Digestive Enzymes Advantage Ingredients & Drug Interactions
by F3 Nutrition
What is this page for?
First and foremost: checking Digestive Enzymes Advantage against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Digestive Enzymes Advantage is a dietary supplement by F3 Nutrition with 9 active ingredients. Its ingredients are commonly taken for digestive support for protein digestion, wound cleaning (debridement of dead tissue), sore throat and inflammation.Based on those ingredients, 92 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Papaya whole fruit powder, Papain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Digestive Enzymes Advantage by F3 Nutrition
Ask about any prescription or over-the-counter medication and we check it for interactions with Digestive Enzymes Advantage by F3 Nutrition — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Digestive Enzymes Advantage by F3 Nutrition
Four independent checks of what is known — a summary of the available information, not a grade of the product itself.
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
The stated purpose hasn't been mapped to our evidence data yet.
Why this rating?
- We haven't mapped this product's purpose to our evidence data yet — it'll be graded on the next content refresh.
Every active ingredient lists its own amount on the label.
Why this rating?
- The label discloses an exact amount for 9 of its 9 active ingredients.
- No proprietary blends here — you can verify the dose of every single component.
The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.
Why this rating?
- 2 of the 5 matched ingredients can interact with medications — Papain, Papaya.
- The most serious interaction on file is rated Moderate.
- Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
- For scale: 92 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.
Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.
Why this rating?
- We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
- Pregnancy & breastfeeding safety ratings cover 5 of 5.
- General safety write-ups exist for 5 of 5.
- Remember: this measures how much safety information exists. Thin data is not the same as being safe.
HelloPharmacist summaryFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Assessment coverage: 6 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2013.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Digestive Enzymes Advantage, straight from the product label.
| Brand | F3 Nutrition |
|---|---|
| Barcode (UPC) | 818789010048 |
| Net contents | 90 Capsule(s) |
| Market status | Off market |
| Date entered into DSLD | Feb 25, 2013 |
| DSLD ID | 18611 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Digestive Enzymes Advantage by F3 Nutrition, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Amylase | 3400 SKB | -- |
| Papain | 7000 TU | -- |
| Protease | 11000 HUT | -- |
| Lipase | 200 FIP | -- |
| Lactase | 425 LACU | -- |
| Cellulase | 1800 CU | -- |
| Acid Protease | 34 SAP | -- |
| Amyloglucosidase | 22 AG | -- |
| Papaya whole fruit powder | 200 mg | -- |
Other ingredients: Cellulose, Rice Flour, Vegetable Magnesium Stearate, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions
DO NOT PURCHASE IF SEAL IS BROKEN
WARNING: Consult your physician prior to using this product if you are pregnant, nursing, taking medications, or have a medical condition.
DO NOT INGEST FRESHPACK
General Statements
Fit - Form - Function
Supports Food Digestion Eases Bloating & Gas Helps to Increase Energy
E7830901
Digestion Advantage! Digestive Enzymes assist in regulating all of the metabolic processes in our bodies while also ensuring that all of the nutrients we consume are fully absorbed.
This broad spectrum blend of effective digestive enzymes will provide for proper digestion and effective assimilation of nutrients from any food source.
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
DIRECTIONS: As a dietary supplement, take 1 or more capsules daily with each meal. SUGGESTED USE: Take 1 capsule with small meals and healthy snacks, more than 1 capsule may be beneficial for larger or heavy meals.
Formulation
No Sugar, No Artificial Flavors, No Artificial Colors, No Preservatives, Sodium Free, Yeast Free.
F3(TM) Nutrition's Digestive Enzymes are plant based enzymes in vegetarian capsules.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Storage
Store in a cool, dry place.
General
Item # 10017
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Digestive Enzymes Advantage by F3 Nutrition label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Digestive Enzymes Advantage by F3 Nutrition
These are the 9 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Amylase
Papain
Interacts with2 drugs
Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food an...
Papain monograph & interactionsProtease
No knowninteractions
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...
Protease monograph & interactionsLipase
No knowninteractions
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy fo...
Lipase monograph & interactionsLactase
No knowninteractions
Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can red...
Lactase monograph & interactionsCellulase
Acid Protease
No knowninteractions
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...
Acid Protease monograph & interactionsAmyloglucosidase
Papaya whole fruit powder
Interacts with92 drugs
Papaya is a tropical fruit that is nutritious and generally safe to eat as food, and it contains an enzyme called papain used as a digestive aid and m...
Papaya whole fruit powder monograph & interactionsOther (inactive) ingredients: Cellulose, Rice Flour, Vegetable Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.
Digestive Enzymes Advantage by F3 Nutrition Drug Interactions
Digestive Enzymes Advantage contains 9 ingredients, and 2 of them have known drug interactions. Altogether they interact with 92 medications. Here’s the picture, then you can look up your own drug.
Want to check YOUR meds against Digestive Enzymes Advantage?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Digestive Enzymes Advantage interact with 92 drugs. Click any drug to see the details.
2 of the 9 ingredients in Digestive Enzymes Advantage interact with drugs. Each result below shows which ingredient is responsible. Papaya whole fruit powder Papain
AcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Digestive Enzymes Advantage — through 1 ingredient. Tap an ingredient for the detail:
Papaya Whole Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Whole Fruit Powder + Acarbose interactionAcetohexamideDymelor
How Acetohexamide interacts with Digestive Enzymes Advantage — through 1 ingredient. Tap an ingredient for the detail:
Papaya Whole Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Whole Fruit Powder + Acetohexamide interactionAlbiglutideTanzeum
How Albiglutide interacts with Digestive Enzymes Advantage — through 1 ingredient. Tap an ingredient for the detail:
Papaya Whole Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Whole Fruit Powder + Albiglutide interactionAlogliptinNesina
How Alogliptin interacts with Digestive Enzymes Advantage — through 1 ingredient. Tap an ingredient for the detail:
Papaya Whole Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Whole Fruit Powder + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Digestive Enzymes Advantage — through 1 ingredient. Tap an ingredient for the detail:
Papaya Whole Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Whole Fruit Powder + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Digestive Enzymes Advantage — through 1 ingredient. Tap an ingredient for the detail:
Papaya Whole Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Whole Fruit Powder + Alogliptin, Pioglitazone interactionAmiodaroneCordarone, Pacerone
How Amiodarone interacts with Digestive Enzymes Advantage — through 1 ingredient. Tap an ingredient for the detail:
Papaya Whole Fruit PowderAmiodarone (cordarone) Moderate
Interaction Summary
Theoretically, papaya extract may increase the levels and clinical effects of amiodarone.
Read the full Papaya Whole Fruit Powder + Amiodarone interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with Digestive Enzymes Advantage — through 1 ingredient. Tap an ingredient for the detail:
Papaya Whole Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Whole Fruit Powder + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionCanagliflozinInvokana
How Canagliflozin interacts with Digestive Enzymes Advantage — through 1 ingredient. Tap an ingredient for the detail:
Papaya Whole Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Whole Fruit Powder + Canagliflozin interactionCanagliflozin, MetforminInvokamet
How Canagliflozin, Metformin interacts with Digestive Enzymes Advantage — through 1 ingredient. Tap an ingredient for the detail:
Papaya Whole Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Whole Fruit Powder + Canagliflozin, Metformin interactionCanagliflozin, Metformin HydrochlorideInvokamet XR
How Canagliflozin, Metformin Hydrochloride interacts with Digestive Enzymes Advantage — through 1 ingredient. Tap an ingredient for the detail:
Papaya Whole Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Whole Fruit Powder + Canagliflozin, Metformin Hydrochloride interactionChlorpropamideChlorpropam, Diabinese
How Chlorpropamide interacts with Digestive Enzymes Advantage — through 1 ingredient. Tap an ingredient for the detail:
Papaya Whole Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Whole Fruit Powder + Chlorpropamide interactionDapagliflozinFarxiga
How Dapagliflozin interacts with Digestive Enzymes Advantage — through 1 ingredient. Tap an ingredient for the detail:
Papaya Whole Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Whole Fruit Powder + Dapagliflozin interactionDapagliflozin Propanediol, MetforminXigduo XR
How Dapagliflozin Propanediol, Metformin interacts with Digestive Enzymes Advantage — through 1 ingredient. Tap an ingredient for the detail:
Papaya Whole Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Whole Fruit Powder + Dapagliflozin Propanediol, Metformin interactionDapagliflozin Propanediol, Saxagliptin HydrochlorideQtern
How Dapagliflozin Propanediol, Saxagliptin Hydrochloride interacts with Digestive Enzymes Advantage — through 1 ingredient. Tap an ingredient for the detail:
Papaya Whole Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Whole Fruit Powder + Dapagliflozin Propanediol, Saxagliptin Hydrochloride interactionDapagliflozin, Metformin Hydrochloride, Saxagliptin HydrochlorideQternmet XR
How Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interacts with Digestive Enzymes Advantage — through 1 ingredient. Tap an ingredient for the detail:
Papaya Whole Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Whole Fruit Powder + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionDasiglucagon HydrochlorideZegalogue
How Dasiglucagon Hydrochloride interacts with Digestive Enzymes Advantage — through 1 ingredient. Tap an ingredient for the detail:
Papaya Whole Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Whole Fruit Powder + Dasiglucagon Hydrochloride interactionDulaglutideTrulicity
How Dulaglutide interacts with Digestive Enzymes Advantage — through 1 ingredient. Tap an ingredient for the detail:
Papaya Whole Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Whole Fruit Powder + Dulaglutide interactionEmpagliflozinJardiance
How Empagliflozin interacts with Digestive Enzymes Advantage — through 1 ingredient. Tap an ingredient for the detail:
Papaya Whole Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Whole Fruit Powder + Empagliflozin interactionEmpagliflozin, Linagliptin, Metformin HydrochlorideTrijardy XR
How Empagliflozin, Linagliptin, Metformin Hydrochloride interacts with Digestive Enzymes Advantage — through 1 ingredient. Tap an ingredient for the detail:
Papaya Whole Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Whole Fruit Powder + Empagliflozin, Linagliptin, Metformin Hydrochloride interactionEmpagliflozin, MetforminSynjardy
How Empagliflozin, Metformin interacts with Digestive Enzymes Advantage — through 1 ingredient. Tap an ingredient for the detail:
Papaya Whole Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Whole Fruit Powder + Empagliflozin, Metformin interactionEmpagliflozin, Metformin HydrochlorideSynjardy XR
How Empagliflozin, Metformin Hydrochloride interacts with Digestive Enzymes Advantage — through 1 ingredient. Tap an ingredient for the detail:
Papaya Whole Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Whole Fruit Powder + Empagliflozin, Metformin Hydrochloride interactionErtugliflozinSteglatro
How Ertugliflozin interacts with Digestive Enzymes Advantage — through 1 ingredient. Tap an ingredient for the detail:
Papaya Whole Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Whole Fruit Powder + Ertugliflozin interactionErtugliflozin, Metformin HydrochlorideSegluromet
How Ertugliflozin, Metformin Hydrochloride interacts with Digestive Enzymes Advantage — through 1 ingredient. Tap an ingredient for the detail:
Papaya Whole Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Whole Fruit Powder + Ertugliflozin, Metformin Hydrochloride interactionExenatideBydureon, Byetta
How Exenatide interacts with Digestive Enzymes Advantage — through 1 ingredient. Tap an ingredient for the detail:
Papaya Whole Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Whole Fruit Powder + Exenatide interactionExenatide SyntheticBydureon BCISE
How Exenatide Synthetic interacts with Digestive Enzymes Advantage — through 1 ingredient. Tap an ingredient for the detail:
Papaya Whole Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Whole Fruit Powder + Exenatide Synthetic interactionGliclazideDiamicron
How Gliclazide interacts with Digestive Enzymes Advantage — through 1 ingredient. Tap an ingredient for the detail:
Papaya Whole Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Whole Fruit Powder + Gliclazide interactionGlimepirideAmaryl
How Glimepiride interacts with Digestive Enzymes Advantage — through 1 ingredient. Tap an ingredient for the detail:
Papaya Whole Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Whole Fruit Powder + Glimepiride interactionGlipizideGlucotrol, Glucotrol XL
How Glipizide interacts with Digestive Enzymes Advantage — through 1 ingredient. Tap an ingredient for the detail:
Papaya Whole Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Whole Fruit Powder + Glipizide interactionGlipizide, MetforminMetaglip
How Glipizide, Metformin interacts with Digestive Enzymes Advantage — through 1 ingredient. Tap an ingredient for the detail:
Papaya Whole Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Whole Fruit Powder + Glipizide, Metformin interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Digestive Enzymes Advantage with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Papaya whole fruit powder
Amiodarone (Cordarone)
Theoretically, papaya extract may increase the levels and clinical effects of amiodarone.
Animal research in rats shows that a single oral dose of papaya extract, as well as multiple doses of papaya extract daily over 14 days, prior to a single dose of amiodarone delays the time to maximum amiodarone concentration. However, only the 14-day papaya extract regimen increases systemic amiodarone exposure by 60% to 70%. This interaction has not been reported in humans.
Antidiabetes Drugs
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects. It is unclear if other forms of papaya have the same effect.
A small low-quality clinical study in patients with type 2 diabetes who are taking glibenclamide shows that taking a fermented papaya preparation 3 grams daily for 2 months decreases fasting and postprandial blood glucose levels when compared to baseline. Additionally, of the 25 patients in the study, 9 required a reduction in glibenclamide dose.
Levothyroxine (Synthroid, Others)
Theoretically, consuming large quantities of papaya fruit can reduce the clinical effects of levothyroxine.
In one case-report, a 37-year-old male with a history of thyroidectomy who was stabilized on levothyroxine for 5 years presented with hypothyroidism after consuming 5-6 papaya fruits daily for 14 days during vacation. In a controlled re-challenge test involving 5-6 papayas daily, the patient remained euthyroid for 7 days, but developed mild hypothyroidism after 14 days. Both times, thyroid levels normalized 40-45 days after discontinuing papaya.
Warfarin (Coumadin)
Theoretically, concomitant use of warfarin with papain-containing papaya extract might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.
Papain
Warfarin (Coumadin)
Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.
Brand information
Manufacturer and brand details for Digestive Enzymes Advantage, from the product label.
F3 Nutrition
See all F3 Nutrition products- Name
- F3(TM) Nutrition
- Street Address
- 624 S. Military Trail
- City
- Deerfield Beach
- State
- FL
- ZipCode
- 33442
- Phone Number
- (866) 218-1255
- Web Address
- www.f3nutrition.com
Digestive Enzymes Advantage by F3 Nutrition: Common Questions
Does Digestive Enzymes Advantage by F3 Nutrition interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Digestive Enzymes Advantage is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Digestive Enzymes Advantage’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Papain
Interacts with 2 drugsPapain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...
Read the full Papain monograph → Herb & supplement monographProteolytic Enzymes (proteases)
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...
Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monographLipase
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...
Read the full Lipase monograph → Herb & supplement monographLactase
Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...
Read the full Lactase monograph → Herb & supplement monographPapaya
Interacts with 92 drugsPapaya is a tropical fruit that is nutritious and generally safe to eat as food, and it contains an enzyme called papain used as a digestive aid and meat tenderizer. Papaya leaf extract is b...
Read the full Papaya monograph →Sources & How We Checked
Digestive Enzymes Advantage's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 30 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Papain 11 references
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
- Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
- Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
- Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
- Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
- Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
- Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
- Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
- Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
- Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed
Proteolytic Enzymes (proteases) 3 references
- Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
- Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
- Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed
See these in context on the Proteolytic Enzymes (proteases) monograph →
Lipase 1 reference
- Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed
Lactase 1 reference
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