Major interaction on record — check this product against your medications before combining. Based on 2 of 4 ingredients. Check your meds →
Dietary supplement

Cran-Aloe Ingredients & Drug Interactions

by Country Life

Cran-Aloe label
See full label image
Liquid Category: Botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cran-Aloe against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Cran-Aloe is a dietary supplement by Country Life with 4 active ingredients. Its ingredients are commonly taken for minor burns and skin irritation, wound healing, constipation.Based on those ingredients, 1,003 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are organic Cranberry powder, Aloe Polysaccharides. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Cran-Aloe by Country Life

Ask about any prescription or over-the-counter medication and we check it for interactions with Cran-Aloe by Country Life — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Cran-Aloe by Country Life

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Cran-Aloe contains three active ingredients: two forms of aloe (aloe polysaccharides and organic aloe vera) and organic cranberry powder. Both aloe ingredients come from the same plant monograph and carry the same interaction and safety profile.

The product also contains water, organic agave syrup, organic cranberry juice concentrate, natural flavor, and xanthan gum as inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: cranberry and aloe vera support.
  • We looked for evidence on: Burns, Constipation, Urinary tract infections (UTIs), Wound healing, bladder health, digestive health.
  • The strongest evidence on file: Aloe is rated "Possibly Effective" for Burns (Natural Medicines).
  • Also on file: Aloe is rated "Possibly Effective" for Constipation.
  • Also on file: Cranberry is rated "Possibly Effective" for Urinary tract infections (UTIs).

Aloe is possibly effective for acne, obesity, diabetes, psoriasis, burns, and constipation based on the evidence we hold. Cranberry is possibly effective for urinary tract infections, but we don't have established evidence for age-related cognitive decline, benign prostatic hyperplasia, cancer prevention, fatty liver disease, or chronic fatigue syndrome.

Because this is a combination product, what it may do depends on which condition you're thinking about — and it's worth talking to your pharmacist or doctor about whether the evidence supports it for your specific use.

The evidence, ingredient by ingredient Aloe Cranberry

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Aloe gel applied topically is generally well tolerated, but oral aloe — especially the latex — can cause serious side effects, particularly with long-term use or high doses. Common side effects include belly pain, cramps, and diarrhea.

Rarely, long-term use can lead to low potassium (hypokalemia), muscle weakness, heart rhythm problems, and pigment spots in the intestinal lining. Cranberry is generally well tolerated in normal amounts, but concentrated supplement doses haven't been well studied — common side effects are diarrhea and stomach upset.

During pregnancy, avoid taking aloe by mouth because the latex can stimulate the uterus and act as a strong laxative. During breastfeeding, avoid aloe because safety data are limited and it has laxative effects.

Cranberry is likely safe during pregnancy and lactation, but check with your provider before using concentrated supplements.

Side effects, ingredient by ingredient Aloe Cranberry

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Aloe, Cranberry.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; heart-rhythm medications.
  • For scale: 1,004 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, double-check digoxin (Lanoxin) or any heart medications, blood thinners and antiplatelet drugs (warfarin, aspirin), diabetes medications, diuretics and water pills, cholesterol-lowering drugs (especially atorvastatin), blood pressure medications (nifedipine), and any stimulant laxatives. These carry the most serious risks — Major or Moderate severity.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Consider this product only if you've confirmed your medications don't interact using the checker below. If you take digoxin, blood thinners, diabetes drugs, diuretics, or cholesterol medications, you need to talk with your pharmacist first — the interactions here can be serious.

If you're pregnant or breastfeeding, avoid aloe entirely. This is not a substitute for medical treatment of infections.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cran-Aloe, straight from the product label.

Brand Country Life
Barcode (UPC) 015794091240
Net contents 32 fl. Oz.; 1 QT; 944 mL
Market status On market
Date entered into DSLD Jul 24, 2015
DSLD ID 47381
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Organic, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cran-Aloe by Country Life, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 fl. Oz.
Maximum serving Sizes:
2 fl. Oz.
Servings per container
16
UPC/BARCODE
015794091240
IngredientAmount% DV
Calories15 {Calories}--
Total Carbohydrates4 Gram(s)1%
Sugar3 Gram(s)--
Aloe Polysaccharides30 mg--
organic Aloe Vera59 mL--
organic Cranberry powder1000 NP--

Other ingredients: Water, organic Agave syrup, organic Cranberry juice concentrate, Natural flavor, Xanthan Gum

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General

Product No. 9124 03A13NOPF

Precautions

Do not accept if seal is broken.

Keep out of reach of children.

CAUTION: If you are pregnant or nursing, taking medication or planning a surgery, consult your doctor before using this product.

If any adverse reactions occur, stop taking the product and consult your doctor.

Suggested/Recommended/Usage/Directions

Shake well before use.

Take only as directed.

Directions: Adults take two capfuls (2 fl. oz) (59 mL) daily or as directed by your health care professional.

Storage

Store between 59(0)-86(0) F. Refrigerate after opening.

Formula

Realfood Organics(R) Cran-Aloe includes 1,000 mg of cranberry powder.

More clinical research has been published on this 100% inner fillet Aloe Vera than any other form of Aloe Vera on the market. Every ounce of Realfood Organics(R) Cran-Aloe Vera delivers 15 mg of naturally occurring polysaccharides.

Realfood Organics(R) Liquid Cran-Aloe is a unique formulation using certified organic ACTIValoe(R).

100% Inner Fillet Aloe Vera

100% Inner Fillet Aloe Vera

Brand IP Statement(s)

The juice of this 100% inner fillet Aloe Vera is delicately extracted and its freshness preserved using advanced technology and the unique Omatrix(R) process. The Omatrix(R) process is a patented Low Temperature Short Time (LTST) drying process that retains heat-sensitive nutritional and functional Aloe Vera natural components such as the important mono- and polysaccharides.

Realfood organics(R)

ACTIValoe(R) and Qmatrix(R) are registered trademarks of Aloecorp, Inc.

(C)2013 Country Life

Formulation

Highly purified Omatrix(R) ACTIValoe(R) does not contain the high levels of undesirable components, such as aloin, that are often associated with diarrhea.

Gluten-Free

~ YES CERTIFIED VEGAN BY THE AVA

~ YES CERTIFIED GUTEN-FREE BY GFCO.ORG

NO GMOS ~ NO YEAST, WHEAT OR CORN ~ NO MILK OR SOY ~ NO ARTIFICIAL COLORS ~ NO MILK OR SOY ~ NO ARTIFICIAL COLORS ~ NO ARTIFICIAL FLAVORS ~ NO ARTIFICIAL SWEETENERS

General Statements

~ Emerging science suggests this Aloe Vera will: ~ Increase the absorption of Vitamin B12 when one ounce is used daily. ~ Increase the absorption of Vitamins E and C when only two ounces are used daily.

~ The 100% inner fillet Aloe Vera has been researched for its support of immune, cardiovascular, digestive and antioxidant health when eight ounces are used daily.

~ Supports urinary tract health

YES RECYCLABLE PACKAGING ~ YES MANUFACTURING SUPPORTS WIND POWER

This liquid formulation not only tastes good, but helps support urinary tract health.

As a reminder, discuss the supplements and medications that you take with your health care providers.

Our PLEDGE of INTEGRITY ~ AUTHENTICITY ~ CLEANLINESS ~ FRESHNESS ~ CONSISTENCY ~ ACCURACY

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

USDA ORGANIC

QUALITY ASSURANCE INTERNATIONAL CERTIFIED ORGANIC

ACTIValoe(R)

Qmatrix(R) PROPRIETARY PROCESSING

Certified Organic by Quality Assurance International

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cran-Aloe by Country Life label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cran-Aloe label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cran-Aloe by Country Life

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 fl. Oz. Dosage formLiquid Servings per container16 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

3 Gram(s) per serving

Aloe Polysaccharides

Interacts with
461 drugs
30 mg per serving

Aloe vera gel is widely used on the skin for minor burns and irritation, and some research suggests it may help. Aloe latex (the yellow part) is a str...

Aloe Polysaccharides monograph & interactions

Organic Aloe Vera

Interacts with
461 drugs
59 mL per serving

Aloe vera gel is widely used on the skin for minor burns and irritation, and some research suggests it may help. Aloe latex (the yellow part) is a str...

Organic Aloe Vera monograph & interactions

Organic Cranberry powder

Interacts with
712 drugs
1000 NP per serving

Cranberry is best known for helping to prevent repeated urinary tract infections (UTIs) in some people, and the evidence here is moderate but mixed. I...

Organic Cranberry powder monograph & interactions

Other (inactive) ingredients: Water, Organic Agave syrup, Organic Cranberry juice concentrate, Natural flavor, Xanthan Gum. These complete the product’s ingredient list but are not active constituents.

Interaction report

Cran-Aloe by Country Life Drug Interactions

Want to check YOUR meds against Cran-Aloe?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,003Drugs
1 Major 903 Moderate 99 Minor

Ingredients driving the most interactions

organic Cranberry powder 712
Aloe Polysaccharides 461

Individual Drug Interactions

The ingredients in Cran-Aloe interact with 1,003 drugs. Click any drug to see the details.

2 of the 4 ingredients in Cran-Aloe interact with drugs. Each result below shows which ingredient is responsible. organic Cranberry powder Aloe Polysaccharides

Each ingredient & the kinds of drugs it affects

For each ingredient in Cran-Aloe with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

organic Cranberry powder6 drug types · 712 drugs

Atorvastatin (Lipitor)

Theoretically, cranberry might increase levels and adverse effects of atorvastatin.
In one case report, a patient taking atorvastatin experienced upper back pain, rhabdomyolysis, and abnormal liver function after drinking cranberry juice 16 ounces daily for 2 weeks. Theoretically, this may have been caused by inhibition of cytochrome P450 3A4 (CYP3A4) enzymes by cranberry juice, as atorvastatin is a CYP3A4 substrate. Creatinine kinase and liver enzymes normalized within 2 weeks of stopping cranberry juice. Patients taking atorvastatin should avoid large quantities of cranberry juice.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
A case of upper back pain, rhabdomyolysis, and abnormal liver function has been reported for a patient taking atorvastatin, a CYP3A4 substrate, in combination with cranberry juice 16 ounces daily for 2 weeks. Creatinine kinase and liver enzymes normalized within 2 weeks of stopping cranberry juice. Also, animal research suggests that cranberry juice, administered intraduodenally 30 minutes prior to nifedipine, a CYP3A4 substrate, inhibits nifedipine metabolism and increases the area under the concentration-time curve by 1.6-fold compared to control.

Likelihood Possible Evidence D
Nifedipine (Procardia)

Theoretically, cranberry might increase the levels and adverse effects of nifedipine.
Animal research suggests that cranberry juice, administered intraduodenally 30 minutes prior to nifedipine treatment, inhibits nifedipine metabolism and increases the area under the concentration-time curve by 1.6-fold compared to control. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, cranberry might increase the levels and adverse effects of warfarin. However, research is conflicting.
There is contradictory evidence about the effect of cranberry juice on warfarin. Case reports have linked cranberry juice consumption to increases in the international normalized ratio (INR) in patients taking warfarin, resulting in severe spontaneous bleeding and excessive postoperative bleeding. Daily consumption of cranberry sauce for one week has also been linked to an increase in INR in one case report. In a small study in healthy young males, taking a high dose of 3 grams of cranberry juice concentrate capsules, equivalent to 57 grams of fruit daily, for 2 weeks produced a 30% increase in the area under the INR-time curve after a single 25-mg dose of warfarin. However, 3 very small clinical studies in patients stabilized on warfarin reported that cranberry juice 250 mL once or twice daily for 7 days (27% cranberry juice or pure cranberry juice) or 240 mL once daily for 14 days does not significantly increase INR or affect plasma warfarin levels. The reasons for these discrepant findings are unclear. It is possible that the form and dose of cranberry may play a role, as cranberry extracts and juices contain different constituents. Additionally, an in vitro study evaluating 5 different cranberry juices found varying effects, with only a cranberry concentrate, and not diluted cranberry juices, inhibiting CYP2C9. However, this concentrate did not inhibit CYP2C9 activity in humans.

Likelihood Possible Evidence B
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates. However, research is conflicting.
There is contradictory evidence about the effect of cranberry on CYP2C9 enzymes. In vitro evidence suggests that flavonoids in cranberry inhibit CYP2C9 enzymes. However, clinical research shows that cranberry juice does not significantly affect the levels, metabolism, or elimination of the CYP2C9 substrates flurbiprofen or diclofenac. Also, in patients stabilized on warfarin, drinking cranberry juice 250 mL daily for 7 days does not significantly increase the anticoagulant activity of warfarin, a CYP2C9 substrate. Additional pharmacokinetic research shows that cranberry juice does not increase peak plasma concentrations or area under the concentration-time curve of warfarin.

Likelihood Unlikely Evidence B
Diclofenac (Voltaren, Others)

Theoretically, cranberry might modestly increase the levels and adverse effects of diclofenac.
In vitro evidence suggests that cranberry juice inhibits diclofenac metabolism by human liver microsomes. However, drinking cranberry juice does not seem to affect diclofenac metabolism in humans.

Likelihood Unlikely Evidence B
organic Cranberry powder full monograph & interactions

Aloe Polysaccharides7 drug types · 461 drugs

Digoxin (Lanoxin)

Theoretically, aloe latex might increase the risk of adverse effects when taken with cardiac glycosides.
Overuse of aloe latex can increase the risk of adverse effects from cardiac glycoside drugs, such as digoxin, due to potassium depletion. Overuse of aloe, along with cardiac glycoside drugs, can increase the risk of toxicity.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that aloe gel can inhibit platelet aggregation. This inhibition was greater than that seen with celecoxib, but less than that seen with aspirin.

Likelihood Possible Evidence D
Antidiabetes Drugs

Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Preliminary clinical research suggests aloe gel might lower blood glucose levels and have additive effects when used with antidiabetes drugs. Monitor blood glucose levels closely.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Overuse of aloe latex might compound diuretic-induced potassium loss, increasing the risk of hypokalemia.

Likelihood Possible Evidence D
Stimulant Laxatives

Theoretically, aloe latex might increase the risk for fluid and electrolyte loss when taken with stimulant laxatives.
Due to cathartic laxative effects of aloe latex, concomitant use with other stimulant laxatives might compound fluid and electrolyte loss.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, aloe latex might increase the risk of bleeding when taken with warfarin.
Aloe latex has stimulant laxative effects. In some people aloe latex can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding. Advise patients who take warfarin not to take excessive amounts of aloe vera.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, aloe might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that aloe extract induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Aloe Polysaccharides full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Cran-Aloe, from the product label.

Country Life

See all Country Life products
Name
Country Life, LLC
Street Address
180 Vanderbilt Motor Parkway
City
Hauppauge
State
NY
ZipCode
11788
Web Address
CountryLifeVitamins.com
Pharmacist Counseling Corner

Cran-Aloe by Country Life: Common Questions

Does Cran-Aloe by Country Life interact with any medications?
Yes. Based on its ingredients, Cran-Aloe has a known interaction with 1,003 medications, including 1 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Cran-Aloe contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Cran-Aloe if I'm pregnant?
No. Avoid aloe by mouth during pregnancy because the latex can stimulate your uterus and act as a strong laxative. Cranberry is likely safe during pregnancy, but because this product contains aloe, it's not recommended. Talk to your doctor or midwife first.
Can I breastfeed while taking Cran-Aloe?
No. Both aloe and breastfeeding aren't a good match — aloe has limited safety data for nursing and acts as a laxative. Cranberry is likely safe, but aloe is the concern here. Check with your pediatrician or pharmacist.
What are the most common side effects?
From aloe: belly pain, cramps, and diarrhea. From cranberry: diarrhea and stomach upset. With normal use these are mild, but if you take high doses or use it long-term, aloe can cause more serious problems.
Does this product actually work for UTIs?
Cranberry is possibly effective for urinary tract infections based on our data. But this product also contains aloe, which isn't used for UTI treatment. If UTIs are why you're interested, ask your pharmacist whether cranberry alone or a cranberry-specific product might be a better fit.
Is this safe to take with my water pill?
Not without checking with your pharmacist first. Aloe can lower your potassium, and water pills do that too — together they raise the risk of dangerously low potassium levels. Let us know what water pill you take and we can check it.
Can I take this long-term?
Long-term use of aloe by mouth, especially in high doses, is linked to serious side effects like low potassium, muscle weakness, and heart rhythm problems. This isn't designed as a long-term supplement. Talk to your doctor about how long is safe for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Cran-Aloe is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cran-Aloe label
Go deeper

The Full Monographs Behind Cran-Aloe’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Aloe

Interacts with 461 drugs

Aloe vera gel is widely used on the skin for minor burns and irritation, and some research suggests it may help. Aloe latex (the yellow part) is a strong laxative that can cause cramping and...

Read the full Aloe monograph → Herb & supplement monograph

Cranberry

Interacts with 712 drugs

Cranberry is best known for helping to prevent repeated urinary tract infections (UTIs) in some people, and the evidence here is moderate but mixed. It is not a reliable treatment for an act...

Read the full Cranberry monograph →
Sources

Sources & How We Checked

Cran-Aloe's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 74 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Aloe 41 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Wichtl MW. Herbal Drugs and Phytopharmaceuticals. Ed. N.M. Bisset. Stuttgart: Medpharm GmbH Scientific Publishers, 1994.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Nusko G, Schneider B, Schneider I, et al. Anthranoid laxative use is not a risk factor for colorectal neoplasia: results of a prospective case control study. Gut 2000;46:651-5. PubMed
  5. Luyckx VA, Ballantine R, Claeys M, et al. Herbal remedy-associated acute renal failure secondary to Cape aloes. Am J Kidney Dis 2002;39:E13. PubMed
  6. Rajasekaran S, Sivagnanam K, Ravi K, Subramanian S. Hypoglycemic effect of Aloe vera gel on streptozotocin-induced diabetes in experimental rats. J Med Food 2004;7:61-6.
  7. Williams MS, Burk M, Loprinzi CL, et al. Phase III double-blind evaluation of an aloe vera gel as a prophylactic agent for radiation-induced skin toxicity. Int J Radiat Oncol Biol Phys 1996;36:345-9. PubMed
  8. Vogler BK, Ernst E. Aloe vera: a systematic review of its clinical effectiveness. Br J Gen Pract 1999;49:823-8.
  9. Bottenberg MM, Wall GC, Harvey RL, Habib S. Oral aloe vera-induced hepatitis. Ann Pharmacother 2007;41:1740-3. PubMed
  10. Rabe C, Musch A, Schirmacher P, et al. Acute hepatitis induced by an Aloe vera preparation: a case report. World J Gastroenterol 2005;11:303-4. PubMed
  11. Kanat O, Ozet A, Ataergin S. Aloe vera-induced acute toxic hepatitis in a healthy young man. Eur J Int Med 2006;17:589. PubMed
  12. Mueller SO, Stopper H. Characterization of the genotoxicity of anthraquinones in mammalian cells. Biochim Biophys Acta 1999;1428:406-14. PubMed
  13. Schorkhuber M, Richter M, Dutter A, et al. Effect of anthraquinone laxatives on the proliferation and urokinase secretion of normal, premalignant and malignant colonic epithelial cells. Eur J Cancer 1998;34:1091-8. PubMed
  14. Yang HN, Kim DJ, Kim YM, et al. Aloe-induced toxic hepatitis. J Korean Med Sci 2010;25:492-5. PubMed
  15. Choonhakarn C, Busaracome P, Sripanidkulchai B, et al. A prospective, randomized clinical trial comparing topical aloe vera with 0.1% triamcinolone acetonide in mild to moderate plaque psoriasis. J.Eur.Acad.Dermatol.Venereol. 2010;24:168-72. PubMed
  16. Ishii Y, Tanizawa H, Takino Y. Studies of aloe. IV. Mechanism of cathartic effect. (3). Biol Pharm Bull. 1994;17:495-7. PubMed
  17. Ishii Y, Tanizawa H, Takino Y. Studies of aloe. V. Mechanism of cathartic effect. (4). Biol Pharm Bull. 1994;17:651-3. PubMed
  18. Nelemans FA. Clinical and toxicological aspects of anthraquinone laxatives. Pharmacology. 1976;14 Suppl 1:73-7. PubMed
  19. Paulsen E, Korsholm L, Brandrup F. A double-blind, placebo-controlled study of a commercial Aloe vera gel in the treatment of slight to moderate psoriasis vulgaris. J Eur Acad Dermatol Venereol. 2005;19:326-31.
  20. Huseini HF, Kianbakht S, Hajiaghaee R, et al. Anti-hyperglycemic and anti-hypercholesterolemic effects of Aloe vera leaf gel in hyperlipidemic type 2 diabetic patients: a randomized double-blind placebo-controlled clinical trial. Planta Med. 2012;78:311-6
  21. Ferreira, M., Teixeira, M., Silva, E., and Selores, M. Allergic contact dermatitis to Aloe vera. Contact Dermatitis 2007;57(4):278-279.
  22. Choonhakarn, C., Busaracome, P., Sripanidkulchai, B., and Sarakarn, P. The efficacy of aloe vera gel in the treatment of oral lichen planus: a randomized controlled trial. Br J Dermatol 2008;158(3):573-577. PubMed
  23. Baretta, Z., Ghiotto, C., Marino, D., and Jirillo, A. Aloe-induced hypokalemia in a patient with breast cancer during chemotherapy. Ann.Oncol. 2009;20(8):1445-1446. PubMed
  24. Hunter, D. and Frumkin, A. Adverse reactions to vitamin E and aloe vera preparations after dermabrasion and chemical peel. Cutis 1991;47(3):193-196.
  25. Alvarez-Perea, A., Garcia, A. P., Hernandez, A. L., de, Barrio M., and Baeza, M. L. Urticaria due to aloe vera: a new sensitizer? Ann.Allergy Asthma Immunol. 2010;105(5):404-405. PubMed
  26. Hogan, D. J. Widespread dermatitis after topical treatment of chronic leg ulcers and stasis dermatitis. CMAJ. 2-15-1988;138(4):336-338.
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Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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