Major interaction on record — check this product against your medications before combining. Based on 6 of 14 ingredients. Check your meds →
Dietary supplement

Devigest ADS 400 mg Ingredients & Drug Interactions

by Arthur Andrew Medical

Devigest ADS 400 mg label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Devigest ADS 400 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Devigest ADS 400 mg is a dietary supplement by Arthur Andrew Medical with 14 active ingredients. Its ingredients are commonly taken for bone health and osteoporosis prevention, dietary calcium deficiency, heartburn relief (calcium carbonate antacids).Based on those ingredients, 209 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Calcium, Potassium, Papain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Devigest ADS 400 mg by Arthur Andrew Medical

Ask about any prescription or over-the-counter medication and we check it for interactions with Devigest ADS 400 mg by Arthur Andrew Medical — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Devigest ADS 400 mg by Arthur Andrew Medical

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 3 of its 14 active ingredients.
  • “Devigest Proprietary Blend” is a proprietary blend — the label gives one combined amount (638 mg) without saying how much of each component you get.

Devigest ADS contains 14 ingredients, including the active minerals calcium and potassium, plus several digestive enzymes: amylase (which breaks down starch), papain (from papaya, breaks down protein), protease, lipase (breaks down fat), lactase (breaks down milk sugar), cellulase, peptidase, glucoamylase, alpha-galactosidase, and xylanase. It also includes hemicellulase and a proprietary blend labeled Devigest.

The capsule itself contains cellulose as an inactive ingredient.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: digestive support and gluten/casein tolerance.
  • We looked for evidence on: Celiac disease, Dyspepsia, Lactose intolerance, food sensitivity, gluten sensitivity, casein sensitivity.
  • The strongest evidence on file: Lactase is rated "Effective" for Lactose intolerance (Natural Medicines).
  • Also on file: Calcium is rated "Effective" for Dyspepsia.
  • Also on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia, Celiac disease.

Calcium in this product is effective for kidney failure, dyspepsia (indigestion), hypocalcemia (low blood calcium), hyperkalemia (high potassium), and likely effective for osteoporosis. For the digestive enzymes—papain, protease, lipase, lactase, and the others—the evidence is either insufficient to rate their effectiveness or we hold no rating data.

Lactase alone is effective for lactose intolerance.

The evidence, ingredient by ingredient Calcium Potassium Papain Proteolytic Enzymes (proteases) Lipase Lactase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Calcium is generally well-tolerated at recommended doses, though high doses can cause problems. Common side effects from calcium are belching, constipation, diarrhea, flatulence, and stomach upset.

Rare serious concerns include kidney stones and calciphylaxis; there is also concern that very high doses (over 2,000 mg daily) might increase prostate cancer risk and that calcium intake above recommended levels may be linked to cardiovascular disease, though research on this has been debated. Papain is generally tolerated as a food but supplements may irritate the digestive tract and cause allergic reactions (itchy eyes, runny nose, sneezing, abdominal cramps); high doses may be unsafe, rarely causing esophageal perforation or severe inflammation.

Protease, lipase, and lactase are generally well-tolerated but may cause digestive upset or allergic reactions in sensitive people. Potassium is well-tolerated from food but supplemental potassium can cause dangerously high blood levels, especially in people with kidney disease; high levels can cause heart rhythm problems, low blood pressure, and mental confusion.

Side effects, ingredient by ingredient Calcium Potassium Papain Proteolytic Enzymes (proteases) Lipase Lactase

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 3 of the 6 matched ingredients can interact with medications — Papain, Calcium, Potassium.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; heart-rhythm medications; lithium.
  • For scale: 209 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, check with your pharmacist or doctor if you use intravenous ceftriaxone (an antibiotic—Major risk), dolutegravir or elvitegravir for HIV (Major risk, calcium blocks them), any blood-pressure drug including potassium-sparing diuretics, ACE inhibitors, or ARBs (Moderate risk of high potassium), warfarin (a blood thinner, Moderate risk from papain), levothyroxine for thyroid (Moderate risk, calcium blocks it), or heart medications like diltiazem or sotalol (Moderate risk). These are the drug types where interaction data is documented; if you're on any of these, bring the bottle to your pharmacy before you start.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product's main concern is its calcium and potassium content—both interact with several common blood-pressure and heart medications, HIV drugs, thyroid medication, and blood thinners. If you take any prescription medication, especially for blood pressure, heart rhythm, HIV, thyroid function, or blood thinning, check your exact drugs with the tool on this page or talk with your pharmacist or doctor before starting.

The digestive enzymes are generally well-tolerated, but the mineral interactions are significant enough that you need personalized guidance before taking this.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 14 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 19, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Devigest ADS 400 mg, straight from the product label.

Brand Arthur Andrew Medical
Barcode (UPC) 855571001273
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD May 19, 2022
DSLD ID 263463
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Devigest ADS 400 mg by Arthur Andrew Medical, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
4 Capsule(s)
Servings per container
90
UPC/BARCODE
855571001273
IngredientAmount% DV
Calcium24 mg1.8%
Amylase0 NP--
Papain0 NP--
Protease0 NP--
Lipase0 NP--
Lactase0 NP--
Cellulase0 NP--
Peptidase0 NP--
Glucoamylase0 NP--
Alpha-Galactosidase0 NP--
Xylanase0 NP--
Hemicellulase0 NP--
Potassium20 mg0.4%
Devigest Proprietary Blend638 mg--
Devigest Protease Blend52 mg--

Other ingredients: Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Devigest Advanced Digestive Support works with your digestive system to support comfortable digestion. Devigest features a unique Dipeptyl Peptidase (DPPIV) enzyme that specifically targets gluten and casein. It has also been enhanced to function over a broad pH range, allowing for complete digestion throughout the entire digestive system. Large amounts of lactase are included for adequate digestion of dairy sugars, and alpha galactosidase has been added to support the digestion of gassy foods, decreasing the amount of flatulence, abdominal bloating and digestive discomfort.

Advanced digestive support Devigest Supports: Normalized gluten tolerance Reduced food irritations/sensitivities Complete food assimilation Healthy gastrointestinal pH Reduced occasional gas/bloating Pharmaceutical grade

Devigest is free of dairy, gluten, and soy allergens. Contains no artificial colors or preservatives.

Non GMO

AVA Certified Vegetarian American Vegetarian Association

Suggested/Recommended/Usage/Directions

Suggested Use: Take Devigest with 8 oz of water at the beginning of each meal or as directed by your healthcare practitioner. Additional capsules may be taken during periods of occasional discomfort. Daily Maintenance: 1-2 capsules per meal. Increased Support: 4 capsules per meal.

FDA Statement of Identity

Dietary Supplement

Precautions

Keep out of reach of children.

Storage

Store in a cool dry place with lid tightly closed.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

AVA Certified Vegetarian American Vegetarian Association Star-K (Kosher) GRAS Generally Recognized as Safe

Formula

Star-K (Kosher)

General Statements

For more information about the benefits of Devigest, please call 800-448-5015, visit www.arthurandandrew.com or write to: Arthur Andrew Medical, 8350 E Raintree dr #101 Scottsdale, AZ 85260.

Brand IP Statement(s)

Copyright Arthur Andrew Medical Inc.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Devigest ADS 400 mg by Arthur Andrew Medical label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Devigest ADS 400 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Devigest ADS 400 mg by Arthur Andrew Medical

These are the 14 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Calcium

Interacts with
168 drugs
24 mg per serving Form: Calcium Carbonate

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet f...

Calcium monograph & interactions

Potassium

Interacts with
62 drugs
20 mg per serving Form: Potassium Bicarbonate

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Potassium monograph & interactions

Devigest Proprietary Blend

638 mg per serving
  • › Amylase
  • › Papain
  • › Protease
  • › Lipase
  • › Lactase
  • › Cellulase
  • › Peptidase
  • › Glucoamylase
  • › Alpha-Galactosidase
  • › Xylanase
  • › Hemicellulase

Devigest Protease Blend

52 mg per serving Form: Protease

Other (inactive) ingredients: Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Devigest ADS 400 mg by Arthur Andrew Medical Drug Interactions

Want to check YOUR meds against Devigest ADS 400 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
209Drugs
7 Major 188 Moderate 14 Minor

Ingredients driving the most interactions

Calcium 168
Potassium 62
Papain 2

Individual Drug Interactions

The ingredients in Devigest ADS 400 mg interact with 209 drugs. Click any drug to see the details.

3 of the 14 ingredients in Devigest ADS 400 mg interact with drugs. Each result below shows which ingredient is responsible. Calcium Potassium Papain

Each ingredient & the kinds of drugs it affects

For each ingredient in Devigest ADS 400 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Calcium18 drug types · 168 drugs

Ceftriaxone (Rocephin)

Co-administration of intravenous calcium and ceftriaxone can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys.
Avoid administering intravenous calcium in any form, such as parenteral nutrition or Lactated Ringers, within 48 hours of intravenous ceftriaxone. Case reports in neonates show that administering intravenous ceftriaxone and calcium can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys. In several cases, neonates have died as a result of this interaction. So far there are no reports in adults; however, there is still concern that this interaction might occur in adults.

Likelihood Probable Evidence D
Dolutegravir (Tivicay)

Calcium seems to reduce levels of dolutegravir.
Advise patients to take dolutegravir either 2 hours before or 6 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium carbonate 1200 mg concomitantly with dolutegravir 50 mg reduces plasma levels of dolutegravir by almost 40%. Calcium appears to decrease levels of dolutegravir through chelation.

Likelihood Probable Evidence B
Elvitegravir (Vitekta)

Calcium seems to reduce levels of elvitegravir.
Advise patients to take elvitegravir either 2 hours before or 2 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium along with elvitegravir can reduce blood levels of elvitegravir through chelation.

Likelihood Probable Evidence B
Aluminum

Calcium citrate might increase aluminum absorption and toxicity. Other types of calcium do not increase aluminum absorption.
Calcium citrate can increase the absorption of aluminum when taken with aluminum hydroxide. The increase in aluminum levels may become toxic, particularly in individuals with kidney disease. However, the effect of calcium citrate on aluminum absorption is due to the citrate anion rather than calcium cation. Calcium acetate does not appear to increase aluminum absorption.

Likelihood Possible Evidence B
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Calcium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and calcium can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, calcium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Calcium reduces the absorption of bisphosphonates.
Advise patients to take bisphosphonates at least 30 minutes before calcium, but preferably at a different time of day. Calcium supplements decrease absorption of bisphosphonates.

Likelihood Probable Evidence C
Calcipotriene (Dovonex)

Taking calcipotriene with calcium might increase the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with calcium supplements might increase the risk of hypercalcemia.

Likelihood Possible Evidence B
Digoxin (Lanoxin)

Using intravenous calcium with digoxin might increase the risk of fatal cardiac arrhythmias.
Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. However, one retrospective analysis of clinical data suggests that intravenous calcium does not increase the risk of dysrhythmias or mortality in patients receiving digoxin.

Likelihood Possible Evidence B
Diltiazem (Cardizem, Others)

Theoretically, calcium may reduce the therapeutic effects of diltiazem.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, calcium might increase this risk of hypercalcemia and reduce the effectiveness of diltiazem.

Likelihood Probable Evidence D
Levothyroxine (Synthroid, Others)

Calcium seems to reduce the absorption and effectiveness of levothyroxine.
Advise patients to take levothyroxine and calcium supplements at least 4 hours apart. Calcium reduces levothyroxine absorption, probably by forming insoluble complexes. Calcium carbonate supplements reduce effectiveness of levothyroxine in patients with hypothyroidism.

Likelihood Probable Evidence B
Lithium

Theoretically, concomitant use of calcium and lithium may increase this risk of hypercalcemia.
Clinical research suggests that long-term use of lithium may cause hypercalcemia in 10% to 60% of patients. Theoretically, concomitant use of lithium and calcium supplements may further increase this risk.

Likelihood Possible Evidence B
Quinolone Antibiotics

Calcium seems to reduce the absorption of quinolone antibiotics.
Advise patients to take oral quinolones at least 2 hours before or 4-6 hours after calcium supplements or calcium-fortified foods. Taking calcium at the same time as oral quinolones can reduce quinolone absorption. Calcium binds to quinolones in the gut.

Likelihood Probable Evidence B
Raltegravir (Isentress)

Calcium may reduce levels of raltegravir.
Pharmacokinetic research shows that taking a single dose of calcium carbonate 3000 mg along with raltegravir 400 mg twice daily modestly decreases the mean area under the curve of raltegravir, but the decrease does not necessitate a dose adjustment of raltegravir. However, a case of elevated HIV-1 RNA levels and documented resistance to raltegravir has been reported for a patient taking calcium carbonate 1 gram three times daily plus vitamin D3 (cholecalciferol) 400 IU three times daily in combination with raltegravir 400 mg twice daily for 11 months. It is thought that calcium reduced raltegravir levels by chelation, leading to treatment failure.

Likelihood Possible Evidence B
Sotalol (Betapace)

Calcium seems to reduce the absorption of sotalol.
Advise patients to separate doses by at least 2 hours before or 4-6 hours after calcium. Calcium appears to reduce the absorption of sotalol, probably by forming insoluble complexes.

Likelihood Possible Evidence B
Tetracycline Antibiotics

Calcium seems to reduce the absorption of tetracycline antibiotics.
Advise patients to take oral tetracyclines at least 2 hours before, or 4-6 hours after calcium supplements. Taking calcium at the same time as oral tetracyclines can reduce tetracycline absorption. Calcium binds to tetracyclines in the gut.

Likelihood Probable Evidence C
Thiazide Diuretics

Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Thiazides reduce calcium excretion by the kidneys. Using thiazides along with moderately large amounts of calcium carbonate increases the risk of milk-alkali syndrome (hypercalcemia, metabolic alkalosis, renal failure). Patients may need to have their serum calcium levels and/or parathyroid function monitored regularly.

Likelihood Probable Evidence C
Verapamil (Calan, Others)

Theoretically, calcium may reduce the therapeutic effects of verapamil.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, use of calcium supplements may increase this risk of hypercalcemia and reduce the effectiveness of verapamil.

Likelihood Probable Evidence D
Calcium Channel Blockers

Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.
Intravenous calcium is used to decrease the effects of calcium channel blockers in the management of overdose. Intravenous calcium gluconate has been used before intravenous verapamil (Isoptin) to prevent or reduce the hypotensive effects without affecting the antiarrhythmic effects. But there is no evidence that dietary or supplemental calcium when taken orally interacts with calcium channel blockers.

Likelihood Unlikely Evidence D
Calcium full monograph & interactions

Potassium3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
Potassium full monograph & interactions

Papain1 drug type · 2 drugs

Warfarin (Coumadin)

Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papain full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Devigest ADS 400 mg, from the product label.

Arthur Andrew Medical

See all Arthur Andrew Medical products
Name
Arthur Andrew Medical
Street Address
8350 E Raintree Dr #101
City
Scottsdale
State
AZ
ZipCode
85260
Phone Number
800-448-5015
Web Address
www.arthurandrew.com
Pharmacist Counseling Corner

Devigest ADS 400 mg by Arthur Andrew Medical: Common Questions

Does Devigest ADS 400 mg by Arthur Andrew Medical interact with any medications?
Yes. Based on its ingredients, Devigest ADS 400 mg has a known interaction with 209 medications, including 7 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Devigest ADS 400 mg contains 14 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is calcium safe during pregnancy and breastfeeding?
The data shows calcium is likely safe in pregnancy when you stay within recommended amounts—adequate calcium is important during pregnancy—unless your doctor advises otherwise. During breastfeeding, calcium needs can be met through diet; use recommended amounts and check with your provider. For the other ingredients in this product, safety data during pregnancy and breastfeeding is limited or absent, so talk with your doctor before taking it while pregnant or nursing.
What are the digestive enzymes in this supposed to do?
The product contains several digestive enzymes: amylase breaks down starch, papain and protease break down protein, lipase breaks down fat, and lactase breaks down milk sugar. The evidence for how well most of these work in supplement form is insufficient or not established in our data. Lactase is effective for lactose intolerance.
Can papain cause side effects?
Papain is generally tolerated as a food, but supplements may irritate your digestive tract. Common side effects from papain supplements are allergic reactions—itchy watery eyes, runny nose, sneezing, abdominal cramps, sweating, and diarrhea—in people sensitive to it. High doses may be unsafe and could rarely cause serious stomach problems like esophageal perforation.
Is this product safe for people with kidney disease?
This product contains both calcium and potassium. Potassium supplements can cause dangerously high blood levels in people with kidney disease, so you should not take this without medical guidance if you have kidney problems. Talk with your doctor or pharmacist before starting.
Can I take this with my blood-pressure medication?
It depends on which medication you take. The potassium in this product increases the risk of dangerously high potassium levels if you're on potassium-sparing diuretics, ACE inhibitors, or ARBs—all common blood-pressure drugs. Calcium also interacts with some heart and blood-pressure medications. Check your exact prescription with your pharmacist or doctor before starting this product.
What common side effects does calcium cause?
The most common side effects from oral calcium are belching, constipation, diarrhea, flatulence, and stomach upset. These are usually mild if you're taking it as directed.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Devigest ADS 400 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Devigest ADS 400 mg label
Go deeper

The Full Monographs Behind Devigest ADS 400 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Calcium

Interacts with 168 drugs

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet falls short. Most people do best getting...

Read the full Calcium monograph → Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph → Herb & supplement monograph

Papain

Interacts with 2 drugs

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...

Read the full Papain monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph → Herb & supplement monograph

Lactase

Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...

Read the full Lactase monograph →
Sources

Sources & How We Checked

Devigest ADS 400 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 90 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Calcium 62 references
  1. Shils M, Olson A, Shike M. Modern Nutrition in Health and Disease. 8th ed. Philadelphia, PA: Lea and Febiger, 1994.
  2. Hernandez-Avila M, Gonzalez-Cossio T, Hernandez-Avila JE, et al. Dietary calcium supplements to lower blood lead levels in lactating women: a randomized placebo-controlled trial. Epidemiology 2003;14:206-12.. PubMed
  3. Thys-Jacobs S, Ceccarelli S, Bierman A, et al. Calcium supplementation in premenstrual syndrome: a randomized crossover trial. J Gen Intern Med 1989;4:183-9. PubMed
  4. Maton PN, Burton ME. Antacids revisited: a review of their clinical pharmacology and recommended therapeutic use. Drugs 1999;57:855-70.
  5. Clemens JD, Feinstein AR. Calcium carbonate and constipation: a historical review of medical mythopoeia. Gastroenterology 1977;72:957-61. DOI
  6. Saunders D, Sillery J, Chapman R. Effect of calcium carbonate and aluminum hydroxide on human intestinal function. Dig Dis Sci 1988;33:409-13. PubMed
  7. Friedman PA, Bushinsky DA. Diuretic effects on calcium metabolism. Semin Nephrol 1999;19:551-6.
  8. Koo WK, Walters JC, Esterlitz J, et al. Maternal calcium supplementation and fetal bone mineralization. Obstet Gynecol 1999;94:577-82. DOI
  9. Raman L, Rajalakshmi K, Krishnamachari KAVR, et al. Effect of calcium supplementation to undernourished mothers during pregnancy on the bone density of the neonates. Am J Clin Nutr 1978; 31:466-9. DOI
  10. Murry JJ, Healy MD. Drug-mineral interactions: a new responsibility for the hospital dietician. J Am Diet Assoc 1991;91:66-73.
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Lipase 1 reference
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Lactase 1 reference
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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