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Dietary supplement

Concentrated ChlorophylI 100 mg Ingredients & Drug Interactions

by 21st Century

Concentrated ChlorophylI 100 mg label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Concentrated ChlorophylI 100 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Concentrated ChlorophylI 100 mg is a dietary supplement by 21st Century with 2 active ingredients. Its ingredients are commonly taken for preventing or treating copper deficiency, supporting red blood cell formation, bone and connective tissue health.Based on those ingredients, 366 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Chlorophyll Copper Complex, Copper. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Concentrated ChlorophylI 100 mg by 21st Century

Ask about any prescription or over-the-counter medication and we check it for interactions with Concentrated ChlorophylI 100 mg by 21st Century — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Concentrated ChlorophylI 100 mg by 21st Century

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product has 2 active ingredients: copper (100 mg total from both sources) and chlorophyll copper complex. Copper is a mineral your body needs in small amounts for nerve function, immunity, and bone health.

Chlorophyll copper complex is a plant-derived form of chlorophyll—the pigment that makes plants green—that's been chemically modified to be absorbed better by mouth. The softgel also contains gelatin, glycerin, purified water, and refined soybean oil as inactive ingredients to hold and deliver the capsule.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Body and breath odor control.
  • We looked for evidence on: Body odor, Fecal odor, Urinary odor, Halitosis, Internal deodorant.
  • The closest evidence on file: Chlorophyllin is rated "Possibly Ineffective" for Urinary odor (Natural Medicines).
  • Also on file: Chlorophyllin is rated "Insufficient Reliable Evidence To Rate" for Body odor, Fecal odor.

Copper is likely effective for treating copper deficiency. However, the evidence doesn't support it for Alzheimer disease (possibly ineffective), and there isn't enough reliable evidence to rate it for acne, chemotherapy-related anemia, or brain tumors.

Chlorophyll copper complex shows insufficient evidence for the conditions it's marketed for—urinary odor, acne, cancer prevention, constipation, gas, and low white blood cell counts (leukopenia). In short, if you're deficient in copper, this may help; for other uses, the science doesn't back it up yet.

The evidence, ingredient by ingredient Copper Chlorophyllin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Copper is generally well tolerated in the amounts found in food and standard supplements, but excess copper can be toxic. Rarely, contact dermatitis (a skin rash from direct contact) has been reported.

There's also evidence that people with diabetes have higher copper levels in their blood than those without; it's unclear whether elevated copper worsens diabetes. Chlorophyll copper complex is generally well tolerated short-term, but long-term safety data are limited.

It's been linked in case reports to photosensitization (sun sensitivity) and a rare blistering condition called pseudoporphyria after people drank chlorophyll drinks.

Side effects, ingredient by ingredient Copper Chlorophyllin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Chlorophyllin, Copper.
  • The most serious interaction on file is rated Moderate.
  • For scale: 366 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this, double-check with your pharmacist if you're on penicillamine (a Moderate interaction—it binds to the drug and blocks absorption), photosensitizing medications like certain antibiotics (Moderate—additive sun sensitivity risk), or birth control pills (Minor—may raise copper levels). No interactions are documented for any other drug categories in our data.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you have a copper deficiency and no medication interactions, this product may help. If you take penicillamine, birth control pills, or photosensitizing drugs, check with your pharmacist first—interactions are possible.

People with diabetes should be aware of the copper-blood level connection and discuss it with their doctor. Talk to your pharmacist before starting, especially if you're on any prescription.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 24, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Concentrated ChlorophylI 100 mg, straight from the product label.

Brand 21st Century
Barcode (UPC) 740985271278
Net contents 120 Softgel(s)
Market status On market
Date entered into DSLD Aug 24, 2012
DSLD ID 11144
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Concentrated ChlorophylI 100 mg by 21st Century, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Softgel(s)
Maximum serving Sizes:
2 Softgel(s)
Servings per container
60
UPC/BARCODE
740985271278
IngredientAmount% DV
Copper0.8 mg40%
Chlorophyll Copper Complex100 mg--

Other ingredients: Gelatin, Glycerin, purified Water, refined Soybean Oil

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Take two (2) softgels once to twice daily with any meal for maximum daily results, or as directed by a health care provider. Do not exceed six (6) softgels daily.

Precautions

Keep out of reach of children.

Do not use if product appears to be tampered with or seal is broken.

Storage

Store at room temperature.

Formulation

Gluten Free.

No Added Sugar, Salt, Yeast, Artificial Flavors or Colors.

General Statements

Unconditionally guaranteed for purity, freshness and label potency.

Supports the Reduction of Digestive Tract Odor*

General

1207

FDA Statement of Identity

DIETARY SUPPLEMENT

Seals/Symbols

MADE IN USA

FDA Disclaimer Statement

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand IP Statement(s)

21ST Century(R)...for a healthier future.

21st Century's(R) concentrated chlorophyll copper complex may help reduce odor within digestive tract*

Formula

Extracted from the highest quality alfalfa leaves.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Concentrated ChlorophylI 100 mg by 21st Century label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Concentrated ChlorophylI 100 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Concentrated ChlorophylI 100 mg by 21st Century

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Softgel(s) Dosage formSoftgel Capsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Copper

Interacts with
31 drugs
0.8 mg per serving Form: Copper Chlorophyll

Copper is an essential trace mineral your body needs in small amounts for making red blood cells, supporting nerves and bones, and helping enzymes wor...

Copper monograph & interactions

Chlorophyll Copper Complex

Interacts with
335 drugs
100 mg per serving

Chlorophyllin is a water-soluble, semi-synthetic form of chlorophyll most often used to help control body and fecal odor and to support wound healing....

Chlorophyll Copper Complex monograph & interactions

Other (inactive) ingredients: Gelatin, Glycerin, Purified Water, Refined Soybean Oil. These complete the product’s ingredient list but are not active constituents.

Interaction report

Concentrated ChlorophylI 100 mg by 21st Century Drug Interactions

Want to check YOUR meds against Concentrated ChlorophylI 100 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
366Drugs
336 Moderate 30 Minor

Ingredients driving the most interactions

Chlorophyll Copper Complex 335
Copper 31

Individual Drug Interactions

The ingredients in Concentrated ChlorophylI 100 mg interact with 366 drugs. Click any drug to see the details.

2 of the 2 ingredients in Concentrated ChlorophylI 100 mg interact with drugs. Each result below shows which ingredient is responsible. Chlorophyll Copper Complex Copper

Each ingredient & the kinds of drugs it affects

For each ingredient in Concentrated ChlorophylI 100 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Chlorophyll Copper Complex1 drug type · 335 drugs

Photosensitizing Drugs

Theoretically, concomitant use of chlorophyllin with photosensitizing drugs may have additive effects.
Chlorophyllin is a semi-synthetic derivative of chlorophyll. Chlorophyll has been reported to cause photosensitization. Orally, chlorophyll has also been associated with the development of pseudoporphyria in multiple case reports.

Likelihood Probable Evidence B
Chlorophyll Copper Complex full monograph & interactions

Copper2 drug types · 31 drugs

Penicillamine (Cuprimine, Depen)

Theoretically, taking copper with penicillamine might decrease the absorption of penicillamine; separate dosing by at least 2 hours.
Copper chelates penicillamine, which decreases its absorption and may reduce its clinical effects.

Likelihood Probable Evidence D
Contraceptive Drugs

Theoretically, taking copper with contraceptive drugs might increase the levels and toxic effects of copper.
A meta-analysis of clinical studies suggests that chronic use of oral contraceptives increases serum copper levels by a mean of 57 mcg/dL. In most people, this resulted in levels above the normal reference range for copper.

Likelihood Possible Evidence D
Copper full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Concentrated ChlorophylI 100 mg, from the product label.

21st Century

See all 21st Century products
Name
21st Century HealthCare, Inc.
Street Address
2119 S. Wilson Street
City
Tempe
State
AZ
ZipCode
85282
Web Address
www.21stcenturyvitamins.com
Pharmacist Counseling Corner

Concentrated ChlorophylI 100 mg by 21st Century: Common Questions

Does Concentrated ChlorophylI 100 mg by 21st Century interact with any medications?
Yes. Based on its ingredients, Concentrated ChlorophylI 100 mg has a known interaction with 366 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Concentrated ChlorophylI 100 mg contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe during pregnancy?
Copper is rated likely safe and possibly unsafe in pregnancy—the data are mixed. Chlorophyll copper complex should be avoided in pregnancy because there isn't enough safety data. Talk with your doctor or pharmacist about whether you need a copper supplement and in what dose.
Can I take this while breastfeeding?
Copper in recommended amounts is likely safe while nursing. Chlorophyll copper complex should be avoided because its safety while breastfeeding is unknown. Ask your pharmacist or doctor which component, if either, is right for you.
Does chlorophyll actually work for odor or digestion?
The evidence doesn't support chlorophyll for urinary odor—it's possibly ineffective. For constipation and gas, there isn't enough reliable evidence to say whether it works. If those are your reasons for considering this product, there are better-studied options.
What are the side effects?
Copper rarely causes a skin rash from contact. Chlorophyll has been linked in case reports to sun sensitivity and blistering—especially if you consume it regularly or in high amounts. Most people don't report problems short-term, but long-term safety data are thin.
Will copper help my Alzheimer's disease?
No. The evidence actually suggests copper is possibly ineffective for Alzheimer's. Don't rely on this product for that condition.
Are there fillers in this?
Yes. The softgel capsule contains gelatin, glycerin, purified water, and refined soybean oil—these are the inactive ingredients that make up the capsule and help deliver it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Concentrated ChlorophylI 100 mg label
Go deeper

The Full Monographs Behind Concentrated ChlorophylI 100 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Copper

Interacts with 31 drugs

Copper is an essential trace mineral your body needs in small amounts for making red blood cells, supporting nerves and bones, and helping enzymes work. Most people get enough copper from fo...

Read the full Copper monograph → Herb & supplement monograph

Chlorophyllin

Interacts with 335 drugs

Chlorophyllin is a water-soluble, semi-synthetic form of chlorophyll most often used to help control body and fecal odor and to support wound healing. The best evidence is for its use as a d...

Read the full Chlorophyllin monograph →
Sources

Sources & How We Checked

Concentrated ChlorophylI 100 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 17 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Copper 11 references
  1. Murry JJ, Healy MD. Drug-mineral interactions: a new responsibility for the hospital dietician. J Am Diet Assoc 1991;91:66-73.
  2. Campbell IA, Elmes PC. Ethambutol and the eye: zinc and copper (letter). Lancet 1975;2:711. DOI
  3. Segal S, Kaminski S. Drug-nutrient interactions. American Druggist 1996 Jul;42-8.
  4. Kozak SF, Inderlied CB, Hsu HY, et al. The role of copper on ethambutol's antimicrobial action and implications for ethambutol-induced optic neuropathy. Diag Microbiol Infect Dis 1998;30:83-7. PubMed
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  6. Cantilena LR, Klaassen CD. The effect of chelating agents on the excretion of endogenous metals. Toxicol Appl Pharmacol 1982;63:344-50.
  7. Babic Z, Tariba B, Kovacic J, Pizent A, Varnai VM, Macan J. Relevance of serum copper elevation induced by oral contraceptives: a meta-analysis. Contraception. 2013 Jun;87(6):790-800. PubMed
  8. Qui Q, Zhang F, Zhu W, Wu J, Liang M. Copper in diabetes mellitus: a meta-analysis and systematic review of plasma and serum studies. Biol Trace Elem Res 2017;177(1):53-63.
  9. Walker-Smith PK, Keith DJ, Kennedy CT, Sansom JE. Allergic contact dermatitis caused by copper. Contact Dermatitis 2016;75(3):186-7. PubMed
  10. Gallentine A. Third-degree burn on the neuropathic lower extremity in a patient with diabetes while wearing a copper-containing compression sock: a case report. Wound Manag Prev 2021;67(12):26-29. DOI
  11. Chung KJ, Chin YM, Wong MS, Sanmugam A, Singaravel S, Nah SA. Effectiveness of table salt versus copper sulphate in treating umbilical granuloma: A pilot randomized controlled trial. J Pediatr Surg 2022;57(2):261-265. PubMed

See these in context on the Copper monograph →

Chlorophyllin 6 references
  1. Nahata MC, Slencsak CA, Kamp J. Effect of chlorophyllin on urinary odor in incontinent geriatric patients. Drug Intell Clin Pharm 1983;17:732-4. PubMed
  2. Mathews-Roth MM. Carotenoids in erythropoietic protoporphyria and other photosensitivity diseases. Ann N Y Acad Sci, 1993; 691:127-38. PubMed
  3. Belen'kii, G. B. and Krikun, B. L. [Treatment of herpes simplex and herpes zoster by chlorophyll preparations]. Sov.Med. 1971;34(1):151-152.
  4. Rossi E, Borchard K, Cole JM. Pseudoporphyria following self-medication with chlorophyll. Australas J Dermatol. 2015 Feb;56(1):47-8. PubMed
  5. Zhao CY, Frew JW, Muhaidat J, et al. Chlorophyll-induced pseudoporphyria with ongoing photosensitivity after cessation - a case series of four patients. J Eur Acad Dermatol Venereol 2016;30(7):1239-42. PubMed
  6. Tomankova K, Kejlova K, Binder S, et al. In vitro cytotoxicity and phototoxicity study of cosmetics colorants. Toxicol In Vitro. 2011 Sep;25(6):1242-50. PubMed

See these in context on the Chlorophyllin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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