibitory properties of eugenol and sodium eugenol acetate. Gen Pharmacol 1996;27:629-33. PubMed
  5. Malson JL, Lee EM, Murty R, et al. Clove cigarette smoking: biochemical, physiological, and subjective effects. Pharmacol Biochem Behav 2003;74:739-45. PubMed
  6. Kirsch CM, Yenokida GG, Jensen WA, et al. Non-cardiogenic pulmonary oedema due to the intravenous administration of clove oil. Thorax 1990;45:235-6. PubMed
  7. Pallares, D. E. Link between clove cigarettes and urticaria? Postgrad.Med 10-1-1999;106(4):153. PubMed
  8. Barnard, D. R. Repellency of essential oils to mosquitoes (Diptera: Culicidae). J Med Entomol. 1999;36(5):625-629. PubMed
  9. Sanchez-Perez, J. and Garcia-Diez, A. Occupational allergic contact dermatitis from eugenol, oil of cinnamon and oil of cloves in a physiotherapist. Contact Dermatitis 1999;41(6):346-347. PubMed
  10. Andersen, K. E., Johansen, J. D., Bruze, M., Frosch, P. J., Goossens, A., Lepoittevin, J. P., Rastogi, S., White, I., and Menne, T. The time-dose-response relationship for elicitation of contact dermatitis in isoeugenol allergic individuals. Toxicol.Appl PubMed
  11. Alqareer, A., Alyahya, A., and Andersson, L. The effect of clove and benzocaine versus placebo as topical anesthetics. J Dent 2006;34(10):747-750. PubMed
  12. Lane, B. W., Ellenhorn, M. J., Hulbert, T. V., and McCarron, M. Clove oil ingestion in an infant. Hum.Exp Toxicol. 1991;10(4):291-294. PubMed
  13. Quirce, S., Fernandez-Nieto, M., del, Pozo, V, Sastre, B., and Sastre, J. Occupational asthma and rhinitis caused by eugenol in a hairdresser. Allergy 2008;63(1):137-138. PubMed
  14. Srivastava, K. C. and Malhotra, N. Acetyl eugenol, a component of oil of cloves (Syzygium aromaticum L.) inhibits aggregation and alters arachidonic acid metabolism in human blood platelets. Prostaglandins Leukot.Essent.Fatty Acids 1991;42(1):73-81. PubMed
  15. Dyrbye, B. A., Dubois, L., Vink, R., and Horn, J. A patient with clove oil intoxication. Anaesth.Intensive Care 2012;40(2):365-366.
  16. Guidotti, T. L., Laing, L., and Prakash, U. B. Clove cigarettes. The basis for concern regarding health effects. West J Med 1989;151(2):220-228.
  17. Anonymous. Evaluation of the health hazard of clove cigarettes. Council on Scientific Affairs. JAMA 12-23-1988;260(24):3641-3644. DOI
  18. Romaguera, C., Alomar, A., Camarasa, J. M., Garcia, Bravo B., Garcia, Perez A., Grimalt, F., Guerra, P., Lopez, Gorretcher B., Pascual, A. M., Miranda, A., and . Contact dermatitis in children. Contact Dermatitis 1985;12(5):283-284. PubMed
  19. Hackett, P. H., Rodriguez, G., and Roach, R. C. Clove cigarettes and high-altitude pulmonary edema. JAMA 6-28-1985;253(24):3551-3552. DOI
  20. Isaacs, G. Permanent local anaesthesia and anhidrosis after clove oil spillage. Lancet 4-16-1983;1(8329):882. PubMed
  21. Saeed, S. A. and Gilani, A. H. Antithrombotic activity of clove oil. J Pak Med Assoc 1994;44(5):112-115.
  22. Hartnoll, G., Moore, D., and Douek, D. Near fatal ingestion of oil of cloves. Arch.Dis Child 1993;69(3):392-393. PubMed
  23. Srivastava, K. C. Antiplatelet principles from a food spice clove (Syzygium aromaticum L) [corrected]. Prostaglandins Leukot.Essent.Fatty Acids 1993;48(5):363-372.
  24. Jiang Q, Wu Y, Zhang H, et al. Development of essential oils as skin permeation enhancers: penetration enhancement effect and mechanism of action. Pharmaceutical Biol. 2017;55(1):1592-1600. PubMed
  25. Mohan R, Jose S, Mulakkal J, Karpinsky-Semper D, Swick AG, Krishnakumar IM. Water-soluble polyphenol-rich clove extract lowers pre- and post-prandial blood glucose levels in healthy and prediabetic volunteers: an open label pilot study. BMC Complement Alt PubMed
  26. Alharbi NFM, Ahad A, Bin Jardan YA, Al-Jenoobi FI. Effect of eugenol on cytochrome P450 1A2, 2C9, 2D6, and 3A4 activity in human liver microsomes. Saudi Pharm J 2024;32(7):102118. PubMed

See these in context on the Clove monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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