Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Estro-D-Tox Ingredients & Drug Interactions

by MDLogic

Estro-D-Tox label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Estro-D-Tox against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Estro-D-Tox is a dietary supplement by MDLogic with 4 active ingredients. Its ingredients are commonly taken for estrogen/hormone balance, acne and hormonal skin issues, prostate health support.Based on those ingredients, 900 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Diindolylmethane, BroccoPhane, Calcium-D-Glucarate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Estro-D-Tox by MDLogic

Ask about any prescription or over-the-counter medication and we check it for interactions with Estro-D-Tox by MDLogic — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Estro-D-Tox by MDLogic

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • “Calcium-D-Glucarate” is listed as a grouped ingredient — the label gives one combined amount (50 mg) without saying how much of each component you get.
  • “BroccoPhane” is listed as a grouped ingredient — the label gives one combined amount (100 mg) without saying how much of each component you get.

Estro-D-Tox contains four active ingredients. Calcium is a mineral essential for bone strength and many body functions.

Diindolylmethane is a compound found in cruciferous vegetables like broccoli and cabbage. Sulforaphane is a plant compound also from cruciferous vegetables, studied for prostate health.

The fourth ingredient, cyanidin-3-glucoside, is a plant pigment from foods like berries, but we hold no detailed monograph data on it. The product also contains inactive ingredients — cellulose, microcrystalline cellulose, monolaurin, and chlorophyll — which serve as binders and capsule material.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Estrogen metabolism and detoxification support.
  • We looked for evidence on: Breast cancer, Cervical dysplasia, Endometrial cancer, Ovarian cancer, Prostate cancer, Uterine cancer — and 3 related terms.
  • The strongest evidence on file: Sulforaphane is rated "Possibly Effective" for Prostate cancer (Natural Medicines).
  • Also on file: Calcium is rated "Possibly Ineffective" for Breast cancer.
  • Also on file: Calcium is rated "Insufficient Reliable Evidence To Rate" for Ovarian cancer, Endometrial cancer, Prostate cancer.

Calcium in this product is effective for kidney failure, indigestion (dyspepsia), low blood calcium (hypocalcemia), high potassium (hyperkalemia), and likely effective for bone loss (osteoporosis). Sulforaphane is possibly effective for prostate cancer prevention, though the evidence base for the other ingredients' claimed uses — like benign prostate enlargement, breast and colorectal cancer prevention, cervical dysplasia, and breast pain — is not established in our data.

Diindolylmethane's effectiveness for these conditions also shows insufficient reliable evidence to rate.

The evidence, ingredient by ingredient Diindolylmethane Calcium D-glucarate Calcium Broccoli Sulforaphane

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Calcium is generally well tolerated when taken at recommended doses, though high amounts can cause trouble. Common side effects are belching, constipation, diarrhea, gas, and stomach upset.

Rare but serious concerns include kidney stones and calciphylaxis. Very high calcium intake (over 1500–2000 mg daily) has been weakly linked in some research to increased prostate cancer risk and cardiovascular disease, though this remains debated.

Diindolylmethane is generally well tolerated short-term, but long-term safety isn't well established; common side effects include diarrhea, gas, headache, nausea, rash, and vomiting, with rare cases of a severe rash called DRESS reported. Sulforaphane from food is safe, but concentrated supplements have fewer long-term studies; it can cause stomach upset, heartburn, headache, and in rare cases seizures have been reported in individuals with autism.

Side effects, ingredient by ingredient Diindolylmethane Calcium D-glucarate Calcium Broccoli Sulforaphane

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Calcium, Diindolylmethane, Sulforaphane.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: heart-rhythm medications; lithium.
  • For scale: 876 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before taking this product if you use HIV integrase inhibitors (dolutegravir, elvitegravir, or raltegravir), intravenous ceftriaxone (Rocephin), levothyroxine (Synthroid) or other thyroid medications, sotalol (Betapace), diltiazem (Cardizem) or other calcium-channel blockers, calcipotriene (Dovonex), estrogen-based medications or hormone replacement therapy, diuretics (water pills), or drugs processed through liver enzymes CYP1A2, CYP3A4, or CYP2E1. These interactions range from Major to Minor severity — the interaction tool will pinpoint your specific medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Estro-D-Tox is mainly a calcium and plant-compound product. If you take any HIV medications, thyroid drugs, heart drugs, or diuretics (water pills), you'll want to check your exact medications against the interaction tool on this page — calcium in particular needs careful timing.

If you're pregnant or breastfeeding, talk with your pharmacist or doctor first, especially about diindolylmethane and sulforaphane, which have limited safety data in those situations.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Estro-D-Tox, straight from the product label.

Brand MDLogic
Barcode (UPC) 897395002456
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Nov 22, 2024
DSLD ID 320640
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Estro-D-Tox by MDLogic, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
897395002456
IngredientAmount% DV
Calcium5 mg--
Diindolylmethane300 mg--
Calcium-D-Glucarate50 mg--
Sulforaphane400 mg--
Cyanidin-3-Glucoside2.5 mg--
BroccoPhane100 mg--

Other ingredients: Cellulose, Microcrystalline Cellulose, Monolaurin, Chlorophyll

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Recommended use: As a dietary supplement, take two (2) capsule daily, or as recommended by a healthcare professional.

Precautions

Warning: Consult with a health care professional before use and/or if you are pregnant, lactating or undergoing treatment for a medical condition.

Do not exceed recommended dosage. Discontinue use if any adverse reactions occur and contact a health care professional. Do not use if seal under cap is broken or missing.

Keep out of reach of children.

Storage

Store tightly closed in a cool, dry place.

Seals/Symbols

Made in the USA from Global Ingredients Manufactured by a GMP Certified Company

Formulation

Gluten Free BPA Free

Promotes healthy hormone level in women & men Supports detoxification & healthy cellular function

This product contains no milk, soy, egg, fish, peanuts, crustacean shellfish (lobster, crab or shrimp), tree nuts, wheat, gluten or yeast. No artificial colors or flavors.

Brand IP Statement(s)

Supplementing Life MD Logic Est. 2005

Broccophane is a trademark of Cyvex

FDA Statement of Identity

Dietary Supplement

General Statements

Scan me!

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See for yourself

Estro-D-Tox by MDLogic label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Estro-D-Tox label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Estro-D-Tox by MDLogic

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Diindolylmethane

Interacts with
269 drugs
300 mg per serving

Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and...

Diindolylmethane monograph & interactions

Calcium-D-Glucarate

Interacts with
126 drugs
50 mg per serving

Calcium D-glucarate is a supplement form of a natural compound found in fruits and vegetables that is promoted for 'detoxification' and helping the bo...

Calcium-D-Glucarate monograph & interactions

Cyanidin-3-Glucoside

2.5 mg per serving Form: Blackberry Fruit Extract

BroccoPhane

Interacts with
187 drugs
100 mg per serving Form: Broccoli Sprout Concentrate

Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for...

BroccoPhane monograph & interactions

Other (inactive) ingredients: Cellulose, Microcrystalline Cellulose, Monolaurin, Chlorophyll. These complete the product’s ingredient list but are not active constituents.

Interaction report

Estro-D-Tox by MDLogic Drug Interactions

Want to check YOUR meds against Estro-D-Tox?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
900Drugs
7 Major 892 Moderate 1 Minor

Ingredients driving the most interactions

Diindolylmethane 269
BroccoPhane 187
Calcium-D-Glucarate 126

Individual Drug Interactions

The ingredients in Estro-D-Tox interact with 900 drugs. Click any drug to see the details.

3 of the 4 ingredients in Estro-D-Tox interact with drugs. Each result below shows which ingredient is responsible. Diindolylmethane BroccoPhane Calcium-D-Glucarate

Each ingredient & the kinds of drugs it affects

For each ingredient in Estro-D-Tox with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Diindolylmethane3 drug types · 269 drugs

Diuretic Drugs

Theoretically, diindolylmethane might increase the risk of hyponatremia if used with sodium-depleting diuretics.
Large doses of diindolylmethane (600 mg daily) have been associated with two cases of asymptomatic hyponatremia in clinical research.

Likelihood Possible Evidence B
Estrogens

Theoretically, diindolylmethane might increase or decrease the effects of estrogens.
Diindolylmethane might have mild estrogenic or antiestrogenic effects. Theoretically, large amounts of diindolylmethane might interfere with hormone replacement therapy.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
In vitro evidence suggests that diindolylmethane can induce CYP1A2. Theoretically, it might increase metabolism of CYP1A2 substrates and lower serum concentrations. This interaction has not been reported in humans.

Likelihood Unlikely Evidence D
Diindolylmethane full monograph & interactions

BroccoPhane2 drug types · 187 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Pharmacokinetic research in humans shows that eating 500 grams of fresh broccoli daily for 6-12 days can increase CYP1A2 activity by 10% to 200%. Induction of CYP1A2 activity by broccoli is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP2A6.
Pharmacokinetic research in humans shows that eating 500 grams of broccoli daily for 6 days increases CYP2A6 activity by 135% to 550%. Induction of CYP2A6 activity is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
BroccoPhane full monograph & interactions

Calcium-D-Glucarate3 drug types · 126 drugs

Alcohol (Ethanol)

Theoretically, concomitant use with alcohol might decrease calcium D-glucarate activity.
There is some evidence that urinary excretion of calcium D-glucarate metabolites increases in people consuming alcohol.

Likelihood Possible Evidence B
Glucuronidated Drugs

Theoretically, calcium D-glucarate might increase the clearance of drugs that undergo glucuronidation.
The calcium D-glucarate metabolite, D-glucaro-1,4-lactone, inhibits the enzyme beta-glucuronidase, reducing deconjugation of glucuronides in the intestine and thereby reducing reabsorption of the drugs.

Likelihood Possible Evidence B
Kanamycin

Theoretically, calcium D-glucarate may reduce plasma levels of kanamycin.
Calcium D-glucarate may increase the rate of kanamycin elimination, which may decrease its clinical and adverse effects.

Likelihood Possible Evidence D
Calcium-D-Glucarate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Estro-D-Tox, from the product label.

MDLogic

See all MDLogic products
Name
MD Logic Wellness Inc. for MD Logic Health
State
Florida
Phone Number
1-877-629-8711
Web Address
www.mdlogichealth.com
Pharmacist Counseling Corner

Estro-D-Tox by MDLogic: Common Questions

Does Estro-D-Tox by MDLogic interact with any medications?
Yes. Based on its ingredients, Estro-D-Tox has a known interaction with 900 medications, including 7 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Estro-D-Tox contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take if I'm pregnant or planning to get pregnant?
Calcium is rated likely safe during pregnancy at recommended doses, and adequate calcium is important then. However, diindolylmethane and sulforaphane (concentrated supplement forms) have not been proven safe in pregnancy, so you'd want to avoid them — stick to what you get from food. Talk with your doctor or pharmacist before starting.
Can I take this while breastfeeding?
Calcium needs can be met during breastfeeding at recommended amounts. Diindolylmethane has no reliable safety information for breastfeeding, so it's best avoided. Sulforaphane from normal food is fine, but concentrated supplement doses aren't well studied in breastfeeding — use caution and check with your provider.
What does sulforaphane actually do in this product?
Sulforaphane is a plant compound from cruciferous vegetables that's possibly effective for prostate cancer prevention based on current evidence. For other uses like cancer prevention broadly or allergies, we don't have enough reliable evidence yet.
Are there common side effects I should expect?
Calcium can cause belching, constipation, diarrhea, gas, and stomach upset. Diindolylmethane may cause diarrhea, gas, headache, nausea, or rash. Sulforaphane might cause stomach upset, heartburn, or headache. Most people tolerate these ingredients well at recommended doses.
What is diindolylmethane and where does it come from?
Diindolylmethane is a compound naturally found in cruciferous vegetables like broccoli and cabbage. It's studied for hormonal and prostate health, though we don't yet have strong evidence it works for those uses.
Can very high doses of calcium cause problems?
Yes. High doses can cause kidney stones and a rare condition called calciphylaxis. Some research also suggests intake over 1500–2000 mg daily may be linked to prostate cancer risk and heart disease, though this is still debated. Stick to recommended amounts unless your doctor says otherwise.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Estro-D-Tox label
Go deeper

The Full Monographs Behind Estro-D-Tox’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Diindolylmethane

Interacts with 269 drugs

Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and cancer prevention. Although early lab s...

Read the full Diindolylmethane monograph → Herb & supplement monograph

Calcium D-glucarate

Interacts with 126 drugs

Calcium D-glucarate is a supplement form of a natural compound found in fruits and vegetables that is promoted for 'detoxification' and helping the body clear excess hormones. Human evidence...

Read the full Calcium D-glucarate monograph → Herb & supplement monograph

Calcium

Interacts with 168 drugs

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet falls short. Most people do best getting...

Read the full Calcium monograph → Herb & supplement monograph

Broccoli

Interacts with 187 drugs

Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for health benefits. Eating broccoli as food...

Read the full Broccoli monograph → Herb & supplement monograph

Sulforaphane

Interacts with 722 drugs

Sulforaphane is a natural compound found in broccoli and other cruciferous vegetables that has shown promising antioxidant and anti-inflammatory effects in lab studies, but strong human evid...

Read the full Sulforaphane monograph →
Sources

Sources & How We Checked

Estro-D-Tox's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 102 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Calcium 62 references
  1. Shils M, Olson A, Shike M. Modern Nutrition in Health and Disease. 8th ed. Philadelphia, PA: Lea and Febiger, 1994.
  2. Hernandez-Avila M, Gonzalez-Cossio T, Hernandez-Avila JE, et al. Dietary calcium supplements to lower blood lead levels in lactating women: a randomized placebo-controlled trial. Epidemiology 2003;14:206-12.. PubMed
  3. Thys-Jacobs S, Ceccarelli S, Bierman A, et al. Calcium supplementation in premenstrual syndrome: a randomized crossover trial. J Gen Intern Med 1989;4:183-9. PubMed
  4. Maton PN, Burton ME. Antacids revisited: a review of their clinical pharmacology and recommended therapeutic use. Drugs 1999;57:855-70.
  5. Clemens JD, Feinstein AR. Calcium carbonate and constipation: a historical review of medical mythopoeia. Gastroenterology 1977;72:957-61. DOI
  6. Saunders D, Sillery J, Chapman R. Effect of calcium carbonate and aluminum hydroxide on human intestinal function. Dig Dis Sci 1988;33:409-13. PubMed
  7. Friedman PA, Bushinsky DA. Diuretic effects on calcium metabolism. Semin Nephrol 1999;19:551-6.
  8. Koo WK, Walters JC, Esterlitz J, et al. Maternal calcium supplementation and fetal bone mineralization. Obstet Gynecol 1999;94:577-82. DOI
  9. Raman L, Rajalakshmi K, Krishnamachari KAVR, et al. Effect of calcium supplementation to undernourished mothers during pregnancy on the bone density of the neonates. Am J Clin Nutr 1978; 31:466-9. DOI
  10. Murry JJ, Healy MD. Drug-mineral interactions: a new responsibility for the hospital dietician. J Am Diet Assoc 1991;91:66-73.
  11. Chan JM, Giovannucci E, Andersson SO, et al. Dairy products, calcium, phosphorous, vitamin D, and risk of prostate cancer. Cancer Causes Control 1998;9:559-66.
  12. Butner LE, Fulco PP, Feldman G, et al. Calcium carbonate-induced hypothyroidism. Ann Intern Med 2000:132:595. PubMed
  13. Schneyer CR. Calcium carbonate and reduction of levothyroxine efficacy. JAMA 1998;279:750. PubMed
  14. Moser LR, Smythe MA, Tisdale JE. The use of calcium salts in the prevention and management of verapamil-induced hypotension. Ann Pharmacother 2000;34:622-9. PubMed
  15. Singh N, Singh PN, Hershman JM. Effect of calcium carbonate on the absorption of levothyroxine. JAMA 2000;283:2822-5. PubMed
  16. Kahela P, Anttila M, Tikkanen R, Sundquist H. Effect of food, food constituents and fluid volume on the bioavailability of sotalol. Acta Pharmacol Toxicol (Copenh) 1979;44:7-12.. PubMed
  17. Pletz MW, Petzold P, Allen A, et al. Effect of calcium carbonate on bioavailability of orally administered gemifloxacin. Antimicrob Agents Chemother 2003;47:2158-60.. PubMed
  18. Bar-Or D, Yoel G. Calcium and calciferol antagonize effect of verapamil in atrial fibrillation. Br Med J 1981;282:1585-6.
  19. Decktor DL, Robinson M, Maton PN, et al. Effects of aluminum/magnesium hydroxide and calcium carbonate on esophageal and gastric pH in subjects with heartburn. Am J Ther 1995;2:546-52. PubMed
  20. Simoneau G. Absence of rebound effect with calcium carbonate. Eur J Drug Metab Pharmacokinet 1996;21:351-7. PubMed
  21. Peters ML, Leonard M, Licata AA. Role of alendronate and risedronate in preventing and treating osteoporosis. Cleve Clin J Med 2001;68:945-51. PubMed
  22. Bourke JF, Mumford R, Whittaker P, et al. The effects of topical calcipotriol on systemic calcium homeostasis in patients with chronic plaque psoriasis. J Am Acad Dermatol 1997;37:929-34.
  23. Gueguen L, Pointillart A. The bioavailability of dietary calcium. J Am Coll Nutr 2000;19:119s-136s. PubMed
  24. Vella A, Gerber TC, Hayes DL, Reeder GS. Digoxin, hypercalcaemia, and cardiac conduction. Postgrad Med J 1999;75:554-6. PubMed
  25. Bania TC, Blaufeux B, Hughes S, et al. Calcium and digoxin vs. calcium alone for severe verapamil toxicity. Acad Emerg Med 2000;7:1089-96. PubMed
  26. Tseng M, Breslow RA, Graubard BI, Ziegler RG. Dairy, calcium, and vitamin D intakes and prostate cancer risk in the National Health and Nutrition Examination Epidemiologic Follow-up Study cohort. Am J Clin Nutr 2005;81:1147-54. PubMed
  27. Weingarten MA, Zalmanovici A, Yaphe J. Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps. Cochrane Database Syst Rev 2004;(1):CD003548. PubMed
  28. Tavani A, Bertuccio P, Bosetti C, et al. Dietary intake of calcium, vitamin D, phosphorus and the risk of prostate cancer. Eur Urol 2005;48:27-33. PubMed
  29. Giovannucci E, Liu Y, Stampfer MJ, Willett WC. A prospective study of calcium intake and incident and fatal prostate cancer. Cancer Epidemiol Biomarkers Prev 2006;15:203-10. PubMed
  30. Rocephin (ceftriaxone) and calcium interaction. Pharmacist's Letter / Prescriber's Letter 2007;23(10):231005.
  31. Bolland MJ, Barber PA, Doughty RN, et al. Vascular events in healthy older women receiving calcium supplementation: randomised control trial. BMJ 2008;336:262-6.
  32. Bolland MJ, Avenell A, Baron JA, et al. Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis. BMJ 2010;341:c3691. PubMed
  33. Calcium supplementation and vascular events. Pharmacist's Letter / Prescriber's Letter 2008;24(3):240306.
  34. Dietary reference intakes for calcium and vitamin D. Institute of Medicine, November 30, 2010. Available at: http://www.iom.edu/~/media/Files/Report%20Files/2010/Dietary-Reference-Intakes-for-Calcium-and-Vitamin-D/Vitamin%20D%20and%20Calcium%202010%20Repo
  35. Coburn JW, Mischel MG, Goodman WG, et al. Calcium citrate markedly enhances aluminum absorption from aluminum hydroxide. Am J Kidney Dis. 1991;17(6):708-11. PubMed
  36. Bradley JS, Wassel RT, Lee L, et al. Intravenous ceftriaxone and calcium in the neonate: assessing the risk for cardiopulmonary adverse events. Pediatrics. 2009;123(4):e609-13. PubMed
  37. Kays MB, Overholser BR, Mueller BA, et al. Effects of sevelamer hydrochloride and calcium acetate on the oral bioavailability of ciprofloxacin. Am J Kidney Dis. 2003;42(6):1253-9. PubMed
  38. Neuhofel, A. L., Wilton, J. H., Victory, J. M., Hejmanowsk, L. G., and Amsden, G. W. Lack of bioequivalence of ciprofloxacin when administered with calcium-fortified orange juice: a new twist on an old interaction. J Clin Pharmacol. 2002;42(4):461-466. DOI
  39. Dickinson, H. O., Nicolson, D. J., Cook, J. V., Campbell, F., Beyer, F. R., Ford, G. A., and Mason, J. Calcium supplementation for the management of primary hypertension in adults. Cochrane.Database.Syst.Rev. 2006;(2):CD004639. PubMed
  40. Jones, B. J. and Twomey, P. J. Requesting patterns for serum calcium concentration in patients on long-term lithium therapy. Int J Clin Pract. 2009;63(1):170-172. PubMed
  41. Levine, M., Nikkanen, H., and Pallin, D. J. The effects of intravenous calcium in patients with digoxin toxicity. J Emerg.Med. 2011;40(1):41-46. PubMed
  42. Castelo-Branco, C., Ciria-Recasens, M., Cancelo-Hidalgo, M. J., Palacios, S., Haya-Palazuelos, J., Carbonell-Abello, J., Blanch-Rubio, J., Martinez-Zapata, M. J., Manasanch, J., and Perez-Edo, L. Efficacy of ossein-hydroxyapatite complex compared with ca
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Diindolylmethane 14 references
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Calcium D-glucarate 5 references
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Sulforaphane 16 references
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Broccoli 5 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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