Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

FishSmart Ultra Ingredients & Drug Interactions

by Renew Life

FishSmart Ultra label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking FishSmart Ultra against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

FishSmart Ultra is a dietary supplement by Renew Life with 3 active ingredients. Its ingredients are commonly taken for digestive support, bloating and gas, fat digestion.Based on those ingredients, 1,054 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Peppermint Oil, Omega-3 Fatty Acids. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against FishSmart Ultra by Renew Life

Ask about any prescription or over-the-counter medication and we check it for interactions with FishSmart Ultra by Renew Life — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of FishSmart Ultra by Renew Life

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • “Omega-3 Fatty Acids” is listed as a grouped ingredient — the label gives one combined amount (650 mg) without saying how much of each component you get.

FishSmart Ultra contains five active ingredients: two omega-3 fatty acids (eicosapentaenoic acid and docosahexaenoic acid), other omega-3 fatty acids, lipase (a digestive enzyme), and peppermint oil. The product is delivered in a softgel capsule with inactive ingredients including gelatin, glycerin, beeswax, lecithin, purified water, natural caramel color, and an enteric coating — a delayed-release shell designed to help the contents reach your intestines rather than break down in your stomach.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Fish oil supplement with digestive support.
  • We looked for evidence on: Dyspepsia, Irritable bowel syndrome (IBS), Abdominal pain, Indigestion, Bloating.
  • The strongest evidence on file: Peppermint is rated "Likely Effective" for Irritable bowel syndrome (IBS) (Natural Medicines).
  • Also on file: Peppermint is rated "Possibly Effective" for Dyspepsia.
  • Also on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia.

Peppermint oil in this product is likely effective for irritable bowel syndrome (IBS) and possibly effective for indigestion (dyspepsia), nausea from chemotherapy, spasm during barium enema procedures, and side effects from endoscopy. The evidence for lipase on digestive issues and premature infant health is currently insufficient to rate.

We hold no effectiveness data on the omega-3 fatty acids in this product.

The evidence, ingredient by ingredient Lipase Peppermint Docosahexaenoic Acid (dha)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Peppermint oil is generally well tolerated when taken by mouth, though some people report abdominal pain, anal burning, belching, diarrhea, dry mouth, heartburn, nausea, or vomiting. Rare allergic reactions including anaphylaxis have been reported.

Lipase has no reported adverse effects in adults, though safety data is limited and it should be used only under medical guidance in people with serious digestive conditions. For pregnancy and breastfeeding: peppermint oil is likely safe, but there is little safety data on supplemental lipase in pregnancy or while breastfeeding — talk with your doctor or pharmacist before use in either case.

Side effects, ingredient by ingredient Lipase Peppermint Docosahexaenoic Acid (dha)

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Peppermint.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs.
  • For scale: 797 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking FishSmart Ultra, check with your doctor or pharmacist if you take medications broken down by liver enzymes CYP3A4, CYP2C9, or CYP2C19 (including blood pressure drugs and many others), cyclosporine, or drugs processed by the CYP1A2 enzyme. Peppermint oil can theoretically raise their blood levels, though most interactions are not yet proven in humans.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

FishSmart Ultra's omega-3s and enzymes may help with digestion and IBS-related symptoms, but the peppermint oil interacts with liver enzymes that metabolize many common medications. Before you start, check your exact prescriptions against the medication checker on this page, and talk with your doctor or pharmacist — especially if you take blood pressure drugs, immunosuppressants, or any medication metabolized by your liver.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about FishSmart Ultra, straight from the product label.

Brand Renew Life
Barcode (UPC) 631257535054
Net contents 45 Enteric Coated Softgel(s)
Market status On market
Date entered into DSLD Mar 24, 2017
DSLD ID 71503
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for FishSmart Ultra by Renew Life, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
3 Softgel(s)
Servings per container
45
UPC/BARCODE
631257535054
IngredientAmount% DV
Calories11 Calorie(s), 33 Calorie(s)--
Calories from Fat9 Calorie(s), 27 Calorie(s)--
Eicosapentaenoic Acid300 mg, 900 mg--
Docosahexaenoic Acid200 mg, 600 mg--
Saturated Fat0.1 Gram(s), 0.3 Gram(s)2%
Trans Fat0 Gram(s), 0 Gram(s)--
Total Fat1 Gram(s), 3 Gram(s)5%
Lipase24 mg, 72 mg--
Other Omega-3 Fatty Acids150 mg, 450 mg--
Peppermint Oil22 mg, 66 mg--
Omega-3 Fatty Acids650 mg, 1950 mg--

Other ingredients: Gelatin, Glycerin, Beeswax, Lecithin, purified Water, natural Caramel color, Enteric Coating

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

FishSmart Ultra is an ultra-concentrated daily fish oil supplement ideal for those with difficult digestion.

Purified and third-party tested to exceed all published U.S. and international standards for PCBs, pesticides, heavy metals and dioxins.

Quality and purity guaranteed

Manufactured in a GMP facility

3X more omega-3 absorption Relieves digestive discomfort Supports heart & joint health

Serving size: 1 to 3 softgels Servings per container: 15 to 45

1,000 mg

Made in USA

Enteric-coated controlled release

FishSMART Ultra: ~ Targeted release ~ No aftertaste ~ Lipase aids digestion Typical uncoated fish oils: ~ Poor breakdown ~ Gastrointestinal discomfort ~ Fishy “repeat” Non-coated capsule dissolves in stomach causing fishy after-taste and poor absorption Lipase Fat-splitting Enzyme Enhances the digestion and absorption of Omega-3 oils FishSMART Ultra: Oil droplets in bile 3 minutes after adding lipase enzyme 1 enteric-coated softgel = 3 uncoated softgels

Enteric-coated Less burping

The total-body benefits of omega-3s Clinical studies indicate that a diet rich in Omega-3 oils provides numerous health benets for the whole body. Fish-derived Omega-3s have been shown to support heart health and immunity, as well as healthy skin and joints and improved mood.

Peppermint oil for enhanced digestion Peppermint oil is a powerful natural digestive aid ideal for those with digestive issues.

Its soothing properties help relax the muscles of the stomach and colon and may help relieve occasional irritable bowel, diarrhea, abdominal cramping and flatulence.

Ultimate purity and potency

Sourced from smaller species of wild, cold-water fish, the omega oils in FishSMART Ultra undergo a minimum of three purification steps to ensure high concentration and freedom from any contaminants.

How does FishSMART Ultra deliver 3x better absorption?

#15543 0511

Formula

Enteric-coated softgels and lipase guarantee 3X more Omega-3 absorption, and added peppermint oil stimulates digestion and helps relieve intestinal discomfort.*

The omega-3 oil for digestive issues

Fish oil with peppermint oil Ultra-concentrated omega-3

Contains: Non-GMO soy

FishSMART Ultra enteric-coated capsules contain peppermint oil and lipase, which aid in digestion and also help reduce fishy aftertaste.

Lipase-enhanced digestion FishSMART Ultra is enhanced with plant-derived lipase, the fat-splitting enzyme, to aid in omega-3 digestion and absorption. Lipase helps break down the fats and prevent fishy burps or aftertaste.

The peppermint oil in FishSMART Ultra stimulates the flow of digestive fluids and helps relieve occasional gas, bloating, nausea and indigestion.

FishSMART Ultra provides superior-quality, purified fish oil rich in Omega-3 DHA and EPA.

Formulation

Contains no GMOs, gluten, yeast, sugar, salt, dairy, eggs, nuts, wheat, corn, binders, preservatives or artificial ingredients.

Storage

Store in a dry place at 59-86(0)F (15-30(0)C).

Precautions

Keep out of reach of children.

Warning: Consult your physician before using this or any product if you are pregnant, nursing, trying to conceive, taking medication or have a medical condition.

Tamper Evident: Do not use if safety seal is broken or missing.

Contains: Non-GMO soy

General

0511

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Purity Potency Guaranteed

Suggested/Recommended/Usage/Directions

Once-daily potency

Directions: Take 1 softgel daily. To maximize your intake of Omega-3, take 3 softgels daily.

Once-daily convenience FishSMART Ultra is more concentrated than other fish oil blends, which means you get all the benefits of the 1,000 mg powerful omega-3 formula in just one daily softgel.

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Renew Life The digestive care company

Ultragest Technology

Our Ultragest enteric coating means more omega-3 oils are delivered directly to the intestines. This targeted release ensures superior absorption with less of the fishy repeat, aftertaste or odor typical with uncoated fish oils.

Ultragest Enteric Coating Oils are delivered directly to the intestines for superior absorption

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

FishSmart Ultra by Renew Life label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

FishSmart Ultra label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in FishSmart Ultra by Renew Life

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container45 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Lipase

No known
interactions
24 mg per serving

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy fo...

Lipase monograph & interactions

Peppermint Oil

Interacts with
796 drugs
22 mg per serving

Peppermint is a popular herb with the best evidence supporting enteric-coated peppermint oil for easing IBS symptoms. It is generally well tolerated f...

Peppermint Oil monograph & interactions

Omega-3 Fatty Acids

Interacts with
375 drugs
650 mg per serving Form: Fish Oil

DHA is an omega-3 fatty acid found in fatty fish and algae that is a building block for the brain, nervous system, and eyes. It is widely used and gen...

Omega-3 Fatty Acids monograph & interactions
  • › Eicosapentaenoic Acid
  • › Docosahexaenoic Acid
  • › Other Omega-3 Fatty Acids

Other (inactive) ingredients: Gelatin, Glycerin, Beeswax, Lecithin, Purified Water, Natural Caramel color, Enteric Coating. These complete the product’s ingredient list but are not active constituents.

Interaction report

FishSmart Ultra by Renew Life Drug Interactions

Want to check YOUR meds against FishSmart Ultra?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,054Drugs
992 Moderate 62 Minor

Ingredients driving the most interactions

Peppermint Oil 796
Omega-3 Fatty Acids 375

Individual Drug Interactions

The ingredients in FishSmart Ultra interact with 1,054 drugs. Click any drug to see the details.

2 of the 3 ingredients in FishSmart Ultra interact with drugs. Each result below shows which ingredient is responsible. Peppermint Oil Omega-3 Fatty Acids

Each ingredient & the kinds of drugs it affects

For each ingredient in FishSmart Ultra with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Peppermint Oil5 drug types · 796 drugs

Cyclosporine (Neoral, Sandimmune)

Theoretically, peppermint oil might increase the levels and adverse effects of cyclosporine.
In animal research, peppermint oil inhibits cyclosporine metabolism and increases cyclosporine levels. Inhibition of cytochrome P450 3A4 (CYP3A4) may be partially responsible for this interaction. An interaction between peppermint oil and cyclosporine has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, peppermint might increase the levels of CYP2C19 substrates.
In vitro research shows that peppermint oil inhibits CYP2C19. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, peppermint might increase the levels of CYP2C9 substrates.
In vitro research shows that peppermint oil inhibits CYP2C9. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Clinical research in healthy volunteers shows that a single dose of peppermint oil 600 mg inhibits CYP3A4 enzymes and increases the AUC of felodipine, a CYP3A4 substrate. However, in vitro research suggests that peppermint oil only inhibits CYP3A4 at very high concentrations.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, peppermint might increase the levels of CYP1A2 substrates.
In vitro and animal research shows that peppermint oil and peppermint leaf inhibit CYP1A2. However, in clinical research, peppermint tea did not significantly affect the metabolism of caffeine, a CYP1A2 substrate. It is possible that the 6-day duration of treatment may have been too short to identify a difference.

Likelihood Possible Evidence B
Peppermint Oil full monograph & interactions

Omega-3 Fatty Acids3 drug types · 375 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, DHA may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Although some clinical evidence suggests that DHA might reduce collagen-stimulated platelet aggregation and thromboxane release, most clinical evidence suggests that DHA alone does not affect blood clotting. However, theoretically, when given in combination with EPA as fish oil, concomitant use with anticoagulant or antiplatelet drugs (including aspirin) might increase risk of bleeding.

Likelihood Unlikely Evidence B
Antidiabetes Drugs

Theoretically, taking DHA with antidiabetes drugs might reduce the effects of these medications.
In people with type 2 diabetes, including those taking oral hypoglycemic medications, DHA seems to increase fasting blood glucose levels.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking DHA with antihypertensive drugs might increase the risk of hypotension.
Fish oils containing DHA can lower blood pressure and might have additive effects in patients treated with antihypertensives; use with caution.

Likelihood Probable Evidence B
Omega-3 Fatty Acids full monograph & interactions
The maker

Brand information

Manufacturer and brand details for FishSmart Ultra, from the product label.

Renew Life

Name
ReNew Life Formulas
City
Palm Harbor
State
FL
ZipCode
34683
Phone Number
1-800-830-1800
Web Address
www.renewlife.com
Pharmacist Counseling Corner

FishSmart Ultra by Renew Life: Common Questions

Does FishSmart Ultra by Renew Life interact with any medications?
Yes. Based on its ingredients, FishSmart Ultra has a known interaction with 1,054 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
FishSmart Ultra contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my IBS?
Peppermint oil in this product is likely effective for IBS, so it may help. Talk with your doctor about whether it's right for your particular symptoms.
Is it safe to take while pregnant?
Peppermint oil itself is likely safe in pregnancy, but there is little safety data on supplemental lipase during pregnancy. Check with your doctor or pharmacist before you start.
What are the omega-3s for?
Eicosapentaenoic acid and docosahexaenoic acid are omega-3 fatty acids that support heart and brain health, though we hold no effectiveness data specific to this product's dose.
Can I take this if I have a sensitive stomach?
Peppermint oil can cause abdominal pain, heartburn, or nausea in some people, and lipase should be used only under medical guidance if you have serious digestive conditions. Talk with your doctor first.
What's the enteric coating for?
The enteric coating is a delayed-release shell that protects the contents from stomach acid so they reach your intestines intact, where they're absorbed more effectively.
Is this safe while breastfeeding?
Peppermint oil is likely safe while breastfeeding, but safety data on supplemental lipase during breastfeeding is limited. Check with your healthcare provider first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if FishSmart Ultra is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

FishSmart Ultra label
Go deeper

The Full Monographs Behind FishSmart Ultra’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph → Herb & supplement monograph

Peppermint

Interacts with 796 drugs

Peppermint is a popular herb with the best evidence supporting enteric-coated peppermint oil for easing IBS symptoms. It is generally well tolerated for most adults, but it can cause heartbu...

Read the full Peppermint monograph → Herb & supplement monograph

Docosahexaenoic Acid (dha)

Interacts with 375 drugs

DHA is an omega-3 fatty acid found in fatty fish and algae that is a building block for the brain, nervous system, and eyes. It is widely used and generally well tolerated, with the stronges...

Read the full Docosahexaenoic Acid (dha) monograph →
Sources

Sources & How We Checked

FishSmart Ultra's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 91 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Peppermint 41 references
  1. Liu JH, Chen GH, Yeh HZ, et al. Enteric-coated peppermint-oil capsules in the treatment of irritable bowel syndrome: a prospective, randomized trial. J Gastroenterol 1997;32:765-8. PubMed
  2. Pittler MH, Ernst E. Peppermint oil for irritable bowel syndrome: a critical review and metaanalysis. Am J Gastroenterol 1998;93:1131-5. PubMed
  3. Kline RM, Kline JJ, Di Palma J, Barbero GJ. Enteric-coated, pH-dependent peppermint oil capsules for the treatment of irritable bowel syndrome in children. J Pediatr 2001;138:125-8. PubMed
  4. Madisch A, Heydenreich CJ, Wieland V, et al. Treatment of functional dyspepsia with a fixed peppermint oil and caraway oil combination preparation as compared to cisapride. A multicenter, reference-controlled, double-blind equivalence study. Arzneimittel
  5. May B, Kuntz HD, Kieser M, Kohler S. Efficacy of a fixed peppermint oil/caraway oil combination in non-ulcer dyspepsia. Arzneimittelforschung 1996;46:1149-53.
  6. Micklefield GH, Greving I, May B. Effects of peppermint oil and caraway oil on gastroduodenal motility. Phytother Res 2000;14:20-3. DOI
  7. Morton CA, Garioch J, Todd P, et al. Contact sensitivity to menthol and peppermint in patients with intra-oral symptoms. Contact Dermatitis 1995;32:281-4. PubMed
  8. May B, Kohler S, Schneider B. Efficacy and tolerability of a fixed combination of peppermint oil and caraway oil in patients suffering from functional dyspepsia. Aliment Pharmacol Ther 2000;14:1671-7. PubMed
  9. Nash P, Gould SR, Bernardo DE. Peppermint oil does not relieve the pain of irritable bowel syndrome. Br J Clin Pract 1986;40:292-3. DOI
  10. Rees WD, Evans BK, Rhodes J. Treating irritable bowel syndrome with peppermint oil. Br Med J 1979;2:835-6. PubMed
  11. Davies SJ, Harding LM, Baranowski AP. A novel treatment of postherpetic neuralgia using peppermint oil. Clin J Pain 2002;18:200-2. PubMed
  12. Weston CF. Anal burning and peppermint oil. Postgrad Med J 1987;63:717. PubMed
  13. Dresser GK, Wacher V, Wong S, et al. Evaluation of peppermint oil and ascorbyl palmitate as inhibitors of cytochrome P4503A4 activity in vitro and in vivo. Clin Pharmacol Ther 2002;72:247-55. PubMed
  14. Wacher VJ, Wong S, Wong HT. Peppermint oil enhances cyclosporine oral bioavailability in rats: comparison with D-alpha-tocopheryl poly(ethylene glycol 1000) succinate (TPGS) and ketoconazole. J Pharm Sci 2002;91:77-90.
  15. Lawson MJ, Knight RE, Tran K, et al. Failure of enteric-coated peppermint oil in the irritable bowel syndrome: a randomized double-blind crossover study. J Gastroenterol Hepatol 1988;3:235-8. DOI
  16. Unger M, Frank A. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Commun Mass Spectrom 2004;1 PubMed
  17. Maliakal PP, Wanwimolruk S. Effect of herbal teas on hepatic drug metabolizing enzymes in rats. J Pharm Pharmacol 2001;53:1323-9. PubMed
  18. Rogers SN, Pahor AL. A form of stomatitis induced by excessive peppermint consumption. Dent Update 1995;22:36-7.
  19. Cappello G, Spezzaferro M, Grossi L, et al. Peppermint oil (Mintoil) in the treatment of irritable bowel syndrome: a prospective double blind placebo-controlled randomized trial. Dig Liver Dis 2007;39:530-6. PubMed
  20. Moghadam BK, Gier R, and Thurlow T. Extensive oral mucosal ulcerations caused by misuse of a commercial mouthwash. Cutis 1999;64:131-134.
  21. Andersen, K. E. Contact allergy to toothpaste flavors. Contact Dermatitis 1978;4(4):195-198. PubMed
  22. Barnard, D. R. Repellency of essential oils to mosquitoes (Diptera: Culicidae). J Med Entomol. 1999;36(5):625-629. PubMed
  23. Tamir, S., Davidovich, Z., Attal, P., and Eliashar, R. Peppermint oil chemical burn. Otolaryngol.Head Neck Surg. 2005;133(5):801-802. PubMed
  24. Kalavala, M., Hughes, T. M., Goodwin, R. G., Anstey, A. V., and Stone, N. M. Allergic contact dermatitis to peppermint foot spray. Contact Dermatitis 2007;57(1):57-58. PubMed
  25. Vermaat, H., van Meurs, T., Rustemeyer, T., Bruynzeel, D. P., and Kirtschig, G. Vulval allergic contact dermatitis due to peppermint oil in herbal tea. Contact Dermatitis 2008;58(6):364-365. PubMed
  26. Merat, S., Khalili, S., Mostajabi, P., Ghorbani, A., Ansari, R., and Malekzadeh, R. The effect of enteric-coated, delayed-release peppermint oil on irritable bowel syndrome. Dig.Dis.Sci. 2010;55(5):1385-1390. PubMed
  27. Tran, A., Pratt, M., and DeKoven, J. Acute allergic contact dermatitis of the lips from peppermint oil in a lip balm. Dermatitis 2010;21(2):111-115. DOI
  28. Hitz, Lindenmuller, I and Lambrecht, J. T. Oral care. Curr Probl.Dermatol 2011;40:107-115.
  29. Shavakhi, A., Ardestani, S. K., Taki, M., Goli, M., and Keshteli, A. H. Premedication with peppermint oil capsules in colonoscopy: a double blind placebo-controlled randomized trial study. Acta Gastroenterol Belg 2012;75(3):349-353.
  30. Lech, Y., Olesen, K. M., Hey, H., Rask-Pedersen, E., Vilien, M., and Ostergaard, O. [Treatment of irritable bowel syndrome with peppermint oil. A double- blind study with a placebo]. Ugeskr.Laeger 10-3-1988;150(40):2388-2389.
  31. Parys, B. T. Chemical burns resulting from contact with peppermint oil mar: a case report. Burns Incl.Therm.Inj. 1983;9(5):374-375. PubMed
  32. Bayat R, Borici-Mazi R. A case of anaphylaxis to peppermint. Allergy Asthma Clin Immunol. 2014;10(1):6. PubMed
  33. Rich G, Shah A, Koloski N, et al. A randomized placebo-controlled trial on the effects of Menthacarin, a proprietary peppermint- and caraway-oil-preparation, on symptoms and quality of life in patients with functional dyspepsia. Neurogastroenterol Motil 2 PubMed
  34. Douros A, Bronder E, Andersohn F, et al. Herb-Induced Liver Injury in the Berlin Case-Control Surveillance Study. Int J Mol Sci 2016;17(1). PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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