Fenugreek Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Fenugreek against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Fenugreek is a dietary supplement by Mama's Select with 1 active ingredient. Its ingredients are commonly taken for blood sugar control, boosting breast milk supply, high cholesterol.Based on those ingredients, 389 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic Fenugreek seed powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Fenugreek by Mama's Select
Ask about any prescription or over-the-counter medication and we check it for interactions with Fenugreek by Mama's Select — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Fenugreek by Mama's Select
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: organic fenugreek seed powder. Fenugreek is a plant seed used traditionally to support blood sugar control, sexual function, and menstrual comfort.
The capsules also contain inactive ingredients—rice flour, magnesium stearate, silicon dioxide, and vegetable cellulose—which are fillers and binders that help form and preserve the capsule.
Does it work?
Not established
In our data, fenugreek seed is rated possibly effective for sexual dysfunction, sexual arousal, dysmenorrhea (painful periods), and type 2 diabetes. Clinical research does show that fenugreek can lower fasting blood sugar and post-meal glucose levels in adults with diabetes.
The evidence for sexual function is based on smaller studies, so the effect isn't certain. The strength of the evidence for each use is not equal, so talk with your pharmacist or doctor about whether fenugreek makes sense for your particular goal.
How safe is it?
Well-documented data
Fenugreek seed is generally well tolerated in food amounts, but supplement doses can cause side effects. The most common ones are abdominal pain, bloating, diarrhea, indigestion, gas, and nausea.
Rare but serious allergic reactions—including swelling of the airways, wheezing, and anaphylaxis—have been reported. Some people who take fenugreek develop an unusual body odor in their urine and sweat.
Fenugreek is rated likely unsafe in pregnancy because it may affect the uterus; the safety data advises against medicinal use during pregnancy. For breastfeeding, fenugreek is rated possibly safe, though evidence is limited—discuss it with your provider before using it to boost milk supply.
Meds to double-check
Moderate interaction found
Before you take Mama's Select Fenugreek, double-check it with your pharmacist if you're on any blood thinner or antiplatelet drug (such as warfarin or clopidogrel), diabetes medication, theophylline, phenytoin, sildenafil, or metoprolol. All of these interactions are rated Moderate.
Fenugreek may reduce how well some of these drugs work or add to their effects in ways that matter.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
Fenugreek may help with blood sugar control and sexual function, but it has documented interactions with blood thinners, diabetes drugs, and several other medications. If you take any prescription medication—especially for blood clotting, diabetes, heart rhythm, seizures, or breathing—check with your pharmacist before adding this supplement.
Pregnant women should avoid medicinal doses; breastfeeding mothers should discuss it with their provider first.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Fenugreek, straight from the product label.
| Brand | Mama's Select |
|---|---|
| Barcode (UPC) | X000XWL3AR |
| Net contents | 120 Veggie Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Feb 25, 2021 |
| DSLD ID | 244108 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Women (not pregnant or lactating), Adult Female (18 - 50 Years), Lactating |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Fenugreek by Mama's Select, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| organic Fenugreek seed powder | 1220 mg | -- |
Other ingredients: Rice Flour, Magnesium Stearate, Silicon Dioxide, Vegetable Cellulose
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Advanced formula "High potency" Designed to promote natural milk production
FDA Statement of Identity
Dietary Supplement
Seals/Symbols
Made in the U.S.A.
GMP Good Manufacturing Practice Consistent Quality
Suggested/Recommended/Usage/Directions
Suggested Use: Nursing women take 2 capsules 3 times daily preferably with meals, or as directed by a health care practitioner.
Precautions
Tamper Resistance: Please do not use if safety seal is broken or missing.
Caution: Not for use during pregnancy.
Warnings: Do not use if you are under the age of 18.
Do not exceed recommended serving.
Consult your health care provider prior to using this or any other dietary supplement, especially if you are taking any medications, over the counter products, or other dietary supplements, or if you have or suspect you may have any medical condition.
Immediately discontinue use and call your health care provider if you experience any adverse reaction.
Keep out of reach of children.
Storage
Store in a cool, dry place.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
General Statements
Please recycle
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Fenugreek by Mama's Select label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Fenugreek by Mama's Select
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size2 Veggie Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Organic Fenugreek seed powder
Interacts with389 drugs
Fenugreek is a common kitchen spice that is also taken as a supplement, mainly for blood sugar, cholesterol, and to support breast milk production. So...
Organic Fenugreek seed powder monograph & interactionsOther (inactive) ingredients: Rice Flour, Magnesium Stearate, Silicon Dioxide, Vegetable Cellulose. These complete the product’s ingredient list but are not active constituents.
Fenugreek by Mama's Select Drug Interactions
HelloPharmacist Interaction Report
Mama's Select Fenugreek contains a single active ingredient—fenugreek seed powder—that interacts with a significant number of medications.
The most serious documented concern is with blood thinners and antiplatelet drugs. Fenugreek seed can add to the effects of anticoagulants (blood thinners like warfarin) and antiplatelet medications (such as clopidogrel), which could increase bleeding risk.
Read the full breakdown — every affected drug type, severity by severity
Beyond blood thinners, fenugreek may lower blood sugar when combined with diabetes medications, potentially causing low blood sugar (hypoglycemia). It may also reduce how your body handles theophylline (a breathing medication), phenytoin (a seizure drug), and sildenafil (Viagra)—making those medications less effective.
Additionally, it could add to the blood-pressure-lowering effects of metoprolol and similar beta-blockers.
Altogether, these interactions span 386 individual medications. Because fenugreek's strength can vary widely between products, the real-world risk of some of these interactions remains unclear.
Before you start this supplement, check your exact medications with the search tool on this page—especially if you take any blood thinner, diabetes medication, heart drug, or seizure medication.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Fenugreek?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Fenugreek interact with 389 drugs. Click any drug to see the details.
1 of the 1 ingredient in Fenugreek interact with drugs. Each result below shows which ingredient is responsible. organic Fenugreek seed powder
Ephedrine, Guaifenesin, Phenobarbital, TheophyllineMudrane GG
How Ephedrine, Guaifenesin, Phenobarbital, Theophylline interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Organic Fenugreek Seed PowderTheophylline Moderate
Interaction Summary
Theoretically, fenugreek may reduce the levels and clinical effects of theophylline.
Read the full Organic Fenugreek Seed Powder + Ephedrine, Guaifenesin, Phenobarbital, Theophylline interactionEphedrine, Hydroxyzine, TheophyllineAmi Rax, Marax
How Ephedrine, Hydroxyzine, Theophylline interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Organic Fenugreek Seed PowderTheophylline Moderate
Interaction Summary
Theoretically, fenugreek may reduce the levels and clinical effects of theophylline.
Read the full Organic Fenugreek Seed Powder + Ephedrine, Hydroxyzine, Theophylline interactionEphedrine, Phenobarbital, Potassium Iodide, TheophyllineMudrane, Quadrinal
How Ephedrine, Phenobarbital, Potassium Iodide, Theophylline interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Organic Fenugreek Seed PowderTheophylline Moderate
Interaction Summary
Theoretically, fenugreek may reduce the levels and clinical effects of theophylline.
Read the full Organic Fenugreek Seed Powder + Ephedrine, Phenobarbital, Potassium Iodide, Theophylline interactionEphedrine, Phenobarbital, TheophyllineTedral
How Ephedrine, Phenobarbital, Theophylline interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Organic Fenugreek Seed PowderTheophylline Moderate
Interaction Summary
Theoretically, fenugreek may reduce the levels and clinical effects of theophylline.
Read the full Organic Fenugreek Seed Powder + Ephedrine, Phenobarbital, Theophylline interactionEptifibatideIntegrilin
How Eptifibatide interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Organic Fenugreek Seed PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Organic Fenugreek Seed Powder + Eptifibatide interactionErtugliflozinSteglatro
How Ertugliflozin interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Organic Fenugreek Seed PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Organic Fenugreek Seed Powder + Ertugliflozin interactionErtugliflozin, Metformin HydrochlorideSegluromet
How Ertugliflozin, Metformin Hydrochloride interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Organic Fenugreek Seed PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Organic Fenugreek Seed Powder + Ertugliflozin, Metformin Hydrochloride interactionEsomeprazole, NaproxenVimovo
How Esomeprazole, Naproxen interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Organic Fenugreek Seed PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Organic Fenugreek Seed Powder + Esomeprazole, Naproxen interactionExenatideBydureon, Byetta
How Exenatide interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Organic Fenugreek Seed PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Organic Fenugreek Seed Powder + Exenatide interactionExenatide SyntheticBydureon BCISE
How Exenatide Synthetic interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Organic Fenugreek Seed PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Organic Fenugreek Seed Powder + Exenatide Synthetic interactionFamotidine, IbuprofenDuexis
How Famotidine, Ibuprofen interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Organic Fenugreek Seed PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Organic Fenugreek Seed Powder + Famotidine, Ibuprofen interactionFish Oil TriglyceridesOmegaven
How Fish Oil Triglycerides interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Organic Fenugreek Seed PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Organic Fenugreek Seed Powder + Fish Oil Triglycerides interactionFondaparinuxArixtra
How Fondaparinux interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Organic Fenugreek Seed PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Organic Fenugreek Seed Powder + Fondaparinux interactionFosphenytoinCerebyx
How Fosphenytoin interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Organic Fenugreek Seed PowderPhenytoin (dilantin) Moderate
Interaction Summary
Theoretically, fenugreek might decrease plasma levels of phenytoin.
Read the full Organic Fenugreek Seed Powder + Fosphenytoin interactionFosphenytoin SodiumSesquient
How Fosphenytoin Sodium interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Organic Fenugreek Seed PowderPhenytoin (dilantin) Moderate
Interaction Summary
Theoretically, fenugreek might decrease plasma levels of phenytoin.
Read the full Organic Fenugreek Seed Powder + Fosphenytoin Sodium interactionGliclazideDiamicron
How Gliclazide interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Organic Fenugreek Seed PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Organic Fenugreek Seed Powder + Gliclazide interactionGlimepirideAmaryl
How Glimepiride interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Organic Fenugreek Seed PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Organic Fenugreek Seed Powder + Glimepiride interactionGlipizideGlucotrol, Glucotrol XL
How Glipizide interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Organic Fenugreek Seed PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Organic Fenugreek Seed Powder + Glipizide interactionGlipizide, MetforminMetaglip
How Glipizide, Metformin interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Organic Fenugreek Seed PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Organic Fenugreek Seed Powder + Glipizide, Metformin interactionGlucagonBaqsimi, Glucagon
How Glucagon interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Organic Fenugreek Seed PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Organic Fenugreek Seed Powder + Glucagon interactionGlucoseIV Glucose
How Glucose interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Organic Fenugreek Seed PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Organic Fenugreek Seed Powder + Glucose interactionGlyburideAlbert Glyburide, Diabeta, Glycron, Glynase, Glynase PresTab, Micronase +1 more
How Glyburide interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Organic Fenugreek Seed PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Organic Fenugreek Seed Powder + Glyburide interactionGlyburide, MetforminGlucovance
How Glyburide, Metformin interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Organic Fenugreek Seed PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Organic Fenugreek Seed Powder + Glyburide, Metformin interactionGuaifenesin, TheophyllineBronchial, Mudrane GG-2, Quibron, Quibron-300, Theolair-Plus
How Guaifenesin, Theophylline interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Organic Fenugreek Seed PowderTheophylline Moderate
Interaction Summary
Theoretically, fenugreek may reduce the levels and clinical effects of theophylline.
Read the full Organic Fenugreek Seed Powder + Guaifenesin, Theophylline interactionHeparinHeparin
How Heparin interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Organic Fenugreek Seed PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Organic Fenugreek Seed Powder + Heparin interactionHydrochlorothiazide, MetoprololLopressor HCT
How Hydrochlorothiazide, Metoprolol interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Organic Fenugreek Seed PowderAntihypertensive Drugs, Metoprolol (toprol) Moderate
Interaction Summary
Fenugreek may also have an additive effect on blood pressure-lowering medications.
Read the full Organic Fenugreek Seed Powder + Hydrochlorothiazide, Metoprolol interactionHydrocodone, IbuprofenVicoprofen
How Hydrocodone, Ibuprofen interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Organic Fenugreek Seed PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Organic Fenugreek Seed Powder + Hydrocodone, Ibuprofen interactionIbrutinibImbruvica
How Ibrutinib interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Organic Fenugreek Seed PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Organic Fenugreek Seed Powder + Ibrutinib interactionIbuprofenAdvil, Arthrofen, Brufen, Brufen Retard, Calodor, Calprofen +14 more
How Ibuprofen interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Organic Fenugreek Seed PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Organic Fenugreek Seed Powder + Ibuprofen interactionIbuprofen LysineNeoProfen
How Ibuprofen Lysine interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Organic Fenugreek Seed PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Organic Fenugreek Seed Powder + Ibuprofen Lysine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Fenugreek with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
organic Fenugreek seed powder
Anticoagulant/Antiplatelet Drugs
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Some of the constituents in fenugreek have antiplatelet effects in animal and in vitro research. However, common fenugreek products might not contain sufficient concentrations of these constituents for clinical effects. A clinical study in patients with coronary artery disease or diabetes shows that taking fenugreek seed powder 2.5 grams twice daily for 3 months does not affect platelet aggregation, fibrinolytic activity, or fibrinogen levels .
Antidiabetes Drugs
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Clinical research shows that fenugreek seed can reduce fasting blood glucose and 2-hour postprandial glucose levels in adults with type 2 diabetes.
Clopidogrel (Plavix)
Theoretically, fenugreek seed might alter the clinical effects of clopidogrel by inhibiting its conversion to the active form.
Animal research shows that fenugreek seed 200 mg/kg daily for 14 days increases the maximum serum concentration of clopidogrel by 21%. It is unclear how this affects the pharmacokinetics of the active metabolite of clopidogrel; however, this study found that concomitant use of fenugreek seed and clopidogrel prolonged bleeding time by an additional 11%.
Metoprolol (Toprol)
Theoretically, fenugreek seed might have additive hypotensive effects when used with metoprolol.
Animal research shows that fenugreek seed 300 mg/kg daily for 2 weeks decreases systolic and diastolic blood pressure by 9% and 11%, respectively, when administered alone, and by 15% and 22%, respectively, when given with metoprolol 10 mg/kg.
Phenytoin (Dilantin)
Theoretically, fenugreek might decrease plasma levels of phenytoin.
Animal research shows that taking fenugreek seeds for 1 week decreases maximum concentrations and the area under the curve of a single dose of phenytoin by 44% and 72%, respectively. This seems to be related to increased clearance. So far, this interaction has not been reported in humans.
Sildenafil (Viagra)
Theoretically, concurrent use of sildenafil and fenugreek might reduce levels and therapeutic effects of sildenafil.
Animal research shows that taking fenugreek seeds for 1 week reduces maximum concentrations and the area under the curve of a single dose of sildenafil by 27% and 48%, respectively. So far, this interaction has not been reported in humans.
Theophylline
Theoretically, fenugreek may reduce the levels and clinical effects of theophylline.
Animal research shows that fenugreek 50 grams daily for 7 days reduces the maximum serum concentration (Cmax) of theophylline by 28% and the area under the plasma drug concentration-time curve (AUC) by 22%.
Warfarin (Coumadin)
Theoretically, fenugreek might have additive effects with warfarin and increase the international normalized ratio (INR).
Some fenugreek constituents have antiplatelet effects, although these might not be present in concentrations that are clinically significant. In one case report, a patient taking warfarin experienced an increased INR when starting to take fenugreek in combination with boldo.
Antihypertensive Drugs
Fenugreek may also have an additive effect on blood pressure-lowering medications. Studies on animals have shown that fenugreek seed can decrease both systolic and diastolic blood pressure by up to 22% when combined with metoprolol. Therefore, it is essential to monitor your blood pressure regularly if you are taking fenugreek and metoprolol together or any other antihypertensive drugs.
Brand information
Manufacturer and brand details for Fenugreek, from the product label.
Mama's Select
See all Mama's Select products- Name
- Mama's Select
- Street Address
- Suite 5731
- City
- Frisco
- State
- TX
- ZipCode
- 75035
- Web Address
- www.MamasSelect.com
Fenugreek by Mama's Select: Common Questions
Does Fenugreek by Mama's Select interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm pregnant?
Is it safe to use while breastfeeding?
What side effects might I notice?
Does fenugreek actually help blood sugar?
Can I use this for sexual function?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Fenugreek is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Fenugreek’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Fenugreek's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 30 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Fenugreek 30 references
- Madar Z, Thorne R. Dietary fiber. Prog Food Nutr Sci 1987;11:153-74.
- Sharma RD, Raghuram TC, Rao NS. Effect of fenugreek seeds on blood glucose and serum lipids in type I diabetes. Eur J Clin Nutr 1990;44:301-6.
- Patil SP, Niphadkar PV, Bapat MM. Allergy to fenugreek (Trigonella foenum graecum). Ann Allergy Asthma Immunol 1997;78:297-300. PubMed
- Lambert J, Cormier J. Potential interaction between warfarin and boldo-fenugreek. Pharmacotherapy 2001;21:509-12. PubMed
- Bordia A, Verma SK, Srivastava KC. Effect of ginger (Zingiber officinale Rosc.) and fenugreek (Trigonella foenumgraecum L.) on blood lipids, blood sugar and platelet aggregation in patients with coronary artery disease. Prostaglandins Leukot Essent Fatty PubMed
- Yalcin SS, Tekinalp G, Ozalp I. Peculiar odor of traditional food and maple syrup urine disease. Pediatr Int 1999;41:108-9. PubMed
- Sewell AC, Mosandl A, Bohles H. False diagnosis of maple syrup urine disease owing to ingestion of herbal tea. N Engl J Med 1999;341:769.. PubMed
- Abdo MS, al-Kafawi AA. Experimental studies on the effect of Trigonella foenum-graecum (abstract). Planta Med 1969;17:14-8.
- Gupta A, Gupta R, Lal B. Effect of Trigonella foenum-graecum (fenugreek) seeds on glycaemic control and insulin resistance in type 2 diabetes mellitus: a double blind placebo controlled study. J Assoc Physicians India 2001;49:1057-61.
- Gabay MP. Galactogogues: medications that induce lactation. J Hum Lact 2002;18:274-9. PubMed
- Chevassus H, Gaillard JB, Farret A, et al. A fenugreek seed extract selectively reduces spontaneous fat intake in overweight subjects. Eur J Clin Pharmacol 2010;66(5):449-55. PubMed
- Turkyilmaz C, Onal E, Hirfanoglu IM, et al. The effect of galactagogue herbal tea on breast milk production and short-term catch-up of birth weight in the first week of life. J Altern Complement Med 2011;17(2):139-42. PubMed
- Swafford S, Berens P. Effect of fenugreek on breast milk volume. Abstract presented at: 5th International Meeting of the Academy of Breastfeeding Medicine; September 11-13,2000, Tucson, Arizona.
- Abdel-Barry, J. A., Abdel-Hassan, I. A., Jawad, A. M., and al Hakiem, M. H. Hypoglycaemic effect of aqueous extract of the leaves of Trigonella foenum-graecum in healthy volunteers. East Mediterr.Health J 2000;6(1):83-88. DOI
- Parvizpur, A., Ahmadiani, A., and Kamalinejad, M. Probable role of spinal purinoceptors in the analgesic effect of Trigonella foenum (TFG) leaves extract. J Ethnopharmacol 3-8-2006;104(1-2):108-112. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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