Interactions on record — worth a quick check against your medications. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

Digest Keto Ingredients & Drug Interactions

by Enzymedica

Digest Keto label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Digest Keto against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Digest Keto is a dietary supplement by Enzymedica with 3 active ingredients. Its ingredients are commonly taken for digestive health and bloating, diarrhea support, immune support.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bacillus subtilis. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Digest Keto by Enzymedica

Ask about any prescription or over-the-counter medication and we check it for interactions with Digest Keto by Enzymedica — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Digest Keto by Enzymedica

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “Protein Digestion” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Fat Digestion” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Digest Keto contains three active ingredients. Lipase is an enzyme that helps break down dietary fats.

Bacillus subtilis is a beneficial bacterium (a probiotic strain) intended to support digestive health. The product also contains proprietary blends called Protein Digestion and Fat Digestion, which contain their own component enzymes.

The inactive ingredients are cellulose and water.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: fat and protein digestion support.
  • We looked for evidence on: Constipation, Dyspepsia, Flatulence, Pancreatitis, Indigestion, Bloating — and 2 related terms.
  • The closest evidence on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia (Natural Medicines).
  • Also on file: Bacillus Subtilis is rated "Insufficient Reliable Evidence To Rate" for Constipation, Dyspepsia, Flatulence, Pancreatitis.

The evidence supporting these ingredients is limited. Bacillus subtilis is rated possibly effective for antibiotic-associated diarrhea—that's the one condition where there's some evidence it may help.

For everything else in this product—including lipase for indigestion or other digestive complaints, and Bacillus subtilis for constipation, athletic performance, diabetes, and eczema—the evidence we hold is insufficient to rate whether it works.

The evidence, ingredient by ingredient Bacillus Subtilis Lipase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lipase is generally well tolerated in supplement form, though people with serious digestive conditions should use it only under medical guidance. No adverse effects have been reported in adults, though a thorough safety evaluation hasn't been done.

Bacillus subtilis is generally well tolerated in healthy adults, but quality and safety can vary by product and strain. Headache and diarrhea have been reported rarely.

There isn't enough safety data on either ingredient during pregnancy or breastfeeding, so check with your doctor or pharmacist for personalized advice before use. We don't have safety data on file for Keto Thera-Blend.

Side effects, ingredient by ingredient Bacillus Subtilis Lipase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Bacillus Subtilis.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Antibiotic drugs are the main medication type to watch—taking them at the same time as this product may make the Bacillus subtilis less effective. Separate the doses, and ask your doctor or pharmacist how long apart to space them.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product may be worth considering if you're looking for digestive enzyme support, though the evidence for most uses is still limited. If you take antibiotics, make sure to talk with your doctor or pharmacist before starting—timing matters.

Anyone with serious digestive conditions should check with their doctor first. Run your exact medications through the search tool on this page to be sure.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Digest Keto, straight from the product label.

Brand Enzymedica
Barcode (UPC) 670480251157
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Aug 23, 2023
DSLD ID 296525
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Digest Keto by Enzymedica, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
670480251157
IngredientAmount% DV
Lipase0 NP--
Bacillus subtilis0 NP--
Protein Digestion0 NP--
Fat Digestion0 NP--
Keto Thera-Blend0 NP--

Other ingredients: Cellulose, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Enzymedica Natural Digestive Health & Wellness

Formulation

Digest Keto for Fat & Protein Digestion Supports quick digestion for Keto Diets Relief of occasional constipation

Non GMO Certified by NSF

Vegan

2 capsules Digest these Keto staples: 1 Florida Avocado 31g of fat 9 g of protein 3 large eggs 14g of fat 19g of protein 6 strips bacon 21g of fat 18g of protein About 75 Almonds 43g of fat 16g of protein Lipase and Keto therapy-blends break down up to 44g fat and 20g protein, respectively.

Contains no gluten, milk, casein, soy, egg, artificial colors or flavors.

Ultimate Results Each serving quickly breaks down and optimizes up to 20g of protein and 44g of fat Occasional Constipation Relief Probiotic powered to relieve occasional constipation Muscle Support Keto Thera-blend to support protein digestion and nutrient absorption

Seals/Symbols

Non GMO Certified by NSF

FDA Statement of Identity

Dietary Supplement

General Statements

Nutrition Source: USDA Food Composition Database by National Agriculture Library v.3.9.5.3_2019-06-13

Enzymedica supports AHA Autism Hope Alliance Green Mountain Energy Vitamin Angels Proud supporter

Suggested/Recommended/Usage/Directions

Recommended use: 2 capsules with each meal.

Storage

Keep closed in a dry place; avoid excessive heat.

Precautions

Do not use if safety seal is broken or missing.

Please keep out of reach of children

Formula

Keto Diet Support

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Digest Keto by Enzymedica label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Digest Keto label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Digest Keto by Enzymedica

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Bacillus subtilis

Interacts with
182 drugs
0 NP per serving

Bacillus subtilis is a spore-forming probiotic bacterium found in soil and some fermented foods, and it is used mainly to support gut health and diges...

Bacillus subtilis monograph & interactions

Protein Digestion

0 NP per serving
  • › Keto Thera-Blend

Fat Digestion

0 NP per serving

Other (inactive) ingredients: Cellulose, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Digest Keto by Enzymedica Drug Interactions

Want to check YOUR meds against Digest Keto?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Bacillus subtilis 182

Individual Drug Interactions

The ingredients in Digest Keto interact with 182 drugs. Click any drug to see the details.

1 of the 3 ingredients in Digest Keto interact with drugs. Each result below shows which ingredient is responsible. Bacillus subtilis

Each ingredient & the kinds of drugs it affects

For each ingredient in Digest Keto with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bacillus subtilis1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B. subtilis.
Since B. subtilis preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. subtilis preparations by at least 2 hours.

Likelihood Probable Evidence D
Bacillus subtilis full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Digest Keto, from the product label.

Enzymedica

See all Enzymedica products
Name
Enzymedica, Inc.
Street Address
771 Commerce Drive
City
Venice
State
FL
ZipCode
34292-1731
Phone Number
1-888-918-1118
Web Address
www.enzymedica.com
Pharmacist Counseling Corner

Digest Keto by Enzymedica: Common Questions

Does Digest Keto by Enzymedica interact with any medications?
Yes. Based on its ingredients, Digest Keto has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Digest Keto contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm on antibiotics?
The antibiotic may kill the live Bacillus subtilis in this supplement, so it won't work as intended. Talk with your doctor or pharmacist about timing your doses separately—they can tell you how far apart to take them.
Is this safe to use during pregnancy or breastfeeding?
There isn't enough safety data on either lipase or Bacillus subtilis during pregnancy or breastfeeding to know one way or the other. Check with your doctor or pharmacist for personalized advice before taking it.
What does lipase do?
Lipase is an enzyme that helps break down fats from food so your body can digest and absorb them better.
Does this actually work for digestive issues?
The evidence is limited. Bacillus subtilis is rated possibly effective for diarrhea that follows antibiotic use, but for other digestive complaints like indigestion or constipation, we don't have enough evidence to say whether it works.
What's Bacillus subtilis?
It's a live, beneficial bacterium—a probiotic strain—intended to support your digestive health and gut balance.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Digest Keto is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Digest Keto label
Go deeper

The Full Monographs Behind Digest Keto’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bacillus Subtilis

Interacts with 182 drugs

Bacillus subtilis is a spore-forming probiotic bacterium found in soil and some fermented foods, and it is used mainly to support gut health and digestion. Early research is promising for ce...

Read the full Bacillus Subtilis monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph →
Sources

Sources & How We Checked

Digest Keto's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Bacillus Subtilis 10 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Lampropoulos PK, Gkentzi D, Tzifas S, Dimitriou G. Neonatal sepsis due to Bacillus subtilis. Cureus 2021;13(9):e17692. PubMed
  3. La Jeon Y, Yang JJ, Kim MJ, et al. Combined Bacillus licheniformis and Bacillus subtilis infection in a patient with oesophageal perforation. J Med Microbiol 2012;61(Pt 12):1766-1769. PubMed
  4. Wallet F, Crunelle V, Roussel-Delvallez M, Fruchart A, Saunier P, Courcol RJ. Bacillus subtilis as a cause of cholangitis in polycystic kidney and liver disease. Am J Gastroenterol 1996;91(7):1477-8.
  5. Velasco E, Martins CA, Tabak D, Bouzas LF. "Bacillus subtilis" infection in a patient submitted to a bone marrow transplantation. Rev Paul Med 1992;110(3):116-7.
  6. Kato A, Yoshifuji A, Komori K, et al. A case of Bacillus subtilis var. natto bacteremia caused by ingestion of natto during COVID-19 treatment in a maintenance hemodialysis patient with multiple myeloma. J Infect Chemother 2022;28(8):1212-1215. PubMed
  7. Freedman KE, Hill JL, Wei Y, et al. Examining the gastrointestinal and immunomodulatory effects of the novel probiotic Bacillus subtilis DE111. Int J Mol Sci 2021;22(5):2453. PubMed
  8. Lefevre M, Racedo SM, Denayrolles M, et al. Safety assessment of Bacillus subtilis CU1 for use as a probiotic in humans. Regul Toxicol Pharmacol 2017;83:54-65. PubMed
  9. Hanifi A, Culpepper T, Mai V, et al. Evaluation of Bacillus subtilis R0179 on gastrointestinal viability and general wellness: a randomised, double-blind, placebo-controlled trial in healthy adults. Benef Microbes 2015;6(1):19-27. PubMed
  10. Tokano M, Tarumoto N, Imai K, et al. A case of bacterial meningitis caused by Bacillus subtilis var. natto. Intern Med. 2022. Epub ahead of print.

See these in context on the Bacillus Subtilis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team