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Dietary supplement

D-Ribose Pure Powder Ingredients & Drug Interactions

by Best Naturals

D-Ribose Pure Powder label
See full label image
Powder Category: Fiber And Other Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking D-Ribose Pure Powder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

D-Ribose Pure Powder is a dietary supplement by Best Naturals with 1 active ingredient. Its ingredients are commonly taken for energy and fatigue, athletic performance and recovery, fibromyalgia symptoms.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are D-Ribose Powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against D-Ribose Pure Powder by Best Naturals

Ask about any prescription or over-the-counter medication and we check it for interactions with D-Ribose Pure Powder by Best Naturals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of D-Ribose Pure Powder by Best Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product is D-Ribose, a naturally occurring sugar that your cells use to make energy. It's the single active ingredient in this powder—no fillers or other active compounds.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Ribose's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: energy production and cellular synthesis.
  • We looked for evidence on: Athletic performance, Chronic fatigue syndrome (CFS), Fibromyalgia, Congestive heart failure (CHF), Coronary artery bypass graft (CABG) surgery, Coronary heart disease (CHD) — and 4 related terms.
  • The closest evidence on file: Ribose is rated "Possibly Ineffective" for Athletic performance (Natural Medicines).
  • Also on file: Ribose is rated "Possibly Ineffective" for McArdle disease.
  • Also on file: Ribose is rated "Insufficient Reliable Evidence To Rate" for Coronary heart disease (CHD), Chronic fatigue syndrome (CFS), Congestive heart failure (CHF), Fibromyalgia, and more.

The evidence for D-Ribose is mixed and often thin. For athletic performance, muscle soreness, and two heart-related conditions (congestive heart failure and recovery after bypass surgery), the research doesn't support its use or is too limited to say either way.

For restless legs syndrome, there simply isn't enough reliable evidence to know whether it works.

The evidence, ingredient by ingredient Ribose

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

D-Ribose is generally well tolerated short-term—up to a month in studies. The most common side effects taken by mouth are diarrhea, nausea, gastrointestinal discomfort, headache, and low blood sugar.

Some people report anxiety, lightheadedness, or increased appetite, though lowering the dose has resolved these in some cases. Long-term safety hasn't been well studied.

The safety data advises against use during pregnancy and while breastfeeding because there isn't enough information to know it's safe in those situations. Talk with your doctor or pharmacist if you're pregnant, planning to become pregnant, or breastfeeding.

Side effects, ingredient by ingredient Ribose

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Ribose.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check all antidiabetes drugs and insulin with your pharmacist before starting this product. Both can cause moderate-severity interactions that raise the risk of low blood sugar when combined with D-Ribose.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

D-Ribose is generally well tolerated short-term, but evidence it actually works for its popular uses is weak or absent. The bigger concern is its effect on blood sugar—if you take diabetes or insulin medication, you'll need to clear this with your doctor or pharmacist first.

Pregnancy and breastfeeding are also reasons to avoid it unless your healthcare provider advises otherwise.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about D-Ribose Pure Powder, straight from the product label.

Brand Best Naturals
Barcode (UPC) 817716014999
Net contents 1 lb(s); 454 Gram(s)
Market status On market
Date entered into DSLD Jun 16, 2022
DSLD ID 270483
Product type Fiber And Other Nutrients
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for D-Ribose Pure Powder by Best Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
5 Gram(s)
Maximum serving Sizes:
5 Gram(s)
Servings per container
91
UPC/BARCODE
817716014999
IngredientAmount% DV
Calories20 Calorie(s)--
Total Carbohydrates5 Gram(s)2%
D-Ribose Powder5 Gram(s)--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Ribose is a naturally occurring pentose (5-carbon) sugar found in all living cells. It is an essential component, utilized by the body to synthesize DNA, RNA and produce energy. Ribose is a fundamental building block of adenosine triphosphate (ATP-the substance in which the body stores intracellular energy), the preferential source of energy for skeletal muscle and heart tissue. Certain research publications indicate that D-Ribose may help support the following: Supports healthy energy level in heart & muscle tissue Support body's crucial antioxidant defenses

Precautions

Caution: For adults only, if you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of the reach of children.

Do not use if safety seal is broken or missing.

Storage

Keep in cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Packaged in USA

GMP Good Manufacturing Practice Product

Formulation

Premium formula

3rd party lab tested

No artificial color, flavor or sweetener, no preservatives, no starch, no milk, no soy, no egg, no lactose, no gluten, no wheat, no yeast, no fish. Sodium free.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 1 1/2 level teaspoons daily prior to exercise. Serious athletes may want to double the dosage during training. Consider taking this product in combination with Best Naturals CoQ10, Magnesium, L-Carnitine and Creatine.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

D-Ribose Pure Powder by Best Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

D-Ribose Pure Powder label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in D-Ribose Pure Powder by Best Naturals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size5 Gram(s) Dosage formPowder Servings per container91 Amounts shown are per serving.

D-Ribose Powder

Interacts with
86 drugs
5 Gram(s) per serving

Ribose (D-ribose) is a simple sugar your body makes naturally and uses to build energy molecules like ATP. Some people take it for fatigue, fibromyalg...

D-Ribose Powder monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

D-Ribose Pure Powder by Best Naturals Drug Interactions

Want to check YOUR meds against D-Ribose Pure Powder?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

D-Ribose Powder 86

Individual Drug Interactions

The ingredients in D-Ribose Pure Powder interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in D-Ribose Pure Powder interact with drugs. Each result below shows which ingredient is responsible. D-Ribose Powder

Each ingredient & the kinds of drugs it affects

For each ingredient in D-Ribose Pure Powder with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

D-Ribose Powder2 drug types · 86 drugs

Antidiabetes Drugs

Theoretically, taking ribose in combination with antidiabetes drugs might increase the risk of hypoglycemia.
In clinical research, ribose decreases serum glucose levels in a dose-dependent manner.

Likelihood Probable Evidence B
Insulin

Theoretically, taking ribose with insulin could increase the hypoglycemic effect of insulin.
In clinical pharmacokinetic studies, oral administration of ribose modestly increased serum insulin levels.

Likelihood Possible Evidence B
D-Ribose Powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for D-Ribose Pure Powder, from the product label.

Best Naturals

See all Best Naturals products
Name
Best Naturals
Street Address
PO Box 394
City
Kenilworth
State
NJ
ZipCode
07033
Phone Number
1-877-659-6004
Web Address
www.shopbestnaturals.com
Pharmacist Counseling Corner

D-Ribose Pure Powder by Best Naturals: Common Questions

Does D-Ribose Pure Powder by Best Naturals interact with any medications?
Yes. Based on its ingredients, D-Ribose Pure Powder has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
D-Ribose Pure Powder contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take D-Ribose if I'm on diabetes medication?
Not without clearing it first with your own doctor or pharmacist. D-Ribose may lower blood sugar, and combining it with diabetes drugs or insulin could increase the risk of dangerously low blood sugar. Your provider can check your specific medications and advise you.
What are the most common side effects?
Diarrhea, nausea, gastrointestinal discomfort, headache, and low blood sugar are the most frequently reported when taken by mouth. A few people also experience anxiety or lightheadedness, and these sometimes improve if you lower the dose.
Is D-Ribose safe to take long-term?
The safety data only covers short-term use—up to about a month. Long-term safety hasn't been well studied, so if you're thinking of using it regularly, talk with your pharmacist or doctor.
Does D-Ribose help with athletic performance or muscle soreness?
The evidence doesn't support its use for athletic performance, and for muscle soreness there simply isn't enough reliable research to know either way. If those are your reasons for considering it, you may want to discuss other options with your doctor.
Can I take D-Ribose while pregnant or breastfeeding?
The safety data advises against it—there isn't enough information to know it's safe during pregnancy or while breastfeeding. Talk with your doctor or pharmacist if you're pregnant, planning pregnancy, or nursing.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if D-Ribose Pure Powder is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

D-Ribose Pure Powder label
Go deeper

The Full Monographs Behind D-Ribose Pure Powder’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Ribose

Interacts with 86 drugs

Ribose (D-ribose) is a simple sugar your body makes naturally and uses to build energy molecules like ATP. Some people take it for fatigue, fibromyalgia, exercise recovery, or heart conditio...

Read the full Ribose monograph →
Sources

Sources & How We Checked

D-Ribose Pure Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Ribose 8 references
  1. Segal S, Foley J. The metabolism of D-ribose in man. J Clin Invest 1958;37:719-35. PubMed
  2. Perlmutter NS, Wilson RA, Angello DA, et al. Ribose facilitates thallium-201 redistribution in patients with coronary artery disease. J Nucl Med 1991;32:193-200.
  3. Hegewald MG, Palac RT, Angello DA, et al. Ribose infusion accelerates thallium redistribution with early imaging compared with late 24-hour imaging without ribose. J Am Coll Cardiol 1991;18:1671-81. PubMed
  4. Pliml W, von Arnim T, Stalein A, et al. Effects of ribose on excercise-induced ischaemia in stable coronary artery disease. Lancet 1992;340:507-10.
  5. Burke ER. D-Ribose What You Need To Know. Garden City Park, NY: Avery Publishing Group 1999;1-43.
  6. Gross M, Reiter S, Zollner N. Metabolism of D-ribose administered continuously to healthy persons and to patients with myoadenylate deaminase deficiency. Klin Wochenschr 1989;67:1205-13. PubMed
  7. Teitelbaum JE, Johnson C, St Cyr J. The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study. J Altern Complement Med 2006;12:857-62. PubMed
  8. Thompson J, Neutel J, Homer K, Tempero K, Shah A, Khankari R. Evaluation of D-ribose pharmacokinetics, dose proportionality, food effect, and pharmacodynamics after oral solution administration in healthy male and female subjects. J Clin Pharmacol 2014;54 PubMed

See these in context on the Ribose monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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