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Dietary supplement

D-Ribose 750 mg Unflavored Ingredients & Drug Interactions

by Muscle Empire

D-Ribose 750 mg Unflavored label
See full label image
Powder Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking D-Ribose 750 mg Unflavored against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

D-Ribose 750 mg Unflavored is a dietary supplement by Muscle Empire with 1 active ingredient. Its ingredients are commonly taken for energy and fatigue, athletic performance and recovery, fibromyalgia symptoms.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bioenergy Ribose. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against D-Ribose 750 mg Unflavored by Muscle Empire

Ask about any prescription or over-the-counter medication and we check it for interactions with D-Ribose 750 mg Unflavored by Muscle Empire — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of D-Ribose 750 mg Unflavored by Muscle Empire

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.

This product contains one active ingredient: ribose (labeled as Bioenergy Ribose), a five-carbon sugar that your cells use to produce energy. Each serving provides 750 mg of ribose in an unflavored powder form with no other inactive ingredients listed.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Ribose's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: cellular energy and recovery support.
  • We looked for evidence on: Athletic performance, Chronic fatigue syndrome (CFS), Fibromyalgia, Congestive heart failure (CHF), Coronary artery bypass graft (CABG) surgery, Coronary heart disease (CHD) — and 4 related terms.
  • The closest evidence on file: Ribose is rated "Possibly Ineffective" for Athletic performance (Natural Medicines).
  • Also on file: Ribose is rated "Possibly Ineffective" for McArdle disease.
  • Also on file: Ribose is rated "Insufficient Reliable Evidence To Rate" for Coronary heart disease (CHD), Chronic fatigue syndrome (CFS), Congestive heart failure (CHF), Fibromyalgia, and more.

The evidence for ribose is mixed and limited. It's rated possibly ineffective for athletic performance and for McArdle disease (a rare muscle disorder).

For restless legs syndrome, muscle soreness, congestive heart failure, and recovery after bypass surgery, we don't have enough reliable evidence to say whether it works or not. If you're considering it for one of these purposes, talk with your doctor about whether a trial makes sense for you.

The evidence, ingredient by ingredient Ribose

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Ribose is generally well tolerated in the short term (up to about a month), but long-term safety hasn't been well studied. The main concern is that it can lower blood sugar.

Common side effects include diarrhea, nausea, headache, and gastrointestinal discomfort — and in some cases, low blood sugar itself. A small number of people reported lightheadedness, increased appetite, or mild anxiety; lowering the dose resolved these symptoms.

There isn't enough safety data to use ribose during pregnancy or while breastfeeding — talk with your doctor or pharmacist for personalized advice if either applies to you.

Side effects, ingredient by ingredient Ribose

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Ribose.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check these medication types before using D-Ribose: insulin (Moderate severity — ribose can boost insulin's blood-sugar-lowering effect) and antidiabetes drugs like metformin and sulfonylureas (Moderate severity — ribose may increase the risk of low blood sugar). If you're on either, confirm with your own doctor or pharmacist before you start.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

D-Ribose may appeal to athletes or people with certain heart or muscle conditions, but the evidence that it actually works is weak or absent. The real caution is if you take insulin or any blood sugar medication — ribose can lower your glucose further.

Check your exact medications with your doctor or pharmacist before starting, and know that long-term safety remains unclear.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about D-Ribose 750 mg Unflavored, straight from the product label.

Brand Muscle Empire
Barcode (UPC) 798711493050
Net contents 500 Gram(s); 1.1 lbs
Market status On market
Date entered into DSLD Mar 24, 2017
DSLD ID 71634
Product type Non-nutrient/non-botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for D-Ribose 750 mg Unflavored by Muscle Empire, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.75 Gram(s)
Maximum serving Sizes:
0.75 Gram(s)
Servings per container
665
UPC/BARCODE
798711493050
IngredientAmount% DV
Bioenergy Ribose0 NP--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Ribose is the vital structural backbone of critical cellular compounds called purines and pyrimidines. Our bodies must have an adequate supply of purines and pyrimidines to form major cellular constituents such as our genetic material (DNA and RNA), numerous cofactors and certain vitamins. But more importantly, ribose is the backbone of adenosine triphosphate (ATP)-the source for all cellular energy. Ribose is the starting point and the rate limiting compound in the synthesis of these fundamental cellular compounds and the availability of ribose determines the rate at which they can be made by our cells and tissues.

D-Ribose 750mg per serving

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take one serving (1 scoop) with 8-16 ounces of water or suitable beverage. Taken 1-3 times daily for best use. Optimal dosage may vary for each individual: consult with your qualified health professional to see if a higher dose is right for you.

Morning Pre During Post Night

General Statements

Bioenergy Ribose is unique in this metabolic role. No other compound can replace ribose in the important job of regulating the metabolic processes involved in synthesizing purines and pyrimidines. And without these vital structural components, our bodies would quickly run out of energy, could not make proteins and our cells would lose the ability to replicate. Energy recovery and tissue repair are slower in heart and muscle cells, especially after overwork or exercise. Ribose drives the process that replenishes ATP and other energy components in these cells.

Optimized ATP production for cellular energy Metabolic regulating of purines & pyrimidines Supports muscle energy, endurance, & repair

665 Servings

Scoop inside Serving Scoop included (may settle during shipping)

General

PART#83625-5006T VER 2.1 REV 08 05 2015

Seals/Symbols

Q Premium quality Dietary Supplement

Lab tested for purity and quality

Packed in USA

Brand IP Statement(s)

Powered by: Bioenergy Ribose

Bioenergy Ribose D-Ribose is a unique 5 carbon carbohydrate that can be used as a standalone product or added to a variety of functional foods, beverages, and nutraceuticals. it is natural, safe and clinically proven.

FDA Statement of Identity

Dietary Supplement

Formulation

Allergens: This product contains no soy, dairy & dairy byproducts, eggs, fish, shellfish, wheat, gluten, tree nuts, or sesame seeds.

Precautions

Warning: Keep out of the reach of children. Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions and/or taking prescription drug(s) or OTC medication(s).

Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions and/or taking prescription drug(s) or OTC medication(s).

Always consult with a qualified health physician before taking any new dietary supplement.

Do not use or consume if inner seal is broken.

FDA Disclaimer Statement

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any diseases.

Storage

Store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

D-Ribose 750 mg Unflavored by Muscle Empire label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

D-Ribose 750 mg Unflavored label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in D-Ribose 750 mg Unflavored by Muscle Empire

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.75 Gram(s) Dosage formPowder Servings per container665 Amounts shown are per serving.

Bioenergy Ribose

Interacts with
86 drugs
0 NP per serving Form: D-Ribose, Powder

Ribose (D-ribose) is a simple sugar your body makes naturally and uses to build energy molecules like ATP. Some people take it for fatigue, fibromyalg...

Bioenergy Ribose monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

D-Ribose 750 mg Unflavored by Muscle Empire Drug Interactions

Want to check YOUR meds against D-Ribose 750 mg Unflavored?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Bioenergy Ribose 86

Individual Drug Interactions

The ingredients in D-Ribose 750 mg Unflavored interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in D-Ribose 750 mg Unflavored interact with drugs. Each result below shows which ingredient is responsible. Bioenergy Ribose

Each ingredient & the kinds of drugs it affects

For each ingredient in D-Ribose 750 mg Unflavored with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bioenergy Ribose2 drug types · 86 drugs

Antidiabetes Drugs

Theoretically, taking ribose in combination with antidiabetes drugs might increase the risk of hypoglycemia.
In clinical research, ribose decreases serum glucose levels in a dose-dependent manner.

Likelihood Probable Evidence B
Insulin

Theoretically, taking ribose with insulin could increase the hypoglycemic effect of insulin.
In clinical pharmacokinetic studies, oral administration of ribose modestly increased serum insulin levels.

Likelihood Possible Evidence B
Bioenergy Ribose full monograph & interactions
The maker

Brand information

Manufacturer and brand details for D-Ribose 750 mg Unflavored, from the product label.

Muscle Empire

See all Muscle Empire products
Name
Supplement Partners, LLC.
Street Address
3820 W Happy Valley Rd Ste 141 - #420
City
Glendale
State
AZ
ZipCode
85310
Web Address
MUSCLEEMPIRE.COM
Pharmacist Counseling Corner

D-Ribose 750 mg Unflavored by Muscle Empire: Common Questions

Does D-Ribose 750 mg Unflavored by Muscle Empire interact with any medications?
Yes. Based on its ingredients, D-Ribose 750 mg Unflavored has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
D-Ribose 750 mg Unflavored contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take D-Ribose if I have diabetes or take blood sugar medication?
Not without checking first. Ribose can lower your blood glucose, and combined with insulin or antidiabetes drugs, that risk goes up. Talk with your doctor or pharmacist about your specific medications and whether ribose is safe for you.
Does D-Ribose actually improve athletic performance or reduce muscle soreness?
The evidence doesn't support it. Studies rate ribose as possibly ineffective for athletic performance, and we don't have reliable evidence that it reduces muscle soreness, even though people often try it for that reason.
What are the most common side effects?
Diarrhea, nausea, headache, and gastrointestinal discomfort are the most reported. A few people have also felt lightheaded, more anxious, or had increased appetite — but lowering the dose resolved these in the studies where it was tried.
Can I take D-Ribose while pregnant or breastfeeding?
There isn't enough safety data, so the guidance is to avoid it during pregnancy and while breastfeeding. Talk with your doctor or pharmacist about whether it's right for you if either applies.
How long can I safely take D-Ribose?
It's been studied as generally well tolerated for up to about a month, but we don't have good long-term safety data. If you're thinking of using it beyond that, ask your doctor or pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if D-Ribose 750 mg Unflavored is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

D-Ribose 750 mg Unflavored label
Go deeper

The Full Monographs Behind D-Ribose 750 mg Unflavored’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Ribose

Interacts with 86 drugs

Ribose (D-ribose) is a simple sugar your body makes naturally and uses to build energy molecules like ATP. Some people take it for fatigue, fibromyalgia, exercise recovery, or heart conditio...

Read the full Ribose monograph →
Sources

Sources & How We Checked

D-Ribose 750 mg Unflavored's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Ribose 8 references
  1. Segal S, Foley J. The metabolism of D-ribose in man. J Clin Invest 1958;37:719-35. PubMed
  2. Perlmutter NS, Wilson RA, Angello DA, et al. Ribose facilitates thallium-201 redistribution in patients with coronary artery disease. J Nucl Med 1991;32:193-200.
  3. Hegewald MG, Palac RT, Angello DA, et al. Ribose infusion accelerates thallium redistribution with early imaging compared with late 24-hour imaging without ribose. J Am Coll Cardiol 1991;18:1671-81. PubMed
  4. Pliml W, von Arnim T, Stalein A, et al. Effects of ribose on excercise-induced ischaemia in stable coronary artery disease. Lancet 1992;340:507-10.
  5. Burke ER. D-Ribose What You Need To Know. Garden City Park, NY: Avery Publishing Group 1999;1-43.
  6. Gross M, Reiter S, Zollner N. Metabolism of D-ribose administered continuously to healthy persons and to patients with myoadenylate deaminase deficiency. Klin Wochenschr 1989;67:1205-13. PubMed
  7. Teitelbaum JE, Johnson C, St Cyr J. The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study. J Altern Complement Med 2006;12:857-62. PubMed
  8. Thompson J, Neutel J, Homer K, Tempero K, Shah A, Khankari R. Evaluation of D-ribose pharmacokinetics, dose proportionality, food effect, and pharmacodynamics after oral solution administration in healthy male and female subjects. J Clin Pharmacol 2014;54 PubMed

See these in context on the Ribose monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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