Fibermucil Ingredients & Drug Interactions
by ProCaps
What is this page for?
First and foremost: checking Fibermucil against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Fibermucil is a dietary supplement by ProCaps with 3 active ingredients. Its ingredients are commonly taken for constipation, diarrhea, high cholesterol.Based on those ingredients, 2,083 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Dietary Fiber, Lactobacillus sporogenes. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Fibermucil by ProCaps
Ask about any prescription or over-the-counter medication and we check it for interactions with Fibermucil by ProCaps — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
Ask the Pharmacist
A licensed pharmacist will answer your question by email — free, usually within 24 hours.
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HelloPharmacist Scorecard of Fibermucil by ProCaps
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Partial disclosure
Fibermucil contains four active ingredients: two soluble fibers (psyllium powder and soluble fiber) and two insoluble fibers, plus a live probiotic called Lactobacillus sporogenes. The fibers work to add bulk to your stool and help move things along in your digestive tract.
The probiotic contributes beneficial bacteria to your gut. The capsule itself is made from gelatin.
Does it work?
Strong evidence
The probiotic ingredient has possibly effective evidence for constipation and irritable bowel syndrome (IBS). For antibiotic-associated diarrhea, athletic performance, cancer, and nonalcoholic fatty liver disease, the evidence isn't established well enough to rate it.
We don't have effectiveness information on file for the fiber components.
How safe is it?
Well-documented data
Lactobacillus sporogenes is generally well tolerated in healthy adults, but the overall safety evidence for probiotic products varies and isn't as complete as we'd like. There isn't enough reliable safety data to rule out all concerns—talk to your doctor before using, especially if you're very ill, severely immunocompromised, have a central line or other indwelling catheter, or are a preterm infant.
Rare cases of serious infection have been reported in those high-risk groups using probiotics.
Meds to double-check
Moderate interaction found
If you take antibiotics, separate them from this product by a few hours—the antibiotic can weaken the live probiotic. No other interactions are documented for the ingredients we could check.
The bottom line
Scorecard at a glancePartially disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Fibermucil might help with constipation or IBS symptoms if the fiber and probiotic components work for you. If you take antibiotics, time them separately from this supplement.
If you're immunocompromised, have a central catheter, or are very ill, check with your doctor first—the live organisms here carry a small but real infection risk in those settings.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Fibermucil, straight from the product label.
| Brand | ProCaps |
|---|---|
| Barcode (UPC) | 392943 |
| Net contents | 360 Easy-To-Swallow Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jun 25, 2025 |
| DSLD ID | 331552 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), No Allergies, Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Fibermucil by ProCaps, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 0 Calorie(s) | -- |
| Total Carbohydrates | 1 Gram(s) | 1% |
| Dietary Fiber | 1.1 Gram(s) | 4% |
| Psyllium, Powder | 1.2 Gram(s) | -- |
| Soluble Fiber | 0.9 Gram(s) | -- |
| Lactobacillus sporogenes | 0 NP | -- |
| Insoluble Fiber | 0.2 Gram(s) | -- |
Other ingredients: Gelatin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested Use Consume two capsules daily—preferably with food. You can increase or decrease your intake as required or as guided by your physician.
General Statements
For questions about the use of this product call 800.800.1200. Questions? Reorders? 800.800.1200 procaps.com Andrew Lessman
Precautions
Notice Always consume fiber with ample liquid. Do not use if you have issues swallowing. If abdominal discomfort results, discontinue use and contact physician.
Psyllium husk may cause rare allergic reactions.
Consume prescription medicines at least an hour before or after this product.
Formulation
Since 1979, Unsurpassed purity, quality and efficacy. 100% Solar production Zero-carbon footprint 100% Solar
Mild Natural Non-bloating
It contains no additives and provides an unparalleled, natural source of fiber without fiber’s typical unpleasant problems. Unlike typical fiber products and drinks there are no added colors, flavors, calories or synthetic ingredients.
Contains no common allergens
Contains no milk, soy, yeast, wheat, gluten, sodium, salt, sugar, fat, cholesterol, color, preservative, common allergens, genetically modified (GMO) ingredients, or manufacturing additives.
Brand IP Statement(s)
Copyright 2024 ProCaps Laboratories
Formula
Natural psyllium fiber in small capsules Rich in water-soluble and bulk fiber plus Lactobacillus friendly flora
FIBERMUCIL is a pure, encapsulated psyllium husk powder from the high-fiber Plantago ovata plant. It contains no additives and provides an unparalleled, natural source of fiber without fiber’s typical unpleasant problems. Fibermucil is delivered as a gentle, ultra-fine powder in small, easy-to-swallow capsules. Dietary fiber provides a myriad of health benefits and is often considered the most overlooked ingredient in the American diet. Fiber supports weight loss by providing feelings of fullness. It is also well established that the soluble fiber abundant in Fibermucil is an easy means of supporting healthy cholesterol levels and heart health. Natural Fibermucil also acts as a gentle sponge and broom naturally promoting regularity and transit time while cleansing the digestive tract of undigested food, debris, toxins and digestive by-products. Decades of clinical science have consistently proven the extensive health benefits of a fiber-rich diet to all body systems. Fibermucil provides a gentle, but powerful source of Mother Nature’s best source of dietary fiber without the undesirable ingredients or unpleasant problems associated with typical fiber products.
FDA Statement of Identity
Dietary Supplement
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Fibermucil by ProCaps label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Fibermucil by ProCaps
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container180 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Dietary Fiber
Interacts with2,025 drugs
Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. I...
Dietary Fiber monograph & interactions- › Soluble Fiber
- › Insoluble Fiber
Psyllium, Powder
Lactobacillus sporogenes
Interacts with182 drugs
Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, a...
Lactobacillus sporogenes monograph & interactionsOther (inactive) ingredients: Gelatin. These complete the product’s ingredient list but are not active constituents.
Fibermucil by ProCaps Drug Interactions
HelloPharmacist Interaction Report
Fibermucil by ProCaps contains four ingredients, and we could only fully check one of them for drug interactions.
Lactobacillus sporogenes (listed here under its scientific name Bacillus coagulans) interacts with antibiotics—a Moderate severity interaction. Because this is a live probiotic organism, antibiotics can kill it off and reduce how well it works.
You'll want to space out your antibiotic doses and this supplement by a few hours if you're taking both.
Read the full breakdown — every affected drug type, severity by severity
We don't hold interaction data for psyllium powder, soluble fiber, or insoluble fiber, so we can't tell you whether they interact with your medications. That doesn't mean they don't—it just means we haven't checked them yet.
Already, these interactions span 182 individual medications. Before you start Fibermucil, run your complete list of prescriptions through the checker on this page, especially if you take antibiotics.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Fibermucil?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Fibermucil interact with 2,083 drugs. Click any drug to see the details.
2 of the 3 ingredients in Fibermucil interact with drugs. Each result below shows which ingredient is responsible. Dietary Fiber Lactobacillus sporogenes
Penicillin G, ProcainePenicillin G Procaine
How Penicillin G, Procaine interacts with Fibermucil — through 1 ingredient. Tap an ingredient for the detail:
Lactobacillus SporogenesAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.
Read the full Lactobacillus Sporogenes + Penicillin G, Procaine interactionPenicillin VPen-Vee
How Penicillin V interacts with Fibermucil — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus SporogenesAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.
Read the full Lactobacillus Sporogenes + Penicillin V interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Penicillin V interactionPenicillin V PotassiumBeepen-VK, Ledercillin, Pen VK, Pen-Vee K, V-Cillin K, Veetids
How Penicillin V Potassium interacts with Fibermucil — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus SporogenesAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.
Read the full Lactobacillus Sporogenes + Penicillin V Potassium interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Penicillin V Potassium interactionPenicillin VkRobicillin
How Penicillin Vk interacts with Fibermucil — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus SporogenesAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.
Read the full Lactobacillus Sporogenes + Penicillin Vk interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Penicillin Vk interactionPentamidinePentam 300
How Pentamidine interacts with Fibermucil — through 1 ingredient. Tap an ingredient for the detail:
Lactobacillus SporogenesAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.
Read the full Lactobacillus Sporogenes + Pentamidine interactionPhenazopyridine, SulfamethizoleThiosulfil-A, Thiosulfil-A Forte
How Phenazopyridine, Sulfamethizole interacts with Fibermucil — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus SporogenesAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.
Read the full Lactobacillus Sporogenes + Phenazopyridine, Sulfamethizole interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Phenazopyridine, Sulfamethizole interactionPhenazopyridine, SulfisoxazoleAzo-Gantrisin
How Phenazopyridine, Sulfisoxazole interacts with Fibermucil — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus SporogenesAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.
Read the full Lactobacillus Sporogenes + Phenazopyridine, Sulfisoxazole interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Phenazopyridine, Sulfisoxazole interactionPiperacillinPipracil
How Piperacillin interacts with Fibermucil — through 1 ingredient. Tap an ingredient for the detail:
Lactobacillus SporogenesAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.
Read the full Lactobacillus Sporogenes + Piperacillin interactionPiperacillin , TazobactamZosyn
How Piperacillin , Tazobactam interacts with Fibermucil — through 1 ingredient. Tap an ingredient for the detail:
Lactobacillus SporogenesAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.
Read the full Lactobacillus Sporogenes + Piperacillin , Tazobactam interactionPivampicillinPondicillin
How Pivampicillin interacts with Fibermucil — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus SporogenesAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.
Read the full Lactobacillus Sporogenes + Pivampicillin interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Pivampicillin interactionPivmecillinamSelexid
How Pivmecillinam interacts with Fibermucil — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus SporogenesAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.
Read the full Lactobacillus Sporogenes + Pivmecillinam interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Pivmecillinam interactionPlazomicin SulfateZemdri
How Plazomicin Sulfate interacts with Fibermucil — through 1 ingredient. Tap an ingredient for the detail:
Lactobacillus SporogenesAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.
Read the full Lactobacillus Sporogenes + Plazomicin Sulfate interactionPretomanidPretomanid
How Pretomanid interacts with Fibermucil — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus SporogenesAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.
Read the full Lactobacillus Sporogenes + Pretomanid interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Pretomanid interactionPyrazinamideTebrazid
How Pyrazinamide interacts with Fibermucil — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus SporogenesAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.
Read the full Lactobacillus Sporogenes + Pyrazinamide interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Pyrazinamide interactionQuinupristin, DalfopristinSynercid
How Quinupristin, Dalfopristin interacts with Fibermucil — through 1 ingredient. Tap an ingredient for the detail:
Lactobacillus SporogenesAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.
Read the full Lactobacillus Sporogenes + Quinupristin, Dalfopristin interactionRetapamulinAltabax, Altargo
How Retapamulin interacts with Fibermucil — through 1 ingredient. Tap an ingredient for the detail:
Lactobacillus SporogenesAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.
Read the full Lactobacillus Sporogenes + Retapamulin interactionRifabutinMycobutin
How Rifabutin interacts with Fibermucil — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus SporogenesAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.
Read the full Lactobacillus Sporogenes + Rifabutin interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Rifabutin interactionRifampinRifadin, Rifadin Injection, Rimactane, Rofactor
How Rifampin interacts with Fibermucil — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus SporogenesAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.
Read the full Lactobacillus Sporogenes + Rifampin interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Rifampin interactionRifamycinAemcolo
How Rifamycin interacts with Fibermucil — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus SporogenesAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.
Read the full Lactobacillus Sporogenes + Rifamycin interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Rifamycin interactionRifapentinePriftin
How Rifapentine interacts with Fibermucil — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus SporogenesAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.
Read the full Lactobacillus Sporogenes + Rifapentine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Rifapentine interactionRifaximinXifaxan
How Rifaximin interacts with Fibermucil — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus SporogenesAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.
Read the full Lactobacillus Sporogenes + Rifaximin interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Rifaximin interactionSaxagliptin, Metformin XrKombiglyze
How Saxagliptin, Metformin Xr interacts with Fibermucil — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs, Metformin (glucophage) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Saxagliptin, Metformin Xr interactionSecnidazoleSolosec
How Secnidazole interacts with Fibermucil — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus SporogenesAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.
Read the full Lactobacillus Sporogenes + Secnidazole interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Secnidazole interactionSitagliptin, MetforminZituvimet
How Sitagliptin, Metformin interacts with Fibermucil — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs, Metformin (glucophage) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Sitagliptin, Metformin interactionSparfloxacinZagam
How Sparfloxacin interacts with Fibermucil — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus SporogenesAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.
Read the full Lactobacillus Sporogenes + Sparfloxacin interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Sparfloxacin interactionSpectinomycinTrobicin
How Spectinomycin interacts with Fibermucil — through 1 ingredient. Tap an ingredient for the detail:
Lactobacillus SporogenesAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.
Read the full Lactobacillus Sporogenes + Spectinomycin interactionStreptomycinStreptomycin
How Streptomycin interacts with Fibermucil — through 1 ingredient. Tap an ingredient for the detail:
Lactobacillus SporogenesAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.
Read the full Lactobacillus Sporogenes + Streptomycin interactionSulbactam, DurlobactamXacduro
How Sulbactam, Durlobactam interacts with Fibermucil — through 1 ingredient. Tap an ingredient for the detail:
Lactobacillus SporogenesAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.
Read the full Lactobacillus Sporogenes + Sulbactam, Durlobactam interactionSulfadiazineSulfadiazine
How Sulfadiazine interacts with Fibermucil — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus SporogenesAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.
Read the full Lactobacillus Sporogenes + Sulfadiazine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Sulfadiazine interactionSulfadiazine, Sulfamerazine, SulfamethazineTerfonyl, Triple Sulfoid
How Sulfadiazine, Sulfamerazine, Sulfamethazine interacts with Fibermucil — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus SporogenesAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.
Read the full Lactobacillus Sporogenes + Sulfadiazine, Sulfamerazine, Sulfamethazine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Sulfadiazine, Sulfamerazine, Sulfamethazine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Fibermucil with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Dietary Fiber
Carbamazepine (Tegretol)
Theoretically, black psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Theoretically, black psyllium might reduce carbamazepine absorption. A preliminary study using blond psyllium reported decreased carbamazepine bioavailability due to binding of the drug to psyllium, as well as reduction of available fluid in the gut for dissolution of the drug. This interaction may also occur with black psyllium.
Lithium
Theoretically, taking black psyllium at the same time as lithium might reduce lithium absorption.
The fiber in black psyllium might reduce lithium absorption and plasma levels. Some case reports describe a reduction in plasma lithium levels with concomitant administration of blond psyllium. This was reversed when psyllium was stopped. This interaction may also occur with black psyllium.
Metformin (Glucophage)
Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Animal research shows that concurrent consumption of blond psyllium with metformin slows and increases the absorption of metformin. This interaction may also occur with black psyllium. To avoid changes in absorption, take psyllium 30-60 minutes after metformin.
Olanzapine (Zyprexa)
Theoretically, taking black psyllium at the same time as olanzapine might reduce olanzapine absorption.
The fiber in black psyllium might decrease the absorption of olanzapine. A single case report describes a reduction in the effectiveness of olanzapine when it was concomitantly administered with an unspecified type of psyllium 3 grams orally twice daily. This effect was reversed when psyllium was stopped.
Digoxin (Lanoxin)
Theoretically, taking black psyllium at the same time as digoxin might reduce digoxin absorption and decrease digoxin levels.
Psyllium might bind digoxin in the gut. However, some clinical evidence suggests that psyllium does not impact digoxin absorption.
Ethinyl Estradiol
Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Concurrent use of blond psyllium with ethinyl estradiol results in a slight increase in the extent of ethinyl estradiol absorption and a slower rate of absorption. This is unlikely to be clinically significant.
Oral Drugs
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol. Case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine. Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin. Although many of these studies evaluated blond psyllium, the fiber content in black psyllium may have similar effects.
Lactobacillus sporogenes
Antibiotic Drugs
Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B. coagulans.
B. coagulans preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. coagulans preparations by at least two hours.
Brand information
Manufacturer and brand details for Fibermucil, from the product label.
ProCaps
See all ProCaps products- Name
- ProCaps Labs
- City
- Henderson
- State
- NV
- ZipCode
- 89011
- Phone Number
- 800.800.1200
- Web Address
- ProCaps.com
Fibermucil by ProCaps: Common Questions
Does Fibermucil by ProCaps interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will this help my constipation?
Can I take this while on antibiotics?
Is this safe if I'm pregnant or breastfeeding?
What's Lactobacillus sporogenes in here?
Are there any side effects I should know about?
Does this have any fillers?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Fibermucil is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Fibermucil’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Black Psyllium
Interacts with 2,025 drugsBlack psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. It is best known and most studied for rel...
Read the full Black Psyllium monograph → Herb & supplement monographBacillus Coagulans
Interacts with 182 drugsBacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, and certain types of diarrhea. The eviden...
Read the full Bacillus Coagulans monograph →Sources & How We Checked
Fibermucil's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 38 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Black Psyllium 18 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
- Etman M. Effect of a bulk forming laxative on the bioavailablility of carbamazepine in man. Drug Dev Ind Pharm 1995;21:1901-6.
- Perlman BB. Interaction between lithium salts and ispaghula husk. Lancet 1990;335:416.
- Vaswani SK, Hamilton RG, Valentine MD, Adkinson NF. Psyllium laxative-induced anaphylaxis, asthma, and rhinitis. Allergy 1996;51:266-8. PubMed
- Lantner RR, Espiritu BR, Zumerchik P, Tobin MC. Anaphylaxis following ingestion of a psyllium-containing cereal. JAMA 1990;264:2534-6. DOI
- Kaplan MJ. Anaphylactic reaction to "Heartwise." N Engl J Med 1990;323:1072-3. DOI
- Nordstrom M, Melander A, Robertsson E, Steen B. Influence of wheat bran and of a bulk-forming ispaghula cathartic on the bioavailability of digoxin in geriatric in-patients. Drug Nutr Interact 1987;5:67-9..
- Robinson DS, Benjamin DM, McCormack JJ. Interaction of warfarin and nonsystemic gastrointestinal drugs. Clin Pharmacol Ther 1971;12:491-5. PubMed
- Garcia JJ, Fernandez N, Diez MJ, et al. Influence of two dietary fibers in the oral bioavailability and other pharmacokinetic parameters of ethinyloestradiol. Contraception 2000;62:253-7. PubMed
- Fernandez N, Lopez C, Díez R, et al. Drug interactions with the dietary fiber Plantago ovata husk. Expert Opin Drug Metab Toxicol 2012;8(11):1377-86.
- Semen plantaginis in: WHO Monographs on Selected Medicinal Plants, volume 1. World Health Organization, Geneva, 1999. Available at http://apps.who.int/medicinedocs/en/d/Js2200e/. Accessed November 26, 1026.
- Code of Federal Regulations, Title 21 (21CFR 101.17). Food labeling warning, notice, and safe handling statements. Available at www.ecfr.gov/cgi-bin/text-idx?SID=20f647d3b74161501f46564b915b4048&mc=true&node=se21.2.101_117&rgn=div8. Accessed December 3, 2
- Code of Federal Regulations, Title 21 (21CFR 201.319). Specific labeling requirements - water-soluble gums, hydrophilic gums, and hydrophilic mucilloids. Available at www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=201.319. Accessed Dece
- Diez R, Garcia JJ, Diez MJ, Sierra M, Sahagun AM, Fernandez N. Influence of Plantago ovata husk (dietary fiber) on the bioavailability and other pharmacokinetic parameters of metformin in diabetic rabbits. BMC Complement Altern Med. 2017 Jun 7;17(1):298. PubMed
- Chiu AC, Sherman SI. Effects of pharmacological fiber supplements on levothyroxine absorption. Thyroid. 1998;8(8):667-71. PubMed
- Merrick C, Madden CA, Capurso NA. A Case of Blunted Orally Disintegrating Olanzapine Effect Due to Coadministered Psyllium. J Clin Psychiatry 2021;82(2):20cr13633. PubMed
Bacillus Coagulans 20 references
- Saxelin M, Chuang NH, Chassy B, et al. Lactobacilli and bacteremia in southern Finland 1989-1992. Clin Infect Dis 1996;22:564-6. PubMed
- Tynkkynen S, Singh KV, Varmanen P. Vancomycin resistance factor of Lactobacillus rhamnosus GG in relation to enterococcal vancomycin resistance (van) genes. Int J Food Microbiol 1998;41:195-204. PubMed
- Klein G, Zill E, Schindler R, et al. Peritonitis associated with vancomycin-resistant Lactobacillus rhamnosus in a continuous ambulatory peritoneal dialysis patient; organism identification, antibiotic therapy, and case report. J Clin Microbiol 1998;36:
- Kalima P, Masterton RG, Roddie PH, et al. Lactobacillus rhamnosus infection in a child following bone marrow transplant. J Infect 1996;32:165-7. PubMed
- Goldin BR. Health Benefits of probiotics. Br J Nutr 1998;80:S203-7. DOI
- Rautio M, Jousimies-Somer H, Kauma H, et al. Liver abscess due to Lactobacillus rhamnosus strain indistinguishable from L. rhamnosus strain GG. Clin Infect Dis 1999;28:1159-60.
- MacGregor G, Smith AJ, Thakker B, Kinsella J. Yoghurt biotherapy: contraindicated in immunosuppressed patients? Postgrad Med J 2002;78:366-7. PubMed
- Land MH, Rouster-Stevens K, Woods CR, et al. Lactobacillus sepsis associated with probiotic therapy. Pediatrics 2005;115:178-81.
- De Groote MA, Frank DN, Dowell E, et al. Lactobacillus rhamnosus GG bacteremia associated with probiotic use in a child with short gut syndrome. Pediatr Infect Dis J 2005;24:278-80. PubMed
- Vahabnezhad E, Mochon AB, Wozniak LJ, Ziring DA. Lactobacillus bacteremia associated with probiotic use in a pediatric patient with ulcerative colitis. J Clin Gastroenterol. 2013;47(5):437-9. PubMed
- Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
- Sendil S, Shrimanker I, Mansoora Q, Goldman J, Nookala VK. Lactobacillus rhamnosus bacteremia in an immunocompromised renal transplant patient. Cureus. 2020;12(2):e6887. PubMed
- Albarillo FS, Shah U, Joyce C, Slade D. Lactobacillus rhamnosus Infection: A single-center 4-year descriptive analysis. J Glob Infect Dis. 2020;12(3):119-123. PubMed
- Pasala S, Singer L, Arshad T, Roach K. Lactobacillus endocarditis in a healthy patient with probiotic use. IDCases. 2020;22:e00915. PubMed
- Agrawal S, Tuchman ES, Bruce MJ, Theodorou ME. Fatal Lactobacillus endocarditis in a patient with transcatheter aortic valve replacement. BMJ Case Rep. 2020;13(11):e236835.
- Antoun M, Hattab Y, Akhrass FA, Hamilton LD. Uncommon pathogen, Lactobacillus, causing infective endocarditis: Case report and review. Case Rep Infect Dis. 2020;2020:8833948. PubMed
- Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
- Franko B, Vaillant M, Recule C, Vautrin E, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics. Med Mal Infect. 2013;43(4):171-3. PubMed
- Campbell RE, Miller A, Afroze A. Native valve endocarditis secondary to Lactobacillus paracasei bacteremia. Consultant. 2020;60(9):27-8. DOI
- Kato K, Funabashi N, Takaoka H, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics with advanced and severe bicuspid aortic valve stenosis complicated with diffuse left ventricular mid-layer fibrosis. Int J Cardiol. 2016;224:157-161. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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