Drug & supplement interaction

Coltsfoot + Amlodipine

Amlodipine brand name: Norliqva.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Coltsfoot has a moderate interaction with Amlodipine. Theoretically, excessive doses of coltsfoot may interfere with antihypertensive or cardiovascular therapy.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Coltsfoot and Amlodipine

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIHYPERTENSIVE DRUGS

Why this applies to Amlodipine

Amlodipine falls under ANTIHYPERTENSIVE DRUGS — the group Coltsfoot interacts with.

Theoretically, excessive doses of coltsfoot may interfere with antihypertensive or cardiovascular therapy.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist with amlodipine and coltsfoot. Amlodipine works by relaxing your blood vessels to bring your blood pressure down and ease chest pain. The concern on file is mostly theoretical: in large amounts, some of the plant compounds in coltsfoot might nudge your blood pressure or heart in a way that works against your blood pressure medicine. In plain terms, your amlodipine could end up not controlling things as well as it should.

I'll be honest, this is based on weak, anecdotal evidence, not solid human studies, so I wouldn't lose sleep over a small or occasional amount. My bigger worry is that raw coltsfoot can contain liver-damaging compounds, so I'd steer clear of it regardless. If you're set on trying it, please run it by your pharmacist or doctor first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Wilson BE, Hobbs WN. Case report: pseudoephedrine-associated thyroid storm: thyroid hormone-catecholamine interactions. Am J Med Sci 1993;306:317-9. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Coltsfoot Also Interacts With Other Medications

Coltsfoot has 373 moderate known drug interactions in our database — the Amlodipine one above is one of them. If you take anything else, check it against the full list below.

Moderate 373 No known interaction 2,457 (incl. Amlodipine)
Taking anything else?

Check Another of Your Medications Against Coltsfoot

Covers the 2,830 medications we’ve checked against Coltsfoot. Pick one to open its full report.

From our Q&A

Questions About Coltsfoot or Amlodipine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Coltsfoot or Amlodipine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Amlodipine

This page covers Coltsfoot only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Amlodipine page lists 232 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Coleus (major) and Grapefruit (major).

By severity: 7 major · 183 moderate · 42 minor.

From our pharmacist’s overview on the Amlodipine page

“Millions of people take amlodipine (Norvasc, Norliqva) for high blood pressure, and plenty add a supplement or two without a second thought. With this drug, that casualness costs.”

Reviewed by 2 · Jul 18, 2026

Open the Amlodipine interaction page

One more smart check

Taking Coltsfoot as Part of a Dietary Supplement Product? Check It for Interactions

We hold 60 real supplement products containing Coltsfoot, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Coltsfoot. Your product may carry other ingredients that interact with Amlodipine too, on top of Coltsfoot — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Coltsfoot and Amlodipine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Coltsfoot
Steady interest

#1,106 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Amlodipine
Top 10

#3 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Coltsfoot

What is Coltsfoot?

Coltsfoot
  • Cough
  • Sore throat
  • Bronchitis and congestion
  • Loosening mucus (expectorant)
  • Asthma symptoms

Coltsfoot is a traditional herb long used to soothe coughs and clear mucus, but solid human evidence for these uses is lacking. More importantly, the raw plant can contain liver-toxic pyrrolizidine alkaloids, so it carries real safety concerns and is best avoided unless you use a product certified to be free of these compounds.

Read the full Coltsfoot monograph & all interactions
Medication

About Amlodipine

What Is Amlodipine Used For?

Brand name: Norliqva

Amlodipine treats high blood pressure (hypertension) in adults and children aged 6–17 years. Lowering blood pressure reduces the risk of strokes and heart attacks. Sdamlo (oral solution) is specifically indicated for hypertension in adults and pediatric patients 6 years of age and older.

Amlodipine also treats coronary artery disease in adults, including chronic stable angina (chest pain with exertion), vasospastic angina (Prinzmetal's or variant angina, caused by coronary artery spasms), and documented coronary artery disease in patients without heart failure or significantly reduced heart pumping function.

See full Amlodipine drug information
Keep checking

Other Drugs & Coltsfoot

Browse every other medication we’ve checked against Coltsfoot — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
373Moderate
0Minor
2,456No known interaction
373 Moderate 2,456 No interaction
Moderate

373 interactions

Showing 60 of 373 moderate interactions — see all 373 on the Coltsfoot page.

No interaction 2,456 drugs checked — show the list

We also checked Coltsfoot against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,456 medications checked with no known interaction — see the full Coltsfoot list.

See the full Coltsfoot interactions page
See every supplement checked against Amlodipine, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Coltsfoot monograph › Uses, safety, and every drug interaction in one place Amlodipine supplement interactions › Every supplement checked against Amlodipine, ranked by severity Amlodipine drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Coltsfoot and Amlodipine Together: Common Questions

Can you take Coltsfoot with Amlodipine?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Coltsfoot and Amlodipine interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Amlodipine and Coltsfoot?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.