Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Deflect O Ingredients & Drug Interactions

by D'Adamo Personalized Nutrition

Deflect O label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Deflect O against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Deflect O is a dietary supplement by D'Adamo Personalized Nutrition with 6 active ingredients. Its ingredients are commonly taken for soothing sore throat and cough, digestive upset and constipation, thickening or binding agent in products.Based on those ingredients, 2,207 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Gum Tragacanth, Sodium Alginate, Bladderwrack Seaweed. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Deflect O by D'Adamo Personalized Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Deflect O by D'Adamo Personalized Nutrition — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Deflect O by D'Adamo Personalized Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Deflect O contains six active ingredients. Gum Tragacanth and Sodium Alginate are both hydrocolloidal fibers — thickening agents that form a gel-like substance in your digestive tract.

L-Cysteine is an amino acid that your body uses to make glutathione, an antioxidant. Larch Arabinogalactan is a fiber derived from larch trees.

N-Acetyl D-Glucosamine (NAG) is a form of glucosamine, a building block for cartilage and connective tissue. Bladderwrack Seaweed is a sea vegetable.

The product also contains three inactive ingredients: cellulose, rice extract, and rice concentrate, which serve as fillers and binders in the capsule.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: lectin blocking formula for type O individuals.
  • We looked for evidence on: Joint pain, Knee pain, Osteoarthritis.
  • The strongest evidence on file: Glucosamine is rated "Likely Effective" for Osteoarthritis (Natural Medicines).
  • Also on file: Glucosamine is rated "Insufficient Reliable Evidence To Rate" for Joint pain, Knee pain.

N-Acetyl D-Glucosamine is rated Likely Effective for osteoarthritis, one of the more established uses in our data. For the other ingredients in this product — Gum Tragacanth, Sodium Alginate, L-Cysteine, Larch Arabinogalactan, and Bladderwrack Seaweed — the evidence we hold is insufficient to rate their effectiveness for the conditions they're intended to address, meaning we don't have enough reliable data to confirm whether they work.

The evidence, ingredient by ingredient Tragacanth Algin L-cysteine Larch Arabinogalactan Glucosamine Fucus Vesiculosus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

N-Acetyl D-Glucosamine is generally well tolerated by mouth, with most common side effects being bloating, constipation, cramps, diarrhea, heartburn, and nausea. Rarely, allergic reactions can occur — one review found that 72% of reported adverse events involved hypersensitivity reactions, from mild (itching, hives) to severe, with anaphylaxis reported in 1.5% of cases.

Asthma flare-ups have also been reported. Larch Arabinogalactan can cause bloating and flatulence in some people.

Gum Tragacanth may trigger asthma symptoms in those sensitive to quillaia bark. Regarding pregnancy and breastfeeding: L-Cysteine is rated Likely Safe during pregnancy.

For Gum Tragacanth, the safety data advises against medicinal amounts during pregnancy and breastfeeding. For Sodium Alginate, N-Acetyl D-Glucosamine, and Larch Arabinogalactan, we don't hold enough safety data for pregnancy or breastfeeding — talk with your doctor or pharmacist for personalized guidance.

For Bladderwrack Seaweed, no pregnancy or breastfeeding data is on file.

Side effects, ingredient by ingredient Tragacanth Algin L-cysteine Larch Arabinogalactan Glucosamine Fucus Vesiculosus

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 6 of the 6 matched ingredients can interact with medications — Algin, Tragacanth, Fucus Vesiculosus, Glucosamine, Larch Arabinogalactan, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; lithium.
  • For scale: 2,208 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take warfarin (Coumadin) or any blood thinner, stop — N-Acetyl D-Glucosamine can significantly increase bleeding risk. Chemotherapy drugs like etoposide or doxorubicin need a check too, as glucosamine may reduce their effect.

Immunosuppressants (drugs to prevent transplant rejection), antidiabetes drugs, and any regular oral medication should be reviewed, since multiple ingredients in this product can alter how they work. Check each one with your pharmacist before you start.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Deflect O is mainly of interest if you're looking at N-Acetyl D-Glucosamine for osteoarthritis support, which has some evidence behind it. But if you take warfarin, any immunosuppressants, chemotherapy, or antidiabetes drugs, you'll want to check with your pharmacist first — the interactions here are real.

Even if you don't take prescription medications, it's worth a quick search below to be sure.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Deflect O, straight from the product label.

Brand D'Adamo Personalized Nutrition
Net contents 120 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jun 22, 2023
DSLD ID 287134
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Deflect O by D'Adamo Personalized Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
IngredientAmount% DV
Gum Tragacanth100 mg--
Sodium Alginate400 mg--
L-Cysteine100 mg--
Larch Arabinogalactan200 mg--
N-Acetyl D-Glucosamine500 mg--
Bladderwrack Seaweed200 mg--

Other ingredients: Cellulose, Rice extract, Rice concentrate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Right for your type O Lectin blocking formula designed for type 0 individuals

FDA Statement of Identity

Dietary Supplement

Formulation

Stearate free encapsulation

Dr. Peter D'Adamo has identified dietary lectins (proteins found in many common food) as an important influence on the body's immune system and metabolism. As a result of this research, he has designed specific 'lectin blocking' formulas to help support the body's immune system and metabolism.

This product contains no sugar, salt, gluten, wheat, yeast, corn, soy, eggs or dairy, no preservatives, color or flavors, and no artificial ingredients.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Contains crustacean from N-acetyl D-glucosamine (isolated from crab shell)

Suggested/Recommended/Usage/Directions

Directions: Two (2) capsules 2-3 daily with meals as a dietary supplement or as directed by a physician.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Deflect O by D'Adamo Personalized Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Deflect O label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Deflect O by D'Adamo Personalized Nutrition

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Gum Tragacanth

Interacts with
2,022 drugs
100 mg per serving

Tragacanth is a plant gum used mainly as a thickener and emulsifier in foods, cosmetics, and medicines, and traditionally to soothe the throat and gut...

Gum Tragacanth monograph & interactions

Sodium Alginate

Interacts with
2,022 drugs
400 mg per serving

Algin (alginate) is a fiber-like substance from brown seaweed that is widely used as a thickener, gel, and binder in foods and medicines. Its best-kno...

Sodium Alginate monograph & interactions

L-Cysteine

Interacts with
86 drugs
100 mg per serving

L-cysteine is a sulfur-containing amino acid your body uses to make proteins and the antioxidant glutathione. Most people get enough from food, and su...

L-Cysteine monograph & interactions

Larch Arabinogalactan

Interacts with
121 drugs
200 mg per serving

Larch arabinogalactan is a soluble fiber from larch trees that is mainly used as a prebiotic and for immune support. Early research is interesting but...

Larch Arabinogalactan monograph & interactions

N-Acetyl D-Glucosamine

Interacts with
170 drugs
500 mg per serving

Glucosamine is a natural compound found in cartilage and joint fluid, and it is one of the most popular supplements for osteoarthritis, especially of...

N-Acetyl D-Glucosamine monograph & interactions

Bladderwrack Seaweed

Interacts with
891 drugs
200 mg per serving

Fucus vesiculosus (bladderwrack) is a brown seaweed rich in iodine that has been used traditionally for thyroid concerns, weight, and skin. There is l...

Bladderwrack Seaweed monograph & interactions

Other (inactive) ingredients: Cellulose, Rice extract, Rice concentrate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Deflect O by D'Adamo Personalized Nutrition Drug Interactions

Want to check YOUR meds against Deflect O?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,207Drugs
2 Major 2,127 Moderate 78 Minor

Ingredients driving the most interactions

Gum Tragacanth 2,022
Sodium Alginate 2,022
Bladderwrack Seaweed 891
N-Acetyl D-Glucosamine 170
Larch Arabinogalactan 121

Individual Drug Interactions

The ingredients in Deflect O interact with 2,207 drugs. Click any drug to see the details.

6 of the 6 ingredients in Deflect O interact with drugs. Each result below shows which ingredient is responsible. Gum Tragacanth Sodium Alginate Bladderwrack Seaweed N-Acetyl D-Glucosamine Larch Arabinogalactan L-Cysteine

Each ingredient & the kinds of drugs it affects

For each ingredient in Deflect O with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Gum Tragacanth1 drug type · 2,022 drugs

Oral Drugs

Theoretically, tragacanth might alter absorption of oral drugs.
Tragacanth contains hydrocolloidal fiber which can decrease, increase, or not affect oral drug absorption. To avoid changes in absorption, take tragacanth 30-60 minutes after oral medications.

Likelihood Possible Evidence D
Gum Tragacanth full monograph & interactions

Sodium Alginate1 drug type · 2,022 drugs

Oral Drugs

Theoretically, algin can alter the absorption of oral drugs. Laboratory research shows that algin, when consumed as part of the diet or used as a thickening agent in infant formula, reduces the absorption of certain minerals. Also, algin has been used as a tablet binder and disintegrant to enhance drug bioavailability. To avoid changes in absorption, take algin 30-60 minutes after oral medications.

Likelihood Possible Evidence D
Sodium Alginate full monograph & interactions

Bladderwrack Seaweed9 drug types · 891 drugs

Amiodarone (Cordarone)

Theoretically, combining Fucus vesiculosus with amiodarone might cause excessively high iodine levels.
Fucus vesiculosus contains high concentrations of iodine. Amiodarone contains 37.3% iodine and can increase iodine levels. Concomitant use might increase the risk of having excessive iodine levels and adversely affecting thyroid function. Monitor thyroid function.

Likelihood Probable Evidence D
Antithyroid Drugs

Due to its iodine content, Fucus vesiculosus might alter the effects of antithyroid drugs.
Fucus vesiculosus contains high concentrations of iodine. Iodine in high doses has been reported to cause both hyperthyroidism and hypothyroidism, depending on the individual's past medical history. Taking Fucus vesiculosus while using antithyroid drugs could alter the effects of the antithyroid drugs.

Likelihood Possible Evidence D
Lithium

Concomitant use of Fucus vesiculosus and lithium has resulted in hyperthyroidism.
There is a case of hyperthyroidism occurring in a patient taking Fucus vesiculosus and lithium. Monitor thyroid hormones closely in patients taking lithium and Fucus vesiculosus concomitantly.

Likelihood Possible Evidence D
Thyroid Hormone

Due to its iodine content, Fucus vesiculosus might alter the effects of thyroid hormone.
Fucus vesiculosus contains high concentrations of iodine. Iodine in high doses has been reported to cause both hyperthyroidism and hypothyroidism, depending on the individual's past medical history. Taking Fucus vesiculosus while using thyroid hormone could alter the effects of thyroid hormone.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, taking Fucus vesiculosus with antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
In vitro evidence suggests that a constituent of Fucus vesiculosus, known as fucoidan, has anticoagulant effects. However, in clinical research, fucoidan does not seem to have significant anticoagulant activity when taken orally, possibly due to poor absorption.

Likelihood Unlikely Evidence D
Cytochrome P450 2C8 (Cyp2C8) Substrates

Theoretically, concomitant use of Fucus vesiculosus with CYP2C8 substrates might increase the risk for adverse effects.
In vitro research shows that fucoidan, a constituent of Fucus vesiculosus, inhibits CYP2C8. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, concomitant use of Fucus vesiculosus with CYP2C9 substrates might increase the risk for adverse effects.
In vitro research shows that fucoidan, a constituent of Fucus vesiculosus, inhibits CYP2C9. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, concomitant use of Fucus vesiculosus with CYP2D6 substrates might alter the effects of these substrates.
In vitro research shows that fucoidan, a constituent of Fucus vesiculosus, both inhibits and induces CYP2D6. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, concomitant use of Fucus vesiculosus with CYP3A4 substrates might increase the risk for adverse effects.
In vitro research shows that fucoidan, a constituent of Fucus vesiculosus, inhibits CYP3A4. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Bladderwrack Seaweed full monograph & interactions

N-Acetyl D-Glucosamine4 drug types · 170 drugs

Warfarin (Coumadin)

Glucosamine might increase the anticoagulant effects of warfarin and increase the risk of bruising and bleeding.
In two individual case reports, glucosamine/chondroitin combinations were associated with a significant increase in international normalized ratio (INR) in patients previously stabilized on warfarin. In one case, the increase in INR occurred only after tripling the dose of a glucosamine/chondroitin supplement from 500 mg/400 mg daily to 1500/1200 mg daily. Additionally, 20 voluntary case reports to the U.S. Food & Drug Administration (FDA) have linked glucosamine plus chondroitin with increased INR, bruising, and bleeding in patients who were also taking warfarin. There have also been 20 additional case reports to the World Health Organization (WHO) that link glucosamine alone to increased INR in patients taking warfarin. The mechanism of this interaction is unclear. Glucosamine is a small component of heparin, but is not thought to have anticoagulant activity; however, animal research suggests that it might have antiplatelet activity.

Likelihood Probable Evidence D
Topoisomerase Ii Inhibitors

Theoretically glucosamine may induce resistance to topoisomerase II inhibitors.
In vitro research suggests that glucosamine might induce resistance to etoposide (VP16, VePesid) and doxorubicin (Adriamycin) by reducing inhibition of topoisomerase II, an enzyme required for DNA replication in tumor cells. This effect has not been reported in humans.

Likelihood Possible Evidence D
Acetaminophen (Tylenol, Others)

Acetaminophen might interfere with the activity of glucosamine sulfate by interacting with the sulfate portion.
Anecdotal reports suggest that adding glucosamine to an acetaminophen regimen might decrease pain control in patients with osteoarthritis. Some research suggests that the sulfate portion of glucosamine sulfate might contribute to its effect in osteoarthritis. Since acetaminophen metabolism requires sulfur and reduces serum sulfate concentrations, acetaminophen could theoretically interfere with the action of glucosamine sulfate. Conversely, the administration of sulfate could theoretically decrease the effectiveness of acetaminophen in sulfate-deficient people by increasing its clearance.

Likelihood Possible Evidence B
Antidiabetes Drugs

Despite initial concerns, it is unlikely that glucosamine will interfere with the effects of antidiabetes drugs.
In vitro and animal research has suggested that glucosamine might increase insulin resistance or decrease insulin production. This has raised concerns that taking glucosamine might worsen diabetes and decrease the effectiveness of diabetes drugs. However, clinical research suggests that glucosamine does not have adverse effects on blood glucose or glycated hemoglobin (HbA1C) in healthy, obese, or type 2 diabetes patients.

Likelihood Unlikely Evidence B
N-Acetyl D-Glucosamine full monograph & interactions

Larch Arabinogalactan1 drug type · 121 drugs

Immunosuppressants

Theoretically, larch arabinogalactan might interfere with immunosuppression therapy due to immunostimulant effects. Immunosuppressant drugs include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), corticosteroids (glucocorticoids), and other drugs.

Likelihood Possible Evidence D
Larch Arabinogalactan full monograph & interactions

L-Cysteine1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking L-cysteine supplements with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that L-cysteine can have hypoglycemic effects.

Likelihood Possible Evidence D
L-Cysteine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Deflect O, from the product label.

D'Adamo Personalized Nutrition

See all D'Adamo Personalized Nutrition products
Name
North American Pharmacal, Inc.
Street Address
149 Water Street, 1st FL
City
Norwalk
State
CT
ZipCode
06854
Phone Number
1-877-266-8973
Web Address
www.4yourtype.com
Pharmacist Counseling Corner

Deflect O by D'Adamo Personalized Nutrition: Common Questions

Does Deflect O by D'Adamo Personalized Nutrition interact with any medications?
Yes. Based on its ingredients, Deflect O has a known interaction with 2,207 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Deflect O contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is N-Acetyl D-Glucosamine in this product the same as glucosamine sulfate?
No — this product contains N-Acetyl D-Glucosamine (NAG), which is a different form of glucosamine. The interaction data we hold for glucosamine covers the form in this product, so it applies to Deflect O.
What are the most common side effects I might notice?
If you experience side effects, they're most likely to be bloating, constipation, cramps, diarrhea, heartburn, or nausea from the N-Acetyl D-Glucosamine. Larch Arabinogalactan can also cause bloating and flatulence in some people.
Can I take this if I'm pregnant?
L-Cysteine is rated Likely Safe during pregnancy, but we don't hold enough safety data for the other ingredients to say yes or no either way. Talk with your doctor or pharmacist for personalized advice based on your situation.
Can I take this if I'm breastfeeding?
Safety data for breastfeeding is limited or absent for most ingredients in this product. Gum Tragacanth advises against medicinal amounts while breastfeeding. Check with your doctor or pharmacist before using it.
Does this product have any fillers or other inactive ingredients?
Yes — it contains cellulose, rice extract, and rice concentrate as inactive ingredients to bind and fill the capsule.
Will this help my osteoarthritis?
N-Acetyl D-Glucosamine, the form in this product, is rated Likely Effective for osteoarthritis based on our data. The evidence for the other ingredients in Deflect O is insufficient to say they work for their intended uses.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Deflect O label
Go deeper

The Full Monographs Behind Deflect O’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tragacanth

Interacts with 2,022 drugs

Tragacanth is a plant gum used mainly as a thickener and emulsifier in foods, cosmetics, and medicines, and traditionally to soothe the throat and gut. There is very little solid human resea...

Read the full Tragacanth monograph → Herb & supplement monograph

Algin

Interacts with 2,022 drugs

Algin (alginate) is a fiber-like substance from brown seaweed that is widely used as a thickener, gel, and binder in foods and medicines. Its best-known medical use is in heartburn products,...

Read the full Algin monograph → Herb & supplement monograph

L-cysteine

Interacts with 86 drugs

L-cysteine is a sulfur-containing amino acid your body uses to make proteins and the antioxidant glutathione. Most people get enough from food, and supplements are usually well tolerated, bu...

Read the full L-cysteine monograph → Herb & supplement monograph

Larch Arabinogalactan

Interacts with 121 drugs

Larch arabinogalactan is a soluble fiber from larch trees that is mainly used as a prebiotic and for immune support. Early research is interesting but limited, and most claims are not yet fi...

Read the full Larch Arabinogalactan monograph → Herb & supplement monograph

Glucosamine

Interacts with 170 drugs

Glucosamine is a natural compound found in cartilage and joint fluid, and it is one of the most popular supplements for osteoarthritis, especially of the knee. The evidence is mixed, with so...

Read the full Glucosamine monograph → Herb & supplement monograph

Fucus Vesiculosus

Interacts with 891 drugs

Fucus vesiculosus (bladderwrack) is a brown seaweed rich in iodine that has been used traditionally for thyroid concerns, weight, and skin. There is little solid human evidence to support mo...

Read the full Fucus Vesiculosus monograph →
Sources

Sources & How We Checked

Deflect O's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 88 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tragacanth 2 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

See these in context on the Tragacanth monograph →

Algin 3 references
  1. Harmuth-Hoene, A. E. and Schelenz, R. Effect of dietary fiber on mineral absorption in growing rats. J Nutr 1980;110(9):1774-1784. PubMed
  2. Bosscher D, Van Caillie-Bertrand M, Deelstra H. Effect of thickening agents, based on soluble dietary fiber, on the availability of calcium, iron, and zinc from infant formulas. Nutrition. 2001;17(7-8):614-8. PubMed
  3. Beneke CE, Viljoen AM, Hamman JH. Polymeric plant-derived excipients in drug delivery. Molecules. 2009;14(7):2602-20. PubMed

See these in context on the Algin monograph →

L-cysteine 2 references
  1. Dowlati Y, Maheux M, Meyer JH. The effect of oral L-cysteine on breast milk and plasma cysteine concentrations. Neuropsychiatr Dis Treat 2020;16:3163-3172.
  2. Lee S, Han KH, Nakamura Y, et al. Dietary L-cysteine improves the antioxidative potential and lipid metabolism in rats fed a normal diet. Biosci Biotechnol Biochem 2013;77(7):1430-4.

See these in context on the L-cysteine monograph →

Larch Arabinogalactan 8 references
  1. D'Adamo P. Larch arabinogalactan. J Naturopath Med 1996;6:33-7.
  2. Kelly GS. Larch arabinogalactan: Clinical relevance of a novel immune-enhancing polysaccharide. Alt Med Rev 1999;4:96-103.
  3. Marett R, Slavin JL. No long-term benefits of supplementation with arabinogalactan on serum lipids and glucose. J Am Diet Assoc 2004;104:636-9.
  4. Robinson RR, Feirtag J, Slavin JL. Effects of dietary arabinogalactan on gastrointestinal and blood parameters in healthy human subjects. J Am Coll Nutr 2001;20:279-85. PubMed
  5. Udani JK, Singh BB, Barrett ML, Singh VJ. Proprietary arabinogalactan extract increases antibody response to the pneumonia vaccine: a randomized, double-blind, placebo-controlled, pilot study in healthy volunteers. Nutr J 2010;9:32. PubMed
  6. Grube B, Stier H, Riede L, Gruenwald J. Tolerability of a proprietary larch arabinogalactan extract: a randomized, double-blind, placebo-controlled clinical trial in healthy subjects. Food Nutr Sci 2012;3:1533-8. DOI
  7. Dion C, Chappuis E, Ripoll C. Does larch arabinogalactan enhance immune function? A review of mechanistic and clinical trials. Nutr Metab (Lond) 2016;13:28. PubMed
  8. Riede L, Grube B, Gruenwald J. Larch arabinogalactan effects on reducing incidence of upper respiratory tract infections. Curr Med Res Opin 2013;29(3):251-8.

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Glucosamine 58 references
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Fucus Vesiculosus 15 references
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  15. Mathew L, Burney M, Gaikwad A, et al. Preclinical evaluation of safety of fucoidan extracts from Undaria pinnatifida and Fucus vesiculosus for use in cancer treatment. Integr Cancer Ther 2017;16(4):572-84.

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