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Dietary supplement

Blessed Thistle Ingredients & Drug Interactions

by Mama's Select

Blessed Thistle label
See full label image
Capsule Category: Botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Blessed Thistle against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Blessed Thistle is a dietary supplement by Mama's Select with 1 active ingredient. Its ingredients are commonly taken for digestive upset and poor appetite, boosting bile flow, general bitter tonic.Based on those ingredients, 36 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Blessed Thistle. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Blessed Thistle by Mama's Select

Ask about any prescription or over-the-counter medication and we check it for interactions with Blessed Thistle by Mama's Select — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Blessed Thistle by Mama's Select

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Mama's Select Blessed Thistle is a single-ingredient supplement — just blessed thistle in a capsule. The capsule itself contains vegetable cellulose, rice flour, magnesium stearate, and silicon dioxide as inactive ingredients.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: promote natural milk production.
  • We looked for evidence on: Lactation, Breast milk supply, Galactagogue.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

We don't have reliable evidence that blessed thistle works for dyspepsia (indigestion or stomach upset), which is what it's traditionally used for. The data we hold rates the evidence as insufficient, so we can't say whether it'll help your symptoms.

The evidence, ingredient by ingredient Blessed Thistle

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Blessed thistle is often well tolerated in small amounts, but human safety data are limited. Higher doses — particularly more than 5 grams per cup of tea — can cause stomach irritation and vomiting.

It can also trigger an allergic skin reaction in people sensitive to plants in the ragweed family (ragweed, chrysanthemums, marigolds, daisies, and related herbs). During pregnancy, the safety data advises against using blessed thistle — it's traditionally thought to affect the uterus and lacks solid safety research.

If you're breastfeeding and considering blessed thistle to support milk supply, there isn't enough data to know if it's safe, so talk with your doctor or pharmacist first.

Side effects, ingredient by ingredient Blessed Thistle

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Blessed Thistle.
  • The most serious interaction on file is rated Minor.
  • For scale: 36 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with us before taking this product if you're on H2-blockers, antacids, or proton pump inhibitors (PPIs) for stomach acid or reflux. Blessed thistle may reduce how well these medications work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

Blessed thistle is traditionally used for digestion and milk supply, but we don't have solid evidence it works. If you take stomach acid-reducing medications, check with us first — blessed thistle may make them less effective.

The safety data in pregnancy advises against it; for breastfeeding, talk with your pharmacist about whether it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Blessed Thistle, straight from the product label.

Brand Mama's Select
Barcode (UPC) X000YZDOFF
Net contents 120 Veggie Capsule(s)
Market status On market
Date entered into DSLD Feb 25, 2021
DSLD ID 244092
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Women (not pregnant or lactating), Adult Female (18 - 50 Years), Lactating
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Blessed Thistle by Mama's Select, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
X000YZDOFF
IngredientAmount% DV
Blessed Thistle800 mg--

Other ingredients: Vegetable Cellulose, Rice Flour, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

High Potency Designed to promote natural milk production

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Made in the U.S.A.

GMP Good Manufacturing Practice Consistent Quality

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 2 capsules three times daily, preferably with a meal or as directed by a healthcare professional.

Precautions

Tamper Resistance: Please do not use if safety seal is broken or missing.

Caution: Not for use during pregnancy.

Warnings: Do not use if you are under the age of 18.

Do not exceed recommended serving.

Consult your health care provider prior to using this or any other dietary supplement, especially if you are taking any medications, over the counter products, or other dietary supplements, or if you have or suspect you may have any medical condition.

Immediately discontinue use and call your health care provider if you experience any adverse reaction.

Keep out of reach of children.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Please recycle

Advanced formula

Brand IP Statement(s)

Mama Select

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Blessed Thistle by Mama's Select label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Blessed Thistle label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Blessed Thistle by Mama's Select

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Blessed Thistle

Interacts with
36 drugs
800 mg per serving

Blessed thistle is a bitter herb traditionally used to stimulate appetite and ease mild digestive complaints. High-quality human studies are lacking,...

Blessed Thistle monograph & interactions

Other (inactive) ingredients: Vegetable Cellulose, Rice Flour, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Blessed Thistle by Mama's Select Drug Interactions

Want to check YOUR meds against Blessed Thistle?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
36Drugs
36 Minor

Ingredients driving the most interactions

Blessed Thistle 36

Individual Drug Interactions

The ingredients in Blessed Thistle interact with 36 drugs. Click any drug to see the details.

1 of the 1 ingredient in Blessed Thistle interact with drugs. Each result below shows which ingredient is responsible. Blessed Thistle

Each ingredient & the kinds of drugs it affects

For each ingredient in Blessed Thistle with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Blessed Thistle3 drug types · 36 drugs

Antacids

Theoretically, blessed thistle might decrease the effectiveness of antacids.
There are reports that blessed thistle increases stomach acid.

Likelihood Possible Evidence D
H2-Blockers

Theoretically, blessed thistle might decrease the effectiveness of H2-blockers.
There are reports that blessed thistle increases stomach acid.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Theoretically, blessed thistle might decrease the effectiveness of PPIs.
There are reports that blessed thistle increases stomach acid.

Likelihood Possible Evidence D
Blessed Thistle full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Blessed Thistle, from the product label.

Mama's Select

See all Mama's Select products
Name
Mama's Select
Street Address
Suite 5731
City
Frisco
State
TX
ZipCode
75035
Web Address
www.MamasSelect.com
Pharmacist Counseling Corner

Blessed Thistle by Mama's Select: Common Questions

Does Blessed Thistle by Mama's Select interact with any medications?
Yes. Based on its ingredients, Blessed Thistle has a known interaction with 36 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Blessed Thistle contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Blessed Thistle while pregnant?
No. Blessed thistle is traditionally thought to affect the uterus and lacks solid safety data in pregnancy, so the safety data advises against it. Talk with your doctor before considering any supplement during pregnancy.
Is it safe to use if I'm breastfeeding?
Blessed thistle is used traditionally to support milk supply, but safety studies are limited. There isn't enough data to know for sure, so check with your doctor or pharmacist for personalized advice.
What does blessed thistle actually do?
It's traditionally used to support digestion and milk supply in nursing mothers. We don't have reliable evidence it works for indigestion, though — the data we hold rates that evidence as insufficient.
Can blessed thistle cause side effects?
In small amounts, it's often well tolerated. Higher doses — more than 5 grams per cup of tea — can cause stomach irritation and vomiting. It can also trigger an allergic skin reaction if you're sensitive to the ragweed family of plants.
Does blessed thistle affect my stomach acid medications?
Yes. Blessed thistle is reported to increase stomach acid, which can make H2-blockers, antacids, and proton pump inhibitors (PPIs) less effective. Check your exact medications with the search tool on this page before you start.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Blessed Thistle label
Go deeper

The Full Monographs Behind Blessed Thistle’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Blessed Thistle

Interacts with 36 drugs

Blessed thistle is a bitter herb traditionally used to stimulate appetite and ease mild digestive complaints. High-quality human studies are lacking, so its benefits are not well proven. It...

Read the full Blessed Thistle monograph →
Sources

Sources & How We Checked

Blessed Thistle's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Blessed Thistle 2 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

See these in context on the Blessed Thistle monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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