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Dietary supplement

DLPA 1000 mg Ingredients & Drug Interactions

by Vitamatic

DLPA 1000 mg label
See full label image
Tablet Or Pill Category: Amino Acid/protein
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking DLPA 1000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

DLPA 1000 mg is a dietary supplement by Vitamatic with 1 active ingredient. Its ingredients are commonly taken for depression and mood, skin condition vitiligo, pain conditions.Based on those ingredients, 16 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are DL-Phenylalanine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against DLPA 1000 mg by Vitamatic

Ask about any prescription or over-the-counter medication and we check it for interactions with DLPA 1000 mg by Vitamatic — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of DLPA 1000 mg by Vitamatic

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

DLPA 1000 mg contains one active ingredient: DL-phenylalanine, an amino acid (a building block of protein) that your body can convert into other compounds involved in mood and pain signaling. The tablet also contains several inactive ingredients — di-calcium phosphate, microcrystalline cellulose, magnesium stearate, silicon dioxide, and croscarmellose sodium — which are fillers and binders that hold the tablet together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Phenylalanine's overall clinical evidence instead.

Moderate

Some clinical evidence supports Phenylalanine for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Vitiligo — rated "Possibly Effective" (Natural Medicines).

The evidence for DL-phenylalanine is mixed and limited. It's rated possibly effective for vitiligo (a skin condition).

For ADHD, the data suggests it's possibly ineffective. For alcohol use disorder and multiple sclerosis, there isn't enough reliable evidence to say whether it works or not.

Talk with your doctor about whether this supplement makes sense for what you're trying to address.

The evidence, ingredient by ingredient Phenylalanine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Taken by mouth in typical doses, DL-phenylalanine is generally well tolerated. The most common side effects are anxiety, constipation, headache, heartburn, insomnia, nausea, and sedation.

You should avoid supplement doses of this product during pregnancy and while breastfeeding because safety data is lacking. Also, if you have phenylketonuria (PKU), a rare genetic condition, don't use phenylalanine supplements — even food amounts need careful management for you.

Side effects, ingredient by ingredient Phenylalanine

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Phenylalanine.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: Parkinson's medications.
  • For scale: 16 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Vitamatic DLPA, check with your doctor or pharmacist if you take levodopa (a Major interaction), baclofen or an MAOI antidepressant (both Moderate). These are the main medication types where phenylalanine can cause problems.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.

This supplement may appeal to people exploring it for vitiligo or other uses where evidence is emerging. If you take levodopa for Parkinson disease, baclofen for muscle spasticity, or an MAOI antidepressant, you need to clear this with your doctor or pharmacist first — the interactions are real and could affect how well your medications work.

Pregnant or breastfeeding? Skip it and talk with your healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 21, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about DLPA 1000 mg, straight from the product label.

Brand Vitamatic
Barcode (UPC) 810078471165
Net contents 120 Tablet(s)
Market status On market
Date entered into DSLD Feb 21, 2023
DSLD ID 283023
Product type Amino Acid/protein
Supplement form Tablet Or Pill
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for DLPA 1000 mg by Vitamatic, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
120
UPC/BARCODE
810078471165
IngredientAmount% DV
DL-Phenylalanine1000 mg--

Other ingredients: Di-Calcium Phosphate, Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide, Croscarmellose Sodium

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Caution: Consult with your healthcare provider if you are pregnant, nursing, taking any medications, or planning any medical procedures.

Do not use if the safety seal is broken or missing.

Keep out of reach of children.

Do not exceed recommended dose. Food supplements should not be used as a substitute for a varied and balanced diet and healthy lifestyle.

Storage

Store in a cool, dry place.

Formulation

Free of sugar, starch, yeast, soy, wheat, egg, artificial colors, flavors, and preservatives.

Essential amino acid Supports central nervous system

Non GMO

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

DL-Phenylalanine

Seals/Symbols

GMP Good Manufacturing Practice Certified Made in U.S.A.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 1 tablet daily with 8 to 12 oz of water or as directed by your healthcare provider.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

DLPA 1000 mg by Vitamatic label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

DLPA 1000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in DLPA 1000 mg by Vitamatic

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container120 Amounts shown are per serving.

DL-Phenylalanine

Interacts with
16 drugs
1000 mg per serving

Phenylalanine is an essential amino acid the body uses to make brain chemicals like dopamine and norepinephrine. Some people take it for mood, vitilig...

DL-Phenylalanine monograph & interactions

Other (inactive) ingredients: Di-Calcium Phosphate, Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide, Croscarmellose Sodium. These complete the product’s ingredient list but are not active constituents.

Interaction report

DLPA 1000 mg by Vitamatic Drug Interactions

Want to check YOUR meds against DLPA 1000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
16Drugs
5 Major 11 Moderate

Ingredients driving the most interactions

DL-Phenylalanine 16

Individual Drug Interactions

The ingredients in DLPA 1000 mg interact with 16 drugs. Click any drug to see the details.

1 of the 1 ingredient in DLPA 1000 mg interact with drugs. Each result below shows which ingredient is responsible. DL-Phenylalanine

Each ingredient & the kinds of drugs it affects

For each ingredient in DLPA 1000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

DL-Phenylalanine3 drug types · 16 drugs

Levodopa

Phenylalanine, especially in high doses, can reduce the effectiveness of levodopa.
Phenylalanine competes with levodopa for carrier-mediated transport into the brain. The resulting reduction in levels of levodopa in the brain can exacerbate tremor, rigidity, and the "on-off" phenomenon in patients with Parkinson disease.

Likelihood Probable Evidence B
Baclofen

Concomitant intake of phenylalanine may reduce the intestinal absorption of baclofen.
Phenylalanine and baclofen share the same intestinal carrier for absorption; phenylalanine competitively inhibits the absorption of baclofen, reducing its plasma levels.

Likelihood Possible Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use of L-phenylalanine and non-selective MAOIs might increase the risk of hypertensive crisis.
L-phenylalanine is metabolized to tyrosine. Some evidence suggests that L-phenylalanine, given with the non-selective MAOI pargyline, might prevent the elimination of tyramine, increasing the risk of hypertensive crisis. However, this was not reported in a small number of patients when using L-phenylalanine with the partially selective MAO-B inhibitor, selegiline.

Likelihood Possible Evidence D
DL-Phenylalanine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for DLPA 1000 mg, from the product label.

Vitamatic

See all Vitamatic products
Name
Vitamatic
Street Address
PO Box 406
City
Raritan
State
NJ
ZipCode
08869
Phone Number
1-973-400-9165
Web Address
www.vitamaticusa.com
Pharmacist Counseling Corner

DLPA 1000 mg by Vitamatic: Common Questions

Does DLPA 1000 mg by Vitamatic interact with any medications?
Yes. Based on its ingredients, DLPA 1000 mg has a known interaction with 16 medications, including 5 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
DLPA 1000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm pregnant or breastfeeding?
Safety data is lacking, so avoid supplement doses during pregnancy and breastfeeding. Talk with your doctor or pharmacist about what's right for you in these situations.
What are the most common side effects?
Anxiety, constipation, headache, heartburn, insomnia, nausea, and sedation are the most commonly reported. Most people tolerate it well at typical doses, but everyone's different.
Does this work for ADHD?
The data we have suggests it's possibly ineffective for ADHD. Your doctor can talk through whether this is the right choice for you.
What is phenylalanine, and what does it do?
Phenylalanine is an amino acid your body uses to make other compounds that affect mood and pain signaling. Your body gets it from food (meat, dairy, nuts) and can also make it from other amino acids.
I have PKU — is this safe for me?
No. If you have phenylketonuria, avoid phenylalanine supplements. Even food amounts need careful management for you, so talk with your doctor.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if DLPA 1000 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

DLPA 1000 mg label
Go deeper

The Full Monographs Behind DLPA 1000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Phenylalanine

Interacts with 16 drugs

Phenylalanine is an essential amino acid the body uses to make brain chemicals like dopamine and norepinephrine. Some people take it for mood, vitiligo, or pain, but the evidence is mostly l...

Read the full Phenylalanine monograph →
Sources

Sources & How We Checked

DLPA 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 23 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Phenylalanine 23 references
  1. Rouse B, Azen C, Koch R, et al. Maternal phenylketonuria collaborative Study (MPKUCS) offspring: facial anomalies, malformations, and early neurological sequelae. Am J Med Genet 1997;69:89-95. DOI
  2. Sturtevant FM. Use of aspartame in pregnancy. Int J Fertil 1985;30:85-7.
  3. Silkaitis RP, Mosnaim AD. Pathways linking L-phenylalanine and 2-phenylethylamine with p-tyramine in rabbit brain. Brain Res 1976;114:105-15.
  4. Lehmann WD, Theobald N, Fischer R, Heinrich HC. Stereospecificity of phenylalanine plasma kinetics and hydroxylation in man following oral application of a stable isotope-labelled pseudo-racemic mixture of L- and D-phenylalanine. Clin Chim Acta 1983;128 PubMed
  5. Mosnik DM, Spring B, Rogers K, Baruah S. Tardive dyskinesia exacerbated after ingestion of phenylalanine by schizophrenic patients. Neuropsychopharmacology 1997;16:136-46. PubMed
  6. Siddiqui AH, Stolk LM, Bhaggoe R, et al. L-phenylalanine and UVA irradiation in the treatment of vitiligo. Dermatology 1994;88:215-8. PubMed
  7. Birkmayer W, Riederer P, Linauer W, Knoll J. L-deprenyl plus L-phenylalanine in the treatment of depression. J Neural Transm 1984;59:81-7. PubMed
  8. Nutt JG, Woodward WR, Hammerstad JP, et al. The "on-off" phenomenon in Parkinson's disease. Relation to levodopa absorption and transport. N Engl J Med 1984;310:483-8. PubMed
  9. Baruzzi A, Contin M, Riva R, et al. Influence of meal ingestion time on pharmacokinetics of orally administered levodopa in parkinsonian patients. Clin Neuropharmacol 1987;10:527-37. PubMed
  10. Juncos JL, Fabbrini G, Mouradian MM, et al. Dietary influences on the antiparkinsonian response to levodopa. Arch Neurol 1987;44:1003-5. PubMed
  11. Eriksson T, Granerus AK, Linde A, et al. "On-off" phenomenon in Parkinson's disease: relationship between dopa and other large neutral amino acids in plasma. Neurology 1988;38:1245-8. PubMed
  12. Baker GB, Bornstein RA, Rouget AC, et al. Phenylethylaminergic mechanisms in attention-deficit disorder. Biol Psychiatry 1991;29:15-22.. PubMed
  13. Wood DR, Reimherr FW, Wender PH. Treatment of attention deficit disorder with DL-phenylalanine. Psychiatry Res 1985;16:21-6.. PubMed
  14. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids (Macronutrients). Washington, DC: National Academy Press, 2002. Available at: http://www.n
  15. Cederbaum S. Phenylketonuria: an update. Curr Opin Pediatr 2002;14:702-6. PubMed
  16. Cejudo-Ferragud, E., Nacher, A., Polache, A., Cercos-Fortea, T., Merino, M., and Casabo, V. G. Evidence of competitive inhibition for the intestinal absorption of baclofen by phenylalanine. Int J of Pharm (Amsterdam) 1996;132:63-69. DOI
  17. Fischer, E., Heller, B., Nachon, M., and Spatz, H. Therapy of depression by phenylalanine. Preliminary note. Arzneimittelforschung. 1975;25(1):132.
  18. Beckmann, H., Strauss, M. A., and Ludolph, E. Dl-phenylalanine in depressed patients: an open study. J.Neural Transm. 1977;41(2-3):123-134. PubMed
  19. Sabelli, H. C., Fawcett, J., Gusovsky, F., Javaid, J. I., Wynn, P., Edwards, J., Jeffriess, H., and Kravitz, H. Clinical studies on the phenylethylamine hypothesis of affective disorder: urine and blood phenylacetic acid and phenylalanine dietary supplem
  20. Cotzias, G. C., Van Woert, M. H., and Schiffer, L. M. Aromatic amino acids and modification of parkinsonism. N Engl.J Med 2-16-1967;276(7):374-379. PubMed
  21. Kravitz, H. M., Sabelli, H. C., and Fawcett, J. Dietary supplements of phenylalanine and other amino acid precursors of brain neuroamines in the treatment of depressive disorders. J Am Osteopath.Assoc 1984;84(1 Suppl):119-123. DOI
  22. Mann, J., Peselow, E. D., Snyderman, S., and Gershon, S. D-phenylalanine in endogenous depression. Am.J.Psychiatry 1980;137(12):1611-1612. PubMed
  23. Katoulis AC, Alevizou A, Bozi E, et al. A randomized, double-blind, vehicle-controlled study of a preparation containing undecylenoyl phenylalanine 2% in the treatment of solar lentigines. Clin Exp Dermatol 2010;35(5):473-6. PubMed

See these in context on the Phenylalanine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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