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Dietary supplement

Eupatorium Per. Boneset Ingredients & Drug Interactions

by Wise Woman Herbals

Eupatorium Per. Boneset label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Eupatorium Per. Boneset against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Eupatorium Per. Boneset is a dietary supplement by Wise Woman Herbals with 1 active ingredient. Its ingredients are commonly taken for colds and flu, fever, body aches.Based on those ingredients, 87 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Boneset. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Eupatorium Per. Boneset by Wise Woman Herbals

Ask about any prescription or over-the-counter medication and we check it for interactions with Eupatorium Per. Boneset by Wise Woman Herbals — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Eupatorium Per. Boneset by Wise Woman Herbals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (2 mL) without saying how much of each component you get.

This liquid contains one active ingredient: boneset (Eupatorium perfoliatum). The product also holds spring water and alcohol as inactive ingredients.

Boneset is a traditional herb used to support the body during cold symptoms, though the evidence for this use isn't well established in the data we have.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Boneset product and its label doesn't state a use — see Boneset's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for boneset in treating the common cold is insufficient to rate in the data we hold. We can't confirm whether it works for that purpose based on reliable studies.

The evidence, ingredient by ingredient Boneset

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Boneset carries important safety cautions. It may cause nausea, severe diarrhea, and vomiting.

More seriously, plants in the boneset genus contain liver-toxic alkaloids, and liver damage is possible—especially at higher doses. The safety data advises against use during pregnancy and while breastfeeding because of potential toxicity and the risk that harmful alkaloids could pass to an infant.

Because safety information is limited, use it only short-term and with care, if at all.

Side effects, ingredient by ingredient Boneset

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Boneset.
  • The most serious interaction on file is rated Moderate.
  • For scale: 88 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, check whether you're on a CYP3A4 inducer (a Moderate interaction), such as carbamazepine. Because 85 individual medications have documented interactions with boneset, use the search tool on this page to verify your exact prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a product with real safety concerns. If you're considering it for cold symptoms, know that the evidence for its effectiveness isn't established.

Pregnant or breastfeeding? Don't use it.

On any regular medications, especially seizure or heart drugs? Check with your pharmacist first—85 medications interact with components of this product.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 24, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Eupatorium Per. Boneset, straight from the product label.

Brand Wise Woman Herbals
Barcode (UPC) 748840008991
Net contents 2 Fluid oz.; 60 mL
Market status On market
Date entered into DSLD May 24, 2023
DSLD ID 284821
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Eupatorium Per. Boneset by Wise Woman Herbals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
10 Drop(s)
Maximum serving Sizes:
40 Drop(s)
Servings per container
30
UPC/BARCODE
748840008991
IngredientAmount% DV
Proprietary Blend2 mL--
Boneset0 NP--

Other ingredients: spring Water, Alcohol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: Shake well. Add 10-40 drops to water, 1-4 times per day.

General Statements

The presence of particulate matter in this product is normal.

Botanical Formula

Precautions

Caution: Do not exceed suggested use. Not for long term use.

Keep out of the reach of children.

FDA Statement of Identity

Dietary Supplement

Storage

Store in a cool, dry area away from direct sunlight with the lid tightly sealed.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Eupatorium Per. Boneset by Wise Woman Herbals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Eupatorium Per. Boneset label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Eupatorium Per. Boneset by Wise Woman Herbals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size10 Drop(s) Dosage formLiquid Servings per container30 Amounts shown are per serving.

Proprietary Blend

2 mL per serving

Other (inactive) ingredients: Spring Water, Alcohol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Eupatorium Per. Boneset by Wise Woman Herbals Drug Interactions

Want to check YOUR meds against Eupatorium Per. Boneset?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
87Drugs
87 Moderate

Ingredients driving the most interactions

Boneset 87

Individual Drug Interactions

The ingredients in Eupatorium Per. Boneset interact with 87 drugs. Click any drug to see the details.

1 of the 1 ingredient in Eupatorium Per. Boneset interact with drugs. Each result below shows which ingredient is responsible. Boneset

Each ingredient & the kinds of drugs it affects

For each ingredient in Eupatorium Per. Boneset with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Boneset1 drug type · 87 drugs

Cytochrome P450 3A4 (Cyp3A4) Inducers

Boneset belongs to the genus Eupatorium, and many species of this genus contain hepatotoxic pyrrolizidine alkaloids (PAs). Hepatotoxic PAs are substrates of cytochrome P450 3A4 (CYP3A4). Theoretically, drugs that induce CYP3A4 might increase the conversion of PAs to toxic metabolites. Some drugs that induce CYP3A4 include carbamazepine (Tegretol), phenobarbital, phenytoin (Dilantin), rifampin, rifabutin (Mycobutin), and others.

Likelihood Possible Evidence D
Boneset full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Eupatorium Per. Boneset, from the product label.

Wise Woman Herbals

See all Wise Woman Herbals products
Name
Wise Woman Herbals
City
Creswell
State
OR
ZipCode
97426
Phone Number
541.895.5152
Web Address
wisewomanherbals.com
Pharmacist Counseling Corner

Eupatorium Per. Boneset by Wise Woman Herbals: Common Questions

Does Eupatorium Per. Boneset by Wise Woman Herbals interact with any medications?
Yes. Based on its ingredients, Eupatorium Per. Boneset has a known interaction with 87 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Eupatorium Per. Boneset contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I use boneset if I'm pregnant or breastfeeding?
No. The safety data advises against it during pregnancy and while breastfeeding because of potential toxicity to you and your baby, plus the risk that harmful alkaloids could pass into breast milk. Talk with your doctor or pharmacist about safer options.
What side effects might I experience?
Boneset has been reported to cause nausea and severe diarrhea and vomiting. Liver damage is also possible, particularly at higher doses. Limited safety data means other effects may exist that we don't yet know about.
How is this product supposed to work?
Boneset is a traditional herb used to support the body during cold symptoms. However, the evidence for this use isn't well established in the data we hold, so we can't confirm it works.
What's in this liquid besides the boneset?
The liquid contains spring water and alcohol as inactive ingredients. The active part is the boneset extract.
Should I use this short-term or long-term?
Use it short-term only, if at all, because of limited safety data and the presence of potentially liver-toxic alkaloids. Talk with your pharmacist about whether this product is right for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Eupatorium Per. Boneset is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Eupatorium Per. Boneset label
Go deeper

The Full Monographs Behind Eupatorium Per. Boneset’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Boneset

Interacts with 87 drugs

Boneset is a traditional North American herb long used in teas for fevers, colds, and flu, but modern human studies are very limited. It contains compounds (pyrrolizidine alkaloids) that may...

Read the full Boneset monograph →
Sources

Sources & How We Checked

Eupatorium Per. Boneset's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Boneset 5 references
  1. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
  2. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
  3. Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. PubMed
  4. Gassinger, C. A., Wunstel, G., and Netter, P. [A controlled clinical trial for testing the efficacy of the homeopathic drug eupatorium perfoliatum D2 inthe treatment of common cold (author's transl)]. Arzneimittelforschung. 1981;31(4):732-736.
  5. Colegate SM, Upton R, Gardner DR, Panter KE, Betz JM. Potentially toxic pyrrolizidine alkaloids in Eupatorium perfoliatum and three related species. Implications for herbal use as boneset. Phytochem Anal. 2018;29(6):613-626.

See these in context on the Boneset monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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