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Dietary supplement

Coltsfoot Leaf 450 mg Ingredients & Drug Interactions

by TerraVita Premium Collection

Coltsfoot Leaf 450 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Coltsfoot Leaf 450 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Coltsfoot Leaf 450 mg is a dietary supplement by TerraVita Premium Collection with 1 active ingredient. Its ingredients are commonly taken for cough, sore throat, bronchitis and congestion.Based on those ingredients, 374 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Coltsfoot. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Coltsfoot Leaf 450 mg by TerraVita Premium Collection

Ask about any prescription or over-the-counter medication and we check it for interactions with Coltsfoot Leaf 450 mg by TerraVita Premium Collection — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Coltsfoot Leaf 450 mg by TerraVita Premium Collection

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains a single active ingredient: coltsfoot leaf at 450 mg per capsule. The capsule itself is made from gelatin and water as inactive ingredients.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Coltsfoot product and its label doesn't state a use — see Coltsfoot's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

We don't hold effectiveness ratings for coltsfoot in our data, so the evidence for its intended use isn't established here.

The evidence, ingredient by ingredient Coltsfoot

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Coltsfoot carries a serious safety concern: it contains pyrrolizidine alkaloids (PA), compounds that can damage your liver and lungs. Chronic exposure to these alkaloids has been linked to veno-occlusive disease, a condition affecting blood vessels in the liver, which can cause pain, vomiting, diarrhea, fluid buildup in the belly, and liver enlargement within weeks.

If you do consider coltsfoot, use only certified PA-free products, though even then the safety data is limited. Avoid coltsfoot entirely if you're pregnant — the potential liver toxicity and harm to the baby make it unsafe.

Also avoid it while breastfeeding, because the toxic alkaloids can pass into breast milk and reach your baby.

Side effects, ingredient by ingredient Coltsfoot

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Coltsfoot.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 375 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before using this product if you take blood thinners or antiplatelet drugs (including aspirin, warfarin, clopidogrel, enoxaparin, heparin, and others), blood pressure medications, or CYP3A4-inducing drugs (such as carbamazepine, phenobarbital, phenytoin, rifampin, or rifabutin). These are Moderate-severity interactions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Coltsfoot isn't recommended as a routine supplement due to its liver and lung toxicity risk from pyrrolizidine alkaloids. If you take blood thinners, blood pressure medications, or CYP3A4-inducing drugs, this product is especially not for you.

If you're pregnant or breastfeeding, skip it. Talk to your pharmacist or doctor before considering it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 21, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Coltsfoot Leaf 450 mg, straight from the product label.

Brand TerraVita Premium Collection
Barcode (UPC) 064435117467
Net contents 100 Capsule(s)
Market status On market
Date entered into DSLD Feb 21, 2023
DSLD ID 286571
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Coltsfoot Leaf 450 mg by TerraVita Premium Collection, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
100
UPC/BARCODE
064435117467
IngredientAmount% DV
Coltsfoot450 mg--

Other ingredients: Gelatin, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

A Dietary Supplement

Brand IP Statement(s)

Copyright 2004 TerraVita - Distributed by ZooScape LLC, All Rights Reserved.

Suggested/Recommended/Usage/Directions

Directions Take 1 capsule, 3 times daily, with meals.

General Statements

TerraVita is an exclusive line of premium natural products that use the finest, purest and most potent ingredients in the world. TerraVita's hallmarks are the highest possible standards of purity, potency, stability and freshness. All products are prepared with the greatest quality control, from raw materials through the entire manufacturing process, right up to the moment your product is sealed for freshness and shipped to you.

Please recycle!

FDA Disclaimer Statement

Statements not evaluated by FDA. Product not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Coltsfoot Leaf 450 mg by TerraVita Premium Collection label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Coltsfoot Leaf 450 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Coltsfoot Leaf 450 mg by TerraVita Premium Collection

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.

Coltsfoot

Interacts with
374 drugs
450 mg per serving

Coltsfoot is a traditional herb long used to soothe coughs and clear mucus, but solid human evidence for these uses is lacking. More importantly, the...

Coltsfoot monograph & interactions

Other (inactive) ingredients: Gelatin, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Coltsfoot Leaf 450 mg by TerraVita Premium Collection Drug Interactions

Want to check YOUR meds against Coltsfoot Leaf 450 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
374Drugs
374 Moderate

Ingredients driving the most interactions

Coltsfoot 374

Individual Drug Interactions

The ingredients in Coltsfoot Leaf 450 mg interact with 374 drugs. Click any drug to see the details.

1 of the 1 ingredient in Coltsfoot Leaf 450 mg interact with drugs. Each result below shows which ingredient is responsible. Coltsfoot

Each ingredient & the kinds of drugs it affects

For each ingredient in Coltsfoot Leaf 450 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Coltsfoot3 drug types · 374 drugs

Anticoagulant/Antiplatelet Drugs

Concomitant use might increase the risk of bleeding due to decreased platelet aggregation. Coltsfoot has been reported to inhibit platelet aggregation; avoid concomitant use. Some of these drugs include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, excessive doses of coltsfoot may interfere with antihypertensive or cardiovascular therapy.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Inducers

Hepatotoxic pyrrolizidine alkaloids (PA) are substrates of cytochrome P450 3A4 (CYP3A4). Theoretically, drugs that induce CYP3A4 might increase the conversion of PAs to toxic metabolites. Some drugs that induce CYP3A4 include carbamazepine (Tegretol), phenobarbital, phenytoin (Dilantin), rifampin, rifabutin (Mycobutin), and others.

Likelihood Possible Evidence D
Coltsfoot full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Coltsfoot Leaf 450 mg, from the product label.

TerraVita Premium Collection

See all TerraVita Premium Collection products
Name
TerraVita Fine Whole Herbs
City
Brampton
State
Ontario
Pharmacist Counseling Corner

Coltsfoot Leaf 450 mg by TerraVita Premium Collection: Common Questions

Does Coltsfoot Leaf 450 mg by TerraVita Premium Collection interact with any medications?
Yes. Based on its ingredients, Coltsfoot Leaf 450 mg has a known interaction with 374 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Coltsfoot Leaf 450 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is coltsfoot safe during pregnancy?
No — the safety data advises against it. Coltsfoot contains liver-toxic alkaloids that may harm the baby. Avoid it if you're pregnant.
Can I take this while breastfeeding?
No. The toxic alkaloids in coltsfoot can pass into breast milk and reach your baby, so it's not safe while breastfeeding.
What are the main side effects of coltsfoot?
The major concern is liver and lung damage from pyrrolizidine alkaloids. You might develop veno-occlusive disease, which causes belly pain, vomiting, diarrhea, fluid buildup in the abdomen, and liver enlargement.
Does this product have any fillers or other inactive ingredients?
Yes — each capsule contains gelatin and water as inactive ingredients. The active ingredient is 450 mg of coltsfoot leaf.
What does coltsfoot do in the body?
We don't have effectiveness data for coltsfoot in our records, so we can't tell you what it's intended to do or whether it works.
Should I use certified PA-free coltsfoot products instead?
Certified PA-free (pyrrolizidine alkaloid-free) products are safer if you do choose to use coltsfoot, but the overall safety profile is still limited. Your best bet is to talk with your pharmacist about whether coltsfoot is right for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Coltsfoot Leaf 450 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Coltsfoot Leaf 450 mg label
Go deeper

The Full Monographs Behind Coltsfoot Leaf 450 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Coltsfoot

Interacts with 374 drugs

Coltsfoot is a traditional herb long used to soothe coughs and clear mucus, but solid human evidence for these uses is lacking. More importantly, the raw plant can contain liver-toxic pyrrol...

Read the full Coltsfoot monograph →
Sources

Sources & How We Checked

Coltsfoot Leaf 450 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Coltsfoot 8 references
  1. Roulet M, Laurini R, Rivier L, Calame A. Hepatic veno-occlusive disease in newborn infant of a woman drinking herbal tea. J Pediatr 1988;112:433-6. PubMed
  2. WHO working group. Pyrrolizidine alkaloids. Environmental Health Criteria, 80. WHO: Geneva, 1988.
  3. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
  4. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
  5. Wilson BE, Hobbs WN. Case report: pseudoephedrine-associated thyroid storm: thyroid hormone-catecholamine interactions. Am J Med Sci 1993;306:317-9. PubMed
  6. Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. PubMed
  7. Hwang SB, Chang MN, Garcia ML, et al. L-652,469--a dual receptor antagonist of platelet activating factor and dihydropyridines from Tussilago farfara L. Eur J Pharmacol 1987;141:269-81. PubMed
  8. Freshour JE, Odle B, Rikhye S, Stewart DW. Coltsfoot as a potential cause of deep vein thrombosis and pulmonary embolism in a patient also consuming kava and blue vervain. J Diet Suppl 2012;9:149-54. PubMed

See these in context on the Coltsfoot monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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