Major interaction on record — check this product against your medications before combining. Based on 6 of 13 ingredients. Check your meds →
Dietary supplement

Digestive Bitters Maple Ingredients & Drug Interactions

by Urban Moonshine

Digestive Bitters Maple label
See full label image
Liquid Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Digestive Bitters Maple against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Digestive Bitters Maple is a dietary supplement by Urban Moonshine with 13 active ingredients. Its ingredients are commonly taken for water retention (diuretic), digestive upset, liver and gallbladder support.Based on those ingredients, 1,184 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are org. Ginger, org. Fennel, org. Dandelion. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Digestive Bitters Maple by Urban Moonshine

Ask about any prescription or over-the-counter medication and we check it for interactions with Digestive Bitters Maple by Urban Moonshine — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Digestive Bitters Maple by Urban Moonshine

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 13 active ingredients.
  • “Proprietary Blend (Combination)” is a proprietary blend — the label doesn't break down how much of each component you get.

This liquid formula contains 13 ingredients, of which dandelion, burdock, yellow dock, ginger, fennel, and gentian are the active herbal components — each traditionally used to support digestion and stimulate appetite. The product also contains water, alcohol (as a preservative), gum arabic, essential oils, and maple syrup for flavor and texture.

There are no inactive fillers listed.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: optimize digestive function and support liver health.
  • We looked for evidence on: Dyspepsia, Flatulence, Nausea and vomiting, Constipation, Gastritis, Gastroesophageal reflux disease (GERD) — and 4 related terms.
  • The strongest evidence on file: Ginger is rated "Possibly Effective" for Pregnancy-induced nausea and vomiting (Natural Medicines).
  • Also on file: Ginger is rated "Possibly Ineffective" for Chemotherapy-induced nausea and vomiting (CINV).
  • Also on file: Fennel is rated "Insufficient Reliable Evidence To Rate" for Constipation, Dyspepsia, Flatulence, Irritable bowel syndrome (IBS), and more.

The evidence we hold doesn't establish that this product works for any specific condition. For its individual ingredients: ginger shows possibly effective evidence for pregnancy-related nausea and vomiting and menstrual cramps, and possibly effective for osteoarthritis — but fennel shows possibly effective evidence only for menstrual cramps.

For the other active ingredients — dandelion, burdock, yellow dock, and gentian — we have insufficient reliable evidence to rate their effectiveness for the conditions studied. As a digestive bitter formula, the product's traditional role is to stimulate digestive secretions and appetite, but clinical evidence for that claim isn't documented in our data.

The evidence, ingredient by ingredient Dandelion Burdock Yellow Dock Ginger Fennel Gentian

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of these ingredients are generally well tolerated at food amounts in healthy adults. However, ginger is the safest among them — it's likely safe in pregnancy and lactation at moderate doses, though you should check with your doctor first if you're pregnant.

Dandelion is well tolerated as food but may cause diarrhea, heartburn, or stomach upset at supplement doses; allergy is possible, especially in people sensitive to ragweed or related plants. Burdock is likely safe as a food and short-term in healthy adults, but has limited human safety data; avoid medicinal amounts in pregnancy and while breastfeeding.

Yellow dock is the most cautious ingredient — it acts as a laxative and contains compounds that can build up if overused, potentially causing low potassium, kidney stones, or calcium loss; avoid it in pregnancy and while nursing. Fennel and gentian are less studied at concentrated supplement doses; fennel has hormone-like effects and should be avoided in medicinal amounts during pregnancy and lactation, while gentian's safety in pregnancy and lactation isn't well established, so it's best avoided.

If you're pregnant, nursing, or have a chronic condition, talk with your doctor or pharmacist before using this product.

Side effects, ingredient by ingredient Dandelion Burdock Yellow Dock Ginger Fennel Gentian

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 6 of the 6 matched ingredients can interact with medications — Burdock, Fennel, Yellow Dock, Dandelion, Gentian, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; heart-rhythm medications; lithium.
  • For scale: 1,185 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take: blood thinners or antiplatelet drugs (warfarin, phenprocoumon, aspirin), heart and blood pressure medications (digoxin, nifedipine, losartan), diuretics, diabetes medications, kidney or lithium medications, fluoroquinolone or other antibiotics (especially ciprofloxacin), birth control pills or hormone replacement therapy, cancer medications (especially tamoxifen), or any drug metabolized by CYP1A2, CYP3A4, or P-glycoprotein pathways. The Major-severity interactions are with diuretics and digoxin via yellow dock; Moderate interactions span multiple categories across the formula's other active ingredients.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This digestive bitters product is rooted in traditional herbal practice and may appeal to you if you're seeking a plant-based digestive aid, though clinical evidence for its effectiveness is limited. It's not suitable if you take blood thinners, heart medications, diabetes drugs, diuretics, or certain antibiotics — these require a careful interaction check with your own doctor or pharmacist.

Likewise, if you're pregnant, nursing, or managing a chronic condition, discuss this product with your healthcare provider before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 13 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Digestive Bitters Maple, straight from the product label.

Brand Urban Moonshine
Barcode (UPC) 851588002081
Net contents 2 fl. Oz.; 59 mL
Market status On market
Date entered into DSLD Sep 25, 2015
DSLD ID 50640
Product type Other Combinations
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Digestive Bitters Maple by Urban Moonshine, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.25 tsp
Maximum serving Sizes:
0.25 tsp
Servings per container
48
UPC/BARCODE
851588002081
IngredientAmount% DV
Water0 NP--
organic Alcohol0 NP--
org. Gum Arabic0 NP--
org. Essential Oils0 NP--
org. Maple syrup0 NP--
org. Dandelion0 NP--
org. Burdock0 NP--
org. Yellow Dock0 NP--
org. Ginger0 NP--
org. Orange0 NP--
org. Fennel0 NP--
org. Angelica0 NP--
org. Gentian0 NP--
Proprietary Blend (Combination)0 NP--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Handcrafted Digestif

Certified by VOF

Natural sediment occurs in this product.

Urban Moonshine Digestive Bitters are used to optimize digestive function and relieve gas, bloating, and upset stomach; occasional nausea and heartburn; as well as to support liver function and healthy skin. Our Bitters are formulated from exceptional blends of Vermont herbs and roots, complemented by a few worldly exotics- a delicious, quality medicinal. To your health and well-being! -Jovial King

Call for supplement fact information.

Suggested/Recommended/Usage/Directions

Shake well before using.

Suggested use: To optimize digestive function, enjoy 1/4 tsp (approx. 1 full dropper) of our Bitters before or after meals, up to 6 times a day, and salute to your health.

Precautions

Not to be used during pregnancy.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

USDA ORGANIC

FDA Statement of Identity

Herbal Supplement

Formulation

Gluten Free.

Formula

30%-35% Alcohol

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Digestive Bitters Maple by Urban Moonshine label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Digestive Bitters Maple label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Digestive Bitters Maple by Urban Moonshine

These are the 13 active ingredients this product is made of. Select any to open its full monograph.

Serving size0.25 tsp Dosage formLiquid Servings per container48 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend (Combination)

0 NP per serving
Interaction report

Digestive Bitters Maple by Urban Moonshine Drug Interactions

Want to check YOUR meds against Digestive Bitters Maple?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,184Drugs
76 Major 1,054 Moderate 54 Minor

Ingredients driving the most interactions

org. Ginger 1,007
org. Fennel 740
org. Dandelion 457
org. Gentian 172
org. Burdock 122

Individual Drug Interactions

The ingredients in Digestive Bitters Maple interact with 1,184 drugs. Click any drug to see the details.

6 of the 13 ingredients in Digestive Bitters Maple interact with drugs. Each result below shows which ingredient is responsible. org. Ginger org. Fennel org. Dandelion org. Gentian org. Burdock org. Yellow Dock

Each ingredient & the kinds of drugs it affects

For each ingredient in Digestive Bitters Maple with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

org. Ginger14 drug types · 1,007 drugs

Anticoagulant/Antiplatelet Drugs

Ginger may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs. However, research is conflicting.
Laboratory research suggests that ginger inhibits thromboxane synthetase and decreases platelet aggregation. However, this has not been demonstrated unequivocally in humans, with mixed results from clinical trials. Theoretically, excessive amounts of ginger might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, taking ginger with antidiabetes drugs might increase the risk of hypoglycemia.
Animal and human research suggests that ginger might increase insulin levels and/or decrease blood glucose levels.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Ginger might increase or decrease the levels of CYP3A4 substrates.
In vitro research and some case reports suggest that ginger inhibits CYP3A4 activity. Three case reports from the World Health Organization (WHO) adverse drug reaction database describe increased toxicity in patients taking ginger and cancer medications that are CYP3A4 substrates (imatinib, dabrafenib, and crizotinib). However, the causality of this interaction is unclear due to the presence of multiple interacting drugs and routes of administration.
Conversely, other in vitro research suggests that ginger induces CYP3A4 activity, leading to reduced levels of CYP3A4 substrates. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Losartan (Cozaar)

Theoretically, ginger might increase levels of losartan and the risk of hypotension.
In animal research, ginger increased the levels and hypotensive effects of a single dose of losartan. It is not clear if ginger alters the concentration or effects of losartan when taken continuously. Additionally, this interaction has not been shown in humans.

Likelihood Possible Evidence D
Nifedipine (Procardia)

Ginger may have antiplatelet effects and increase the risk of bleeding if used with nifedipine.
Clinical research shows that combined treatment with ginger 1 gram plus nifedipine 10 mg significantly inhibits platelet aggregation when compared to nifedipine or ginger alone.

Likelihood Possible Evidence B
P-Glycoprotein Substrates

Ginger might increase the absorption and blood levels of P-glycoprotein (P-gp) substrates.
In vitro research and case reports suggest that ginger inhibits drug efflux by P-gp, potentially increasing absorption and serum levels of P-gp substrates. Two case reports from the World Health Organization (WHO) adverse drug reaction database describe increased toxicity in patients taking ginger and cancer medications that are P-gp substrates (trametinib, crizotinib). However, the causality of this interaction is unclear due to the presence of multiple interacting drugs and routes of administration.

Likelihood Possible Evidence D
Phenprocoumon (Marcoumar, Others)

Ginger might increase the risk of bleeding with phenprocoumon.
Phenprocoumon, a warfarin-related anticoagulant, might increase the international normalized ratio (INR) when taken with ginger. There is one case report of a 76-year-old woman with a stable INR on phenprocoumon that increased to greater than 10 when she began consuming dried ginger and ginger tea.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Ginger might increase the risk of bleeding with warfarin.
Laboratory research suggests that ginger might inhibit thromboxane synthetase and decrease platelet aggregation. In one case report, ginger increased the INR when taken with phenprocoumon, which has similar pharmacological effects as warfarin. In another case report, ginger increased the INR when taken with a combination of warfarin, hydrochlorothiazide, and acetaminophen. A longitudinal analysis suggests that taking ginger increases the risk of bleeding in patients taking warfarin for at least 4 months. However, research in healthy people suggests that ginger has no effect on INR, or the pharmacokinetics or pharmacodynamics of warfarin. Until more is known, monitor INRs closely in patients taking large amounts of ginger.

Likelihood Possible Evidence B
Calcium Channel Blockers

Theoretically, taking ginger with calcium channel blockers might increase the risk of hypotension.
Some animal and in vitro research suggests that ginger has hypotensive and calcium channel-blocking effects. Another animal study shows that concomitant administration of ginger and the calcium channel blocker amlodipine leads to greater reductions in blood pressure when compared with amlodipine alone.

Likelihood Unlikely Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically, when taken prior to cyclosporine, ginger might decrease cyclosporine levels.
In an animal model, ginger juice taken 2 hours prior to cyclosporine administration reduced the maximum concentration and area under the curve of cyclosporine by 51% and 40%, respectively. This effect was not observed when ginger juice and cyclosporine were administered at the same time.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, ginger might increase the levels of CYP1A2 substrates.
In vitro research shows that ginger inhibits CYP1A2 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, ginger might increase the levels of CYP2B6 substrates.
In vitro research shows that ginger inhibits CYP2B6 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, ginger might increase the levels of CYP2C9 substrates.
In vitro research shows that ginger inhibits CYP2C9 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Metronidazole (Flagyl)

Theoretically, ginger might increase levels of metronidazole.
In an animal model, ginger increased the absorption and plasma half-life of metronidazole. In addition, the elimination rate and clearance of metronidazole was significantly reduced.

Likelihood Possible Evidence D
org. Ginger full monograph & interactions

org. Fennel6 drug types · 740 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, fennel might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.

Animal research suggests that fennel oil has antithrombotic and antiplatelet effects.

Likelihood Possible Evidence D
Ciprofloxacin (Cipro)

Theoretically, fennel might decrease the levels and clinical effects of ciprofloxacin.

Animal research shows that fennel reduces ciprofloxacin bioavailability by nearly 50%, possibly due to the metal cations such as calcium, iron, and magnesium contained in fennel. This study also found that fennel increased tissue distribution and slowed elimination of ciprofloxacin.

Likelihood Probable Evidence D
Contraceptive Drugs

Theoretically, taking large amounts of fennel might decrease the effects of contraceptive drugs due to competition for estrogen receptors.

Some constituents of fennel have estrogenic activity.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.

In vitro research suggests that fennel inhibits CYP3A4 enzyme activity. This effect has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, taking large amounts of fennel might interfere with hormone replacement therapy due to competition for estrogen receptors.

Some constituents of fennel have estrogenic activity.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, taking large amounts of fennel might decrease the antiestrogenic effect of tamoxifen.

Some constituents of fennel have estrogenic activity, which may interfere with the antiestrogenic activity of tamoxifen.

Likelihood Possible Evidence D
org. Fennel full monograph & interactions

org. Dandelion7 drug types · 457 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking dandelion root along with anticoagulant or antiplatelet drugs might increase the risk of bruising and bleeding.
In vitro research suggests that dandelion root inhibits platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, dandelion might increase the risk for hypoglycemia when used with antidiabetes drugs.
Laboratory research suggests that dandelion extract may have moderate alpha-glucosidase inhibitor activity and might also increase insulin secretion. Also, in a case report, a 58-year-old woman with type 2 diabetes who was being treated with insulin developed hypoglycemia 2 weeks after beginning to eat salads containing dandelion.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, dandelion might increase levels of drugs metabolized by CYP1A2.
Laboratory research suggests that dandelion might inhibit CYP1A2. So far, this interaction has not been reported in humans. However, until more is known, watch for an increase in the levels of drugs metabolized by CYP1A2 in patients taking dandelion.

Likelihood Possible Evidence D
Glucuronidated Drugs

Theoretically, dandelion might increase the clearance of drugs that are UDP-glucuronosyltransferase substrates.
There is some preliminary evidence that dandelion might induce UDP-glucuronosyltransferase, a phase II enzyme.

Likelihood Possible Evidence D
Lithium

Theoretically, through diuretic effects, dandelion might reduce excretion and increase levels of lithium.
Animal research suggests that dandelion has diuretic properties. As diuretics can increase serum lithium levels, the dose of lithium might need to be decreased when taken with dandelion.

Likelihood Probable Evidence D
Potassium-Sparing Diuretics

Theoretically, dandelion might increase the risk of hyperkalemia when taken with potassium-sparing diuretics.
Dandelion contains significant amounts of potassium.

Likelihood Possible Evidence D
Quinolone Antibiotics

Theoretically, dandelion might lower fluoroquinolone levels.
Animal research shows that dandelion reduces absorption of ciprofloxacin and can lower levels by 73%. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
org. Dandelion full monograph & interactions

org. Gentian1 drug type · 172 drugs

Antihypertensive Drugs

Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
In vitro research shows that gentian can cause vasodilation and lower blood pressure.

Likelihood Possible Evidence D
org. Gentian full monograph & interactions

org. Burdock1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

In vitro research shows that lignans from burdock reduce rabbit platelet aggregation by inhibiting platelet activating factor. This interaction has not been reported in humans.

Likelihood Possible Evidence D
org. Burdock full monograph & interactions

org. Yellow Dock3 drug types · 78 drugs

Digoxin (Lanoxin)

Theoretically, yellow dock might increase the risk of digoxin toxicity when used long-term or in large amount.
When yellow dock is used chronically or in large amounts, hypokalemia may occur. This might increase the toxic effects of digoxin.

Likelihood Probable Evidence D
Diuretic Drugs

Theoretically, yellow dock might increase the risk of hypokalemia when taken with diuretics.
When yellow dock is used chronically or in large amounts, hypokalemia may occur, and overuse of yellow dock might compound diuretic-induced potassium loss.

Likelihood Probable Evidence D
Warfarin (Coumadin)

Theoretically, the laxative effects of yellow dock might increase the effects of warfarin, including the risk of bleeding.
The anthraquinones in yellow dock have a mild stimulant laxative effect. Consuming excessive amounts can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding.

Likelihood Possible Evidence D
org. Yellow Dock full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Digestive Bitters Maple, from the product label.

Urban Moonshine

See all Urban Moonshine products
Name
Urban Moonshine
Street Address
255 S. Champlain St.
City
Burlington
State
VT
ZipCode
05401
Phone Number
802-428-4707
Web Address
urbanmoonshine.com
Pharmacist Counseling Corner

Digestive Bitters Maple by Urban Moonshine: Common Questions

Does Digestive Bitters Maple by Urban Moonshine interact with any medications?
Yes. Based on its ingredients, Digestive Bitters Maple has a known interaction with 1,184 medications, including 76 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Digestive Bitters Maple contains 13 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does ginger in this product have any science behind it?
Yes — ginger in this formula has possibly effective evidence for pregnancy-related nausea and vomiting, menstrual cramps, and osteoarthritis. However, the other active ingredients (dandelion, burdock, yellow dock, fennel, gentian) lack established clinical evidence for specific conditions in our data, though they're used traditionally for digestion.
Can I take this while pregnant?
It depends on which ingredient you're most concerned about. Ginger is likely safe at moderate doses in pregnancy, though you should check with your doctor first. Yellow dock, fennel, and angelica are possibly unsafe or have limited data in pregnancy, so they're best avoided. For dandelion, burdock, and gentian, we don't have pregnancy safety ratings on file, so talk with your doctor or pharmacist for personalized advice.
What is yellow dock doing in a digestive product?
Yellow dock is included for its traditional role as a digestive stimulant and mild laxative. However, it's the most cautious ingredient in this formula — used long-term or in large amounts, it can lower potassium and cause other side effects, so short-term use is recommended.
Is this safe if I'm taking blood thinners like warfarin?
No — you need to check with your doctor or pharmacist first. Multiple ingredients (dandelion, burdock, ginger, and fennel) carry Moderate interactions with blood thinners, and yellow dock's laxative effect can increase warfarin's bleeding risk. Don't start this product without clearing it with your healthcare provider.
What are the most common side effects?
From the active ingredients, the most common side effects are gastrointestinal: diarrhea, heartburn, stomach upset, and nausea — especially if you take larger amounts or use the product long-term. Allergy is rare but possible, particularly in people sensitive to plants in the daisy family (like ragweed) or fennel.
Can I take this with my diabetes medication?
Check with your doctor or pharmacist first. Both dandelion and ginger in this product carry Moderate interactions with diabetes medications — they may theoretically increase the risk of low blood sugar. Your doctor may need to adjust your medication dose or monitor your blood sugar more closely.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Digestive Bitters Maple label
Go deeper

The Full Monographs Behind Digestive Bitters Maple’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Dandelion

Interacts with 457 drugs

Dandelion is a common plant used in food and traditional medicine, often promoted as a natural 'water pill' and digestive aid. Human evidence for these uses is very limited, so its benefits...

Read the full Dandelion monograph → Herb & supplement monograph

Burdock

Interacts with 122 drugs

Burdock is a traditional herb most often used for skin problems and as a so-called 'blood purifier,' but high-quality human studies are lacking and most claims are not well proven. It is wid...

Read the full Burdock monograph → Herb & supplement monograph

Yellow Dock

Interacts with 78 drugs

Yellow dock is a traditional herb used mostly as a mild laxative and a digestive and skin tonic. Good-quality human studies are lacking, so its benefits are largely unproven, and its natural...

Read the full Yellow Dock monograph → Herb & supplement monograph

Ginger

Interacts with 1,007 drugs

Ginger is a widely used culinary spice with a long history in traditional medicine, and it has the strongest evidence for helping with nausea and vomiting, including from motion sickness, pr...

Read the full Ginger monograph → Herb & supplement monograph

Fennel

Interacts with 740 drugs

Fennel is a Mediterranean herb widely used as a food and spice, and traditionally taken for digestive complaints, colic, and menstrual cramps. Some small studies suggest possible benefit for...

Read the full Fennel monograph → Herb & supplement monograph

Gentian

Interacts with 172 drugs

Gentian is a very bitter root traditionally used to stimulate appetite and ease mild digestive complaints, often as part of "bitters" before meals. The evidence is mostly traditional and pre...

Read the full Gentian monograph →
Sources

Sources & How We Checked

Digestive Bitters Maple's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 132 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Dandelion 27 references
  1. Maliakal PP, Wanwimolruk S. Effect of herbal teas on hepatic drug metabolizing enzymes in rats. J Pharm Pharmacol 2001;53:1323-9. PubMed
  2. Williams CA, Goldstone F, Greenham J. Flavonoids, cinnamic acids and coumarins from the different tissues and medicinal preparations of Taraxacum officinale. Phytochemistry 1996;42:121-7. PubMed
  3. Hussain Z, Waheed A, Qureshi RA, et al. The effect of medicinal plants of Islamabad and Murree region of Pakistan on insulin secretion from INS-1 cells. Phytother Res 2004;18:73-7. PubMed
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Burdock 11 references
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Yellow Dock 8 references
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Ginger 64 references
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  54. Ahad A, Raish M, Bin Jardan YA, Alam MA, Al-Mohizea AM, Al-Jenoobi FI. Effect of Hibiscus sabdariffa and Zingiber officinale on the antihypertensive activity and pharmacokinetic of losartan in hypertensive rats. Xenobiotica. 2020:1-11.
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  59. Akbarzadeh E, Heydari M, Atarzadeh F, Jaladat AM. Chronic dysuria following ginger (Zingiber officinale) use: a case report. Galen Med J 2018;7:e1086. DOI
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  64. Pochet S, Lechon AS, Lescrainier C, et al. Herb-anticancer drug interactions in real life based on VigiBase, the WHO global database. Sci Rep 2022;12(1):14178. PubMed

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Fennel 17 references
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Gentian 5 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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