Interactions on record — worth a quick check against your medications. Based on 5 of 20 ingredients. Check your meds →
Dietary supplement

DigesTech Ingredients & Drug Interactions

by Onnit

DigesTech label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking DigesTech against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

DigesTech is a dietary supplement by Onnit with 20 active ingredients. Its ingredients are commonly taken for nausea and vomiting, motion sickness, morning sickness in pregnancy.Based on those ingredients, 1,015 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Ginger Root Extract, Fennel. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against DigesTech by Onnit

Ask about any prescription or over-the-counter medication and we check it for interactions with DigesTech by Onnit — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of DigesTech by Onnit

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 5 of its 20 active ingredients.
  • “DigesTech Power Blend” is a proprietary blend — the label gives one combined amount (500 mg) without saying how much of each component you get.

DigesTech contains 20 ingredients designed to break down different food components. The active digestive enzymes include protease (breaks down protein), lipase (breaks down fat), lactase (breaks down milk sugar), various carbohydrate-digesting enzymes (amylase, cellulase, glucoamylase, xylanase, and others), and serratiopeptidase.

The product also includes ginger root extract and fennel for digestive support. Several ingredients—amylase, serratiopeptidase, cellulase, invertase, glucoamylase, xylanase, pectinase, maltase, beta-glucanase, hemicellulase, alpha-galactosidase, bacillus amylase, and AstraZyme—we cannot verify fully because we lack detailed data on them.

The capsules also contain inactive ingredients: rice dextrin, hydroxypropyl methylcellulose (the capsule shell), water, Nu-Flow, and medium-chain triglyceride.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: support healthy gut flora and optimal digestion.
  • We looked for evidence on: Colic, Constipation, Diarrhea, Dyspepsia, Flatulence, Inflammatory bowel disease (IBD) — and 4 related terms.
  • The strongest evidence on file: Lactase is rated "Effective" for Lactose intolerance (Natural Medicines).
  • Also on file: Ginger is rated "Possibly Effective" for Pregnancy-induced nausea and vomiting.
  • Also on file: Ginger is rated "Possibly Ineffective" for Chemotherapy-induced nausea and vomiting (CINV).

The evidence for these ingredients is mixed and incomplete. Lactase is effective for lactose intolerance.

Ginger root extract is possibly effective for pregnancy-related nausea, menstrual pain (dysmenorrhea), and osteoarthritis, though it appears possibly ineffective for exercise-related muscle soreness and chemotherapy nausea. Fennel is possibly effective for menstrual pain.

For most of the other enzymes in this product—protease, lipase, pepsin, and the rest—we either have no effectiveness data on file or the evidence is insufficient to rate them for digestive support or other uses.

The evidence, ingredient by ingredient Ginger Proteolytic Enzymes (proteases) Fennel Lipase Lactase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

The digestive enzymes in DigesTech are generally well tolerated by most adults, though some people may experience mild digestive upset or allergic reactions. Protease, pepsin, and acid-stable protease may rarely trigger allergic reactions in sensitive individuals, especially those with occupational exposure to enzyme powders.

Ginger is generally well tolerated at typical supplement doses, though doses above 5 grams per day increase the risk of side effects like heartburn, diarrhea, and mouth irritation. Fennel is generally safe as a food but requires caution at higher supplement doses.

Lactase is generally well tolerated when used as directed, though rare cases of allergic reactions have been reported. For pregnancy, ginger is likely safe and possibly safe for morning sickness (check with your doctor first), and lactase is likely safe.

However, safety data is limited or absent for protease, pepsin, acid-stable protease, and lipase during pregnancy—use only if your doctor advises it. Fennel is possibly unsafe during pregnancy due to its hormone-like effects and limited safety data.

During breastfeeding, there is little safety data for protease, pepsin, acid-stable protease, and lipase—ask your doctor or pharmacist before use. Ginger is likely safe while breastfeeding, but fennel is possibly unsafe.

For amylase, serratiopeptidase, cellulase, invertase, glucoamylase, xylanase, pectinase, maltase, beta-glucanase, hemicellulase, alpha-galactosidase, bacillus amylase, and AstraZyme, we have no pregnancy or breastfeeding safety data on file.

Side effects, ingredient by ingredient Ginger Proteolytic Enzymes (proteases) Fennel Lipase Lactase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 5 matched ingredients can interact with medications — Fennel, Ginger.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,016 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking DigesTech, double-check with your doctor or pharmacist if you're on blood thinners (anticoagulants like warfarin) or antiplatelet drugs—ginger increases bleeding risk. Also verify if you take diabetes medications (ginger may lower blood sugar), blood-pressure-lowering drugs like losartan (ginger may increase the effect), birth control pills or hormone replacement therapy (fennel may weaken these), ciprofloxacin or other fluoroquinolone antibiotics (fennel may reduce their effectiveness), cancer drugs that use the CYP3A4 pathway (ginger may affect their levels), or tamoxifen (fennel's estrogenic effects may interfere).

No interactions are documented for the other digestive enzymes we could fully check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

DigesTech is a multi-enzyme digestive aid best suited for people seeking general digestive support or those with specific needs like lactose intolerance. If you take blood thinners, diabetes medications, blood-pressure drugs, birth control pills, hormone replacement therapy, or any cancer medications, talk with your doctor or pharmacist before adding this product—the ginger and fennel may affect how those medications work.

Even if you take no medications, a quick conversation with your pharmacist can help you figure out if these enzymes are right for your digestion.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 20 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about DigesTech, straight from the product label.

Brand Onnit
Net contents 15 Packet(s)
Market status On market
Date entered into DSLD Sep 25, 2023
DSLD ID 295152
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for DigesTech by Onnit, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
15
IngredientAmount% DV
Amylase0 NP--
Protease0 NP--
Serratiopeptidase250 mg--
Lipase0 NP--
Lactase0 NP--
Cellulase0 NP--
Invertase0 NP--
Glucoamylase0 NP--
Xylanase0 NP--
Pectinase0 NP--
Maltase0 NP--
Beta-Glucanase0 NP--
Hemicellulase0 NP--
Ginger Root Extract125 mg--
Pepsin130 mg--
Alpha-Galactosidase0 NP--
Fennel125 mg--
acid stable Protease0 NP--
DigesTech Power Blend500 mg--
Bacillus Amylase0 NP--
AstraZyme50 mg--

Other ingredients: Rice Dextrin, Hydroxypropyl Methylcellulose, Water, Nu-Flow, Medium Chain Triglyceride

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Probiotics HCL Enzymes

Probiotics 10 Billion Colony Forming Units At the time of manufacture

Healthy gut biome A gut biome of friendly probiotic bacteria is not only important for digestion, it is also where a great deal of our important nutrients are produced. In addition, these all-important little allies are also responsible for maintaining a healthy immune system. In order to support the gut biome, we include five acid-resistant strains of probiotics, along with S. boulardii and prebiotic food to feed our little buddies.

Essential prebiotics Prebiotics are essential to help support the prebiotic colonies inside your gut. We include one of the best, Jerusalem artichoke, in our formula and complemented it with dandelion. Five Strains of Probiotics Probiotic bacteria are responsible for not only heaping digestion, but also for optimizing mood and supporting immune function. We added five of the most important acid-resistant probiotic strains: L. acidophilus DDS-1, L. plantarum, L. rhamnosus, B. infantis and B. lactis. Saccharomyces boulardii S. boulardii is a unique non-pathogenic, non-colonizing probiotic yeast that supports gastrointestinal health by promoting the production of secretory Immunoglobulin A. With five billion colony-forming units per capsule and its ability to survive stomach acid, this was an ingredient we just couldn't leave out. Digestive Enzymes Our flagship proteolytic enzyme blend, DigesTech, offers assistance with the digestion of all five major categories: fats, protein, dairy, fiber, and carbohydrates. Betaine HCL Hydrochloric acid is the stomach's innate way to assist with the breakdown of food. In combination with enzymes, our betaine HCl forms a potent 1-2 punch to support normal stomach acid function and to support digestion and nutrient absorption.

Formulation

Supplement packets Formulated to help support healthy gut flora & optimal digestion

Unique formula designed to Break down food & absorb nutrients Support the immune system Help support healthy gut flora Digest major macronutrients

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use Adults, as a dietary supplement, take one packet with your largest meal of the day.

Precautions

Consult a medical doctor before taking this or any other nutritional supplement if you are pregnant, nursing, have or suspect a medical condition or are taking any medications.

Keep out of reach of children.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

DigesTech by Onnit label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

DigesTech label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in DigesTech by Onnit

These are the 20 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container15 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Serratiopeptidase

250 mg per serving

Ginger Root Extract

Interacts with
1,007 drugs
125 mg per serving

Ginger is a widely used culinary spice with a long history in traditional medicine, and it has the strongest evidence for helping with nausea and vomi...

Ginger Root Extract monograph & interactions

Pepsin

No known
interactions
130 mg per serving

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Pepsin monograph & interactions

Fennel

Interacts with
740 drugs
125 mg per serving

Fennel is a Mediterranean herb widely used as a food and spice, and traditionally taken for digestive complaints, colic, and menstrual cramps. Some sm...

Fennel monograph & interactions

DigesTech Power Blend

500 mg per serving
  • › Amylase
  • › Protease
  • › Lipase
  • › Lactase
  • › Cellulase
  • › Invertase
  • › Glucoamylase
  • › Xylanase
  • › Pectinase
  • › Maltase
  • › Beta-Glucanase
  • › Hemicellulase
  • › Alpha-Galactosidase
  • › Acid stable Protease
  • › Bacillus Amylase

AstraZyme

50 mg per serving Form: Astragalus Root Extract, Protease, Tienchi Root Extract, Trace Minerals

Other (inactive) ingredients: Rice Dextrin, Hydroxypropyl Methylcellulose, Water, Nu-Flow, Medium Chain Triglyceride. These complete the product’s ingredient list but are not active constituents.

Interaction report

DigesTech by Onnit Drug Interactions

Want to check YOUR meds against DigesTech?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,015Drugs
882 Moderate 133 Minor

Ingredients driving the most interactions

Ginger Root Extract 1,007
Fennel 740

Individual Drug Interactions

The ingredients in DigesTech interact with 1,015 drugs. Click any drug to see the details.

2 of the 20 ingredients in DigesTech interact with drugs. Each result below shows which ingredient is responsible. Ginger Root Extract Fennel

Each ingredient & the kinds of drugs it affects

For each ingredient in DigesTech with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Ginger Root Extract14 drug types · 1,007 drugs

Anticoagulant/Antiplatelet Drugs

Ginger may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs. However, research is conflicting.
Laboratory research suggests that ginger inhibits thromboxane synthetase and decreases platelet aggregation. However, this has not been demonstrated unequivocally in humans, with mixed results from clinical trials. Theoretically, excessive amounts of ginger might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, taking ginger with antidiabetes drugs might increase the risk of hypoglycemia.
Animal and human research suggests that ginger might increase insulin levels and/or decrease blood glucose levels.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Ginger might increase or decrease the levels of CYP3A4 substrates.
In vitro research and some case reports suggest that ginger inhibits CYP3A4 activity. Three case reports from the World Health Organization (WHO) adverse drug reaction database describe increased toxicity in patients taking ginger and cancer medications that are CYP3A4 substrates (imatinib, dabrafenib, and crizotinib). However, the causality of this interaction is unclear due to the presence of multiple interacting drugs and routes of administration.
Conversely, other in vitro research suggests that ginger induces CYP3A4 activity, leading to reduced levels of CYP3A4 substrates. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Losartan (Cozaar)

Theoretically, ginger might increase levels of losartan and the risk of hypotension.
In animal research, ginger increased the levels and hypotensive effects of a single dose of losartan. It is not clear if ginger alters the concentration or effects of losartan when taken continuously. Additionally, this interaction has not been shown in humans.

Likelihood Possible Evidence D
Nifedipine (Procardia)

Ginger may have antiplatelet effects and increase the risk of bleeding if used with nifedipine.
Clinical research shows that combined treatment with ginger 1 gram plus nifedipine 10 mg significantly inhibits platelet aggregation when compared to nifedipine or ginger alone.

Likelihood Possible Evidence B
P-Glycoprotein Substrates

Ginger might increase the absorption and blood levels of P-glycoprotein (P-gp) substrates.
In vitro research and case reports suggest that ginger inhibits drug efflux by P-gp, potentially increasing absorption and serum levels of P-gp substrates. Two case reports from the World Health Organization (WHO) adverse drug reaction database describe increased toxicity in patients taking ginger and cancer medications that are P-gp substrates (trametinib, crizotinib). However, the causality of this interaction is unclear due to the presence of multiple interacting drugs and routes of administration.

Likelihood Possible Evidence D
Phenprocoumon (Marcoumar, Others)

Ginger might increase the risk of bleeding with phenprocoumon.
Phenprocoumon, a warfarin-related anticoagulant, might increase the international normalized ratio (INR) when taken with ginger. There is one case report of a 76-year-old woman with a stable INR on phenprocoumon that increased to greater than 10 when she began consuming dried ginger and ginger tea.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Ginger might increase the risk of bleeding with warfarin.
Laboratory research suggests that ginger might inhibit thromboxane synthetase and decrease platelet aggregation. In one case report, ginger increased the INR when taken with phenprocoumon, which has similar pharmacological effects as warfarin. In another case report, ginger increased the INR when taken with a combination of warfarin, hydrochlorothiazide, and acetaminophen. A longitudinal analysis suggests that taking ginger increases the risk of bleeding in patients taking warfarin for at least 4 months. However, research in healthy people suggests that ginger has no effect on INR, or the pharmacokinetics or pharmacodynamics of warfarin. Until more is known, monitor INRs closely in patients taking large amounts of ginger.

Likelihood Possible Evidence B
Calcium Channel Blockers

Theoretically, taking ginger with calcium channel blockers might increase the risk of hypotension.
Some animal and in vitro research suggests that ginger has hypotensive and calcium channel-blocking effects. Another animal study shows that concomitant administration of ginger and the calcium channel blocker amlodipine leads to greater reductions in blood pressure when compared with amlodipine alone.

Likelihood Unlikely Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically, when taken prior to cyclosporine, ginger might decrease cyclosporine levels.
In an animal model, ginger juice taken 2 hours prior to cyclosporine administration reduced the maximum concentration and area under the curve of cyclosporine by 51% and 40%, respectively. This effect was not observed when ginger juice and cyclosporine were administered at the same time.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, ginger might increase the levels of CYP1A2 substrates.
In vitro research shows that ginger inhibits CYP1A2 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, ginger might increase the levels of CYP2B6 substrates.
In vitro research shows that ginger inhibits CYP2B6 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, ginger might increase the levels of CYP2C9 substrates.
In vitro research shows that ginger inhibits CYP2C9 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Metronidazole (Flagyl)

Theoretically, ginger might increase levels of metronidazole.
In an animal model, ginger increased the absorption and plasma half-life of metronidazole. In addition, the elimination rate and clearance of metronidazole was significantly reduced.

Likelihood Possible Evidence D
Ginger Root Extract full monograph & interactions

Fennel6 drug types · 740 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, fennel might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.

Animal research suggests that fennel oil has antithrombotic and antiplatelet effects.

Likelihood Possible Evidence D
Ciprofloxacin (Cipro)

Theoretically, fennel might decrease the levels and clinical effects of ciprofloxacin.

Animal research shows that fennel reduces ciprofloxacin bioavailability by nearly 50%, possibly due to the metal cations such as calcium, iron, and magnesium contained in fennel. This study also found that fennel increased tissue distribution and slowed elimination of ciprofloxacin.

Likelihood Probable Evidence D
Contraceptive Drugs

Theoretically, taking large amounts of fennel might decrease the effects of contraceptive drugs due to competition for estrogen receptors.

Some constituents of fennel have estrogenic activity.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.

In vitro research suggests that fennel inhibits CYP3A4 enzyme activity. This effect has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, taking large amounts of fennel might interfere with hormone replacement therapy due to competition for estrogen receptors.

Some constituents of fennel have estrogenic activity.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, taking large amounts of fennel might decrease the antiestrogenic effect of tamoxifen.

Some constituents of fennel have estrogenic activity, which may interfere with the antiestrogenic activity of tamoxifen.

Likelihood Possible Evidence D
Fennel full monograph & interactions
The maker

Brand information

Manufacturer and brand details for DigesTech, from the product label.

Onnit

See all Onnit products
Name
Onnit Labs, LLC
City
Austin
State
Texas
ZipCode
78744
Phone Number
(855) 666-4899
Pharmacist Counseling Corner

DigesTech by Onnit: Common Questions

Does DigesTech by Onnit interact with any medications?
Yes. Based on its ingredients, DigesTech has a known interaction with 1,015 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
DigesTech contains 20 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is ginger in this product safe if I take warfarin or another blood thinner?
No—ginger can increase your bleeding risk when combined with blood thinners. You must talk with your doctor or pharmacist before taking DigesTech if you're on warfarin, phenprocoumon, or any anticoagulant or antiplatelet medication. They can advise whether this product is right for you.
Will this help me digest lactose if I'm lactose intolerant?
Yes, lactase is effective for lactose intolerance and is one of the enzymes in this product. However, the product contains multiple other enzymes beyond lactase, so if you only need help with lactose, you could ask your pharmacist about single-ingredient lactase options.
Can I take this while pregnant?
Ginger in the product is likely safe for morning sickness, but fennel is possibly unsafe during pregnancy due to its hormone-like effects and limited safety data. You should talk with your doctor before taking DigesTech while pregnant so they can advise based on your specific situation.
What does the ginger in this do?
Ginger is possibly effective for pregnancy-related nausea, menstrual pain, and osteoarthritis. It's included in DigesTech partly for its digestive support properties, though the evidence for digestive enzymes themselves is incomplete for many uses.
Will this interfere with my birth control pills?
Fennel, one of the ingredients, may theoretically decrease the effects of birth control pills due to its hormone-like activity. Talk with your doctor or pharmacist before starting this product if you rely on hormonal contraception so you can plan accordingly.
Can I take this with my diabetes medication?
Ginger in the product may increase insulin levels or lower blood sugar, raising the risk of hypoglycemia (low blood sugar) if you're on diabetes drugs. Check with your doctor or pharmacist before taking DigesTech so they can monitor you or adjust your dose if needed.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if DigesTech is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

DigesTech label
Go deeper

The Full Monographs Behind DigesTech’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Ginger

Interacts with 1,007 drugs

Ginger is a widely used culinary spice with a long history in traditional medicine, and it has the strongest evidence for helping with nausea and vomiting, including from motion sickness, pr...

Read the full Ginger monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Fennel

Interacts with 740 drugs

Fennel is a Mediterranean herb widely used as a food and spice, and traditionally taken for digestive complaints, colic, and menstrual cramps. Some small studies suggest possible benefit for...

Read the full Fennel monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph → Herb & supplement monograph

Lactase

Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...

Read the full Lactase monograph →
Sources

Sources & How We Checked

DigesTech's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 86 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Lactase 1 reference
  1. Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed

See these in context on the Lactase monograph →

Ginger 64 references
  1. Fischer-Rasmussen W, Kjaer SK, Dahl C, Asping U. Ginger treatment of hyperemesis gravidarum. Eur J Obstet Gynecol Reprod Biol 1991;38:19-24. PubMed
  2. Jewell D, Young G. Interventions for nausea and vomiting in early pregnancy. Cochrane Database Syst Rev 2000;(2):CD000145. PubMed
  3. Vutyavanich T, Kraisarin T, Ruangsri R. Ginger for nausea and vomiting in pregnancy: randomized, double-masked, placebo-controlled trial. Obstet Gynecol 2001;97:577-82. DOI
  4. Backon J. Ginger in preventing nausea and vomiting of pregnancy; a caveat due to its thromboxane synthetase activity and effect on testosterone binding. Eur J Obstet Gynecol Reprod Biol 1991;42:163-4. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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