Interactions on record — worth a quick check against your medications. Based on 2 of 10 ingredients. Check your meds →
Dietary supplement

Ultimate Flora RTS Daily Probiotic 15 Billion Ingredients & Drug Interactions

by Renew Life

Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Ultimate Flora RTS Daily Probiotic 15 Billion is a dietary supplement by Renew Life with 10 active ingredients. Its ingredients are commonly taken for digestive health and regularity, infant colic and gut support, diarrhea (including antibiotic-related).Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bifidobacterium breve, Lactobacillus acidophilus. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Ultimate Flora RTS Daily Probiotic 15 Billion by Renew Life

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 10 active ingredients.
  • “Bifidobacterium breve” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Lactobacillus salivarius” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Ultimate Flora Daily Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

This product contains 10 active probiotic strains—live beneficial bacteria designed to support your gut health. The main players are Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus casei, and Bifidobacterium species.

Each capsule delivers 15 billion live organisms from these cultures. The inactive ingredients are just a vegetable capsule and cellulose.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: digestive health and regularity support.
  • We looked for evidence on: Antibiotic-associated diarrhea, Colic, Constipation, Irritable bowel syndrome (IBS), Lactose intolerance, Rotaviral diarrhea — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Irritable bowel syndrome (IBS).
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Constipation, Inflammatory bowel disease (IBD), Lactose intolerance, Rotaviral diarrhea, and more.

Lactobacillus acidophilus, one of the active strains, is possibly effective for irritable bowel syndrome (IBS), Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis based on the evidence we have on file. It's rated possibly ineffective for atopic disease (allergic conditions), and there isn't enough reliable evidence yet to rate it for acute respiratory distress syndrome.

The effectiveness data for the other strains in this blend isn't established in our records.

The evidence, ingredient by ingredient Bifidobacterium Breve Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children. Oral use can occasionally cause mild gastrointestinal side effects—abdominal discomfort, gas, bloating, diarrhea, or burping—but these are uncommon.

There is a rare theoretical concern that live probiotic organisms could cause serious infection in people with certain conditions, though most cases reported have involved bacteria that were already present elsewhere in the body. Check with your doctor before starting, especially if you have a compromised immune system or a serious underlying illness.

We don't have pregnancy or breastfeeding safety data on file for these ingredients.

Side effects, ingredient by ingredient Bifidobacterium Breve Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Separate this probiotic from antibiotic drugs by a few hours—antibiotics can kill off the live organisms and reduce the probiotic's effectiveness. Check your exact medications with the search tool on this page to be sure.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This probiotic may help if you're dealing with IBS, antibiotic-related diarrhea, or certain infections. If you take antibiotics, time them separately from this product.

Most people tolerate it well, but it's smart to run your current medications through our checker below and touch base with your pharmacist or doctor first, especially if you have any immune system concerns.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 10 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Ultimate Flora RTS Daily Probiotic 15 Billion, straight from the product label.

Brand Renew Life
Barcode (UPC) 631257158772
Net contents 60 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Mar 25, 2021
DSLD ID 243407
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Ultimate Flora RTS Daily Probiotic 15 Billion by Renew Life, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
631257158772
IngredientAmount% DV
Bifidobacterium breve0 NP--
Lactobacillus brevis0 NP--
Lactobacillus plantarum0 NP--
Lactobacillus salivarius0 NP--
Lactobacillus casei0 NP--
Lactobacillus paracasei0 NP--
Lactobacillus acidophilus0 NP--
Lactobacillus rhamnosus0 NP--
Bifidobacterium lactis0 NP--
Total Bifido Probiotic Cultures0 NP--
Total Lacto Probiotic Cultures0 NP--
Total Bifido/Lacto Cultures0 NP--
Ultimate Flora Daily Blend0 NP--

Other ingredients: Vegetable Capsule, Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

The Ultimate Flora Probiotic Difference Higher Culture Count Ultimate Flora Daily Probiotic is a daily maintenance probiotic. Each capsule has 15 billion live cultures of 10 strains of beneficial flora. Delayed Release Capsule Stomach acid can destroy probiotics. Ultimate Flora delayed-release capsules are designed to resist stomach acid more than standard capsules.

Superior Health Begins in the Digestive System Ultimate Flora RTS (Room Temperature Strains) Daily Probiotic contains 10 beneficial Bifido and Lacto probiotic strains working differently to help optimize your digestive health. Why Take Ultimate Flora? As we age, our level of Bifidobacteria declines. Ultimate Flora Daily Probiotic contains 50% Bifido to help maintain a healthy digestive environment. What to Look For in a Daily Probiotic: At least 10 probiotic strains High culture count with Bifido & Lacto strains Delayed release capsule Potency until time of consumption

15 billion live cultures per capsule 10 probiotic strains Room temperature strains

Formulated to provide 15 billion live cultures per capsule at time of consumption, if prior to expiration, under recommended storage conditions. Storage and handling conditions may vary, and may affect the total amount of cultures delivered at consumption.

Formulation

Manufactured in USA

Supports immune health Promotes digestive balance Delayed release

Gluten & dairy free

Free of GMOs, wheat, gluten, soy, dairy, eggs, shellfish, tree nuts, and artificial ingredients. Made in a facility that handles wheat, gluten, soy, and dairy. Individuals extremely sensitive to these ingredients should consult a physician prior to using this product.

Manufactured in a GMP facility Quality and Purity Guaranteed

General Statements

Brenda Watson is a leading expert on natural digestive care. Her Ultimate Flora RTS probiotics are formulated to help balance the digestive system, and promote regularity and vibrant healt

Value Size 60 capsules

Individually sealed

Renew Life The digestive care experts

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

No refrigeration required

Store in dry place at 77 degrees F (25 degrees C) or below

No Refrigeration Required Ultimate Flora RTS (Room Temperature Strains) capsules are conveniently sealed in a double-foil blister to shield the probiotics from moisture and oxygen, prolonging potency at room temperature. Refrigeration, while not required, can be helpful during summer months.

Suggested/Recommended/Usage/Directions

Once daily

Directions: For best results, take 1 capsule daily with or without food.

FDA Statement of Identity

Probiotic Supplement

Precautions

Tamper Evident: Do not use if foil or pouches inside are punctured.

Made in a facility that handles wheat, gluten, soy, and dairy. Individuals extremely sensitive to these ingredients should consult a physician prior to using this product.

Keep out of reach of children.

Warning: Consult your physician before using this or any product if you are pregnant, nursing, trying to conceive, taking medication, or have a medical condition.

See for yourself

Ultimate Flora RTS Daily Probiotic 15 Billion by Renew Life label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Ultimate Flora RTS Daily Probiotic 15 Billion by Renew Life

These are the 10 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Total Bifido/Lacto Cultures

0 NP per serving

Ultimate Flora Daily Blend

0 NP per serving
  • Bifidobacterium breve
  • › Lactobacillus brevis
  • › Lactobacillus plantarum
  • › Lactobacillus salivarius
  • › Lactobacillus casei
  • › Lactobacillus paracasei
  • Lactobacillus acidophilus
  • › Lactobacillus rhamnosus
  • › Bifidobacterium lactis

Other (inactive) ingredients: Vegetable Capsule, Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Ultimate Flora RTS Daily Probiotic 15 Billion by Renew Life Drug Interactions

Want to check YOUR meds against Ultimate Flora RTS Daily Probiotic 15 Billion?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Ultimate Flora RTS Daily Probiotic 15 Billion with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bifidobacterium breve1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B. breve.
Since B. breve preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. breve preparations by at least 2 hours.

Likelihood Probable Evidence D

Lactobacillus acidophilus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
The maker

Brand information

Manufacturer and brand details for Ultimate Flora RTS Daily Probiotic 15 Billion, from the product label.

Renew Life

Name
Renew Life Formulas
City
Palm Harbor
State
FL
ZipCode
34683
Phone Number
1-800-830-1800
Web Address
www.renewlife.com
Pharmacist Counseling Corner

Ultimate Flora RTS Daily Probiotic 15 Billion by Renew Life: Common Questions

Does Ultimate Flora RTS Daily Probiotic 15 Billion by Renew Life interact with any medications?
Yes. Based on its ingredients, Ultimate Flora RTS Daily Probiotic 15 Billion has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Ultimate Flora RTS Daily Probiotic 15 Billion contains 10 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this probiotic while I'm on an antibiotic?
Not at the same time. Antibiotics can kill the live bacteria in this product, making it less effective. Take your antibiotic as directed, then start the probiotic a few hours later or after you finish your course.
What does Lactobacillus acidophilus do?
It's a beneficial gut bacterium that may help with irritable bowel syndrome, antibiotic-related diarrhea, certain infections like Helicobacter pylori and bacterial vaginosis, and possibly other digestive issues. It's one of the main strains in this formula.
Are there any common side effects?
Most people tolerate it well. Some experience mild gas, bloating, abdominal discomfort, or diarrhea when they first start, but these are uncommon. If you have a weakened immune system, talk to your doctor first—there's a rare theoretical concern with serious infection.
Is it safe to take if I'm pregnant or breastfeeding?
We don't have safety data for these ingredients during pregnancy or breastfeeding on file. Talk with your doctor or pharmacist about whether this product is right for you during these times.
How many strains are in this product?
Ten different probiotic strains, delivering 15 billion live organisms per capsule. The main ones are Lactobacillus acidophilus, L. plantarum, L. casei, and Bifidobacterium species.
What's inside the capsule besides the probiotics?
Just a vegetable capsule and cellulose—no unnecessary fillers.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Ultimate Flora RTS Daily Probiotic 15 Billion is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Ultimate Flora RTS Daily Probiotic 15 Billion label
Sources

Sources & How We Checked

Ultimate Flora RTS Daily Probiotic 15 Billion's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 24 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bifidobacterium Breve 9 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  4. Ohishi A, Takahashi S, Ito Y, et al. Bifidobacterium septicemia associated with postoperative probiotic therapy in a neonate with omphalocele. J Pediatr. 2010;156(4):679-81. PubMed
  5. Sakurai Y, Watanabe T, Miura Y, et al. Clinical and bacteriologic characteristics of six cases of Bifidobacterium breve bacteremia due to probiotic administration in the neonatal intensive care unit. Pediatr Infect Dis J 2022;41(1):62-65. PubMed
  6. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
  7. Wakabayashi Y, Nakayama S, Yamamoto A, et al. First case of necrotizing fasciitis and bacteremia caused by Bifidobacteriumbreve. Anaerobe 2022;76:102613.
  8. Takeda Y, Ota K, Kondo A, et al. A case of necrotizing fasciitis caused by Bifidobacterium breve. IDCases 2022;31:e01667. PubMed
  9. Suwantarat N, Romagnoli M, Wakefield T, Carroll KC. Ventriculoperitoneal shunt infection caused by Bifidobacterium breve. Anaerobe 2014;28:1-3. PubMed

See these in context on the Bifidobacterium Breve monograph →

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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