David Winston's Lung Relief Cold/Damp Ingredients & Drug Interactions
What is this page for?
First and foremost: checking David Winston's Lung Relief Cold/Damp against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
David Winston's Lung Relief Cold/Damp is a dietary supplement by Herbalist & Alchemist with 5 active ingredients. Its ingredients are commonly taken for nausea and vomiting, motion sickness, morning sickness in pregnancy.Based on those ingredients, 1,146 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Ginger Rhizome Extract, Thyme herb Extract, Orange Peel Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against David Winston's Lung Relief Cold/Damp by Herbalist & Alchemist
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HelloPharmacist Scorecard of David Winston's Lung Relief Cold/Damp by Herbalist & Alchemist
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
This 5-ingredient liquid contains ginger rhizome extract, osha root extract, orange peel extract, yerba santa leaf extract, and thyme herb extract, blended in a proprietary formula. The active ingredients are mixed in ethyl alcohol and distilled water.
Ginger is included for its warming and digestive properties; osha root and thyme are traditionally used for respiratory support; yerba santa has historically been used for respiratory and digestive function; and orange peel is a citrus flavoring and digestive aid.
Does it work?
Not established
The evidence for this product's ingredients varies. Ginger is possibly effective for pregnancy-related nausea, menstrual cramps (dysmenorrhea), and osteoarthritis, but evidence doesn't support it for exercise-induced muscle soreness or chemotherapy nausea.
For the other ingredients, the data we hold shows insufficient reliable evidence to rate their effectiveness — osha root's use for dyspepsia and respiratory function, yerba santa for weight management, and thyme for bronchitis, colds, or aging skin are all traditional uses not yet backed by solid clinical trial data.
How safe is it?
Well-documented data
Ginger is generally well tolerated in typical amounts, though doses above 5 grams per day raise the risk of side effects. Common mild effects include abdominal discomfort, heartburn, diarrhea, burping, and a peppery irritant feeling in the mouth or throat; in rare cases, it's caused mild heart rhythm changes or bowel obstruction.
Thyme is well tolerated when used in food and medicinally, though it may cause allergic reactions, diarrhea, dizziness, headache, heartburn, or nausea. Osha root and yerba santa have limited human safety data — osha root is traditionally avoided in pregnancy and breastfeeding, and yerba santa safety during pregnancy and lactation has not been studied.
The thyme in this product is likely safe in pregnancy and lactation at food amounts, but medicinal doses of osha root and yerba santa should be avoided unless your doctor approves.
Meds to double-check
Major interaction found
Check the following medication types before using this product. Blood thinners and antiplatelet drugs (Moderate concern from ginger and thyme) — ginger and thyme may increase bleeding risk.
Diabetes medications (Moderate from ginger) — ginger might lower blood sugar further. Liver-processed drugs and cancer medications that are CYP3A4 substrates (Moderate from ginger) — ginger may alter how your body breaks them down.
P-glycoprotein substrates and losartan (Moderate from ginger). Estrogen replacement therapy (Moderate from thyme).
Anticholinergic and cholinergic drugs (Moderate from thyme). Lithium (Moderate from yerba santa).
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.
This product is used for cold and respiratory comfort, but several of its ingredients interact with common medications — especially blood thinners, diabetes drugs, and certain other prescriptions. If you take any medications, check them against the tool on this page before starting.
Talk to your pharmacist or doctor, particularly if you're pregnant, breastfeeding, or taking lithium or estrogen.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about David Winston's Lung Relief Cold/Damp, straight from the product label.
| Brand | Herbalist & Alchemist |
|---|---|
| Barcode (UPC) | 667056133993 |
| Net contents | 2 Fluid Ounce(s); 60 mL |
| Market status | On market |
| Date entered into DSLD | Sep 25, 2025 |
| DSLD ID | 340206 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Kosher |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for David Winston's Lung Relief Cold/Damp by Herbalist & Alchemist, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Blend | 3 mL | -- |
| Ginger Rhizome Extract | 0 NP | -- |
| Osha root extract | 0 NP | -- |
| Orange Peel Extract | 0 NP | -- |
| Yerba Santa leaf extract | 0 NP | -- |
| Thyme herb Extract | 0 NP | -- |
Other ingredients: Ethyl Alcohol, Water, Distilled
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Promotes healthy respiratory function
FDA Statement of Identity
Herbal Supplement
Seals/Symbols
Certified B Corporation
OK (Kosher)
Suggested/Recommended/Usage/Directions
Suggested use: 40-60 drops (2-3 mL) in juice or water. Take 4 times per day. Shake well before using.
Precautions
Contraindications: Do not use during pregnancy or if you have a cold/dry, hot/dry or hot/damp lung condition.
Keep out of children's reach
FDA Disclaimer Statement
This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
Formula
OK (Kosher)
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
David Winston's Lung Relief Cold/Damp by Herbalist & Alchemist label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in David Winston's Lung Relief Cold/Damp by Herbalist & Alchemist
These are the 5 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 mL Dosage formLiquid Servings per container20 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Blend
Other (inactive) ingredients: Ethyl Alcohol, Water, Distilled. These complete the product’s ingredient list but are not active constituents.
David Winston's Lung Relief Cold/Damp by Herbalist & Alchemist Drug Interactions
HelloPharmacist Interaction Report
David Winston's Lung Relief Cold/Damp by Herbalist & Alchemist contains ginger, yerba santa, and thyme — all of which have documented interactions with medications.
Altogether, these interactions span 1,104 individual medications.
Read the full breakdown — every affected drug type, severity by severity
Ginger is the ingredient with the most extensive interaction profile. It may increase bleeding risk if you take blood thinners (anticoagulants) like warfarin or antiplatelet drugs — research is mixed, but the concern is real enough to warrant checking.
Ginger can also theoretically lower blood sugar (hypoglycemia) if combined with diabetes medications, and it may affect how your liver breaks down certain drugs, including some cancer medications and other substrates processed by CYP3A4 (a liver enzyme). It may also increase absorption of P-glycoprotein substrates and could theoretically raise losartan levels and lower blood pressure further.
Thyme and yerba santa add a few more drug interactions to watch. Thyme may have additive blood-thinning effects with anticoagulants or antiplatelet drugs and might interfere with estrogen replacement therapy or anticholinergic medications.
Yerba santa's diuretic properties could theoretically increase lithium levels, potentially requiring a dose adjustment.
Check your exact medications with the search tool on this page before starting this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against David Winston's Lung Relief Cold/Damp?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in David Winston's Lung Relief Cold/Damp interact with 1,146 drugs. Click any drug to see the details.
4 of the 5 ingredients in David Winston's Lung Relief Cold/Damp interact with drugs. Each result below shows which ingredient is responsible. Ginger Rhizome Extract Thyme herb Extract Orange Peel Extract Yerba Santa leaf extract
AtorvastatinAtorvaliq
How Atorvastatin interacts with David Winston's Lung Relief Cold/Damp — through 2 ingredients. Tap an ingredient for the detail:
Orange Peel ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange Peel Extract + Atorvastatin interactionGinger Rhizome ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger Rhizome Extract + Atorvastatin interactionAtorvastatin CalciumLipitor
How Atorvastatin Calcium interacts with David Winston's Lung Relief Cold/Damp — through 2 ingredients. Tap an ingredient for the detail:
Orange Peel ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange Peel Extract + Atorvastatin Calcium interactionGinger Rhizome ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger Rhizome Extract + Atorvastatin Calcium interactionBosentanTracleer
How Bosentan interacts with David Winston's Lung Relief Cold/Damp — through 2 ingredients. Tap an ingredient for the detail:
Orange Peel ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange Peel Extract + Bosentan interactionGinger Rhizome ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger Rhizome Extract + Bosentan interactionBrincidofovirTembexa
How Brincidofovir interacts with David Winston's Lung Relief Cold/Damp — through 1 ingredient. Tap an ingredient for the detail:
Orange Peel ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange Peel Extract + Brincidofovir interactionCeliprololCelicard
How Celiprolol interacts with David Winston's Lung Relief Cold/Damp — through 2 ingredients. Tap an ingredient for the detail:
Orange Peel ExtractP-glycoprotein Substrates, Organic Anion-transporting Polypeptide Substrates (oatp) +1 Major
Interaction Summary
Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Read the full Orange Peel Extract + Celiprolol interactionGinger Rhizome ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Ginger might increase the absorption and blood levels of P-glycoprotein (P-gp) substrates.
Read the full Ginger Rhizome Extract + Celiprolol interactionCerivastatin SodiumBaycol
How Cerivastatin Sodium interacts with David Winston's Lung Relief Cold/Damp — through 1 ingredient. Tap an ingredient for the detail:
Orange Peel ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange Peel Extract + Cerivastatin Sodium interactionCinoxacinCinobac
How Cinoxacin interacts with David Winston's Lung Relief Cold/Damp — through 1 ingredient. Tap an ingredient for the detail:
Orange Peel ExtractOrganic Anion-transporting Polypeptide Substrates (oatp), Quinolone Antibiotics Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange Peel Extract + Cinoxacin interactionCiprofloxacinCiloxan, Cipro, Cipro IV, Cipro XR, Ciprobay, Otiprio
How Ciprofloxacin interacts with David Winston's Lung Relief Cold/Damp — through 1 ingredient. Tap an ingredient for the detail:
Orange Peel ExtractOrganic Anion-transporting Polypeptide Substrates (oatp), Quinolone Antibiotics Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange Peel Extract + Ciprofloxacin interactionCiprofloxacin, HydrocortisoneCipro HC Otic
How Ciprofloxacin, Hydrocortisone interacts with David Winston's Lung Relief Cold/Damp — through 1 ingredient. Tap an ingredient for the detail:
Orange Peel ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange Peel Extract + Ciprofloxacin, Hydrocortisone interactionClinafloxacinClinafloxacin
How Clinafloxacin interacts with David Winston's Lung Relief Cold/Damp — through 1 ingredient. Tap an ingredient for the detail:
Orange Peel ExtractOrganic Anion-transporting Polypeptide Substrates (oatp), Quinolone Antibiotics Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange Peel Extract + Clinafloxacin interactionEnoxacinPenetrex
How Enoxacin interacts with David Winston's Lung Relief Cold/Damp — through 1 ingredient. Tap an ingredient for the detail:
Orange Peel ExtractOrganic Anion-transporting Polypeptide Substrates (oatp), Quinolone Antibiotics Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange Peel Extract + Enoxacin interactionEtoposideEtopophos, VePesid, VP16
How Etoposide interacts with David Winston's Lung Relief Cold/Damp — through 2 ingredients. Tap an ingredient for the detail:
Orange Peel ExtractOrganic Anion-transporting Polypeptide Substrates (oatp), P-glycoprotein Substrates Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange Peel Extract + Etoposide interactionGinger Rhizome ExtractP-glycoprotein Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Ginger might increase the absorption and blood levels of P-glycoprotein (P-gp) substrates.
Read the full Ginger Rhizome Extract + Etoposide interactionEzetimibe, AtorvastatinLiptruzet
How Ezetimibe, Atorvastatin interacts with David Winston's Lung Relief Cold/Damp — through 2 ingredients. Tap an ingredient for the detail:
Orange Peel ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange Peel Extract + Ezetimibe, Atorvastatin interactionGinger Rhizome ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger Rhizome Extract + Ezetimibe, Atorvastatin interactionFexofenadineAllegra
How Fexofenadine interacts with David Winston's Lung Relief Cold/Damp — through 2 ingredients. Tap an ingredient for the detail:
Orange Peel ExtractOrganic Anion-transporting Polypeptide Substrates (oatp), Fexofenadine (allegra) +1 Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange Peel Extract + Fexofenadine interactionGinger Rhizome ExtractCytochrome P450 3a4 (cyp3a4) Substrates, P-glycoprotein Substrates Moderate
Interaction Summary
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger Rhizome Extract + Fexofenadine interactionFexofenadine, PseudoephedrineAllegra D
How Fexofenadine, Pseudoephedrine interacts with David Winston's Lung Relief Cold/Damp — through 2 ingredients. Tap an ingredient for the detail:
Orange Peel ExtractOrganic Anion-transporting Polypeptide Substrates (oatp), Fexofenadine (allegra) +1 Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange Peel Extract + Fexofenadine, Pseudoephedrine interactionGinger Rhizome ExtractP-glycoprotein Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Ginger might increase the absorption and blood levels of P-glycoprotein (P-gp) substrates.
Read the full Ginger Rhizome Extract + Fexofenadine, Pseudoephedrine interactionFluvastatinLescol, Lescol XL
How Fluvastatin interacts with David Winston's Lung Relief Cold/Damp — through 2 ingredients. Tap an ingredient for the detail:
Orange Peel ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange Peel Extract + Fluvastatin interactionGinger Rhizome ExtractCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, ginger might increase the levels of CYP2C9 substrates.
Read the full Ginger Rhizome Extract + Fluvastatin interactionGatifloxacinTequin, Tequin Injection
How Gatifloxacin interacts with David Winston's Lung Relief Cold/Damp — through 1 ingredient. Tap an ingredient for the detail:
Orange Peel ExtractOrganic Anion-transporting Polypeptide Substrates (oatp), Quinolone Antibiotics Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange Peel Extract + Gatifloxacin interactionGemifloxacinFactive
How Gemifloxacin interacts with David Winston's Lung Relief Cold/Damp — through 1 ingredient. Tap an ingredient for the detail:
Orange Peel ExtractOrganic Anion-transporting Polypeptide Substrates (oatp), Quinolone Antibiotics Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange Peel Extract + Gemifloxacin interactionGlyburideAlbert Glyburide, Diabeta, Glycron, Glynase, Glynase PresTab, Micronase +1 more
How Glyburide interacts with David Winston's Lung Relief Cold/Damp — through 2 ingredients. Tap an ingredient for the detail:
Orange Peel ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange Peel Extract + Glyburide interactionGinger Rhizome ExtractAntidiabetes Drugs, Cytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, taking ginger with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Ginger Rhizome Extract + Glyburide interactionGlyburide, MetforminGlucovance
How Glyburide, Metformin interacts with David Winston's Lung Relief Cold/Damp — through 2 ingredients. Tap an ingredient for the detail:
Orange Peel ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange Peel Extract + Glyburide, Metformin interactionGinger Rhizome ExtractCytochrome P450 2c9 (cyp2c9) Substrates, Antidiabetes Drugs Moderate
Interaction Summary
Theoretically, ginger might increase the levels of CYP2C9 substrates.
Read the full Ginger Rhizome Extract + Glyburide, Metformin interactionGrepafloxacinRaxar
How Grepafloxacin interacts with David Winston's Lung Relief Cold/Damp — through 2 ingredients. Tap an ingredient for the detail:
Orange Peel ExtractOrganic Anion-transporting Polypeptide Substrates (oatp), Quinolone Antibiotics Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange Peel Extract + Grepafloxacin interactionGinger Rhizome ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, ginger might increase the levels of CYP1A2 substrates.
Read the full Ginger Rhizome Extract + Grepafloxacin interactionIrinotecanCamptosar, Onivyde
How Irinotecan interacts with David Winston's Lung Relief Cold/Damp — through 2 ingredients. Tap an ingredient for the detail:
Orange Peel ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange Peel Extract + Irinotecan interactionGinger Rhizome ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger Rhizome Extract + Irinotecan interactionIrinotecan Hydrochloride
How Irinotecan Hydrochloride interacts with David Winston's Lung Relief Cold/Damp — through 2 ingredients. Tap an ingredient for the detail:
Orange Peel ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange Peel Extract + Irinotecan Hydrochloride interactionGinger Rhizome ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger Rhizome Extract + Irinotecan Hydrochloride interactionIsoniazid, Pyrazinamide, RifampinRifater
How Isoniazid, Pyrazinamide, Rifampin interacts with David Winston's Lung Relief Cold/Damp — through 1 ingredient. Tap an ingredient for the detail:
Orange Peel ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange Peel Extract + Isoniazid, Pyrazinamide, Rifampin interactionIsoniazid, RifampinRifamate
How Isoniazid, Rifampin interacts with David Winston's Lung Relief Cold/Damp — through 1 ingredient. Tap an ingredient for the detail:
Orange Peel ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange Peel Extract + Isoniazid, Rifampin interactionIvermectinMectizan, Sklice, Soolantra, Stromectol
How Ivermectin interacts with David Winston's Lung Relief Cold/Damp — through 2 ingredients. Tap an ingredient for the detail:
Orange Peel ExtractP-glycoprotein Substrates, Ivermectin (stromectol, Others) Major
Interaction Summary
Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Read the full Orange Peel Extract + Ivermectin interactionGinger Rhizome ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Ginger might increase the absorption and blood levels of P-glycoprotein (P-gp) substrates.
Read the full Ginger Rhizome Extract + Ivermectin interactionLevofloxacinLeva-pak, Levaquin, Levaquin Injection
How Levofloxacin interacts with David Winston's Lung Relief Cold/Damp — through 1 ingredient. Tap an ingredient for the detail:
Orange Peel ExtractOrganic Anion-transporting Polypeptide Substrates (oatp), Quinolone Antibiotics Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange Peel Extract + Levofloxacin interactionLevofloxacin (ophthalmic)Levofloxacin
How Levofloxacin (ophthalmic) interacts with David Winston's Lung Relief Cold/Damp — through 1 ingredient. Tap an ingredient for the detail:
Orange Peel ExtractOrganic Anion-transporting Polypeptide Substrates (oatp), Quinolone Antibiotics Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange Peel Extract + Levofloxacin (ophthalmic) interactionLomefloxacinMaxaquin
How Lomefloxacin interacts with David Winston's Lung Relief Cold/Damp — through 1 ingredient. Tap an ingredient for the detail:
Orange Peel ExtractOrganic Anion-transporting Polypeptide Substrates (oatp), Quinolone Antibiotics Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange Peel Extract + Lomefloxacin interactionLovastatinAltocor, Mevacor
How Lovastatin interacts with David Winston's Lung Relief Cold/Damp — through 2 ingredients. Tap an ingredient for the detail:
Orange Peel ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange Peel Extract + Lovastatin interactionGinger Rhizome ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger Rhizome Extract + Lovastatin interactionEach ingredient & the kinds of drugs it affects
For each ingredient in David Winston's Lung Relief Cold/Damp with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Ginger Rhizome Extract
Anticoagulant/Antiplatelet Drugs
Ginger may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs. However, research is conflicting.
Laboratory research suggests that ginger inhibits thromboxane synthetase and decreases platelet aggregation. However, this has not been demonstrated unequivocally in humans, with mixed results from clinical trials. Theoretically, excessive amounts of ginger might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Antidiabetes Drugs
Theoretically, taking ginger with antidiabetes drugs might increase the risk of hypoglycemia.
Animal and human research suggests that ginger might increase insulin levels and/or decrease blood glucose levels.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Ginger might increase or decrease the levels of CYP3A4 substrates.
In vitro research and some case reports suggest that ginger inhibits CYP3A4 activity. Three case reports from the World Health Organization (WHO) adverse drug reaction database describe increased toxicity in patients taking ginger and cancer medications that are CYP3A4 substrates (imatinib, dabrafenib, and crizotinib). However, the causality of this interaction is unclear due to the presence of multiple interacting drugs and routes of administration.
Conversely, other in vitro research suggests that ginger induces CYP3A4 activity, leading to reduced levels of CYP3A4 substrates. However, this interaction has not been reported in humans.
Losartan (Cozaar)
Theoretically, ginger might increase levels of losartan and the risk of hypotension.
In animal research, ginger increased the levels and hypotensive effects of a single dose of losartan. It is not clear if ginger alters the concentration or effects of losartan when taken continuously. Additionally, this interaction has not been shown in humans.
Nifedipine (Procardia)
Ginger may have antiplatelet effects and increase the risk of bleeding if used with nifedipine.
Clinical research shows that combined treatment with ginger 1 gram plus nifedipine 10 mg significantly inhibits platelet aggregation when compared to nifedipine or ginger alone.
P-Glycoprotein Substrates
Ginger might increase the absorption and blood levels of P-glycoprotein (P-gp) substrates.
In vitro research and case reports suggest that ginger inhibits drug efflux by P-gp, potentially increasing absorption and serum levels of P-gp substrates. Two case reports from the World Health Organization (WHO) adverse drug reaction database describe increased toxicity in patients taking ginger and cancer medications that are P-gp substrates (trametinib, crizotinib). However, the causality of this interaction is unclear due to the presence of multiple interacting drugs and routes of administration.
Phenprocoumon (Marcoumar, Others)
Ginger might increase the risk of bleeding with phenprocoumon.
Phenprocoumon, a warfarin-related anticoagulant, might increase the international normalized ratio (INR) when taken with ginger. There is one case report of a 76-year-old woman with a stable INR on phenprocoumon that increased to greater than 10 when she began consuming dried ginger and ginger tea.
Warfarin (Coumadin)
Ginger might increase the risk of bleeding with warfarin.
Laboratory research suggests that ginger might inhibit thromboxane synthetase and decrease platelet aggregation. In one case report, ginger increased the INR when taken with phenprocoumon, which has similar pharmacological effects as warfarin. In another case report, ginger increased the INR when taken with a combination of warfarin, hydrochlorothiazide, and acetaminophen. A longitudinal analysis suggests that taking ginger increases the risk of bleeding in patients taking warfarin for at least 4 months. However, research in healthy people suggests that ginger has no effect on INR, or the pharmacokinetics or pharmacodynamics of warfarin. Until more is known, monitor INRs closely in patients taking large amounts of ginger.
Calcium Channel Blockers
Theoretically, taking ginger with calcium channel blockers might increase the risk of hypotension.
Some animal and in vitro research suggests that ginger has hypotensive and calcium channel-blocking effects. Another animal study shows that concomitant administration of ginger and the calcium channel blocker amlodipine leads to greater reductions in blood pressure when compared with amlodipine alone.
Cyclosporine (Neoral, Sandimmune)
Theoretically, when taken prior to cyclosporine, ginger might decrease cyclosporine levels.
In an animal model, ginger juice taken 2 hours prior to cyclosporine administration reduced the maximum concentration and area under the curve of cyclosporine by 51% and 40%, respectively. This effect was not observed when ginger juice and cyclosporine were administered at the same time.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, ginger might increase the levels of CYP1A2 substrates.
In vitro research shows that ginger inhibits CYP1A2 activity. However, this interaction has not been reported in humans.
Cytochrome P450 2B6 (Cyp2B6) Substrates
Theoretically, ginger might increase the levels of CYP2B6 substrates.
In vitro research shows that ginger inhibits CYP2B6 activity. However, this interaction has not been reported in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, ginger might increase the levels of CYP2C9 substrates.
In vitro research shows that ginger inhibits CYP2C9 activity. However, this interaction has not been reported in humans.
Metronidazole (Flagyl)
Theoretically, ginger might increase levels of metronidazole.
In an animal model, ginger increased the absorption and plasma half-life of metronidazole. In addition, the elimination rate and clearance of metronidazole was significantly reduced.
Thyme herb Extract
Anticholinergic Drugs
Theoretically, concurrent use of anticholinergic drugs and thyme essential oil might reduce the effects of anticholinergic drugs.
In vitro evidence suggests that thyme essential oil and specific essential oil constituents like thymohydroquinone and carvacrol can inhibit acetylcholinesterase (AChE). However, this effect has not been observed in humans.
Anticoagulant/Antiplatelet Drugs
Theoretically, thyme leaf extract might have additive effects with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that thyme leaf extract has antiplatelet effects. However, this effect has not been observed in humans.
Cholinergic Drugs
Theoretically, concurrent use of cholinergic drugs and thyme essential oil might cause additive cholinergic effects.
In vitro evidence suggests that thyme essential oil and specific essential oil constituents like thymohydroquinone and carvacrol can inhibit acetylcholinesterase (AChE). However, this effect has not been observed in humans.
Estrogens
Theoretically, thyme might competitively inhibit the effects of estrogen replacement therapy.
In vitro research shows that thyme has estrogen receptor-binding activity and phytoestrogen content. However, this effect has not been observed in humans.
Orange Peel Extract
Celiprolol (Celicard)
Consuming sweet orange with celiprolol can decrease oral absorption of celiprolol.
A pharmacokinetic study in healthy volunteers shows that celiprolol levels, after a single dose of 100 mg, are decreased by up to 90% in people who drink sweet orange juice 200 mL three times daily. It's not known if lower consumption of sweet orange juice will have the same effect. Theoretically, this occurs due to short-term inhibition of organic anion transporting polypeptide (OATP). Recommend separating drug administration and consumption of sweet orange by at least 4 hours.
Ivermectin (Stromectol, Others)
Consuming sweet orange juice with ivermectin can decrease the oral absorption of ivermectin.
A pharmacokinetic study in healthy volunteers shows that taking ivermectin orally with sweet orange juice 750 mL over 4 hours reduces the bioavailability of ivermectin. This effect does not seem to be related to effects on P-glycoprotein. The effect on ivermectin is more pronounced in males compared to females.
Organic Anion-Transporting Polypeptide Substrates (Oatp)
Consuming sweet orange juice can decrease oral absorption of OATP substrates. Separate administration by at least 4 hours.
Clinical research shows that consuming sweet orange juice inhibits OATP, which reduces bioavailability of oral drugs that are substrates of OATP. For example, sweet orange juice decreases bioavailability of fexofenadine, a substrate of OATP, by about 72% and of celiprolol, another OATP substrate, by up to 90%. Since sweet orange juice seems to affect OATP for a short time, recommend separating drug administration and consumption of sweet orange juice by at least 4 hours.
Pravastatin (Pravachol)
Consuming sweet orange juice with pravastatin can increase the absorption of pravastatin.
A small pharmacokinetic study in healthy volunteers shows that consuming sweet orange juice 800 mL over 3 hours, including before, during, and after taking pravastatin 10 mg, increases pravastatin levels by about 149%, without affecting pravastatin elimination. Theoretically this effect might be due to modulation of organic anion transporting polypeptides (OATPs) by sweet orange juice. Sweet orange juice does not seem to affect simvastatin levels, but it is not known if sweet orange affects any of the other statins.
Fexofenadine (Allegra)
Consuming sweet orange juice with fexofenadine can decrease oral absorption of fexofenadine.
Clinical research shows that coadministration of sweet orange juice 1200 mL decreases bioavailability of fexofenadine by about 72%. In an animal model, sweet orange juice decreased bioavailability of fexofenadine by 31%. Fexofenadine manufacturer data indicates that concomitant administration of sweet orange juice and fexofenadine results in larger wheal and flare sizes in research models. This suggests that sweet orange reduces the clinical response to fexofenadine. Theoretically, this occurs due to short-term inhibition of organic anion transporting polypeptide (OATP). Recommend separating drug administration and consumption of sweet orange by at least 4 hours.
P-Glycoprotein Substrates
Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Animal and in vitro research suggest that orange juice extract inhibits drug efflux by P-gp, increasing absorption and levels of P-gp substrates. In contrast, pharmacokinetic research in humans shows that drinking large amounts of sweet orange juice decreases absorption and levels of the P-gp substrate celiprolol. This suggests that orange juice actually induces drug efflux by P-gp or affects drug levels by another mechanism such as inhibiting the gut drug transporter called organic anion transporting polypeptide (OATP). Until more is known, sweet orange juice should be used cautiously in people taking P-gp substrates.
Quinolone Antibiotics
Calcium-fortified sweet orange juice might reduce quinolone absorption.
Calcium binds to quinolones in the gut. Theoretically, the calcium in certain fortified orange juices can also bind to quinolone antibiotics and reduce their absorption and levels.
Yerba Santa leaf extract
Lithium
Yerba santa is thought to have diuretic properties. Theoretically, due to these potential diuretic effects, yerba santa might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.
Brand information
Manufacturer and brand details for David Winston's Lung Relief Cold/Damp, from the product label.
Herbalist & Alchemist
See all Herbalist & Alchemist products- Name
- Herbalist & Alchemist, Inc.
- City
- Washington
- State
- NJ
- ZipCode
- 07882
- Phone Number
- 800-611-8235
- Web Address
- www.herbalist-alchemist.com
David Winston's Lung Relief Cold/Damp by Herbalist & Alchemist: Common Questions
Does David Winston's Lung Relief Cold/Damp by Herbalist & Alchemist interact with any medications?
How can one product interact with so many drugs?
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What are the most common side effects of ginger in this formula?
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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The Full Monographs Behind David Winston's Lung Relief Cold/Damp’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Ginger
Interacts with 1,007 drugsGinger is a widely used culinary spice with a long history in traditional medicine, and it has the strongest evidence for helping with nausea and vomiting, including from motion sickness, pr...
Read the full Ginger monograph → Herb & supplement monographOsha
Osha is a root from a wild mountain plant native to the western United States and Mexico, traditionally used by Native American and Hispanic communities for coughs, colds, and sore throats....
Read the full Osha monograph → Herb & supplement monographSweet Orange
Interacts with 246 drugsSweet orange is a common citrus fruit that is a good source of vitamin C, fiber, and antioxidants, and is enjoyed as a food worldwide. Its peel and essential oil are used in aromatherapy and...
Read the full Sweet Orange monograph → Herb & supplement monographYerba Santa
Interacts with 1 drugYerba Santa is an aromatic shrub from the western United States and Mexico that has long been used in folk medicine for coughs, congestion, and other respiratory complaints. Modern scientifi...
Read the full Yerba Santa monograph → Herb & supplement monographThyme
Interacts with 379 drugsThyme is a common kitchen herb that has long been used for coughs, sore throats, and digestive complaints. It is generally safe in the amounts found in food, and some cough products that com...
Read the full Thyme monograph →Sources & How We Checked
David Winston's Lung Relief Cold/Damp's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 101 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Ginger 64 references
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- Stewart JJ, Wood MJ, Wood CD, Mims ME. Effects of ginger on motion sickness susceptibility and gastric function. Pharmacology 1991;42:111-20. PubMed
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- Portnoi G, Chng LA, Karimi-Tabesh L, et al. Prospective comparative study of the safety and effectiveness of ginger for the treatment of nausea and vomiting in pregnancy. Am J Obstet Gynecol 2003;189:1374-7.. PubMed
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- Ghayur MN, Gilani AH. Ginger lowers blood pressure through blockade of voltage-dependent calcium channels. J Cardiovasc Pharmacol 2005;45:74-80. PubMed
- Thomson M, Al-Qattan KK, Al-Sawan SM, et al. The use of ginger (Zingiber officinale Rosc.) as a potential anti-inflammatory and antithrombotic agent. Prostaglandins Leukot Essent Fatty Acids 2002;67:475-8. PubMed
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- Jiang X, Williams KM, Liauw WS, et al. Effect of ginkgo and ginger on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects. Br J Clin Pharmacol 2005;59:425-32. PubMed
- Borrelli F, Capasso R, Aviello G, et al. Effectiveness and safety of ginger in the treatment of pregnancy-induced nausea and vomiting. Obstet Gynecol 2005;105:849-56. PubMed
- Smith C, Crowther C, Wilson K et al. A randomized controlled trial of ginger to treat nausea and vomiting in pregnancy. Obstet Gynecol 2004;103:639-45. PubMed
- Jiang X, Blair EY, McLachlan AJ. Investigation of the effects of herbal medicines on warfarin response in healthy subjects: a population pharmacokinetic-pharmacodynamic modeling approach. J Clin Pharmacol 2006;46:1370-8. PubMed
- Chittumma P, Kaewkiattikun K, Wiriyasiriwach B. Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. J Med Assoc Thai 2007;90:15-20.
- Ozgoli G, Goli M, Moattar F. Comparison of effects of ginger, mefenamic acid, and ibuprofen on pain in women with primary dysmenorrhea. J Altern Complement Med 2009;15:129-32. PubMed
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- Chiang HM, Chao PD, Hsiu SL, et al. Ginger significantly decreased the oral bioavailability of cyclosporine in rats. Am J Chin Med. 2006;34:845-55. PubMed
- Bhandari U, Kanojia R, Pillai KK. Effect of ethanolic extract of Zingiber officinale on dyslipidaemia in diabetic rats. J Ethnopharmacol. 2005;97:227-30. PubMed
- Ojewole JA. Analgesic, antiinflammatory and hypoglycaemic effects of ethanol extract of Zingiber officinale (Roscoe) rhizomes (Zingiberaceae) in mice and rats. Phytother Res. 2006;20:764-72.
- Al-Amin ZM, Thomson M, Al-Qattan KK, et al. Anti-diabetic and hypolipidaemic properties of ginger (Zingiber officinale) in streptozotocin-induced diabetic rats. Br J Nutr. 2006;96:660-6.
- Islam MS, Choi H. Comparative effects of dietary ginger (Zingiber officinale) and garlic (Allium sativum) investigated in a type 2 diabetes model of rats. J Med Food. 2008;11:152-9.
- Cady RK, Goldstein J, Nett R, et al. A double-blind placebo-controlled pilot study of sublingual feverfew and ginger (LipiGesic M) in the treatment of migraine. Headache 2011;51:1078-86.
- Futrell, J. M. and Rietschel, R. L. Spice allergy evaluated by results of patch tests. Cutis 1993;52(5):288-290.
- Sripramote, M. and Lekhyananda, N. A randomized comparison of ginger and vitamin B6 in the treatment of nausea and vomiting of pregnancy. J Med Assoc.Thai. 2003;86(9):846-853.
- Lohsiriwat, S., Rukkiat, M., Chaikomin, R., and Leelakusolvong, S. Effect of ginger on lower esophageal sphincter pressure. J.Med.Assoc.Thai. 2010;93(3):366-372.
- Liu, P. H. and Ho, H. L. Ginger and drug bezoar induced small bowel obstruction. J R.Coll.Surg.Edinb. 1983;28(6):397-398.
- Maghbooli M, Golipour F, Moghimi Esfandabadi A, Yousefi M. Comparison between the efficacy of ginger and sumatriptan in the ablative treatment of the common migraine. Phytother Res 2014;28(3):412-5. PubMed
- Mahluji S, Attari VE, Mobasseri M, Payahoo L, Ostadrahimi A, Golzari SE. Effects of ginger (Zingiber officinale) on plasma glucose level, HbA1c and insulin sensitivity in type 2 diabetic patients. Int J Food Sci Nutr 2013;64(6):682-6.
- Mozaffari-Khosravi H, Talaei B, Jalali BA, Najarzadeh A, Mozayan MR. The effect of ginger powder supplementation on insulin resistance and glycemic indices in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial. Complement PubMed
- Paramdeep G. Efficacy and tolerability of ginger (Zingiber officinale) in patients of osteoarthritis of knee. Indian J Physiol Pharmacol 2013;57(2):177-83.
- Rahnama P, Montazeri A, Huseini HF, Kianbakht S, Naseri M. Effect of Zingiber officinale R. rhizomes (ginger) on pain relief in primary dysmenorrhea: a placebo randomized trial. BMC Complement Altern Med 2012;12:92. PubMed
- Viljoen E, Visser J, Koen N, Musekiwa A. A systematic review and meta-analysis of the effect and safety of ginger in the treatment of pregnancy-associated nausea and vomiting. Nutr J 2014;13:20. PubMed
- Bartels EM, Folmer VN, Bliddal H, et al. Efficacy and safety of ginger in osteoarthritis patients: a meta-analysis of randomized placebo-controlled trials. Osteoarthritis Cartilage. 2015;23(1):13-21. PubMed
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- Ahad A, Raish M, Bin Jardan YA, Alam MA, Al-Mohizea AM, Al-Jenoobi FI. Effect of Hibiscus sabdariffa and Zingiber officinale on the antihypertensive activity and pharmacokinetic of losartan in hypertensive rats. Xenobiotica. 2020:1-11.
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Osha 2 references
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- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
Sweet Orange 17 references
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- FDA, CFSAN. FDA-approved potassium health claim notification for potassium containing foods. 2000. Available at: www.cfsan.fda.gov/~dms/hclm-k.html.
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- Lilja JJ, Juntti-Patinen L, Neuvonen PJ. Orange juice substantially reduces the bioavailability of the beta-adrenergic-blocking agent celiprolol. Clin Pharmacol Ther 2004;75:184-90.
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Thyme 18 references
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