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Dietary supplement

D-Ribose 5,000 mg Powder Ingredients & Drug Interactions

by DC

D-Ribose 5,000 mg Powder label
See full label image
Liquid Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking D-Ribose 5,000 mg Powder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

D-Ribose 5,000 mg Powder is a dietary supplement by DC with 1 active ingredient. Its ingredients are commonly taken for energy and fatigue, athletic performance and recovery, fibromyalgia symptoms.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are D-Ribose. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against D-Ribose 5,000 mg Powder by DC

Ask about any prescription or over-the-counter medication and we check it for interactions with D-Ribose 5,000 mg Powder by DC — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of D-Ribose 5,000 mg Powder by DC

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: D-Ribose at 5,000 mg per serving. Ribose is a five-carbon sugar your cells make naturally and use for energy production and DNA repair.

The powder form has no other inactive ingredients listed.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Ribose's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: energy and cellular ATP production support.
  • We looked for evidence on: Athletic performance, Chronic fatigue syndrome (CFS), Fibromyalgia, Congestive heart failure (CHF), Coronary artery bypass graft (CABG) surgery, Coronary heart disease (CHD) — and 4 related terms.
  • The closest evidence on file: Ribose is rated "Possibly Ineffective" for Athletic performance (Natural Medicines).
  • Also on file: Ribose is rated "Possibly Ineffective" for McArdle disease.
  • Also on file: Ribose is rated "Insufficient Reliable Evidence To Rate" for Coronary heart disease (CHD), Chronic fatigue syndrome (CFS), Congestive heart failure (CHF), Fibromyalgia, and more.

The evidence on D-Ribose is mixed and often limited. For athletic performance and McArdle disease (a rare muscle disorder), the research suggests it's possibly ineffective.

For restless legs syndrome, muscle soreness, congestive heart failure, and recovery after heart bypass surgery, we don't have enough reliable evidence to say whether it works or doesn't. Talk with your doctor if you're considering it for any of these purposes.

The evidence, ingredient by ingredient Ribose

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Short-term use of ribose (up to 1 month) is generally well tolerated. The most common side effects are diarrhea, nausea, gastrointestinal discomfort, headache, and low blood sugar.

A few people also report lightheadedness, increased appetite, and mild anxiety — lowering the dose has resolved these in some cases. Because it lowers blood sugar and long-term safety hasn't been well studied, caution is warranted with regular use.

There isn't enough safety information to recommend D-Ribose during pregnancy or breastfeeding. Talk with your doctor or pharmacist for personalized advice if you're pregnant, planning to become pregnant, or nursing.

Side effects, ingredient by ingredient Ribose

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Ribose.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this product if you use insulin or any antidiabetes drugs (like metformin or sulfonylureas). Both carry moderate risk of low blood sugar when combined with ribose.

These are the only medication types with documented interactions for D-Ribose.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

D-Ribose may be worth considering if you're looking to support energy or cellular recovery and you don't take insulin or diabetes medications. If you do take either, check with your doctor or pharmacist first — blood-sugar interactions are moderate and real.

Side effects are generally mild but can include digestive upset and low blood sugar, especially at higher doses. Have that conversation before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about D-Ribose 5,000 mg Powder, straight from the product label.

Brand DC
Net contents 8 Oz(s); 227 Gram(s)
Market status On market
Date entered into DSLD Jun 16, 2022
DSLD ID 266809
Product type Non-nutrient/non-botanical
Supplement form Liquid
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for D-Ribose 5,000 mg Powder by DC, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
5 Gram(s)
Maximum serving Sizes:
10 Gram(s)
Servings per container
45
IngredientAmount% DV
Calories25 Calorie(s)--
Total Carbohydrates5 Gram(s)2%
Sugars5 Gram(s)--
D-Ribose5000 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

D-Ribose is one of the main fuels that drive the body's cellular engines (i.e), the mitochondria) which in turn produce the ATP that gives your body the energy it needs. Although Ribose is produced naturally by your body's cells not every cell is able to make it quickly. Supplementing with D-Ribose provides its astonishing benefits by giving the cells the fuel they need to rapidly increase ATP levels, and thus restore energy levels naturally throughout the body for long periods of time. In short, D-Ribose is the essential component for your body's basic energy production.

Contains: No artificial color, flavor or sweetener, no preservatives, no starch, no milk, no lactose, no soy, no wheat, no yeast, no fish and is sodium free.

Gluten free

Nutritionally Supports Healthy Cardiovascular Function and ATP Energy Production

Made in USA

Precautions

Tamper Evident: Do not use this product if imprinted foil seal under cap is broken or missing.

Keep out of reach of children.

Caution: If you are pregnant or nursing do not take this product.

Storage

Keep tightly closed. Store at room temperature: 59 degrees - 86 degrees F (15 degrees to 30 degrees C).

General Statements

Mfg. in an FDA registered facility using Good Manufacturing Practices (GMPs).

NOTICE: This product is sold by weight and not by volume. You can be assured of proper weight even though some settling of contents may occur during shipping and handling.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Quali Pure

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take 1 1/2 level teaspoons daily, prior to exercise. During training, serious athletes may want to double the dosage.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

D-Ribose 5,000 mg Powder by DC label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

D-Ribose 5,000 mg Powder label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in D-Ribose 5,000 mg Powder by DC

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size5 Gram(s) Dosage formLiquid Servings per container45 Amounts shown are per serving.

D-Ribose

Interacts with
86 drugs
5000 mg per serving

Ribose (D-ribose) is a simple sugar your body makes naturally and uses to build energy molecules like ATP. Some people take it for fatigue, fibromyalg...

D-Ribose monograph & interactions
Interaction report

D-Ribose 5,000 mg Powder by DC Drug Interactions

Want to check YOUR meds against D-Ribose 5,000 mg Powder?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

D-Ribose 86

Individual Drug Interactions

The ingredients in D-Ribose 5,000 mg Powder interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in D-Ribose 5,000 mg Powder interact with drugs. Each result below shows which ingredient is responsible. D-Ribose

Each ingredient & the kinds of drugs it affects

For each ingredient in D-Ribose 5,000 mg Powder with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

D-Ribose2 drug types · 86 drugs

Antidiabetes Drugs

Theoretically, taking ribose in combination with antidiabetes drugs might increase the risk of hypoglycemia.
In clinical research, ribose decreases serum glucose levels in a dose-dependent manner.

Likelihood Probable Evidence B
Insulin

Theoretically, taking ribose with insulin could increase the hypoglycemic effect of insulin.
In clinical pharmacokinetic studies, oral administration of ribose modestly increased serum insulin levels.

Likelihood Possible Evidence B
D-Ribose full monograph & interactions
The maker

Brand information

Manufacturer and brand details for D-Ribose 5,000 mg Powder, from the product label.

DC

See all DC products
Name
Dee Cee Laboratories, Inc.
Street Address
304 Dee Cee Rd.
City
White House
State
TN
ZipCode
37188
Pharmacist Counseling Corner

D-Ribose 5,000 mg Powder by DC: Common Questions

Does D-Ribose 5,000 mg Powder by DC interact with any medications?
Yes. Based on its ingredients, D-Ribose 5,000 mg Powder has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
D-Ribose 5,000 mg Powder contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will D-Ribose actually improve my athletic performance?
The research suggests it's possibly ineffective for athletic performance. While ribose is involved in energy production at the cellular level, the evidence doesn't support a real benefit in athletic settings.
What are the most common side effects?
Diarrhea, nausea, gastrointestinal discomfort, headache, and low blood sugar are the most common. A few people report lightheadedness, increased appetite, or mild anxiety. Lowering your dose can help resolve nausea or anxiety if they happen.
Is D-Ribose safe to take long-term?
Short-term use up to 1 month is generally well tolerated, but long-term safety hasn't been well studied. That's why caution is advised if you plan to take it regularly. Talk with your pharmacist about how long-term use fits your situation.
Can I take this while pregnant or breastfeeding?
There isn't enough safety information to say it's okay during pregnancy or breastfeeding. It's best avoided until you've discussed it with your doctor or pharmacist for personalized advice.
Does D-Ribose help with muscle soreness?
We don't have enough reliable evidence to say whether it works for muscle soreness. The research on this isn't conclusive yet.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if D-Ribose 5,000 mg Powder is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

D-Ribose 5,000 mg Powder label
Go deeper

The Full Monographs Behind D-Ribose 5,000 mg Powder’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Ribose

Interacts with 86 drugs

Ribose (D-ribose) is a simple sugar your body makes naturally and uses to build energy molecules like ATP. Some people take it for fatigue, fibromyalgia, exercise recovery, or heart conditio...

Read the full Ribose monograph →
Sources

Sources & How We Checked

D-Ribose 5,000 mg Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Ribose 8 references
  1. Segal S, Foley J. The metabolism of D-ribose in man. J Clin Invest 1958;37:719-35. PubMed
  2. Perlmutter NS, Wilson RA, Angello DA, et al. Ribose facilitates thallium-201 redistribution in patients with coronary artery disease. J Nucl Med 1991;32:193-200.
  3. Hegewald MG, Palac RT, Angello DA, et al. Ribose infusion accelerates thallium redistribution with early imaging compared with late 24-hour imaging without ribose. J Am Coll Cardiol 1991;18:1671-81. PubMed
  4. Pliml W, von Arnim T, Stalein A, et al. Effects of ribose on excercise-induced ischaemia in stable coronary artery disease. Lancet 1992;340:507-10.
  5. Burke ER. D-Ribose What You Need To Know. Garden City Park, NY: Avery Publishing Group 1999;1-43.
  6. Gross M, Reiter S, Zollner N. Metabolism of D-ribose administered continuously to healthy persons and to patients with myoadenylate deaminase deficiency. Klin Wochenschr 1989;67:1205-13. PubMed
  7. Teitelbaum JE, Johnson C, St Cyr J. The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study. J Altern Complement Med 2006;12:857-62. PubMed
  8. Thompson J, Neutel J, Homer K, Tempero K, Shah A, Khankari R. Evaluation of D-ribose pharmacokinetics, dose proportionality, food effect, and pharmacodynamics after oral solution administration in healthy male and female subjects. J Clin Pharmacol 2014;54 PubMed

See these in context on the Ribose monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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